Herbicidal pyrazole derivatives

ABSTRACT

A pyrazole derivative having the formula: ##STR1## where A, B, X, Y, Z and Q are described below.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to novel 4-benzoylpyrazole derivatives and selective herbicides containing such derivatives as active ingredients, which are useful particularly as upland field herbicides.

2. Discussion of Background

Various herbicides have been developed for practical use from extensive research and development of herbicides for many years, and such herbicides have contributed to a reduction of the labor force required for controlling weeds or to improvement of the productivity of agricultural or horticultural plants.

Even now, it is still desired to develop a new herbicide having superior herbicidal properties. In particular, it is desired to develop an agricultural or horticultural herbicide which is capable of selectively controlling weeds without adversely affecting the crop plant and at a low dose. However, conventional herbicides do not necessarily provide such desired herbicidal properties.

On the other hand, certain compounds of 4-benzoylpyrazole derivatives are known to have herbicidal activities. For example, pyrazolate (common name) and pyrazoxyfen (common name) are practically used as herbicides for paddy fields. While exhibiting excellent herbicidal activities as paddy field herbicides, these compounds are not suitable as upland herbicides since their herbicidal activities are weak against weeds of upland fields. Among 4-benzoylpyrazole derivatives, it is desired to develop a superior compound useful as an upland field herbicide.

SUMMARY OF THE INVENTION

The present invention provides a pyrazole derivative having the formula: ##STR2## wherein A is an alkyl group having from 1 to 3 carbon atoms, an alkenyl group having from 2 to 4 carbon atoms or an alkynyl group having from 2 to 4 carbon atoms; B is a hydrogen atom, an alkyl group having from 1 to 3 carbon atoms, a halogen atom, a haloalkyl group having from 1 to 3 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, an alkylthio group having from 1 to 3 carbon atoms, an alkoxyalkyl group having from 2 to 4 carbon atoms, an alkylthioalkyl group having from 2 to 4 carbon atoms or an alkoxycarbonyl group having from 2 to 4 carbon atoms; X is an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, a cyano group, a haloalkyl group having from 1 to 6 carbon atoms, an alkoxyalkyl group having from 2 to 6 carbon atoms, an alkylcarbonyl group having from 2 to 6 carbon atoms, an alkoxycarbonyl group having from 2 to 6 carbon atoms, an aminocarbonyl group substituted independently by hydrogen or alkyl having from 1 to 6 carbon atoms, a haloalkoxy group having from 1 to 6 carbon atoms, an alkylthio group having from 1 to 6 carbon atoms or an alkylthioalkyl group having from 2 to 6 carbon atoms; Y is a --COOR1 group (wherein R1 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a cycloalkylalkyl group having from 4 to 8 carbon atoms, an alkynyl group having from 3 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, a halocycloalkyl group having from 3 to 8 carbon atoms, a haloalkynyl group having from 3 to 6 carbon atoms, a haloalkenyl group having from 2 to 6 carbon atoms or a phenyl group which may be substituted by alkyl having from 1 to 3 carbon atoms, halogen, nitro or alkoxy having from 1 to 3 carbon atoms), a --COO--L--OR1 group (wherein L is an alkylene group having from 1 to 6 carbon atoms which may be substituted by alkyl having from 1 to 3 carbon atoms, and R1 is as defined above), a --COO--L--R2 group (wherein L is as defined above, and R2 is a phenyl group which may be substituted by alkyl having from 1 to 3 carbon atoms, halogen, nitro or alkoxy having from 1 to 3 carbon atoms), a --COO--M group (wherein M is a 3 to 6-membered alicyclic residue containing not more than 2 sulfur or oxygen atoms and formed by a linkage of from 1 to 4 carbon atoms), a --COO--L--M group (wherein L and M are as defined above), a COO--L--O--L--R2 group (wherein L and R2 are as defined above), a --COO--L--S(O)_(n) --R1 group (wherein L and R1 are as defined above, and n is an integer of from 0 to 2), a --CON(R3)(R4) group (wherein each of R3 and R4 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a cycloalkylalkyl group having from 4 to 8 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an alkynyl group having from 2 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, a halocycloalkyl group having from 3 to 8 carbon atoms, a haloalkynyl group having from 2 to 6 carbon atoms, a haloalkenyl group having from 2 to 6 carbon atoms or a phenyl group which may be substituted by alkyl having from 1 to 3 carbon atoms, halogen, nitro or alkoxy having from 1 to 3 carbon atoms), a --CON--(CH₂)_(n) group (wherein n is an integer of from 4 to 6), a ##STR3## group (wherein R5 is an alkyl group having from 1 to 3 carbon atoms), a ##STR4## group, a --CONHSO₂ CH₃ group, a --CONHSO₂ CF₃ group, a --COO--L--N(R3)(R4) group (wherein L, R3 and R4 are as defined above), a --COO--L--CO--R1 group (wherein L and R1 are as defined above), a --COO--L--CO--O--R1 group (wherein L and R1 are as defined above), a --COO--L--CN group (wherein L is as defined above), a --COO--L--NO₂ group (wherein L is as defined above), a --COOSi(R5)₃ group (wherein R5 is as defined above), a --COO--N═C(R6)(R7) group (wherein each of R6 and R7 which may be the same or different is an alkyl group having from 1 to 3 carbon atoms), a --COO--N═C--(CH₂)_(n) group (wherein n is an integer of from 4 to 6), a --COO--L--O--SO₂ --R1 group (wherein L and R1 are as defined above), a --COO--L--O--CO--R1 group (wherein L and R1 are as defined above), a --COO--L--O--L--O--R1 group (wherein L and R1 are as defined above), a --COO--L--Si(R5)₃ group (wherein L and R5 are as defined above), a --C(O)S--R1 group (wherein R1 is as defined above), a --C(S)O--R1 group (wherein R1 is as defined above), a --C(S)S--R1 group (wherein R1 is as defined above), a --L--O--R1 (wherein L and R1 are as defined above), a --L--O--L--O--R8 group (wherein L is as defined above, and R8 is a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms), a --L--O--M group (wherein L and M are as defined above), a --L--O--L--M group (wherein L and M are as defined above), a --L--NR8R9 group (wherein R8 is as defined above, and R9 is an alkyl group having from 1 to 6 carbon atoms), a --L--O--CH₂ Ph group (wherein L is as defined above), --L--O--L--COOR9 group (wherein L and R9 are as defined above), a --L--CN group (wherein L is as defined above), a --L--S(O)_(n) --R1 group (wherein L and R1 are as defined above, and n is an integer of from 0 to 2), a --L--S--L--O--R9 group (wherein L and R9 are as defined above), a --L--O--COR9 group (wherein L and R9 are as defined above), a L--O--SO₂ R9 group (wherein L and R9 are as defined above) or a --L--O--L--CN group (wherein L is as defined above); Z is a halogen atom, a nitro group, an alkoxy group having from 1 to 3 carbon atoms, a trifluoromethyl group, a cyano group or a --S(O)_(n) R10 group (wherein R10 is an alkyl group having from 1 to 3 carbon atoms or a haloalkyl group having from 1 to 3 carbon atoms, and n is an integer of from 0 to 2); Q is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted by halogen, an alkenyl group having from 1 to 6 carbon atoms which may be substituted by halogen, an alkynyl group having from 1 to 6 carbon atoms which may be substituted by halogen, a cyanomethyl group, a --C(O)--R11 group (wherein R11 is a phenyl group which may be substituted by the same or different substituents selected from the group consisting of alkyl having from 1 to 6 carbon atoms, alkenyl having from 1 to 6 carbon atoms, alkynyl having from 1 to 6 carbon atoms, haloalkyl having from 1 to 6 carbon atoms, haloalkenyl having from 1 to 6 carbon atoms, haloalkynyl having from 1 to 6 carbon atoms, halogen, nitro and trifluoromethyl, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms or a hydroxyl group), a --S(O)₂ R11 group (wherein R11 is as defined above), a --P(O)(OR11)₂ group (wherein R11 is as defined above), a --L--C(O)--R11 group (wherein L and R11 are as defined above), a --L--C(O)--N(R12)(R13) (wherein L is as defined above, each of R12 and R13 is a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms), a --L--R14 group (wherein L is as defined above, R14 is a phenyl group which may be substituted by the same or different substituents selected from the group consisting of halogen, nitro and trifluoromethyl, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms or a hydroxy group), a --L--N(R12)(R13) group (wherein L, R12 and R13 are as defined above), a --L--OR15 group (wherein R15 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an alkenyl group having from 1 to 6 carbon atoms), a --L--OC(O)R16 group (wherein R16 is an alkyl group having from 1 to 6 carbon atoms or an alkoxy group having from 1 to 6 carbon atoms), a --L--S(O)_(n) R15 group (wherein R15 is as defined above, and n is an integer of 0 or 2), a --L--SC(O)R12 group (wherein R12 is as defined above), ##STR5## group (wherein each of L1 and L2 is a methylene group, an oxygen atom or a sulfur atom, R16 is a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms, and n is an integer of 2 or 3), and a salt thereof.

The present invention also provides a selective herbicidal composition comprising a herbicidally effective amount of at least one pyrazole derivative of the formula I as defined above or its salt and an agricultural carrier or diluent.

Further, the present invention provides a method for selectively controlling weeds, which comprises applying the pyrazole derivative of the formula I as defined above or its salt to the locus to be protected.

Now, the present invention will be described in detail with reference to the preferred embodiments.

In the compound of the formula I of the present invention, A, B, X, Y, Z and Q are preferably selected from the following substituents, respectively:

A: Me, Et, n-Pr, i-Pr, CH₂ CH═CH₂, CH₂ C.tbd.CH

B: H, Me, Et, n-Pr, i-Pr, Cl, Br, CH₂ Cl, CF₃, OMe, OEt, OPr-i, SMe, CH₂ OMe, CH₂ SMe, CO₂ Me, CO₂ Et

X: Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, OMe, OEt, OPr-n, OPr-i, OBu-n, OBu-i, OBu-s, OBu-t, F, Cl, Br, I, NO₂, CN, CH₂ F, CHF₂, CF₃, CH₂ CF₃, CH₂ Cl, CCl₃, CHClMe, CH₂ CH₂ Cl, CHClCH₂ Cl, CH₂ Br, CHBrMe, CH₂ CH₂ Br, CH₂ OMe, CH₂ OEt, CH₂ OPr-n, CH₂ OPr-i, CH₂ OBu-n, CH₂ OBu-i, CH₂ OBu-s, CH₂ OBu-t, CHMeOMe, CHMeOEt, CHMeOPr-n, CHMeOPr-i, CHMeOBu-n, CHMeOBu-i, CHMeOBu-s, CHMeObu-t, CH₂ CH₂ OMe, CH₂ CH₂ OEt, CH₂ CH₂ OPr-i, Ac, COEt, COPr-n, COPr-i, COOMe, COOEt, COOPr-i, CONHMe, CONHEt, CONMe₂, CONEt₂, CONEtMe, OCHF₂, OCF₃, OCH₂ CF₃, SMe, SEt, CH₂ SMe, CH₂ SEt, CHMeSMe, CHMeSEt

Y: CH₂ OH, CH₂ OMe, CH₂ OEt, CH₂ OPr-n, CH₂ OPr-i, CH₂ OBu-n, CH₂ OBu-i, CH₂ OBu-s, CH₂ OBu-t, CH₂ OAm-n, CH₂ OAm-i, CH₂ OAm-t, CH₂ OC₆ H₁₃ -n, ##STR6## CH₂ OCH═CH₂, CH₂ OCH₂ CH═CH₂, CH₂ OCH₂ CMe═CH₂, CH₂ OCHMeCH═CH₂, CH₂ OCH₂ C.tbd.CH, CH₂ OCHMeC.tbd.CH, CH₂ OCMe₂ C.tbd.CH, CH₂ OCH₂ CH₂ F, CH₂ OCH₂ CF₃, CH₂ OCH₂ CH₂ Cl, CH₂ OCH₂ Cl₃, CH₂ OCH₂ CH₂ Br, ##STR7## CH₂ OCH₂ CCl═CH₂, CH₂ OCH₂ CCl═CHCl, CH₂ OCH₂ CH₂ OMe, CH₂ OCH₂ CH₂ OEt, CH₂ OCH₂ CH₂ OPr-i, ##STR8## CH₂ OPh, CH₂ OPh-Cl-4, CH₂ OPh-NO₁ -4, CH₂ NHMe, CH₂ NHEt, CH₂ NMe₂, CH₂ NEt₂, CH₂ NEtMe, CH₂ OCH₂ Ph, CH₂ OCH₂ COOMe, CH₂ OCH₂ COOEt, CH₂ OCHMeCOOMe, CH₂ OCH₂ COOBu-t CH₂ OCHMeCOOEt, CH₂ CN, CH₂ SMe, CH₂ SEt, CH₂ SPr-n, CH₂ SPr-i, CH₂ SBn-t, CH₂ SCH₂ CH═CH₂, CH₂ SCH₂ C.tbd.CH, ##STR9## CH₂ SCH₂ CH₂ Cl, CH₂ SOMe, CH₂ SOEt, CH₂ SO₂ Me, CH₂ SO₂ Et, CH₂ SO₂ Pr-n, CH₂ SO₂ Pr-i, CH₂ SCH₂ CH₂ OMe, CH₂ SCH₂ CH₂ OEt, CH₂ SPh, CH₂ OAc, CH₂ OCOEt, CH₂ OCOPr-i, CH₂ OSO₂ Me, CH₂ OSO₂ Et, CH₂ OCH₂ CH₂ CN, CHMeOH, CHMeOMe, CHMeOEt, CHMeOPr-n, CHMeOPr-i, CHMeOBu-n, CHMeOBu-i, CHMeOBu-s, CHMeOBu-t, ##STR10## CHMeOCH═CH₂, CHMeOCH₂ CH═CH₂, CHMeOCH₂ C.tbd.CH, CHMeOCH₂ CF₃, CHMeOCH₂ CH₂ Cl, CHMeOCH₂ CCl₃, CHMeOCH₂ CH₂ Br, ##STR11## CHMeOCH₂ CH₂ OMe, CHMeOCH₂ CH₂ Et, ##STR12## CHMeOPh, CHMeNHMe, CHMeNMe₂, CHMeNEt₂, CHMeOCH₂ COOMe, CHMeOCH₂ COOEt, CHMeOCHMeCOOMe, CHMeCN, CHMeSMe, CHMeSEt, CHMeSPr-n, CHMeSPr-i, CHMeSCH₂ CH═CH₂, CHMeSCH₂ C.tbd.CH, ##STR13## CHMeSCH₂ CH₂ Cl, CHMeSOMe, CHMeSOEt, CHMeSO₂ Me, CHMeSO₂ Et, CHMeSO₂ Pr-i, CHMeSCH₂ CH₂ OMe CHMeSPh, CHMeOAc, CHMeOCOEt, CHMeOSO₂ Me, CHMeOSO₂ Et, CHMeOCH₂ CH₂ CN, CMe₂ OH, CMe₂ OMe, CMe₂ OEt, CMe₂ OPr-n, CMe₂ OPr-i, CMe₂ OCH═CH₂, CMe₂ OCH₂ CH═CH₂, CMe₂ OCH₂ C.tbd.CH, CMe₂ OCH₂ CH₂ Cl, CMe₂ OCH₂ CH₂ OMe, ##STR14## CMe₂ NHMe, CMe₂ NMe₂, CMe₂ OCH₂ COOMe, CMe₂ CN, CMe₂ SMe, CMe₂ SEt, CMe₂ SO₂ Me, CMe₂ SO₂ Et, CMe₂ OAc, CMe₂ OSO₂ Me, COOH, COOMe, COOEt, COOPr-n, COOPr-i, COOBu-n, COOBu-s, COOBu-i, COOBu-t, COOAm-i, ##STR15## COOCH₂ CH═CH₂, COOCH₂ C.tbd.CH, COOCH₂ CMe═CH₂, COOCH₂ CH₂ Br, COOCH₂ CH₂ Cl COOCH₂ CH₂ F, COOCH₂ CCl₃, COOCH₂ CHF₂, COOCH₂ CF₃, ##STR16## COOCH₂ CCl═CH₂, COOCH₂ CCl═CHCl, COOCH₂ OMe, COOCH₂ CH₂ OMe, COOCH₂ CH₂ OEt, COOCH₂ OEt, COOCH₂ SMe COOCH₂ CH₂ SMe, COOCH₂ CH₂ SEt, COOCH₂ CH₂ SCH₂ CH₂ Cl, COOCH₂ SOMe, COOCH₂ CH₂ SOMe COOCH₂ CH₂ OCH₂ CH₂ Cl, COOCH₂ CH₂ OCH₂ CH₂ Br, COOCH₂ CH₂ OSO₂ Me, COOCH₂ CH₂ OSO₂ Ph-Me-4, COOCH₂ OCH₂ CH₂ OMe, COOCH₂ CH₂ SO₂ Me, COOCH₂ CH₂ SO₂ Et, COOCH₂ SO₂ Me, COOCH₂ CN, COOCH₂ CH₂ CN, COOCH₂ CH₂ CH₂ CN, COOCH₂ CH₂ NHMe, COOCH₂ CH₂ NMe₂, COOCH₂ NMe₂, COOCH₂ CH₂ NO₂, COOCH₂ CH₂ CH₂ NO₂, COOCH₂ OH, ##STR17## COOCH₂ COMe, COOCH₂ COBu-t, COOCh₂ COPr-i, COOCH₂ COPh, COOCH₂ COOMe, COOCH₂ COOEt, COOCHMeCOOMe, COOCMe₂ OOMe, COOCH₂ CH₂ OCH₂ CH═CH₂, COOCH₂ CH₂ OCH₂ C.tbd.CH, COOCH₂ CH₂ OPh, COOCH₂ OPh, COOCH₂ CH₂ OCH₂ Ph, COOCH₂ SiMe₃, COOSiMe₃, COOSiEt₃, COOPh, COOPh-Cl-4, COOPh-Me-4, COOPh-OMe-4, COOPh-NO₂ -4, COOCH₂ Ph, COOCH₂ Ph-Cl-2, COOCH₂ Ph-Cl-4, COOCHMePh, COOCH₂ CH₂ Ph, ##STR18## C(O)SMe, C(O)SEt, C(O)SPr-i, C(O)SPr-n, C(O)SBu-n, C(O)SBu-t, C(O)SBu-s, C(O)SBu-i, C(S)OMe, C(S)OEt, C(S)OPr-i, C(S)OPr-n, C(S)OBu-n, C(S)OBu-t, C(S)OBu-s, C(S)OBu-i, CSSMe, CSSEt, CSSPr-n, CSSPr-i, CONMe₂, CONHMe, CONEt₂, CONHEt, CONHPr-n, CONHPr-i, CONHBu-t, CONHBu-s, CONHBu-i, CONHBu-n, CONHAm-t, CONPr₂ -i, CONPr₂ -n, CONHPh, CONHPh-Me-4, CONHPh-NO₂ -4, ##STR19## CONMeOMe, CONHCH₂ CH═CH₂, CON(CH₂ CH═CH₂)₂, CONHCH₂ C.tbd.CH, CON(CH₂ C.tbd.CH)₂, CONMePh, CONEtPh, CON(Me)Ph-Me-4, CONHSO₂ Me, CONHSO₂ CF₃, COON═CMe₂, ##STR20## COOCH₂ OCOMe, COOCH₂ OCOBu-t, Z: F, Cl, Br, I, NO₂, OMe, OEt, OPr-n, OPr-i, CF₃, CN, SMe, SOMe, SO₂ Me, SCF₃, SOCF₃, SO₂ CF₃

Q: H, Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, CH₂ CH₂ Cl, CH₂ CF₃, CHClMe, CH₂ CH₂ Br, CHClCH₂ Cl, CH₂ CH═CH₂, CH₂ CMe═CH₂, CH₂ CH═CHMe, CH₂ C.tbd.CH, CH₂ CCl═CH₂, CH₂ CN, CH₂ Ph, CH₂ Ph-Cl-2, CH₂ Ph-Cl-3, CH₂ Ph-Me-2, ##STR21## CH₂ Ph-Me₂ -2,4, CH₂ Ph-Me-4, CHMePh, CHEtPh, CH₂ Ph-NO₂ -2, CH₂ Ph-CF₃ -3, CH₂ OMe, CH₂ OEt, CH₂ OH, CHMeOH, CH₂ NHMe, CH₂ NMe₂, CHMeNMe₂, CH₂ COPh, CH₂ COPh-NO₂ -4, CH₂ COPh-Me-4, CH₂ COPh-Cl-4, CH₂ COPh-Me₂ -2,4, CH₂ COPh-CF₃ -4, CH₂ Ac, CH₂ COEt, CHMeAc, CH₂ CO₂ Me, CH₂ CO₂ Et, CH₂ CO₂ Pr-n, CH₂ CO₂ Pr-i, CH₂ CO₂ Bu-t, CH₂ CO₂ H, CHMeCO₂ H, CH₂ CONHMe, CH₂ CONMe₂, CH₂ CONHEt, CH₂ CONEt₂, CH₂ CONPr-n₂, CH₂ OCH₂ CH═CH₂, CH₂ OAc, CH₂ COEt, CH₂ COPr-i, CH₂ COBu-t, CH₂ OCO₂ Me, CH₂ OCO₂ Et, CH₂ OCO₂ Pr-i, CH₂ OCO₂ Bu-t, CH₂ SMe, CH₂ SEt, CH₂ SCH₂ CH═CH.sub. 2, CH₂ SAc, CH₂ SCOBu-t, CH₂ SO₂ Me, CH₂ SO₂ Et, CH₂ SO₂ CH₂ CH═CH₂, CH₂ NHCH₂ CH═CH₂, CH₂ NMeCH₂ CH═CH₂, CH₂ NHAc, CH₂ NHCOEt, CH₂ NHCO₂ Me, CH₂ NHCO₂ Et, CH₂ NMeCO₂ Me, COPh, COPh-Me-4, COPh-NO₂ -2, COPh-Cl₂ -2,4, Ac, COEt, COPr-n, COPr-i, COBu-n, COBu-t, COCH₂ Cl, COCHCl₂, COCCl₃, COCF₃, COCH₂ OMe, COCH₂ OPh, COCH₂ CH═CHCH₃, CO₂ Me, CO₂ Et, CO₂ Bu-t, CO₂ Pr-i, CONHMe, CONMe_(w), CONHEt, CONEt₂, CONPr-n₂, CON(CH₂ CH═CH₂)₂, CONMePh, ##STR22## CO₂ CH₂ Ph, CO₂ Ph, SO₂ Me, SO₂ Et, SO₂ CH₂ CH═CH₂, SO₂ Ph, SO₂ Ph-Me-4, SO₂ Ph-Cl-4, SO₂ Ph-(NO₂)₂ -2,4, SO₂ CF₃, P(═O)(OMe)₂, P(═O)(OEt)₂, P(═O)(OPr-n)₂, P(═O)(OPr-i)₂, P(═S)(OMe)₂, P(═S)(OEt)₂, P(═O)OMeOPh, P(═O)(OCH₂ CH═CH₂)₂, P(═O)OPhOCH₂ CH═CH₂

When Q is a hydrogen atom, the compound may readily form a salt with a metal or with an organic base.

As such a metal, sodium, potassium, calcium, lithium, barium, magnesium, iron, copper, nickel or manganese may be mentioned.

As such an organic base, methylamine, dimethylamine, trimethylamine, ethylamine, diethylamine, triethylamine, n-propylamine, di-n-propylamine, i-propylamine, di-i-propylamine, n-butylamine, i-butylamine, sec-butylamine, tert-butylamine, piperidine, pyrrolidine, morpholine, pyridine, N,N-dimethylaniline or choline may be mentioned.

In the course of researches on the herbicidal properties of various organic compounds with an aim to develop useful herbicides, the present inventors have found that the above-mentioned compound of the present invention exhibits excellent herbicidal activities against narrow leaf weeds (gramineous and cyperaceous weeds) and against broad leaf weeds and no substantial phytotoxicity against useful plants e.g. crop plants such as Zea mays (corn), Sorghum bicolor (sorgo), Triticum spp (wheat) and Hordeum vulgare (barley). The present invetion has been accomplished on the basis of this discovery.

The compound of the present invention exhibits strong herbicidal activities in each of soil treatment, soil incorporaton treatment and foliage treatment. On the other hand, it exhibits no phytotoxicity against crop plants such as Zea mays, Sorghum bicolor, Triticum spp and Hordeum vulgare in a practical application in any of soil treatment, soil incorporation treatment and foliage treatment. Thus, the compound of the present invention has high selectivity and it is extremely effective for controlling weeds during the cultivation of these crop plants. Namely, the compound of the present invention exhibits strong herbicidal activities against noxious weeds such as Setaria viridis (green foxtail), Echinochloa crus-galli (barnyardgrass), Amaranthus lividus (livid amaranth), Polygonum longisetum (persicaria blumei gross), Xanthium strumarium (cocklebur), Abutilon theophrasti (velvet leaf) and Cyperus esculentus (yellow nutsedge), which develop during the cultivation of Zea mays or Sorghum bicolor. The herbicidal activities against gramineous weeds and Cyperus esculentus are remarkably high and extremely unique. Heretofore, during the cultivation of Zea mays or Sorghum bicolor, it has been common to employ atrazine or cyanazine as a triazine-type herbicide, or alachlor or metolachlor as an acid anilide-type herbicide. However, atrazine and cyanazine have poor herbicidal activities against gramineous weeds although they show high activities against broad leaf weeds, and their activities against Cyperus esculentus are very low. On the other hand, alachlor and metolachlor have poor activities against broad leaf weeds although their activities against gramineous weeds are high, and their activities against Cyperus esculentus are very poor. Thus, it has been difficult to eradicate all the weed species by a single application of such herbicides.

As a result of various studies, the present inventors have found the compound of the present invention which exhibits excellent herbicidal effects against a wide range of weeds, and the present invention has been accomplished on the basis of this discovery. The compound of the present invention also has a feature that it exhibits no phytotoxicity against crop plants such as Zea mays, Sorghum bicolor, Triticum spp and Hordeum vulgare and thus can safely be applied to the fields for such crop plants.

Further, the compound of the present invention includes a compound which shows selectivity between Oryza sativa (rice) and Echinochloa crus-galli (barnyardgrass), and it also includes a compound having selectivity for a useful plant such as Gossypium spp (cotton), Beta vulgaris (sugar beat) or Glycine max (soybean).

Heretofore, it has been known that 4-benzoylpyrazole derivatives have excellent herbicidal activities. For example, pyrazolate (common name) is commercially available and widely used for practical application. However, such conventional herbicides are restricted in their application to paddy fields, and their activities are very poor in their application to upland fields. Whereas, as a result of extensive reasearch for many years on 4-benzoylpyrazole derivatives, the present inventors have finally found that the compound of the present invention which simultaneously satisfies the various conditions for substituents in the structure as specified above, exhibits strong herbicidal activities in the application to upland fields in each of soil treatment, soil incorporation and foliage treatment. It has been found that the compound of the present invention exhibits particularly high activities against gramineous weeds and Cyperus esculentus.

The compound of the present invention can readily be prepared by any one of the following reactions. ##STR23##

In the above formulas, A, B, X, Y, Z and Q are as defined above, E is a halogen atom, a methanesulfonyloxy group or a p-toluenesulfonyloxy group. Further, ##STR24## and may be represented by either formula. DCC is N,N'-dicyclohexylcarbodiimide.

Reaction scheme (1) represents a reaction wherein benzoic acid having suitable substituents and 5-hydroxypyrazole are reacted in an inert solvent in the presence of DCC and a base to obtain 4-benzoyl-5-hydroxypyrazole. DCC is used in an amount of from 1.0 to 1.5 mols per mole of the benzoic acid and pyrazole. The solvent may be any solvent so long as it is inert to the reaction. Particularly preferred is tert-butyl alcohol, tert-amyl alcohol or isopropyl alcohol. The base may not necessarily be required. However, in general, the yield can be improved by using a base. There is no particular restriction as to the base, but potassium carbonate or sodium carbonate may preferably be employed. The reaction temperature may range from room temperature to the boiling point of the solvent, but is preferably from 50° to 100° C.

The reaction time is usually from 0.5 to 20 hours.

Reaction scheme (2) shows a reaction wherein benzoyl chloride having suitable substituents and 5-hydroxypyrazole are reacted to form a benzoyl ester, which is then rearranged to a 4-benzoyl compound.

The benzoyl esterification can be accomplished in an inert solvent (such as an aromatic hydrocarbon, a fatty acid ester, a halogenated hydrocarbon, an ether, acetonitrile, dimethylsulfoxide or N,N'-dimethylformamide) or in a two phase system with such a solvent and water or in a mixture of such solvents in the presence of a suitable dehydrochlorinating agent (e.g. an inorganic base such as sodium hydroxide, potassium hydroxide or sodium hydrogencarbonate, or an organic base such as pyridine or triethylamine) at a temperature of from room temperature to 100° C. for from 10 minutes to 5 hours.

The rearrangement reaction can be accomplished by means of a Lewis acid such as anhydrous aluminum chloride or a base. As the base, potassium carbonate, calcium hydroxide or sodium carbonate may be used. The Lewis acid or base is used usually in an amount of from 1 to 10 mol times.

No solvent is required. However, in some cases, it is advantageous to use a solvent having a suitable boiling point to improve the operation efficiency or the yield. As such an advantageous example, use of dioxane or diglyme may be mentioned.

The reaction temperature is usually from 50° to 150° C., and the reaction time is usually from 15 minutes to 10 hours.

Reaction scheme (3) shows a reaction wherein 4-benzoyl-5-hydroxypyrazole is condensed with a halide, a methanesulfonic acid ester or a p-toluenesulfonic acid ester.

For this reaction, it is preferred to employ from 1 to 3 mol times of a dehydrohalogenating agent. As such a dehydrohalogenating agent, an inorganic base such as sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogencarbonate or potassium carbonate, or an organic base such as pyridine or triethylamine, may be mentioned.

There is no particular restriction as to the solvent so long as it is inert to the reaction. A wide range of solvents including an aromatic hydrocarbon, a fatty acid ester, a halogenated hydrocarbon, an ether, a ketone, an aliphatic hydrocarbon, acetonitrile, dimethylsulfoxide and dimethylformamide may be used.

The reaction temperature may be optionally selected within a range of from room temperature to the boiling point of the solvent. The reaction time is usually from 30 minutes to 30 hours.

Reaction scheme (4) shows a reaction wherein 4-benzoyl-5-hydroxypyrazole is converted to a 5-chloro compound by a chlorinating agent, followed by condensation with a suitable alcohol or acid.

As the chlorinating agent, phosphorus oxychloride, phosphorus pentachloride or thionyl chloride may be mentioned.

As the solvent, a wide range of solvents inert to the reaction, such as dimethylformamide, may be employed. However, the reaction can be conducted without any solvent.

The reaction temperature is preferably from 30° to 150° C., and the reaction time is usually from 30 minutes to 10 hours. In some cases, the reaction time may be shortened or the yield may be improved by an addition of a dehydrohalogenating agent.

The condensation reaction with an alcohol or acid is conducted by an addition of a dehydrohalogenating agent.

A such a dehydrohalogenating agent, a base such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium alkoxide or sodium hydride may be employed.

The solvent may be any solvent which is inert to the reaction (such as an aromatic hydrocarbon, an ether, a ketone or N,N'-dimethylformamide). The reaction temperature may be selected within a range of from room temperature to the boiling point of the solvent.

The benzoic acids or benzoyl chlorides used as the starting materials for the compounds of the present invention may readily be prepared by a proprer combination of various known syntheses. For instance, compounds wherein the substituent Z in the benzene ring is --S(O)_(n) CH₃ can be prepared in accordance with the following reaction schemes. ##STR25##

In the above formulas, X and Y are as defined above, and Hal is a halogen atom.

Now, the preparation of benzoic acids will be described in detail with reference to Reference Examples. However, it should be understood that the present invention is by no means restricted by such specific Examples.

REFERENCE EXAMPLE 1 Preparation of 4-methanesulfonyl-3-methoxymethyl-2-methyl benzoic acid and 3-methoxymethyl-2-methyl-4-methylthio benzoic acid (1) 2-Methyl-3-nitrobenzyl alcohol

39.0 g (0.2 mol) of methyl 2-methyl-3-nitrobenzoate was dissolved in 600 ml of tert-butanol, and 19.0 g of sodium borohydride was added thereto. Under refluxing, 150 ml of methanol was dropwise added thereto over a period of 1 hour. The refluxing was continued further for 1 hour to complete the reaction. The reaction mixture was left to cool, and then water was added thereto. The solvent was distilled off under reduced pressure. To the residue, water and chloroform were added, and the organic layer was separated and dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 30.7 g of 2-methyl-3-nitrobenzyl alcohol.

(2) 2-Methyl-3-nitrobenzyl methyl ether

30.1 g (0.18 mol) of 2-methyl-3-nitrobenzyl alcohol obtained in the preceding step was dissolved in 200 ml of benzene, and 0.2 g of tetra-n-butylammonium bromide and a 50% aqueous solution of 20.1 g of sodium hydroxide were added thereto sequentially. Then, 27.2 g of dimethyl sulfate was dropwise added thereto at room temperature. Further, the reaction was conducted for 3 hours under stirring. Water was added to the reaction solution, and the organic layer was separated and washed sequentially with water, a 2% hydrochloric acid aqueous solution, water and a saturated sodium chloride aqueous solution. Then, the solvent was distilled off to obtain 30.9 g of 2-methyl-3-nitrobenzyl methyl ether as an oily substance.

(3) 3-Methoxymethyl-2-methylaniline

To 30.7 g (0.17 mol) of the above-mentioned 2-methyl-3-nitrobenzyl methyl ether, 200 ml of methanol was added. After the compound was dissolved in methanol, 92 ml of concentrated hydrochloric acid was gradually added thereto. Then 30.4 g of iron powder was gradually added so that the reaction temperature became at a level of not higher than 60° C., and the reaction was continued further for 1 hour.

To the reaction solution, 300 ml of water was added, and sodium hydroxide was added until the pH became higher than 8. To the slurry thus obtained, chloroform was added, and the mixture was thoroughly stirred. Then, the solid was separated by filtration, and an organic layer was separated from the filtrate.

This organic layer was washed sequentially with water and a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. Further, the solvent was distilled off under reduced pressure to obtain 23.1 g of 3-methoxymethyl-2-methylaniline as an oily substance.

(4) 3-Methoxymethyl-2-methyl-4-thiocyanoaniline 22.6 g (0.15 mol) of 3-methoxymethyl-2-methylaniline was dissolved in 300 ml of methanol. Then, 36.5 g of sodium thiocyanate was added thereto to obtain a uniform solution. This solution was cooled to 0° C., and 100 ml of a saturated methanol solution of sodium bromide with 25.2 g of bromine was dropwise added thereto so that the reaction temperature did not exceed 5° C. After the dropwise addition, the mixture was stirred at a temperature of not higher than 5° C. for 1 hour and at room temperature for 1 hour to complete the reaction. The reaction solution was poured into 1 liter of water and neutralized with a 5% sodium carbonate aqueous solution. Chloroform was added to extract the oily substance. The chloroform layer was washed with water and a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. Then, the solvent was distilled off under reduced pressure to obtain 29.6 g of the desired product. (5) 3-Methoxymethyl-2-methyl-4-methylthioaniline

29.1 g (0.14 mol) of 3-methoxymethyl-2-methyl-4-thiocyanoaniline was dissolved in 200 ml of ethanol and mixed with 100 ml of an aqueous solution containing 33.6 g of sodium sulfide nonahydrate at room temperature. Then, 21.9 g of methyl iodide was dropwise added thereto, and the mixture was reacted at room temperature for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure, and water and chloroform were added to the residue. Then, the organic layer was separated and washed sequentially with water and a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 25.6 g of the desired product as an oily substance.

(6) 3'-Iodo-2'-methyl-6'-methylthiobenzyl methyl ether

To 25.6 g (0.13 mol) of 3-methoxymethyl-2-methyl-4-methylthioaniline, 100 ml of water and 33 ml of concentrated hydrochloric acid were added to convert it to an aniline hydrochloride. This solution was cooled to 0° C., and 30 ml of an aqueous solution containing 9.3 g of sodium nitrite was dropwise added thereto so that the reaction temperature did not exceed 5° C. After completion of dropwise addition, stirring was continued further for 30 minutes to complete diazotization. 100 ml of an aqueous solution containing 33 g of potassium iodide was heated to 70° C., and the aqueous solution of the diazonium salt obtained above was gradually added thereto and decomposed. The reaction solution was stirred further for 1 hour at 70° C. and then left to cool. The oil component was extracted with benzene. The benzene layer was washed sequentially with water, a saturated sodium hydrogensulfite aqueous solution, water and a saturated sodium chloride aqueous solution. Then, the solvent was distilled off under reduced pressure, and the residue was purified by column chromatography (eluent:benzene) to obtain 30.0 g of the desired product. Melting point: 56.0°-59.0° C.

(7) 3-Methoxymethyl-2-methyl-4-methylthiobenzoic acid

27.7 g (0.09 mol) of 3'-iodo-2'-methyl-6'-methylthiobenzyl methyl ether was dissolved in 100 ml of dried tetrahydrofuran, and 63 ml of a 1.5M n-butyllithium n-hexane solution was dropwise added thereto at -70° C. After the dropwise addition, the mixture was stirred for 15 minutes at the same temperature, and then dried carbon dioxide gas was thoroughly blown into the reaction solution until the heat generation of the reaction solution stopped. After the reaction, the temperature of the solution was returned to room temperature, and water and diethyl ether were added for liquid separation. The aqueous layer thus obtained was further washed twice with diethyl ether, and then concentrated hydrochloric acid was added to bring the pH<1. Precipitated crystals were collected by filtration, thoroughly washed with water and dried to obtain 14.4 g of the desired product. Melting point: 192.0°-194.0° C.

(8) 4-Methanesulfonyl-3-methoxymethyl-2-methylbenzoic acid

To 11.3 g (0.05 mol) of 3-methoxymethyl-2-methyl-4-methylthiobenzoic acid, 120 ml of acetic acid and 120 ml of a 35% hydrogen peroxide aqueous solution were added, and the mixture was reacted at 80° C. for 1 hour. After cooling, the reaction solution was poured into ice water, whereupon precipitated crystals were collected by filtration, then washed with water and dried to obtain 12.3 g of the desired product. Melting point: 129.0°-131.0° C.

REFERENCE EXAMPLE 2 Preparation of 3-methoxycarbonyl-2-methyl-b 4-methylthiobenzoic acid and 4-methanesulfonyl-3-methoxycarbonyl-2-methylbenzoic acid (1) Methyl 3-amino-2-methylbenzoate

40 g of methyl 2-methyl-3-nitrobenzoate was dissolved in 120 ml of methanol, and 157 g of concentrated hydrochloric acid was added thereto. Then, 36.8 g of iron powder was gradually added while maintaining the mixture at a temperature of not higher than 60° C. The mixture was stirred at room temperature for 4 hours and then poured into 1 liter of ice water. The solution was neutralized with sodium carbonate and extracted with chloroform (after filtering off insolubles). The extract was washed with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 27.8 g of the desired product as an oily substance.

(2) Methyl 3-amino-2-methyl-6-thiocyanobenzoate

While maintaining a solution comprising 27.7 g of methyl 3-amino-2-methylbenzoate, 41.5 g of sodium thiocyanate and 250 ml of methanol at a temperature of not higher than 0° C., 100 ml of sodium bromide-saturated methanol with 28.1 g of bromine was slowly dropwise added thereto. The mixture was stirred at room temperature for 3 hours and then poured into 1 liter of ice water. The solution was neutralized with sodium carbonate and then extracted with chloroform. The extract was washed with a saturated sodium chloride aqueous solution and dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 34.0 g of the desired product as an oily substance.

(3) Methyl 3-amino-2-methyl-6-methylthiobenzoate

To a solution comprising 39.5 g of sodium sulfide nonahydrate and 110 ml of water, a solution comprising 32.9 g of methyl 3-amino-2-methyl-6-thiocyanobenzoate and 300 ml of ethanol was dropwise added. The mixture was stirred at room temperature for 1.5 hours, and 24.0 g of methyl iodide was dropwise added under cooling with ice. The mixture was stirred further at room temperature for 2 hours and then concentrated under reduced pressure. A saturated sodium chloride aqueous solution was added thereto, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 30.1 g of the desired product as an oily substance.

(4) Methyl 3-iodo-2methyl-6-methylthiobenzoate 28 g of methyl 3-amino-2-methyl-6-methylthiobenzoate was stirred in 150 ml of concentrated hydrochloric acid at room temperature for 2 hours to convert it to a hydrochloride. Then, while maintaining the mixture at a temperature of not higher than 0° C., a solution comprising 11.9 g of sodium nitrite and 20 ml of water was dropwise added thereto to obtain a diazonium salt solution. The diazonium salt solution was dropwise added to a solution comprising 28.4 g of potassium iodide and 90 ml of water while maintaining the solution at 80° C. After completion of the dropwise addition, the mixture was stirred at 80° C. for 15 minutes and left to cool. Water was added thereto, and the mixture was extracted with chloroform. The extract was washed with an aqueous sodium hydrogensulfite solution and water and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 40 g of the desired product as a crude product. The crude product was purified by silica gel column chromatography (eluted with benzene) to obtain 36.0 g of a purified product as an oily substance. (5) 3-Methoxycarbonyl-2-methyl-4-methylthiobenzoic acid

While maintaining a solution comprising 20.0 g of methyl 3-iodo-2-methyl-6-methylthiobenzoate and 70 ml of dried tetrahydrofuran at a temperature of not higher than -60° C. under a nitrogen atmosphere, 42 ml of a 1.5M n-butyllithium n-hexane solution was dropwise added thereto. Fifteen minutes later, dried carbon dioxide gas was thoroughly blown into the mixture while maintaining it at a temperature of not higher than -50° C. After purging carbon dioxide gas with nitrogen, 12.7 g of diisopropylamine was dropwise added thereto, and the mixture was stirred until the temperature reached room temperature. The mixture was concentrated under reduced pressure. Water was added thereto and the mixture was washed with chloroform. The aqueous solution was acidified with concentrated hydrochloric acid and then extracted with chloroform. The extract was dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 7.5 g of the desired product. Melting point: 178°-178.5° C.

(6) 4-Methanesulfonyl-3-methoxycarbonyl-2-methylbenzoic acid

A solution comprising 5.0 g of 3-methoxycarbonyl-2-methyl-4-methylthiobenzoic acid, 25 ml of acetic acid and 25 ml of hydrogen peroxide (35%) was stirred at 80° C. for 3 hours. After cooling, the mixture was poured into ice water and extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 5.1 g of the desired product. Melting point: 151°-152° C.

REFERENCE EXAMPLE 3 Preparation of 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoic acid (1) Methyl 3-bromomethyl-2-chloro-4-methanesulfonylbenzoate

12.1 g of methyl 2-chloro-4-methanesulfonyl-3-methylbenzoate was dissolved in 250 ml of carbon tetrachloride, and the solution was refluxed under stirring. Then, 7.5 g of bromine and 1 g of benzoyl peroxide were gradually added thereto over a period of 30 minutes, and the solution was further refluxed for 4 hours under heating. After cooling, 200 ml of chloroform was added thereto, and the mixture was washed with a 5% sodium hydrogensulfite aqueous solution. The organic layer was separated and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain a crude product. The crude product was washed with ethyl ether to obtain 13.2 g of crystals of the desired product. Melting point: 77°-78° C.

(2) Methyl 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoate

To 100 ml of tetrahydrofuran, 1.3 g of ethanethiol and 1.5 g of potassium carbonate and then 4.4 g of methyl 3-bromomethyl-2-chloro-4-methanesulfonylbenzoate were added, and the mixture was stirred for 1 day at room temperature. Then, the mixture was stirred further for 1 hour at a temperature of from 50° to 60° C. After cooling, chloroform was added thereto, and the mixture was washed with a dilute potassium carbonate aqueous solution. The chloroform layer was separated and dried. Then, the solvent was distilled off to obtain 4.1 g of methyl 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoate as an oily substance.

(3) 2-Chloro-3-ethylthiomethyl-4-methanesulfonylbenzoic acid

To a solution mixture comprising 50 ml of a 10% sodium hydroxide aqueous solution and 150 ml of methanol, 3.9 g of methyl 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoate was added, and the mixture was stirred at room temperature for 30 minutes. Methanol was distilled off under reduced pressure, and a dilute hydrochloric acid was added to the residue for acid preparation. The mixture was extracted with ethyl acetate, and the extract was dried. Then, the solvent was distilled off to obtain 3.5 g of the desired product. Melting point: 172°-174° C.

REFERENCE EXAMPLE 4 Preparation of 2-chloro-4-methanesulfonyl-3-methoxymethylbenzoic acid (1) Methyl-2-chloro-4-methanesulfonyl-3-methoxymethylbenzoate

To a solution comprising 12.0 g of methyl 3-bromomethyl-2-chloro-4-methanesulfonylbenzoate prepared in Reference Example 3(1) and 100 ml of methanol, 50 ml of a methanol solution containing 1.7 g of sodium methoxide was added, and the mixture was stirred at room temperature overnight. The solvent was distilled off under reduced pressure. Then, dilute hydrochloric acid was added to the residue, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 9.5 g of the desired product as a crude product. The crude product was purified by silica gel column chromatography (eluted with benzene) to obtain 7.5 g of a purified product as an oily substance.

(2) 2-Chloro-4-methanesulfonyl-3-methoxymethylbenzoic acid

To a solution comprising 3.0 g of methyl 2-chloro-4-methanesulfonyl-3-methoxymethylbenzoate and 20 ml of methanol, a solution comprising 0.57 g of sodium hydroxide (93%) and 2 ml of water was added, and the mixture was stirred at room temperature for 30 minutes. After an addition of 10 ml of water, the mixture was concentrated under reduced pressure. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 2.6 g of the desired product. Melting point: 137°-141° C.

REFERENCE EXAMPLE 5 Preparation of 2-chloro-4-methanesulfonyl-3-methoxymethylbenzoic acid (alternative method of Reference Example 4)

The desired product was prepared in the same manner as in Reference Example 1. Melting point: 137°-141° C.

The physical properties of the intermediates were as follows:

(1) 2-Chloro-3-nitrobenzyl alcohol: Oily substance

(2) 2'-Chloro-3'-nitrobenzyl methyl ether: Oily substance

(3) 2-Chloro-3-methoxymethylaniline: Oily substance

(4) 2-Chloro-3-methoxymethyl-4-thiocyanoaniline: Melting point: 90°-96° C.

(5) 2-Chloro-3-methoxymethyl-4-methylthioaniline: Oily substance

(6) 2'-Chloro-3'-iodo-6'-methylthiobenzyl methyl ether: Melting point: 53°-56° C.

REFERENCE EXAMPLE 6 Preparation of 2-chloro-4-methanesulfonyl-3-methoxycarbonyl benzoic acid

The desired product was prepared in the same manner as in Reference Example 2. Melting point 160°-162° C.

The physical properties of the intermediates were as follows:

(1) Methyl 3-amino-2-chlorobenzoate: Oily substance

(2) Methyl 3-amino-2-chloro-6-thiocyanobenzoate: Melting point: 80°-83° C.

(3) Methyl 3-amino-2-chloro-6-methylthiobenzoate: Melting point: 70°-72° C.

(4) Methyl 2-chloro-3-iodo-6-methylthiobenzoate: Oily substance

(5) 2-Chloro-3-methoxycarbonyl-4-methylthiobenzoic acid: Melting point: 176°-179° C.

REFERENCE EXAMPLE 7 Preparation of 4-methanesulfonyl-3-[(2-methoxyethyl)oxycarbonyl]-2-methylbenzoic acid

The desired compound was prepared in the same manner as in Reference Example 2. Melting point: 118°-121° C.

The physical properties of the intermediates were as follows:

(1) 2-Methoxyethyl 3-amino-2-methylbenzoate: Oily substance

(2) 2-Methoxyethyl 3-amino-2-methyl-6-thiocyanobenzoate: Melting point: 79°-81° C.

(3) 2-Methoxyethyl 3-amino-2-methyl-6-methylthiobenzoate: Oily substance

(4) 2-Methoxyethyl 3-iodo-2-methyl-6-methylthiobenzoate: Oily substance

(5) 3-[(2-methoxyethyl)oxycarbonyl]-2-methyl-4-methylthiobenzoic acid: Melting point: 90°-93° C.

REFERENCE EXAMPLE 8 Preparation of 2-methyl-4-methylthio-3-n-propoxycarbonylbenzoic acid and 4-methanesulfonyl-2-methyl-3-n-propoxycarbonylbenzoic acid (1) Methyl 3-bromo-2-methyl-6-methylthiobenzoate

16.1 g of the compound of Reference Example 2(3) was stirred in 150 ml of hydrobromic acid (48%) to convert it into a hydrobromide. While maintaining the solution at a temperature of not higher than 0° C., a solution comprising 7.2 g of sodium nitrite and 20 ml of water was dropwise added to obtain a diazonium salt solution. The diazonium salt solution was dropwise added to a solution comprising 6.0 g of cuprous bromide and 7.7 g of hydrobromic acid (48%) while refluxing the solution under heating. After completion of the dropwise addition, the mixture was further refluxed for 1 hour under heating and then left to cool. Ice water was added thereto, and the mixture was extracted with chloroform. The extract was washed with an aqueous sodium hydrogensulfite solution and water and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 19.2 g of the desired product as a crude product. The crude product was purified by silica gel column chromatography (eluted with benzene) to obtain 17.1 g of a purified product as an oily substance.

(2) 3-Bromo-2-methyl-6-methylthiobenzoic acid

To 100 ml of an ethanol solution containing 17.0 g of methyl 3-bromo-2-methyl-6-methylthiobenzoate, 16 g of a 50% sodium hydroxide aqueous solution was added, and the mixture was refluxed for 3 hours under heating. The reaction mixture was concentrated under reduced pressure. Then, water was added thereto, and the mixture was washed with chloroform. The aqueous layer was acidified with concentrated hydrochloric acid and extracted with chloroform. The extract was dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 15.9 g of the desired product. Melting point: 98°-103° C.

(3) n-Propyl 3-bromo-2-methyl-6-methylthiobenzoate

Thionyl chloride was added to 15.8 g of 3-bromo-2-methyl-6-methylthiobenzoic acid, and the mixture was refluxed for 4 hours under heating. Thionyl chloride was distilled off, and 70 ml of n-propanol was added to the residue under cooling with ice. Then, a solution comprising 7.3 g of pyridine and 20 ml of n-propanol was dropwise added thereto. The mixture was stirred at room temperature overnight and then concentrated under reduced pressure. Then, ethyl acetate was added thereto, and the mixture was washed sequentially with a 5% sodium carbonate aqueous solution, 10% hydrochloric acid and water and then dried over anhydrous sodium sulfate. Then, the solvent was distilled off under reduced pressure to obtain 18 g of the desired product as a crude product. The crude product was purified by silica gel column chromatography (eluted with benzene) to obtain 16.6 g of a purified product as an oily substance.

(4) 3-Bromo-2-methyl-6-methylthiobenzoic acid

This product was prepared in the same manner as in Reference Example 2(5). Melting point: 138°-142° C.

(5) 3-Bromo-6-methanesulfonyl-2-methylbenzoic acid

This compound was prepared in the same manner as in Reference Example 2(6). Melting point: 142°-146° C.

REFERENCE EXAMPLE 9 Preparation of 2-chloro-3-isopropoxycarbonyl-4-methanesulfonylbenzoic acid

This compound was prepared from the compound of Reference Example 6(4) in the same manner as in Reference Example 8(2)-(5). Melting point: 146°-148° C.

The physical properties of the intermediates were as follows:

(1) 2-Chloro-3-iodo-6-methylthiobenzoic acid: Melting point: 155°-159° C.

(2) Isopropyl 2-chloro-3-iodo-6-methylthiobenzoate: Oily substance

(3) 2-Chloro-3-isopropoxycarbonyl-4-methylthiobenzoic acid: Melting point: 114°-118° C.

REFERENCE EXAMPLE 10 Preparation of 3-(1-methoxyethyl)-2-methyl-4-methylthiobenzoic acid and 4-methanesulfonyl-3-(1-methoxyethyl)-2-methylbenzoic acid (1) 2'-Methyl-3'-nitroacetophenone

To 5.4 g of metal magnesium, 5 ml of absolute ethanol and 0.5 ml of carbon tetrachloride were dropwise added under a dry nitrogen stream. Further, 130 ml of dried diethyl ether was added under refluxing, and then a solution comprising 25 ml of a diethyl ether, 35.2 g of diethyl malonate and 20 ml of ethanol was dropwise added at a rate to maintain the refluxing. After completion of the dropwise addition, refluxing was continued for 3 hours to prepare diethyl ethoxymagnesiomalonate. To the solution of diethyl ethoxymagnesiomalonate thus obtained, 150 ml of a diethyl ether solution of 40.0 g of 2-methyl-3-nitrobenzoic acid chloride prepared from 2-methyl-3-nitrobenzoic acid and thionyl chloride, was dropwise added over a period of 20 minutes under refluxing, and the reaction was continued for 2 hours. After cooling, dilute sulfuric acid was added thereto for hydrolysis. The diethyl ether layer was washed sequentially with water and a saturated sodium chloride aqueous solution. Then, the solvent was distilled off under reduced pressure, and the residue was dried to obtain a crude product of diethyl 2-(2-methyl-3-nitrobenzoyl)malonate. To this crude product, a mixture comprising 7.5 ml of concentrated sulfuric acid, 60 ml of acetic acid and 40 ml of water was added, and the mixture was refluxed for 6 hours under heating. Then, the mixture was adjusted to pH>10 with a 20% sodium hydroxide aqueous solution. Precipitated oil component was extracted with chloroform. This chloroform layer was washed sequentially with water and a sodium chloride aqueous solution. Then, the solvent was distilled off under reduced pressure to obtain 34.0 g of the desired product. (Yield: 95%) Melting point: 53.0°-54.0° C.

(2) Preparation of 1-methyl-2'-methyl-3'-nitrobenzyl alcohol

To 50 ml of a methanol solution of 0.5 g of sodium hydroxide, 0.9 g of sodium borohydride was added at 0° C., and then 100 ml of a methanol solution of 14.3 g of 2'-methyl-3'-nitroacetophenone was dropwise added thereto. The temperature of the mixture was returned to room temperature and reacted for 1 hour. After the reaction, the reaction mixture was poured into water and extracted with benzene. The subsequent operation was conducted in a usual manner to obtain 14.3 g of the desired product as an oily substance. (Yield: 99%)

Subsequently, the synthesis was conducted in the same manner as in Reference Example 1 to obtain intermediates (3) to (9).

(3) 1-Methyl-2'-methyl-3'-nitrobenzyl methyl ether: Oily substance

(4) 1-Methyl-3'-amino-2'-methylbenzyl methyl ether: Oily substance

(5) 1-Methyl-3'-amino-2'-methyl-6'-thiocyanobenzyl methyl ether: Solid

(6) 1-Methyl-3'-amino-2'-methyl-6'-methylthiobenzyl methyl ether: Oily substance

(7) 1-Methyl-3'-iodo-2'-methyl-6'-methylthiobenzyl: Oily substance

(8) 3-(1-Methoxyethyl)-2-methyl-4-methylthiobenzoic acid: Oily substance

(9) 4-Methanesulfonyl-3-(1-methoxyethyl)-2-methylbenzoic acid: Melting point: 106°-109° C.

The physical properties of benzoic acids prepared in accordance with the preceding Reference Examples will be given in Tables 1 and 2 including those of the preceding Reference Examples.

                  TABLE 1                                                          ______________________________________                                          ##STR26##                                                                     X     Y              Z         Melting point (°C.)                      ______________________________________                                         Me    CH.sub.2 OMe   SMe       192˜194                                   Me    CH.sub.2 OMe   SO.sub.2 Me                                                                              129˜131                                   Me    CO.sub.2 Me    SMe       178˜178.5                                 Me    CO.sub.2 Me    SO.sub.2 Me                                                                              151˜152                                   Me    CH.sub.2 OEt   SMe       172˜175                                   Me    CH.sub.2 OEt   SO.sub.2 Me                                                                              160˜162                                   Cl    CO.sub.2 Me    Cl        183˜185                                   Me    CHMeOMe        SMe       Oily substance                                  Me    CHMeOMe        SO.sub.2 Me                                                                              106˜109                                   Me    CO.sub.2 Pri   SMe       151˜153                                   Me    CO.sub.2 Pri   SO.sub.2 Me                                                                              153˜155                                   Cl    CH.sub.2 OMe   SO.sub.2 Me                                                                              137˜141                                   Me    CH.sub.2 OPri  SMe       134˜138                                   Me    CH.sub.2 OPri  SO.sub.2 Me                                                                              159˜161                                   Me    CO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                SMe       90˜93                                     Me    CO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                SO.sub.2 Me                                                                              118˜121                                   Cl    CH.sub.2 SEt   SO.sub.2 Me                                                                              172˜174                                   Me    CO.sub.2 Et    SMe       114˜120                                   Me    CO.sub.2 Et    SO.sub.2 Me                                                                              119.7˜ 127.9                              Cl    CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                               SO.sub.2 Me                                                                              93˜95                                     Cl                                                                                    ##STR27##     SO.sub.2 Me                                                                              Oily substance                                  Me                                                                                    ##STR28##     SMe       169˜172                                   Me                                                                                    ##STR29##     SO.sub.2 Me                                                                              129˜134                                   Me    CO.sub.2 Prn   SMe       138˜142                                   Me    CO.sub.2 Prn   SO.sub.2 Me                                                                              142˜146                                   Cl    CH.sub.2 OH    SO.sub.2 Me                                                                              240˜245                                   Cl    CO.sub.2 Me    SMe       176˜179                                   Cl    CO.sub.2 Me    SO.sub.2 Me                                                                              160˜162                                   Cl    CO.sub.2 Pri   SMe       114˜118                                   Cl    CO.sub.2 Pri   SO.sub.2 Me                                                                              146˜148                                   OMe   CO.sub.2 Me    SMe       107˜109                                   OMe   CO.sub.2 Me    SO.sub.2 Me                                                                              113˜119                                   Me    CHEtOMe        SMe       Oily substance                                  Me    CHEtOMe        SO.sub.2 Me                                                                              Oily substance                                  Me    CHMeOEt        SMe       Oily substance                                  Me    CHMeOEt        SO.sub.2 Me                                                                              Oily substance                                  Cl    CH.sub.2 OCH.sub.2 CCH                                                                        SO.sub.2 Me                                                                              166˜169                                   Cl    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                 SO.sub.2 Me                                                                              118˜119                                   Cl    CH.sub.2 OAmn  SO.sub.2 Me                                                                              Oily substance                                  Me    CO.sub.2 Ami   SMe       98˜105                                    Me    CO.sub.2 Ami   SO.sub.2 Me                                                                              107˜113                                   Cl    CH.sub.2 OCH.sub.2 CF.sub.3                                                                   SO.sub.2 Me                                                                              155˜157                                   OMe   CH.sub.2 OMe   SMe       157˜161                                   OMe   CH.sub.2 OMe   SO.sub.2 Me                                                                              Oily substance                                  Me    CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 SMe       138˜144                                   Me    CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                 SO.sub.2 Me                                                                              121˜126                                   ______________________________________                                    

                  TABLE 2                                                          ______________________________________                                         X     Y         Z         .sup.1 H--NMR (δ, ppm) [Solvent]               ______________________________________                                         Me    CHEtOMe   SO.sub.2 Me                                                                              1.19(3H,t), 1.63(3H,d),                                                        2.78(3H,s), 3.18(3H,s),                                                        3.35(2H,q), 5.63(1H,q),                                                        7.81(2H, A-B q), 10.20(1H,s)                                                   [CDCl.sub.3 ]                                        Me    CHMeOEt   SMe       1.00(3H,t), 1.67˜2.26(2H,m),                                             2.46(3H,s), 2.69(3H,s),                                                        3.21(3H,s), 4.91(1H,d-d)                                                       7.48(2H, A-Bq), 10.2(1H,s)                                                     [CDCl.sub.3 ]                                        Me    CHMeOEt   SO.sub.2 Me                                                                              1.04(3H,t), 1.60˜2.20(2H,m),                                             2.66(3H,s), 3.23(6H,s),                                                        5.26(1H,d-d), 7.79(2H, A-B q)                                                  9.0(1H, Broad s)                                                               [CDCl.sub.3 + DMSO-d.sub.6 ]                         OMe   CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                              3.04(3H,s), 3.24(3H,s),                                                        3.71(3H,s), 4.71(2H,s),                                                        7.71(2H,s), 8.88(1H,Broad s)                                                   [CDCl.sub.3 + DMSO-d.sub.6 ]                         ______________________________________                                    

These benzoic acids can readily be led to benzoyl chlorides by chlorinating agents such as phosphorus pentachloride, thionyl chloride and sulfuryl chloride.

By using such benzoic acids or benzoyl chlorides, compounds of the present invention can be readily prepared in accordance with reaction schemes (1) to (4).

The present invention will be described in further detail with reference to Examples. However, it should be understood that the present invention is by no means restricted to such specific Examples.

EXAMPLE 1 Preparation of 1-ethyl-5-hydroxy-4-(4-methanesulfonyl-3-methoxymethyl-2-methylbenzoyl)pyrazole

1.12 g (0.01 mol) of 1-ethyl-5-hydroxypyrazole is dissolved in 30 ml of t-amyl alcohol, and then 2.59 g (0.01 mol) of 4-methanesulfonyl-3-methoxymethyl-2-methylbenzoic acid, 2.06 g (0.01 mol) of N,N'-dicyclohexylcarbodiimide and 0.69 g (0.005 mol) of anhydrous potassium carbonate were sequentially added thereto. The mixture was reacted at a temperature of from 80° to 90° C. for 8 hours under stirring. After completion of the reaction, t-amyl alcohol was distilled off under reduced pressure, and 30 ml of water was added to the residue to dissolve the soluble components. The mixture was subjected to filtration to separate out the insolubles. The aqueous solution thus obtained was washed with chloroform, and concentrated hydrochloric acid was added to adjust pH<1. The precipitated oil component was extracted with chloroform. The solvent was distilled off under reduced pressure, and the residue was purified with silica gel column chromatography (eluent: ethyl acetate/ethanol=9/1) to obtain 2.3 g of the desired product. (Yield: 66%, melting point: 116°-118° C.)

EXAMPLE 2 Preparation of 1-ethyl-5-hydroxy-4-(4-methanesulfonyl-3-methoxycarbonyl-2-methylbenzoyl)pyrazole

1.12 g (0.01 mol) of 1-ethyl-5-hydroxypyrazole was dissolved in 30 ml of t-amyl alcohol, and 2.72 g (0.01 mol) of 4-methanesulfonyl-3-methoxycarbonyl-2-methylbenzoic acid, 2.27 g (0.011 mol) of N,N'-dicyclohexylcarbodiimide and 0.76 g (0.0055 mol) of anhydrous potassium carbonate were sequentially added thereto. The mixture was reacted at 80° C. for 6 hours under stirring. After completion of the reaction, t-amyl alcohol was distilled off under reduced pressure, and then water was added to the residue to dissolve the soluble component. The mixture was subjected to filtration to separate out the insolubles. The aqueous solution thus obtained was washed twice with chloroform, and then concentrated hydrochloric acid was added to adjust pH<1. The precipitated oil component was extracted with chloroform. The chloroform layer was washed sequentially with water and a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. Then, the solvent was distilled off under reduced pressure, and the residue thus obtained was recrystallized from water/ethanol to obtain 2.26 g of the desired product. (Yield: 62%, melting point: 150°-152° C.)

EXAMPLE 3 Preparation of 5-hydroxy-(3-isopropoxycarbonyl-4-methanesulfonyl-2-methylbenzoyl)-1-methylpyrazole

The operation and treatment were conducted in the same manner as in Example 1 except that 1.12 g of 1-ethyl-5-hydroxypyrazole was changed to 0.98 g of 5-hydroxy-1-methylpyrazole, and 2.72 g of 4-methanesulfonyl-3-methoxycarbonyl-2-methylbenzoic acid was changed to 3.00 g of 3-isopropoxycarbonyl-4-methanesulfonyl-2-methylbenzoic acid, to obtain 1.71 g of the desired product. (Yield: 45%, melting point: 192°-194° C.)

EXAMPLE 4 Preparation of 4-(2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoyl)-1-ethyl-5-hydroxypyrazole

3 g of 2-chloro-3-ethylthiomethyl-4-methanesulfonylbenzoic acid, 0.72 g of potassium carbonate, 50 ml of t-amyl alcohol, 1.95 g of N,N'-dicyclohexylcarbodiimide and 4.5 g of a 25% t-amyl alcohol solution of 1-ethyl-5-pyrazolone were mixed and heated under stirring for 4 hours at a temperature of from 70° to 80° C. After cooling, the mixture was distilled under reduced pressure, and 200 ml of water was added to the residue. After filtering off the insolubles, the filtrate was washed with chloroform. Hydrochloric acid was added to the aqueous layer, and the mixture was extracted with chloroform. The extract was dried, and the solvent was distilled off to obtain the desired product as a crude product. The crude product was recrystallized from ethanol to obtain 1.88 g of the purified product. (Melting pont: 142°-145° C.)

EXAMPLE 5 Preparation of 4-(2-chloro-5-ethanesulfonylmethyl-4-methanesulfonylbenzoyl)-1-ethyl-5-hydroxypyrazole

0.5 g of the compound obtained in Example 4 was dissolved in a solution comprising 30 ml of CHCl₃ and 30 ml of THF at room temperature, and 2.2 equivalent of m-chloroperbenzoic acid was added thereto under cooling in ice bath. The mixture was gradually returned to room temperature and stirred for 1 day. The solvent was distilled off, and crystals thus obtained were collected by filtration and washed with ethyl ether to obtain 2.2 g of the desired product. (Melting poing: 133°-135° C.)

EXAMPLE 6 Preparation of 4-(2-chloro-3-ethanesulfinyl-4-methanesulfonylbenzoyl)-1-ethyl-5-hydroxypyrazole

0.45 g of the compound obtained in Example 4 was dissolved in 30 ml of dioxane, and 0.21 g of sodium bromite trihydrate was added thereto. The mixture was stirred at room temperature for 30 minutes, and then water was added thereto. The mixture was extracted with chloroform. The extract was dried, and the solvent was distilled off to obtain a crude product. The crude product was purified by column chromatography (eluted with chloroform/ethanol) to obtain 0.2 g of the desired product as an oily substance.

The physical properties of the compounds prepared in the same manner as the preceding Examples will be given in Tables 3 and 4 including those of the preceding Examples.

                                      TABLE 3                                      __________________________________________________________________________      ##STR30##                                                                     Compound                                                                       No.   A   B  X  Y         Z   Q      Melting point (°C.)                __________________________________________________________________________     1     Me  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      Oily substance                            2     Me  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        CH.sub.2 Ph                                                                           Oily substance                            3     Et  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      116˜118                             4     i-Pr                                                                               H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      Oily substance                            5     Me  H  Me CO.sub.2 H                                                                               SO.sub.2 Me                                                                        H      274˜274.5                           6     Me  H  Me CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      199˜201                             7     Et  H  Me CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      150˜152                             8     Me  H  Me CO.sub.2 Et                                                                              SO.sub.2 Me                                                                        H      174˜174.5                           9     Et  H  Me CO.sub.2 Et                                                                              SO.sub.2 Me                                                                        H      78˜81                               10    Me  H  Me CO.sub.2 Pri                                                                             SO.sub.2 Me                                                                        H      192˜194                             11    Et  H  Me CO.sub.2 Pri                                                                             SO.sub.2 Me                                                                        H      125˜128                             12    Me  H  Cl CO.sub.2 Me                                                                              Cl  H      123˜126                             13    Me  H  Cl CO.sub.2 Me                                                                              Cl  p-TS   Oily substance                            14    Me  H  Me CH.sub.2 OEt                                                                             SO.sub.2 Me                                                                        H      178˜179                             15    Et  H  Me CH.sub.2 OEt                                                                             SO.sub.2 Me                                                                        H      Oily substance                            16    i-Pr                                                                               H  Me CH.sub.2 OEt                                                                             SO.sub.2 Me                                                                        H      Oily substance                            17    Me  Me Me CH.sub.2 OEt                                                                             SO.sub.2 Me                                                                        H      Oily substance                            18    Me  H  Me CHMeOMe   SO.sub.2 Me                                                                        H      238˜240                             19    Et  H  Me CHMeOMe   SO.sub.2 Me                                                                        H      138˜141                             20    Me  H  Cl CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      189˜190                             21    Et  H  Cl CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      151˜154                             22    i-Pr                                                                               H  Cl CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      142˜144                             23    Et  H  Me CH.sub.2 OPri                                                                            SO.sub.2 Me                                                                        H      125˜127                             24    Me  H  Me CO.sub.2 CH.sub.2 CH.sub.2 OMe                                                           SO.sub.2 Me                                                                        H      114˜117                             25    Et  H  Me CO.sub.2 CH.sub.2 CH.sub.2 OMe                                                           SO.sub.2 Me                                                                        H      122˜124                             26    Me  H  Cl CO.sub.2 CH.sub.2 CH.sub.2 OMe                                                           SO.sub.2 Me                                                                        H      157˜161                             27    Et  H  Cl CH.sub.2 SEt                                                                             SO.sub.2 Me                                                                        H      142˜145                             28    Et  H  Cl CH.sub.2 SOEt                                                                            SO.sub.2 Me                                                                        H      Oily substance                            29    Et  H  Cl CH.sub.2 SO.sub.2 Et                                                                     SO.sub.2 Me                                                                        H      133˜135                             30    Et  H  Me CO.sub.2 Prn                                                                             SO.sub.2 Me                                                                        H      Oily substance                            31    Me  H  Cl                                                                                 ##STR31##                                                                               SO.sub.2 Me                                                                        H      Oily substance                            32    Me  H  Me                                                                                 ##STR32##                                                                               SO.sub.2 Me                                                                        H      220˜222                             33    Et  H  Me                                                                                 ##STR33##                                                                               SO.sub.2 Me                                                                        H      179˜183                             34    Me  H  Cl CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      183˜185                             35    Et  H  Cl CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      174˜176                             36    Pri H  Cl CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      138˜140                             37    Et  H  Cl CH.sub.2 OCH.sub.2 C CH                                                                  SO.sub.2 Me                                                                        H      161˜164                             38    Me  H  Cl CH.sub.2 OAmn                                                                            SO.sub.2 Me                                                                        H      Oily substance                            39    Et  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        K      180˜190                             40    Et  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        Na     210˜216                             41    Et  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        NH.sub.3.sup.+ Pri                                                                    95˜102                              42    Me  H  OMe                                                                               CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      195˜198                             43    Me  H  Cl CO.sub.2 Pri                                                                             SO.sub.2 Me                                                                        H      117˜119                             44    Et  H  Cl CO.sub.2 Pri                                                                             SO.sub.2 Me                                                                        H      141˜143                             45    Me  H  Cl CH.sub.2 OCH.sub.2 CF.sub.3                                                              SO.sub.2 Me                                                                        H      167˜170                             46    Et  H  Me CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        1/2 Ca 232˜242                             47    Pri H  Me CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      116˜121                             48    Me  H  OMe                                                                               CH.sub.2 OMe                                                                             SO.sub.2 Me                                                                        H      154˜157                             49    Et  H  Me CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                            SO.sub.2 Me                                                                        H      149˜152                             50    Et  H  OMe                                                                               CO.sub.2 Me                                                                              SO.sub.2 Me                                                                        H      172˜175                             __________________________________________________________________________

The compounds represented by the Compound Nos. in the following Table are the same as represented by the corresponding Compound Nos. in Table 3.

                  TABLE 4                                                          ______________________________________                                         Compound                                                                       No.          .sup.1 H--NMR (δ, ppm) [Solvent]                            ______________________________________                                         1            2.47(3H,s), 3.22(3H,s), 3.50 (3H,s),                                           3.69(3H,s), 4.96(2H,s), 7.30(1H,s),                                            7.78(2H,A-Bq), 10.9(1H) [CDCl.sub.3 ]                             2            2.41(3H,s), 3.17(3H,s), 3.50 (3H,s),                                           4.94(2H,s), 5.53(2H,s), 7.30˜8.12                                        (8H,m) [CDCl.sub.3 ]                                              3            1.44(3H,t), 2.48(3H,s), 3.23 (3H,s),                                           3.51(3H,s), 4.07(2H,q), 4.98(2H,s),                                            7.36(1H,s), 7.82(2H,A-Bq) [CDCl.sub.3 ]                           4            1.48(6H,d), 2.47(3H,s), 3.19 (3H,s),                                           3.48(3H,s), 4.53(1H,m), 4.92(2H,s),                                            7.18(1H,s), 7.69(2H,A-Bq), 9.57(1H)                                            [CDCl.sub.3 ]                                                     13           2.43(3H,s), 3.78(3H,s), 3.94 (3H,s),                                           7.24˜7.81(7H,m) [CDCl.sub.3 ]                               15           1.07(3H,t), 2.27(3H,s), 3.01 (3H,s),                                           3.30˜3.65(5H,m), 4.77(2H,s),                                             6.99(1H,s), 7.48(2H, A-B q),                                                   8.22(1H,s) [CDCl.sub.3 ]                                          28           1.45(3H,t), 3.04(2H,q), 4.05 (2H,q),                                           4.91(2H,q), 7.29(1H,s), 7.70 (1H,s),                                           7.85(2H,q) [CDCl.sub.3 ]                                          30           0.91˜2.03(8H,m), 2.41(3H,s),                                             3.20(3H,s), 3.91˜4.47(4H,m),                                             7.36˜8.08(4H,m), [CDCl .sub.3 ]                             16           1.26(3H,t), 1.49(3H,d), 2.49 (3H,s),                                           3.24(3H,s), 3.69(2H,q), 4.59 (1H,m),                                           5.00(2H,s), 7.28˜8.14(4H,m),                                             [CDCl.sub.3 ]                                                     17           1.27(3H,t), 1.67(3H,s), 2.42 (3H,s),                                           3.23(3H,s), 3.63(3H,s), 3.68 (2H,q), - 5.02(2H,s), 7.7                         (1H,s),                                                                        7.75 (2H,A-B q) [CDCl.sub.3 ]                                     ______________________________________                                    

Compounds which can be prepared in the same manner as the preceding Examples will be given in Table 5 including those of the preceding Examples. However, the present invention is not restricted to such compounds.

Various symbols used in Table 5 has the following meanings. ##STR34##

                                      TABLE 5                                      __________________________________________________________________________     A         B    X        Y                Z     Q                               __________________________________________________________________________     Me        H    Cl       COOMe            MeS   H                               Me        H    Cl       COOMe            MeSO  H                               Me        H    Cl       COOMe            Ms    H                               Me        H    Cl       COOMe            Ms    Q1                              Me        H    Cl       COOMe            Ms    Q2                              Me        H    Cl       COOMe            Ms    Q3                              Me        H    Cl       COOMe            Ms    Q4                              Me        H    Cl       COOMe            Ms    Q5                              Me        H    Cl       COOMe            Ms    Q6                              Me        H    Cl       COOMe            Ms    Q20                             Me        Me   Cl       COOMe            Ms    H                               Me        Cl   Cl       COOMe            Ms    H                               Me        CF.sub.3                                                                            Cl       COOMe            Ms    H                               Me        OMe  Cl       COOMe            Ms    H                               Me        SMe  Cl       COOMe            Ms    H                               Me        H    Cl       COOEt            MeS   H                               Me        H    Cl       COOEt            MeSO  H                               Me        H    Cl       COOEt            Ms    H                               Me        H    Cl       COOEt            Ms    Q1                              Me        H    Cl       COOEt            Ms    Q18                             Me        H    Cl       COOEt            Ms    Q13                             Me        H    Cl       COOEt            Ms    Q4                              Me        H    Cl       COOEt            Ms    Q5                              Me        H    Cl       COOEt            Ms    Q6                              Me        H    Cl       COOEt            Ms    Q22                             Me        Me   Cl       COOEt            Ms    H                               Me        Cl   Cl       COOEt            Ms    H                               Me        CF.sub.3                                                                            Cl       COOEt            Ms    H                               Me        OMe  Cl       COOEt            Ms    H                               Me        SMe  Cl       COOEt            Ms    H                               Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           MeS   H                               Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             Me        Me   Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        Cl   Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        CF.sub.3                                                                            Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        OMe  Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        SMe  Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Cl       COOMe            Cl    H                               Me        H    Cl       COOMe            Cl    Q1                              Me        H    Cl       COOMe            Cl    Q2                              Me        H    Cl       COOMe            Cl    Q3                              Me        H    Cl       COOEt            Cl    H                               Me        H    Cl       COOEt            Cl    Q1                              Me        H    Cl       COOEt            Cl    Q2                              Me        H    Cl       COOEt            Cl    Q3                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              Me        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             MeS   H                               Me        H    Cl       CON(CH.sub.3).sub.2                                                                             MeSO  H                               Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q1                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q18                             Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q13                             Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q4                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q5                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q6                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q22                             Me        Me   Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        Cl   Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        CF.sub.3                                                                            Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        OMe  Cl       CON(CH.sub. 3).sub.2                                                                            Ms    H                               Me        SMe  Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q1                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q2                              Me        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q3                              Me        H    Cl       COOC.sub.4 H.sub.9                                                                              Ms    H                               Me        H    Cl       COOC.sub.4 H.sub.9                                                                              Cl    H                               Me        H    Cl       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               Me        H    Cl       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               Me        H    Cl       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               Me        H    Cl       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               Me        H    Cl       COOC(CH.sub.3).sub.3                                                                            Ms    H                               Me        H    Cl       COOC(CH.sub.3).sub.3                                                                            Cl    H                               Me        H    Cl       CONHMe           Ms    H                               Me        H    Cl       CONHMe           Cl    H                               Me        H    Cl       CONHEt           Ms    H                               Me        H    Cl       CONHEt           Cl    H                               Me        H    Cl       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    Cl       CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               Me        H    Cl       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    Cl       CONHC(CH.sub.3).sub.3                                                                           Cl    H                               Me        H    Cl       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    Cl       CONHC.sub.4 H.sub.9                                                                             Cl    H                               Me        H    Cl       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               Me        H    Cl       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               Me        H    Cl       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               Me        H    Cl       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               Me        H    Cl       CONEt.sub.2      Ms    H                               Me        H    Cl       CONEt.sub.2      Cl    H                               Me        H    Cl       CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Ms    H                               Me        H    Cl       CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Cl    H                               Me        H    Cl       Y1               Ms    H                               Me        H    Cl       Y1               Cl    H                               Me        H    Cl       Y2               Ms    H                               Me        H    Cl       Y2               Cl    H                               Me        H    Cl       Y3               Ms    H                               Me        H    Cl       Y3               Cl    H                               Me        H    Cl       COOPh            Ms    H                               Me        H    Cl       COOPh            Cl    H                               Me        H    Cl       COOCH.sub.2 Ph   Ms    H                               Me        H    Cl       COOCH.sub.2 Ph   Cl    H                               Me        H    Cl       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    Cl       COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               Me        H    Cl       COOCH.sub.2 CCH.sub.2                                                                           Ms    H                               Me        H    Cl       COOCH.sub.2 CCH.sub.2                                                                           Cl    H                               Me        H    Cl       C(O)SMe          Ms    H                               Me        H    Cl       C(O)SMe          Cl    H                               Me        H    Cl       C(O)SEt          Ms    H                               Me        H    Cl       C(O)SEt          Cl    H                               Me        H    Cl       C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    Cl       C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    Cl       C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    Cl       C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    Cl       C(S)OMe          Ms    H                               Me        H    Cl       C(S)OMe          Cl    H                               Me        H    Cl       C(S)OEt          Ms    H                               Me        H    Cl       C(S)OEt          Cl    H                               Me        H    Cl       C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    Cl       C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    Cl       C(S)SMe          Ms    H                               Me        H    Cl       C(S)SMe          Cl    H                               Me        H    Cl       C(S)SEt          Ms    H                               Me        H    Cl       C(S)SEt          Cl    H                               Me        H    Cl       C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    Cl       C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    Me       COOMe            MeS   H                               Me        H    Me       COOMe            MeSO  H                               Me        H    Me       COOMe            Ms    H                               Me        H    Me       COOMe            Ms    Q1                              Me        H    Me       COOMe            Ms    Q2                              Me        H    Me       COOMe            Ms    Q3                              Me        H    Me       COOMe            Ms    Q4                              Me        H    Me       COOMe            Ms    Q5                              Me        H    Me       COOMe            Ms    Q6                              Me        H    Me       COOMe            Ms    Q20                             Me        Me   Me       COOMe            Ms    H                               Me        Cl   Me       COOMe            Ms    H                               Me        CF.sub.3                                                                            Me       COOMe            Ms    H                               Me        OMe  Me       COOMe            Ms    H                               Me        SMe  Me       COOMe            Ms    H                               Me        H    Me       COOEt            MeS   H                               Me        H    Me       COOEt            MeSO  H                               Me        H    Me       COOEt            Ms    Q1                              Me        H    Me       COOEt            Ms    Q18                             Me        H    Me       COOEt            Ms    Q13                             Me        H    Me       COOEt            Ms    Q4                              Me        H    Me       COOEt            Ms    Q5                              Me        H    Me       COOEt            Ms    Q6                              Me        H    Me       COOEt            Ms    Q22                             Me        Me   Me       COOEt            Ms    H                               Me        Cl   Me       COOEt            Ms    H                               Me        CF.sub.3                                                                            Me       COOEt            Ms    H                               Me        OMe  Me       COOEt            Ms    H                               Me        SMe  Me       COOEt            Ms    H                               Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           MeS   H                               Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             Me        Me   Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        Cl   Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        CF.sub.3                                                                            Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        OMe  Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        SMe  Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Me       COOMe            Cl    H                               Me        H    Me       COOMe            Cl    Q1                              Me        H    Me       COOMe            Cl    Q2                              Me        H    Me       COOMe            Cl    Q3                              Me        H    Me       COOEt            Cl    H                               Me        H    Me       COOEt            Cl    Q1                              Me        H    Me       COOEt            Cl    Q2                              Me        H    Me       COOEt            Cl    Q3                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              Me        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             MeS   H                               Me        H    Me       CON(CH.sub.3).sub.2                                                                             MeSO  H                               Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q1                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q18                             Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q13                             Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q4                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q5                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q6                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q22                             Me        Me   Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        Cl   Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        CF.sub.3                                                                            Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        OMe  Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        SMe  Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q1                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q2                              Me        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q3                              Me        H    Me       COOC.sub.4 H.sub.9                                                                              Ms    H                               Me        H    Me       COOC.sub.4 H.sub.9                                                                              Cl    H                               Me        H    Me       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               Me        H    Me       COOCH.sub.2 CH(CH.sub.3 ).sub.2                                                                 Cl    H                               Me        H    Me       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               Me        H    Me       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               Me        H    Me       COO(CH.sub.3).sub.3                                                                             Ms    H                               Me        H    Me       COO(CH.sub.3).sub.3                                                                             Cl    H                               Me        H    Me       CONHMe           Ms    H                               Me        H    Me       CONHMe           Cl    H                               Me        H    Me       CONHEt           Ms    H                               Me        H    Me       CONHEt           Cl    H                               Me        H    Me       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    Me       CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               Me        H    Me       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    Me       CONHC(CH.sub.3).sub.3                                                                           Cl    H                               Me        H    Me       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    Me       CONHC.sub.4 H.sub.9                                                                             Cl    H                               Me        H    Me       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               Me        H    Me       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               Me        H    Me       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               Me        H    Me       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               Me        H    Me       CONEt.sub.2      Ms    H                               Me        H    Me       CONEt.sub.2      Cl    H                               Me        H    Me       CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Ms    H                               Me        H    Me       CON [CH(CH.sub. 3).sub.2 ].sub.2                                                                Cl    H                               Me        H    Me       Y1               Ms    H                               Me        H    Me       Y1               Cl    H                               Me        H    Me       Y2               Ms    H                               Me        H    Me       Y2               Cl    H                               Me        H    Me       Y3               Ms    H                               Me        H    Me       Y3               Cl    H                               Me        H    Me       COOPh            Ms    H                               Me        H    Me       COOPh            Cl    H                               Me        H    Me       COOCH.sub.2 Ph   Ms    H                               Me        H    Me       COOCH.sub.2 Ph   Cl    H                               Me        H    Me       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    Me       COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               Me        H    Me       COOCH.sub.2 CCH  Ms    H                               Me        H    Me       COOCH.sub.2 CCH  Cl    H                               Me        H    Me       C(O)SMe          Ms    H                               Me        H    Me       C(O)SMe          Cl    H                               Me        H    Me       C(O)SEt          Ms    H                               Me        H    Me       C(O)SEt          Cl    H                               Me        H    Me       C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    Me       C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    Me       C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    Me       C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    Me       C(S)OMe          Ms    H                               Me        H    Me       C(S)OMe          Cl    H                               Me        H    Me       C(S)OEt          Ms    H                               Me        H    Me       C(S)OEt          Cl    H                               Me        H    Me       C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    Me       C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    Me       C(S)SMe          Ms    H                               Me        H    Me       C(S)SMe          Cl    H                               Me        H    Me       C(S)SEt          Ms    H                               Me        H    Me       C(S)SEt          Cl    H                               Me        H    Me       C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    Me       C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    OMe      COOMe            MeS   H                               Me        H    OMe      COOMe            MeSO  H                               Me        H    OMe      COOMe            Ms    H                               Me        H    OMe      COOMe            Ms    Q1                              Me        H    OMe      COOMe            Ms    Q2                              Me        H    OMe      COOMe            Ms    Q3                              Me        H    OMe      COOMe            Ms    Q4                              Me        H    OMe      COOMe            Ms    Q5                              Me        H    OMe      COOMe            Ms    Q6                              Me        H    OMe      COOMe            Ms    Q20                             Me        Me   OMe      COOMe            Ms    H                               Me        Cl   OMe      COOMe            Ms    H                               Me        CF.sub.3                                                                            OMe      COOMe            Ms    H                               Me        OMe  OMe      COOMe            Ms    H                               Me        SMe  OMe      COOMe            Ms    H                               Me        H    OMe      COOEt            MeS   H                               Me        H    OMe      COOEt            MeSO  H                               Me        H    OMe      COOEt            Ms    H                               Me        H    OMe      COOEt            Ms    Q1                              Me        H    OMe      COOEt            Ms    Q18                             Me        H    OMe      COOEt            Ms    Q13                             Me        H    OMe      COOEt            Ms    Q4                              Me        H    OMe      COOEt            Ms    Q5                              Me        H    OMe      COOEt            Ms    Q6                              Me        H    OMe      COOEt            Ms    Q22                             Me        Me   OMe      COOEt            Ms    H                               Me        Cl   OMe      COOEt            Ms    H                               Me        CF.sub.3                                                                            OMe      COOEt            Ms    H                               Me        OMe  OMe      COOEt            Ms    H                               Me        SMe  OMe      COOEt            Ms    H                               Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           MeS   H                               Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             Me        Me   OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        Cl   OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        CF.sub. 3                                                                           OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        OMe  OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        SMe  OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    OMe      COOMe            Cl    H                               Me        H    OMe      COOMe            Cl    Q1                              Me        H    OMe      COOMe            Cl    Q2                              Me        H    OMe      COOMe            Cl    Q3                              Me        H    OMe      COOEt            Cl    H                               Me        H    OMe      COOEt            Cl    Q1                              Me        H    OMe      COOEt            Cl    Q2                              Me        H    OMe      COOEt            Cl    Q3                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              Me        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             MeS   H                               Me        H    OMe      CON(CH.sub.3).sub.2                                                                             MeSO  H                               Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q1                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q18                             Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q13                             Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q4                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q5                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q6                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q22                             Me        Me   OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        Cl   OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        CF.sub.3                                                                            OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        OMe  OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        SMe  OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q1                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q2                              Me        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q3                              Me        H    OMe      COOC.sub.4 H.sub.9                                                                              Ms    H                               Me        H    OMe      COOC.sub.4 H.sub.9                                                                              Cl    H                               Me        H    OMe      COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               Me        H    OMe      COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               Me        H    OMe      COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               Me        H    OMe      COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               Me        H    OMe      COOC(CH.sub.3).sub.3                                                                            Ms    H                               Me        H    OMe      COOC(CH.sub.3).sub.3                                                                            Cl    H                               Me        H    OMe      CONHMe           Ms    H                               Me        H    OMe      CONHMe           Cl    H                               Me        H    OMe      CONHEt           Ms    H                               Me        H    OMe      CONHEt           Cl    H                               Me        H    OMe      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    OMe      CONHCH(CH.sub.3 ).sub.2                                                                         Cl    H                               Me        H    OMe      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    OMe      CONHC(CH.sub.3).sub.3                                                                           Cl    H                               Me        H    OMe      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    OMe      CONHC.sub.4 H.sub.9                                                                             Cl    H                               Me        H    OMe      CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               Me        H    OMe      CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               Me        H    OMe      CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               Me        H    OMe      CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               Me        H    OMe      CONEt.sub.2      Ms    H                               Me        H    OMe      CONEt.sub.2      Cl    H                               Me        H    OMe      CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Ms    H                               Me        H    OMe      CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Cl    H                               Me        H    OMe      Y1               Ms    H                               Me        H    OMe      Y1               Cl    H                               Me        H    OMe      Y2               Ms    H                               Me        H    OMe      Y2               Cl    H                               Me        H    OMe      Y3               Ms    H                               Me        H    OMe      Y3               Cl    H                               Me        H    OMe      COOPh            Ms    H                               Me        H    OMe      COOPh            Cl    H                               Me        H    OMe      COOCH.sub.2 Ph   Ms    H                               Me        H    OMe      COOCH.sub.2 Ph   Cl    H                               Me        H    OMe      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    OMe      COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               Me        H    OMe      COOCH.sub.2 CCH  Ms    H                               Me        H    OMe      COOCH.sub.2 CCH  Cl    H                               Me        H    OMe      C(O)SMe          Ms    H                               Me        H    OMe      C(O)SMe          Cl    H                               Me        H    OMe      C(O)SEt          Ms    H                               Me        H    OMe      C(O)SEt          Cl    H                               Me        H    OMe      C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    OMe      C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    OMe      C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    OMe      C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    OMe      C(S)OMe          Ms    H                               Me        H    OMe      C(S)OMe          Cl    H                               Me        H    OMe      C(S)OEt          Ms    H                               Me        H    OMe      C(S)OEt          Cl    H                               Me        H    OMe      C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    OMe      C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    OMe      C(S)SMe          Ms    H                               Me        H    OMe      C(S)SMe          Cl    H                               Me        H    OMe      C(S)SEt          Ms    H                               Me        H    OMe      C(S)SEt          Cl    H                               Me        H    OMe      C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Me        H    OMe      C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Me        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Me        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Me        H    Br       COOMe            Ms    H                               Me        H    Br       COOMe            Cl    H                               Me        H    Br       COOEt            Ms    H                               Me        H    Br       COOEt            Cl    H                               Me        H    Br       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Br       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    Br       CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    Br       CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    Br       CONHMe           Ms    H                               Me        H    Br       CONHEt           Ms    H                               Me        H    Br       CONHC.sub.3 H.sub.7                                                                             Ms    H                               Me        H    Br       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    Br       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    Br       CONEt.sub.2      Ms    H                               Me        H    Br       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    Br       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    Br       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    Br       CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Ms    H                               Me        H    Br       Y1               Ms    H                               Me        H    Br       Y2               Ms    H                               Me        H    Br       COOPh            Ms    H                               Me        H    Br       COOCH.sub.2 Ph   Ms    H                               Me        H    Br       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    Br       COOCH.sub.2 CCH  Ms    H                               Me        H    OEt      COOMe            Ms    H                               Me        H    OEt      COOMe            Cl    H                               Me        H    OEt      COOEt            Ms    H                               Me        H    OEt      COOEt            Cl    H                               Me        H    OEt      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    OEt      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    OEt      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    OEt      CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    OEt      CONHMe           Ms    H                               Me        H    OEt      CONHEt           Ms    H                               Me        H    OEt      CONHC.sub.3 H.sub.7                                                                             Ms    H                               Me        H    OEt      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    OEt      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    OEt      CONEt.sub.2      Ms    H                               Me        H    OEt      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    OEt      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    OEt      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    OEt      CON [CH(CH.sub.3).sub.2 ].sub.2                                                                 Ms    H                               Me        H    OEt      Y1               Ms    H                               Me        H    OEt      Y2               Ms    H                               Me        H    OEt      COOPh            Ms    H                               Me        H    OEt      COOCH.sub.2 Ph   Ms    H                               Me        H    OEt      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    OEt      COOCH.sub.2 CCH  Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOMe            Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOMe            Cl    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOEt            Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOEt            Cl    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHMe           Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHEt           Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.3 H.sub.7                                                                             Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONEt.sub.2      Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     Y1               Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     Y2               Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOPh            Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 Ph   Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 CCH  Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOMe            Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOMe            Cl    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOEt            Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOEt            Cl    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CON(CH.sub.3).sub.2                                                                             Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CON(CH.sub.3).sub.2                                                                             Cl    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHMe           Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHEt           Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.3 H.sub.7                                                                             Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONEt.sub.2      Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      Y1               Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      Y2               Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOPh            Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 Ph   Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 CCH  Ms    H                               Et        H    Cl       COOMe            MeS   H                               Et        H    Cl       COOMe            MeSO  H                               Et        H    Cl       COOMe            Ms    H                               Et        H    Cl       COOMe            Ms    Q1                              Et        H    Cl       COOMe            Ms    Q2                              Et        H    Cl       COOMe            Ms    Q3                              Et        H    Cl       COOMe            Ms    Q4                              Et        H    Cl       COOMe            Ms    Q5                              Et        H    Cl       COOMe            Ms    Q6                              Et        H    Cl       COOMe            Ms    Q20                             Et        Me   Cl       COOMe            Ms    H                               Et        Cl   Cl       COOMe            Ms    H                               Et        CF.sub.3                                                                            Cl       COOMe            Ms    H                               Et        OMe  Cl       COOMe            Ms    H                               Et        SMe  Cl       COOMe            Ms    H                               Et        H    Cl       COOEt            MeS   H                               Et        H    Cl       COOEt            MeSO  H                               Et        H    Cl       COOEt            Ms    H                               Et        H    Cl       COOEt            Ms    Q1                              Et        H    Cl       COOEt            Ms    Q18                             Et        H    Cl       COOEt            Ms    Q13                             Et        H    Cl       COOEt            Ms    Q4                              Et        H    Cl       COOEt            Ms    Q5                              Et        H    Cl       COOEt            Ms    Q6                              Et        H    Cl       COOEt            Ms    Q22                             Et        Me   Cl       COOEt            Ms    H                               Et        Cl   Cl       COOEt            Ms    H                               Et        CF.sub.3                                                                            Cl       COOEt            Ms    H                               Et        OMe  Cl       COOEt            Ms    H                               Et        SMe  Cl       COOEt            Ms    H                               Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           MeS   H                               Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             Et        Me   Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        Cl   Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        CF.sub.3                                                                            Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        OMe  Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               __________________________________________________________________________

                                      TABLE 5                                      __________________________________________________________________________      ##STR35##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Et        SMe  Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Cl       COOMe            Cl    H                               Et        H    Cl       COOMe            Cl    Q1                              Et        H    Cl       COOMe            Cl    Q2                              Et        H    Cl       COOMe            Cl    Q3                              Et        H    Cl       COOEt            Cl    H                               Et        H    Cl       COOEt            Cl    Q1                              Et        H    Cl       COOEt            Cl    Q2                              Et        H    Cl       COOEt            Cl    Q3                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              Et        H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             MeS   H                               Et        H    Cl       CON(CH.sub.3).sub.2                                                                             MeSO  H                               Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    Cl       CON(CH.sub. 2).sub.2                                                                            Ms    Q1                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q18                             Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q13                             Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q4                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q5                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q6                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q22                             Et        Me   Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        Cl   Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        CF.sub.3                                                                            Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        OMe  Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        SMe  Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q1                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q2                              Et        H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q3                              Et        H    Cl       COOC.sub.4 H.sub.9                                                                              Ms    H                               Et        H    Cl       COOC.sub.4 H.sub.9                                                                              Cl    H                               Et        H    Cl       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               Et        H    Cl       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               Et        H    Cl       COOCH.sub.2 CH(CH.sub.3)C.sub.2 H.sub.5                                                         Ms    H                               Et        H    Cl       COOCH(CH.sub.3)C.sub. 2 H.sub.5                                                                 Cl    H                               Et        H    Cl       COOC(CH.sub.3).sub.3                                                                            Ms    H                               Et        H    Cl       COOC(CH.sub.3).sub.3                                                                            Cl    H                               Et        H    Cl       CONHMe           Ms    H                               Et        H    Cl       CONHMe           Cl    H                               Et        H    Cl       CONHEt           Ms    H                               Et        H    Cl       CONHEt           Cl    H                               Et        H    Cl       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    Cl       CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               Et        H    Cl       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    Cl       CONHC(CH.sub.3).sub.3                                                                           Cl    H                               Et        H    Cl       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    Cl       CONHC.sub.4 H.sub.9                                                                             Cl    H                               Et        H    Cl       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               Et        H    Cl       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               Et        H    Cl       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               Et        H    Cl       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               Et        H    Cl       CONEt.sub.2      Ms    H                               Et        H    Cl       CONEt.sub.2      Cl    H                               Et        H    Cl       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    Cl       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Cl    H                               Et        H    Cl       Y1               Ms    H                               Et        H    Cl       Y1               Cl    H                               Et        H    Cl       Y2               Ms    H                               Et        H    Cl       Y2               Cl    H                               Et        H    Cl       Y3               Ms    H                               Et        H    Cl       Y3               Cl    H                               Et        H    Cl       COOPh            Ms    H                               Et        H    Cl       COOPh            Cl    H                               Et        H    Cl       COOCH.sub.2 Ph   Ms    H                               Et        H    Cl       COOCH.sub.2 Ph   Cl    H                               Et        H    Cl       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    Cl       COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               Et        H    Cl       COOCH.sub.2 CCH  Ms    H                               Et        H    Cl       COOCH.sub.2 CCH  Cl    H                               Et        H    Cl       C(O)SMe          Ms    H                               Et        H    Cl       C(O)SMe          Cl    H                               Et        H    Cl       C(O)SEt          Ms    H                               Et        H    Cl       C(O)SEt          Cl    H                               Et        H    Cl       C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    Cl       C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    Cl       C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    Cl       C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    Cl       C(S)OMe          Ms    H                               Et        H    Cl       C(S)OMe          Cl    H                               Et        H    Cl       C(S)OEt          Ms    H                               Et        H    Cl       C(S)OEt          Cl    H                               Et        H    Cl       C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    Cl       C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    Cl       C(S)SMe          Ms    H                               Et        H    Cl       C(S)SMe          Cl    H                               Et        H    Cl       C(S)SEt          Ms    H                               Et        H    Cl       C(S)SEt          Cl    H                               Et        H    Cl       C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    Cl       C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    Me       COOMe            MeS   H                               Et        H    Me       COOMe            MeSO  H                               Et        H    Me       COOMe            Ms    H                               Et        H    Me       COOMe            Ms    H                               Et        H    Me       COOMe            Ms    Q2                              Et        H    Me       COOMe            Ms    Q3                              Et        H    Me       COOMe            Ms    Q4                              Et        H    Me       COOMe            Ms    Q5                              Et        H    Me       COOMe            Ms    Q6                              Et        H    Me       COOMe            Ms    Q20                             Et        Me   Me       COOMe            Ms    H                               Et        Cl   Me       COOMe            Ms    H                               Et        CF.sub.3                                                                            Me       COOMe            Ms    H                               Et        OMe  Me       COOMe            Ms    H                               Et        SMe  Me       COOMe            Ms    H                               Et        H    Me       COOEt            MeS   H                               Et        H    Me       COOEt            MeSO  H                               Et        H    Me       COOEt            Ms    H                               Et        H    Me       COOEt            Ms    Q1                              Et        H    Me       COOEt            Ms    Q18                             Et        H    Me       COOEt            Ms    Q13                             Et        H    Me       COOEt            Ms    Q4                              Et        H    Me       COOEt            Ms    Q5                              Et        H    Me       COOEt            Ms    Q6                              Et        H    Me       COOEt            Ms    Q22                             Et        Me   Me       COOEt            Ms    H                               Et        Cl   Me       COOEt            Ms    H                               Et        CF.sub.3                                                                            Me       COOEt            Ms    H                               Et        OMe  Me       COOEt            Ms    H                               Et        SMe  Me       COOEt            Ms    H                               Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           MeS   H                               Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             Et        Me   Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        Cl   Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        CF.sub.3                                                                            Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        OMe  Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        SMe  Me       COOCH(CH.sub.3).sub. 2                                                                          Ms    H                               Et        H    Me       COOMe            Cl    H                               Et        H    Me       COOMe            Cl    Q1                              Et        H    Me       COOMe            Cl    Q2                              Et        H    Me       COOMe            Cl    Q3                              Et        H    Me       COOEt            Cl    H                               Et        H    Me       COOEt            Cl    Q1                              Et        H    Me       COOEt            Cl    Q2                              Et        H    Me       COOEt            Cl    Q3                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    Me       COOCH(CH(CH.sub.3).sub.2                                                                        Cl    Q1                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              Et        H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             MeS   H                               Et        H    Me       CON(CH.sub.3).sub.2                                                                             MeSO  H                               Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q1                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q18                             Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q13                             Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q4                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q5                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q6                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q22                             Et        Me   Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        Cl   Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        CF.sub.3                                                                            Me       CON(CH.sub. 3).sub.2                                                                            Ms    H                               Et        OMe  Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        SMe  Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q1                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q2                              Et        H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q3                              Et        H    Me       COOC.sub.4 H.sub.9                                                                              Ms    H                               Et        H    Me       COOC.sub.4 H.sub.9                                                                              Cl    H                               Et        H    Me       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               Et        H    Me       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               Et        H    Me       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               Et        H    Me       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               Et        H    Me       COOC(CH.sub.3).sub.3                                                                            Ms    H                               Et        H    Me       COOC(CH.sub.3).sub.3                                                                            Cl    H                               Et        H    Me       CONHMe           Ms    H                               Et        H    Me       CONHMe           Cl    H                               Et        H    Me       CONHEt           Ms    H                               Et        H    Me       CONHEt           Cl    H                               Et        H    Me       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    Me       CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               Et        H    Me       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    Me       CONHC(CH.sub.3).sub.3                                                                           Cl    H                               Et        H    Me       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    Me       CONHC.sub.4 H.sub.9                                                                             Cl    H                               Et        H    Me       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               Et        H    Me       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               Et        H    Me       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               Et        H    Me       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               Et        H    Me       CONEt.sub.2      Ms    H                               Et        H    Me       CONEt.sub.2      Cl    H                               Et        H    Me       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    Me       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Cl    H                               Et        H    Me       Y1               Ms    H                               Et        H    Me       Y1               Cl    H                               Et        H    Me       Y2               Ms    H                               Et        H    Me       Y2               Cl    H                               Et        H    Me       Y3               Ms    H                               Et        H    Me       Y3               Cl    H                               Et        H    Me       COOPh            Ms    H                               Et        H    Me       COOPh            Cl    H                               Et        H    Me       COOCH.sub.2 Ph   Ms    H                               Et        H    Me       COOCH.sub.2 Ph   Cl    H                               Et        H    Me       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    Me       COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               Et        H    Me       COOCH.sub.2 C CH Ms    H                               Et        H    Me       COOCH.sub.2 CCH  Cl    H                               Et        H    Me       C(O)SMe          Ms    H                               Et        H    Me       C(O)SMe          Cl    H                               Et        H    Me       C(O)SEt          Cl    H                               Et        H    Me       C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    Me       C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    Me       C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    Me       C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    Me       C(S)OMe          Ms    H                               Et        H    Me       C(S)OMe          Cl    H                               Et        H    Me       C(S)OEt          Ms    H                               Et        H    Me       C(S)OEt          Cl    H                               Et        H    Me       C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    Me       C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    Me       C(S)SMe          Ms    H                               Et        H    Me       C(S)SMe          Cl    H                               Et        H    Me       C(S)SEt          Ms    H                               Et        H    Me       C(S)SEt          Cl    H                               Et        H    Me       C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    Me       C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    Me       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    OMe      COOMe            MeS   H                               Et        H    OMe      COOMe            MeSO  H                               Et        H    OMe      COOMe            Ms    H                               Et        H    OMe      COOMe            Ms    Q1                              Et        H    OMe      COOMe            Ms    Q2                              Et        H    OMe      COOMe            Ms    Q3                              Et        H    OMe      COOMe            Ms    Q4                              Et        H    OMe      COOMe            Ms    Q5                              Et        H    OMe      COOMe            Ms    Q6                              Et        H    OMe      COOMe            Ms    Q20                             Et        Me   OMe      COOMe            Ms    H                               Et        Cl   OMe      COOMe            Ms    H                               Et        CF.sub.3                                                                            OMe      COOMe            Ms    H                               Et        OMe  OMe      COOMe            Ms    H                               Et        SMe  OMe      COOMe            Ms    H                               Et        H    OMe      COOEt            MeS   H                               Et        H    OMe      COOEt            MeSO  H                               Et        H    OMe      COOEt            Ms    H                               Et        H    OMe      COOEt            Ms    Q1                              Et        H    OMe      COOEt            Ms    Q18                             Et        H    OMe      COOEt            Ms    Q13                             Et        H    OMe      COOEt            Ms    Q4                              Et        H    OMe      COOEt            Ms    Q5                              Et        H    OMe      COOEt            Ms    Q6                              Et        H    OMe      COOEt            Ms    Q22                             Et        Me   OMe      COOEt            Ms    H                               Et        Cl   OMe      COOEt            Ms    H                               Et        CF.sub.3                                                                            OMe      COOEt            Ms    H                               Et        OMe  OMe      COOEt            Ms    H                               Et        SMe  OMe      COOEt            Ms    H                               Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           MeS   H                               Et        H    OMe      COOCH(CH.sub.2).sub.2                                                                           MeSO  H                               Et        H    OMe      COOCH(CH.sub.3).sub. 2                                                                          Ms    H                               Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             Et        Me   OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        Cl   OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        CF.sub.3                                                                            OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        OMe  OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        SMe  OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    OMe      COOMe            Cl    H                               Et        H    OMe      COOMe            Cl    Q1                              Et        H    OMe      COOMe            Cl    Q2                              Et        H    OMe      COOMe            Cl    Q3                              Et        H    OMe      COOEt            Cl    H                               Et        H    OMe      COOEt            Cl    Q1                              Et        H    OMe      COOEt            Cl    Q2                              Et        H    OMe      COOEt            Cl    Q3                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              Et        H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              Et        H    OMe      CON(CH.sub. 3).sub.2                                                                            MeS   H                               Et        H    OMe      CON(CH.sub.3).sub.2                                                                             MeSO  H                               Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q1                              Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q18                             Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q13                             Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q4                              Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q5                              Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q6                              Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q22                             Et        Me   OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        Cl   OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        CF.sub.3                                                                            OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        OMe  OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        SMe  OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q1                              Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q2                              Et        H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q3                              Et        H    OMe      COOC.sub.4 H.sub.9                                                                              Ms    H                               Et        H    OMe      COOC.sub.4 H.sub.9                                                                              Cl    H                               Et        H    OMe      COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               Et        H    OMe      COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               Et        H    OMe      COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               Et        H    OMe      COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               Et        H    OMe      COOC(CH.sub.3).sub.3                                                                            Ms    H                               Et        H    OMe      COOC(CH.sub.3).sub.3                                                                            Cl    H                               Et        H    OMe      CONHMe           Ms    H                               Et        H    OMe      CONHMe           Cl    H                               Et        H    OMe      CONHEt           Ms    H                               Et        H    OMe      CONHEt           Cl    H                               Et        H    OMe      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    OMe      CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               Et        H    OMe      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    OMe      CONHC(CH.sub.3).sub.3                                                                           Cl    H                               Et        H    OMe      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    OMe      CONHC.sub.4 H.sub.9                                                                             Cl    H                               Et        H    OMe      CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               Et        H    OMe      CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               Et        H    OMe      CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               Et        H    OMe      CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               Et        H    OMe      CONEt.sub.2      Ms    H                               Et        H    OMe      CONEt.sub.2      Cl    H                               Et        H    OMe      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    OMe      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Cl    H                               Et        H    OMe      Y1               Ms    H                               Et        H    OMe      Y1               Cl    H                               Et        H    OMe      Y2               Ms    H                               Et        H    OMe      Y2               Cl    H                               Et        H    OMe      Y3               Ms    H                               Et        H    OMe      Y3               Cl    H                               Et        H    OMe      COOPh            Ms    H                               Et        H    OMe      COOPh            Cl    H                               Et        H    OMe      COOCH.sub.2 Ph   Ms    H                               Et        H    OMe      COOCH.sub.2 Ph   Cl    H                               Et        H    OMe      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    OMe      COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               Et        H    OMe      COOCH.sub.2 CCH  Ms    H                               Et        H    OMe      COOCH.sub.2 CCH  Cl    H                               Et        H    OMe      C(O)SMe          Ms    H                               Et        H    OMe      C(O)SMe          Cl    H                               Et        H    OMe      C(O)SEt          Ms    H                               Et        H    OMe      C(O)SEt          Cl    H                               Et        H    OMe      C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    OMe      C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    OMe      C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    OMe      C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    OMe      C(S)OMe          Ms    H                               Et        H    OMe      C(S)OMe          Cl    H                               Et        H    OMe      C(S)OEt          Ms    H                               Et        H    OMe      C(S)OEt          Cl    H                               Et        H    OMe      C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    OMe      C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    OMe      C(S)SMe          Ms    H                               Et        H    OMe      C(S)SMe          Cl    H                               Et        H    OMe      C(S)SEt          Ms    H                               Et        H    OMe      C(S)SEt          Cl    H                               Et        H    OMe      C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               Et        H    OMe      C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               Et        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               Et        H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               Et        H    Br       COOMe            Ms    H                               Et        H    Br       COOMe            Cl    H                               Et        H    Br       COOEt            Ms    H                               Et        H    Br       COOEt            Cl    H                               Et        H    Br       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Br       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    Br       CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    Br       CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    Br       CONHMe           Ms    H                               Et        H    Br       CONHEt           Ms    H                               Et        H    Br       CONHC.sub.3 H.sub.7                                                                             Ms    H                               Et        H    Br       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    Br       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    Br       CONEt.sub.2      Ms    H                               Et        H    Br       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    Br       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    Br       CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    Br       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    Br       Y1               Ms    H                               Et        H    Br       Y2               Ms    H                               Et        H    Br       COOPh            Ms    H                               Et        H    Br       COOCH.sub.2 Ph   Ms    H                               Et        H    Br       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    Br       COOCH.sub.2 CCH  Ms    H                               Et        H    OEt      COOMe            Ms    H                               Et        H    OEt      COOMe            Cl    H                               Et        H    OEt      COOEt            Ms    H                               Et        H    OEt      COOEt            Cl    H                               Et        H    OEt      COOCH(CH.sub.3)hd 2                                                                             Ms    H                               Et        H    OEt      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    OEt      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    OEt      CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    OEt      CONHMe           Ms    H                               Et        H    OEt      CONHEt           Ms    H                               Et        H    OEt      CONHC.sub.3 H.sub.7                                                                             Ms    H                               Et        H    OEt      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    OEt      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    OEt      CONEt.sub.2      Ms    H                               Et        H    OEt      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    OEt      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    OEt      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    OEt      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    OEt      Y1               Ms    H                               Et        H    OEt      Y2               Ms    H                               Et        H    OEt      COOPh            Ms    H                               Et        H    OEt      COOCH.sub.2 Ph   Ms    H                               Et        H    OEt      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    OEt      COOCH.sub.2 CCH  Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOMe            Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOMe            Cl    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOEt            Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOEt            Cl    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    OCH(CH.sub.3).sub. 2                                                                    CONHMe           Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHEt           Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.3 H.sub.7                                                                             Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONEt.sub.2      Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     Y1               Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     Y2               Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOPh            Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 Ph   Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 C CH Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOMe            Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOMe            Cl    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOEt            Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOEt            Cl    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CON(CH.sub.3).sub.2                                                                             Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CON(CH.sub.3).sub.2                                                                             Cl    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHMe           Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHEt           Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.3 H.sub.7                                                                             Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONEt.sub.2      Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.4 H.sub.9                                                                             Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      Y1               Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      Y2               Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOPh            Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 Ph   Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 CCH  Ms    H                               i-Pr      H    Cl       COOMe            MeS   H                               i-Pr      H    Cl       COOMe            MeSO  H                               i-Pr      H    Cl       COOMe            Ms    H                               i-Pr      H    Cl       COOMe            Ms    Q1                              i-Pr      H    Cl       COOMe            Ms    Q2                              i-Pr      H    Cl       COOMe            Ms    Q3                              i-Pr      H    Cl       COOMe            Ms    Q4                              i-Pr      H    Cl       COOMe            Ms    Q5                              i-Pr      H    Cl       COOMe            Ms    Q6                              i-Pr      H    Cl       COOMe            Ms    Q20                             i-Pr      Me   Cl       COOMe            Ms    H                               i-Pr      Cl   Cl       COOMe            Ms    H                               i-Pr      CF.sub.3                                                                            Cl       COOMe            Ms    H                               i-Pr      OMe  Cl       COOMe            Ms    H                               i-Pr      SMe  Cl       COOMe            Ms    H                               i-Pr      H    Cl       COOEt            MeS   H                               i-Pr      H    Cl       COOEt            MeSO  H                               i-Pr      H    Cl       COOEt            Ms    H                               i-Pr      H    Cl       COOEt            Ms    Q1                              i-Pr      H    Cl       COOEt            Ms    Q18                             i-Pr      H    Cl       COOEt            Ms    Q13                             i-Pr      H    Cl       COOEt            Ms    Q4                              i-Pr      H    Cl       COOEt            Ms    Q5                              i-Pr      H    Cl       COOEt            Ms    Q6                              i-Pr      H    Cl       COOEt            Ms    Q22                             i-Pr      Me   Cl       COOEt            Ms    H                               i-Pr      Cl   Cl       COOEt            Ms    H                               i-Pr      CF.sub.3                                                                            Cl       COOEt            Ms    H                               i-Pr      OMe  Cl       COOEt            Ms    H                               i-Pr      SMe  Cl       COOEt            Ms    H                               i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           MeS   H                               i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               i-Pr      H    Cl       COOCH(CH.sub.3 .sub.2                                                                           Ms    H                               i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              i Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             i-Pr      Me   Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      Cl   Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      CF.sub.3                                                                            Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      OMe  Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      SMe  Cl       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Cl       COOMe            Cl    H                               i-Pr      H    Cl       COOMe            Cl    Q1                              i-Pr      H    Cl       COOMe            Cl    Q2                              i-Pr      H    Cl       COOMe            Cl    Q3                              i-Pr      H    Cl       COOEt            Cl    H                               i-Pr      H    Cl       COOEt            Cl    Q1                              i-Pr      H    Cl       COOEt            Cl    Q2                              i-Pr      H    Cl       COOEt            Cl    Q3                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              i-Pr      H    Cl       COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             MeS   H                               i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             MeSO  H                               i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q1                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q18                             i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q13                             i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q4                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q5                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q6                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Ms    Q22                             i-Pr      Me   Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      Cl   Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      CF.sub.3                                                                            Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      OMe  Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      SMe  Cl       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q1                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q2                              i-Pr      H    Cl       CON(CH.sub.3).sub.2                                                                             Cl    Q3                              i-Pr      H    Cl       COOC.sub.4 H.sub.9                                                                              Ms    H                               i-Pr      H    Cl       COOC.sub.4 H.sub.9                                                                              Cl    H                               i-Pr      H    Cl       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               i-Pr      H    Cl       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               i-Pr      H    Cl       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               i-Pr      H    Cl       COOC(CH.sub.3).sub.3                                                                            Ms    H                               i-Pr      H    Cl       COOC(CH.sub.3).sub.3                                                                            Cl    H                               i-Pr      H    Cl       CONHMe           Ms    H                               i-Pr      H    Cl       CONHMe           Cl    H                               i-Pr      H    Cl       CONHEt           Ms    H                               i-Pr      H    Cl       CONHEt           Cl    H                               i-Pr      H    Cl       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    Cl       CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               i-Pr      H    Cl       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    Cl       CONHC(CH.sub.3).sub.3                                                                           Cl    H                               i-Pr      H    Cl       CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    Cl       CONHC.sub.4 H.sub.9                                                                             Cl    H                               i-Pr      H    Cl       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               i-Pr      H    Cl       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               i-Pr      H    Cl       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               i-Pr      H    Cl       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               i-Pr      H    Cl       CONEt.sub.2      Ms    H                               i-Pr      H    Cl       CONEt.sub.2      Cl    H                               i-Pr      H    Cl       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               i-Pr      H    Cl       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Cl    H                               i-Pr      H    Cl       Y1               Ms    H                               i-Pr      H    Cl       Y1               Cl    H                               i-Pr      H    Cl       Y2               Ms    H                               i-Pr      H    Cl       Y2               Cl    H                               i-Pr      H    Cl       Y3               Ms    H                               i-Pr      H    Cl       Y3               Cl    H                               i-Pr      H    Cl       COOPh            Ms    H                               i-Pr      H    Cl       COOPh            Cl    H                               i-Pr      H    Cl       COOCH.sub.2 Ph   Ms    H                               i-Pr      H    Cl       COOCH.sub.2 Ph   Cl    H                               i-Pr      H    Cl       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               i-Pr      H    Cl       COOCH.sub.2 CCH  Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CCH  Cl    H                               i-Pr      H    Cl       C(O)SME          Ms    H                               i-Pr      H    Cl       C(O)SMe          Cl    H                               i-Pr      H    Cl       C(O)SEt          Ms    H                               i-Pr      H    Cl       C(O)SEt          Cl    H                               i-Pr      H    Cl       C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    Cl       C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    Cl       C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               Pr        H    Cl       C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               Pr        H    Cl       C(S)OMe          Ms    H                               i-Pr      H    Cl       C(S)OMe          Cl    H                               i-Pr      H    CL       C(S)OEt          Ms    H                               i-Pr      H    Cl       C(S)OEt          Cl    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR36##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     i-Pr      H    Cl       C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    Cl       C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    Cl       C(S)SMe          Ms    H                               i-Pr      H    Cl       C(S)SMe          Cl    H                               i-Pr      H    Cl       C(S)SEt          Ms    H                               i-Pr      H    Cl       C(S)SEt          Cl    H                               i-Pr      H    Cl       C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    Cl       C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    Cl       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    Me       COOMe            MeS   H                               i-Pr      H    Me       COOMe            MeSO  H                               i-Pr      H    Me       COOMe            Ms    H                               i-Pr      H    Me       COOMe            Ms    Q1                              i-Pr      H    Me       COOMe            Ms    Q2                              i-Pr      H    Me       COOMe            Ms    Q3                              i-Pr      H    Me       COOMe            Ms    Q4                              i-Pr      H    Me       COOMe            Ms    Q5                              i-Pr      H    Me       COOMe            Ms    Q6                              i-Pr      H    Me       COOMe            Ms    Q20                             i-Pr      Me   Me       COOMe            Ms    H                               i-Pr      Cl   Me       COOMe            Ms    H                               i-Pr      CF.sub.3                                                                            Me       COOMe            Ms    H                               i-Pr      OMe  Me       COOMe            Ms    H                               i-Pr      SMe  Me       COOMe            Ms    H                               i-Pr      H    Me       COOEt            MeS   H                               i-Pr      H    Me       COOEt            MeSO  H                               i-Pr      H    Me       COOEt            Ms    H                               i-Pr      H    Me       COOEt            Ms    Q1                              i-Pr      H    Me       COOEt            Ms    Q18                             i-Pr      H    Me       COOEt            Ms    Q13                             i-Pr      H    Me       COOEt            Ms    Q4                              i-Pr      H    Me       COOEt            Ms    Q5                              i-Pr      H    Me       COOEt            Ms    Q6                              i-Pr      H    Me       COOEt            Ms    Q22                             i-Pr      Me   Me       COOEt            Ms    H                               i-Pr      Cl   Me       COOEt            Ms    H                               i-Pr      CF.sub.3                                                                            Me       COOEt            Ms    H                               i-Pr      OMe  Me       COOEt            Ms    H                               i-Pr      SMe  Me       COOEt            Ms    H                               i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           MeS   H                               i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q9                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             i-Pr      Me   Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      Cl   Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      CF.sub.3                                                                            Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      OMe  Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      SMe  Me       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Me       COOMe            Cl    H                               i-Pr      H    Me       COOMe            Cl    Q1                              i-Pr      H    Me       COOMe            Cl    Q2                              i-Pr      H    Me       COOMe            Cl    Q3                              i-Pr      H    Me       COOEt            Cl    H                               i-Pr      H    Me       COOEt            Cl    Q1                              i-Pr      H    Me       COOEt            Cl    Q2                              i-Pr      H    Me       COOEt            Cl    Q3                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              i-Pr      H    Me       COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             MeS   H                               i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             MeSO  H                               i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q1                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q18                             i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q13                             i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q4                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q5                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q6                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Ms    Q22                             i-Pr      Me   Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      Cl   Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      CF.sub.3                                                                            Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      OMe  Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      SMe  Me       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q1                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q2                              i-Pr      H    Me       CON(CH.sub.3).sub.2                                                                             Cl    Q3                              i-Pr      H    Me       COOC.sub.4 H.sub.9                                                                              Ms    H                               i-Pr      H    Me       COOC.sub.4 H.sub.9                                                                              Cl    H                               i-Pr      H    Me       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               i-Pr      H    Me       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               i-Pr      H    Me       COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               i-Pr      H    Me       COOC(CH.sub.3).sub.3                                                                            Ms    H                               i-Pr      H    Me       COOC(CH.sub.3).sub.3                                                                            Cl    H                               i-Pr      H    Me       CONHMe           Ms    H                               i-Pr      H    Me       CONHMe           Cl    H                               i-Pr      H    Me       CONHEt           Ms    H                               i-Pr      H    Me       CONHEt           Cl    H                               i-Pr      H    Me       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    Me       CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               i-Pr      H    Me       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    Me       CONHC(CH.sub.3).sub.3                                                                           Cl    H                               i-Pr      H    Me       CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    Me       CONHC.sub.4 H.sub.9                                                                             Cl    H                               i-Pr      H    Me       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               i-Pr      H    Me       CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               i-Pr      H    Me       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               i-Pr      H    Me       CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               i-Pr      H    Me       CONEt.sub.2      Ms    H                               i-Pr      H    Me       CONEt.sub.2      Cl    H                               i-Pr      H    Me       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               i-Pr      H    Me       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Cl    H                               i-Pr      H    Me       Y1               Ms    H                               i-Pr      H    Me       Y1               Cl    H                               i-Pr      H    Me       Y2               Ms    H                               i-Pr      H    Me       Y2               Cl    H                               i-Pr      H    Me       Y3               Ms    H                               i-Pr      H    Me       Y3               Cl    H                               i-Pr      H    Me       COOPh            Ms    H                               i-Pr      H    Me       COOPh            Cl    H                               i-Pr      H    Me       COOCH.sub.2 Ph   Ms    H                               i-Pr      H    Me       COOCH.sub.2 Ph   Cl    H                               i-Pr      H    Me       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    Me       COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               i-Pr      H    Me       COOCH.sub.2 CCH  Ms    H                               i-Pr      H    Me       COOCH.sub.2 CCH  Cl    H                               i-Pr      H    Me       C(O)SMe          Ms    H                               i-Pr      H    Me       C(O)SMe          Cl    H                               i-Pr      H    Me       C(O)SEt          Ms    H                               i-Pr      H    Me       C(O)SEt          Cl    H                               i-Pr      H    Me       C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    Me       C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    Me       C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    Me       C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    Me       C(S)OMe          Ms    H                               i-Pr      H    Me       C(S)OMe          Cl    H                               i-Pr      H    Me       C(S)OEt          Ms    H                               i-Pr      H    Me       C(S)OEt          Cl    H                               i-Pr      H    Me       C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    Me       C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    Me       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    Me       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    Me       C(S)SMe          Ms    H                               i-Pr      H    Me       C(S)SMe          Cl    H                               i-Pr      H    Me       C(S)SEt          Ms    H                               i-Pr      H    Me       C(S)SEt          Cl    H                               i-Pr      H    Me       C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    Me       C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    Me       C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    Me       C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    OMe      COOMe            MeS   H                               i-Pr      H    OMe      COOMe            MeSO  H                               i-Pr      H    OMe      COOMe            Ms    H                               i-Pr      H    OMe      COOMe            Ms    Q1                              i-Pr      H    OMe      COOMe            Ms    Q2                              i-Pr      H    OMe      COOMe            Ms    Q3                              i-Pr      H    OMe      COOMe            Ms    Q4                              i-Pr      H    OMe      COOMe            Ms    Q5                              i-Pr      H    OMe      COOMe            Ms    Q6                              i-Pr      H    OMe      COOMe            Ms    Q20                             i-Pr      Me   OMe      COOMe            Ms    H                               i-Pr      Cl   OMe      COOMe            Ms    H                               i-Pr      CF.sub.3                                                                            OMe      COOMe            Ms    H                               i-Pr      OMe  OMe      COOMe            Ms    H                               i-Pr      SMe  OMe      COOMe            Ms    H                               i-Pr      H    OMe      COOEt            MeS   H                               i-Pr      H    OMe      COOEt            MeSO  H                               i-Pr      H    OMe      COOEt            Ms    H                               i-Pr      H    OMe      COOEt            Ms    Q1                              i-Pr      H    OMe      COOEt            Ms    Q18                             i-Pr      H    OMe      COOEt            Ms    Q13                             i-Pr      H    OMe      COOEt            Ms    Q4                              i-Pr      H    OMe      COOEt            Ms    Q5                              i-Pr      H    OMe      COOEt            Ms    Q6                              i-Pr      H    OMe      COOEt            Ms    Q22                             i-Pr      Me   OMe      COOEt            Ms    H                               i-Pr      Cl   OMe      COOEt            Ms    H                               i-Pr      CF.sub.3                                                                            OMe      COOEt            Ms    H                               i-Pr      OMe  OMe      COOEt            Ms    H                               i-Pr      SMe  OMe      COOEt            Ms    H                               i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           MeS   H                               i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           MeSO  H                               i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q7                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q12                             i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           MS    Q9                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q4                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q5                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q6                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    Q17                             i-Pr      Me   OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      Cl   OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      CF.sub.3                                                                            OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      OMe  OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      SMe  OMe      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    OMe      COOMe            Cl    H                               i-Pr      H    OMe      COOMe            Cl    Q1                              i-Pr      H    OMe      COOMe            Cl    Q2                              i-Pr      H    OMe      COOMe            Cl    Q3                              i-Pr      H    OMe      COOEt            Cl    H                               i-Pr      H    OMe      COOEt            Cl    Q1                              i-Pr      H    OMe      COOEt            Cl    Q2                              i-Pr      H    OMe      COOEt            Cl    Q3                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q1                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q2                              i-Pr      H    OMe      COOCH(CH.sub.3).sub.2                                                                           Cl    Q3                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             MeS   H                               i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             MeSO  H                               i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q1                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q18                             i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q13                             i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q4                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q5                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q6                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Ms    Q22                             i-Pr      Me   OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      Cl   OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      CF.sub. 3                                                                           OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      OMe  OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      SMe  OMe      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q1                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q2                              i-Pr      H    OMe      CON(CH.sub.3).sub.2                                                                             Cl    Q3                              i-Pr      H    OMe      COOC.sub.4 H.sub.9                                                                              Ms    H                               i-Pr      H    OMe      COOC.sub.4 H.sub.9                                                                              Cl    H                               i-Pr      H    OMe      COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH(CH.sub.3).sub.2                                                                  Cl    H                               i-Pr      H    OMe      COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Ms    H                               i-Pr      H    OMe      COOCH(CH.sub.3)C.sub.2 H.sub.5                                                                  Cl    H                               i-Pr      H    OMe      COOC(CH.sub.3).sub.3                                                                            Ms    H                               i-Pr      H    OMe      COOC(CH.sub.3).sub.3                                                                            Cl    H                               i-Pr      H    OMe      CONHMe           Ms    H                               i-Pr      H    OMe      CONHMe           Cl    H                               i-Pr      H    OMe      CONHEt           Ms    H                               i-Pr      H    OMe      CONHEt           Cl    H                               i-Pr      H    OMe      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    OMe      CONHCH(CH.sub.3).sub.2                                                                          Cl    H                               i-Pr      H    OMe      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    OMe      CONHC(CH.sub.3).sub.3                                                                           Cl    H                               i-Pr      H    OMe      CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    OMe      CONHC.sub.4 H.sub.9                                                                             Cl    H                               i-Pr      H    OMe      CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Ms    H                               i-Pr      H    OMe      CONHCH.sub.2 CH(CH.sub.3).sub.2                                                                 Cl    H                               i-Pr      H    OMe      CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Ms    H                               i-Pr      H    OMe      CONHCH(CH.sub.3)C.sub.2 H.sub.5                                                                 Cl    H                               i-Pr      H    OMe      CONEt.sub.2      Ms    H                               i-Pr      H    OMe      CONEt.sub.2      Cl    H                               i-Pr      H    OMe      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               i-Pr      H    OMe      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Cl    H                               i-Pr      H    OMe      Y1               Ms    H                               i-Pr      H    OMe      Y1               Cl    H                               i-Pr      H    OMe      Y2               Ms    H                               i-Pr      H    OMe      Y2               Cl    H                               i-Pr      H    OMe      Y3               Ms    H                               i-Pr      H    OMe      Y3               Cl    H                               i-Pr      H    OMe      COOPh            Ms    H                               i-Pr      H    OMe      COOPh            Cl    H                               i-Pr      H    OMe      COOCH.sub.2 Ph   Ms    H                               i-Pr      H    OMe      COOCH.sub.2 Ph   Cl    H                               i-Pr      H    OMe      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CHCH.sub.2                                                                          Cl    H                               i-Pr      H    OMe      COOCH.sub.2 C CH Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CCH  Cl    H                               i-Pr      H    OMe      C(O)SMe          Ms    H                               i-Pr      H    OMe      C(O)SMe          Cl    H                               i-Pr      H    OMe      C(O)SEt          Ms    H                               i-Pr      H    OMe      C(O)SEt          Cl    H                               i-Pr      H    OMe      C(O)SCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    OMe      C(O)SCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    OMe      C(O)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    OMe      C(O)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    OMe      C(S)OMe          Ms    H                               i-Pr      H    OMe      C(S)OMe          Cl    H                               i-Pr      H    OMe      C(S)OEt          Ms    H                               i-Pr      H    OMe      C(S)OEt          Cl    H                               i-Pr      H    OMe      C(S)OCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    OMe      C(S)OCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    OMe      C(S)SMe          Ms    H                               i-Pr      H    OMe      C(S)SMe          Cl    H                               i-Pr      H    OMe      C(S)SEt          Ms    H                               i-Pr      H    OMe      C(S)SEt          Cl    H                               i-Pr      H    OMe      C(S)SCH(CH.sub.3).sub.2                                                                         Ms    H                               i-Pr      H    OMe      C(S)SCH(CH.sub.3).sub.2                                                                         Cl    H                               i-Pr      H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Ms    H                               i-Pr      H    OMe      C(S)SC.sub.3 H.sub.7                                                                            Cl    H                               i-Pr      H    Br       COOMe            Ms    H                               i-Pr      H    Br       COOMe            Cl    H                               i-Pr      H    Br       COOEt            Ms    H                               i-Pr      H    Br       COOEt            Cl    H                               i-Pr      H    Br       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Br       COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    Br       CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    Br       CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    Br       CONHMe           Ms    H                               i-Pr      H    Br       CONHEt           Ms    H                               i-Pr      H    Br       CONHC.sub.3 H.sub.7                                                                             Ms    H                               i-Pr      H    Br       CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    Br       CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    Br       CONEt.sub.2      Ms    H                               i-Pr      H    Br       CONHC(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Br       CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    Br       CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    Br       CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               i-Pr      H    Br       Y1               Ms    H                               i-Pr      H    Br       Y2               Ms    H                               i-Pr      H    Br       COOPh            Ms    H                               i-Pr      H    Br       COOCH.sub.2 Ph   Ms    H                               i-Pr      H    Br       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    Br       COOCH.sub.2 C CH Ms    H                               i-Pr      H    OEt      COOMe            Ms    H                               i-Pr      H    OEt      COOMe            Cl    H                               i-Pr      H    OEt      COOEt            Ms    H                               i-Pr      H    OEt      COOEt            Cl    H                               i-Pr      H    OEt      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    OEt      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    OEt      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    OEt      CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    OEt      CONHMe           Ms    H                               i-Pr      H    OEt      CONHEt           Ms    H                               i-Pr      H    OEt      CONHC.sub.3 H.sub.7                                                                             Ms    H                               i-Pr      H    OEt      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    OEt      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    OEt      CONEt.sub.2      Ms    H                               i-Pr      H    OEt      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    OEt      CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    OEt      CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    OEt      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               i-Pr      H    OEt      Y1               Ms    H                               i-Pr      H    OEt      Y2               Ms    H                               i-Pr      H    OEt      COOPh            Ms    H                               i-Pr      H    OEt      COOCH.sub.2 Ph   Ms    H                               i-Pr      H    OEt      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    OEt      COOCH.sub.2 C CH Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOMe            Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOMe            Cl    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOEt            Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOEt            Cl    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHMe           Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHEt           Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.3 H.sub.7                                                                             Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONEt.sub.2      Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     CON[CH(CH.sub.3).sub.2 ] .sub.2                                                                 Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     Y1               Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     Y2               Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOPh            Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 Ph   Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    OCH(CH.sub.3).sub.2                                                                     COOCH.sub.2 CCH  Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOMe            Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOMe            Cl    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOEt            Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOEt            Cl    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOCH(CH.sub.3).sub.2                                                                           Cl    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CON(CH.sub.3).sub.2                                                                             Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CON(CH.sub.3).sub.2                                                                             Cl    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHMe           Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHEt           Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.3 H.sub.7                                                                             Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHCH(CH.sub.3).sub.2                                                                          Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONEt.sub.2      Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHC(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.4 H.sub.9                                                                             Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CONHC.sub.4 H.sub.9                                                                             MS    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      CON[CH(CH.sub.3).sub.2 ].sub.2                                                                  Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      Y1               Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      Y2               Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOPh            Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 Ph   Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    CH.sub.2 OCH.sub.3                                                                      COOCH.sub.2 CCH  Ms    H                               Me        H    NO.sub.2 COOMe            Ms    H                               Me        H    NO.sub.2 COOEt            Ms    H                               Me        H    NO.sub.2 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    NO.sub.2 CONMe.sub.2      Ms    H                               Me        H    NO.sub.2 CONEt.sub.2      Ms    H                               Me        H    NO.sub.2 COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    NO.sub.2 Y1               Ms    H                               Me        H    NO.sub.2 Y2               Ms    H                               Me        H    NO.sub.2 Y3               Ms    H                               Me        H    NO.sub.2 COOPh            Ms    H                               Me        H    NO.sub.2 COOCH.sub.2 Ph   Ms    H                               Me        H    NO.sub.2 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    CF.sub.3 COOMe            Ms    H                               Me        H    CF.sub.3 COOEt            Ms    H                               Me        H    CF.sub.3 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    CF.sub.3 CONMe.sub.2      Ms    H                               Me        H    CF.sub.3 CONEt.sub.2      Ms    H                               Me        H    CF.sub.3 COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    CF.sub.3 Y1               Ms    H                               Me        H    CF.sub.3 Y2               Ms    H                               Me        H    CF.sub.3 Y3               Ms    H                               Me        H    CF.sub.3 COOPh            Ms    H                               Me        H    CF.sub.3 COOCH.sub.2 Ph   Ms    H                               Me        H    CF.sub.3 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    CN       COOMe            Ms    H                               Me        H    CN       COOEt            Ms    H                               Me        H    CN       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    CN       CONMe.sub.2      Ms    H                               Me        H    CN       CONEt.sub.2      Ms    H                               Me        H    CN       COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    CN       Y1               Ms    H                               Me        H    CN       Y2               Ms    H                               Me        H    CN       Y3               Ms    H                               Me        H    CN       COOPh            Ms    H                               Me        H    CN       COOCH.sub.2 Ph   Ms    H                               Me        H    CN       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOMe            Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOEt            Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    CH.sub.2 OEt                                                                            CONMe.sub.2      Ms    H                               Me        H    CH.sub.2 OEt                                                                            CONEt.sub.2      Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    CH.sub.2 OEt                                                                            Y1               Ms    H                               Me        H    CH.sub.2 OEt                                                                            Y2               Ms    H                               Me        H    CH.sub.2 OEt                                                                            Y3               Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOPh            Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOCH.sub.2 Ph   Ms    H                               Me        H    CH.sub.2 OEt                                                                            COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    Et       COOMe            Ms    H                               Me        H    Et       COOEt            Ms    H                               Me        H    Et       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Et       CONMe.sub.2      Ms    H                               Me        H    Et       CONEt.sub.2      Ms    H                               Me        H    Et       COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    Et       Y1               Ms    H                               Me        H    Et       Y2               Ms    H                               Me        H    Et       Y3               Ms    H                               Me        H    Et       COOPh            Ms    H                               Me        H    Et       COOCH.sub.2 Ph   Ms    H                               Me        H    Et       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    i-Pr     COOMe            Ms    H                               Me        H    i-Pr     COOEt            Ms    H                               Me        H    i-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    i-Pr     CONMe.sub.2      Ms    H                               Me        H    i-Pr     CONEt.sub.2      Ms    H                               Me        H    i-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    i-Pr     Y1               Ms    H                               Me        H    i-Pr     Y2               Ms    H                               Me        H    i-Pr     Y3               Ms    H                               Me        H    i-Pr     COOPh            Ms    H                               Me        H    i-Pr     COOCH.sub.2 Ph   Ms    H                               Me        H    i-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    n-Pr     COOMe            Ms    H                               Me        H    n-Pr     COOEt            Ms    H                               Me        H    n-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    n-Pr     CONMe.sub.2      Ms    H                               Me        H    n-Pr     CONEt.sub.2      Ms    H                               Me        H    n-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    n-Pr     Y1               Ms    H                               Me        H    n-Pr     Y2               Ms    H                               Me        H    n-Pr     Y3               Ms    H                               Me        H    n-Pr     COOPh            Ms    H                               Me        H    n-Pr     COOCH.sub.2 Ph   Ms    H                               Me        H    n-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Me        H    I        COOMe            Ms    H                               Me        H    I        COOEt            Ms    H                               Me        H    I        COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    I        CONMe.sub.2      Ms    H                               Me        H    I        CONEt.sub.2      Ms    H                               Me        H    I        COOC.sub.3 H.sub.7                                                                              Ms    H                               Me        H    I        Y1               Ms    H                               Me        H    I        Y2               Ms    H                               Me        H    I        Y3               Ms    H                               Me        H    I        COOPh            Ms    H                               Me        H    I        COOCH.sub.2 Ph   Ms    H                               Me        H    I        COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    NO.sub.2 COOMe            Ms    H                               Et        H    NO.sub.2 COOEt            Ms    H                               Et        H    NO.sub.2 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    NO.sub.2 CONMe.sub.2      Ms    H                               Et        H    NO.sub.2 CONEt.sub.2      Ms    H                               Et        H    NO.sub.2 COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    NO.sub.2 Y1               Ms    H                               Et        H    NO.sub.2 Y2               Ms    H                               Et        H    NO.sub.2 Y3               Ms    H                               Et        H    NO.sub.2 COOPh            Ms    H                               Et        H    NO.sub.2 COOCH.sub.2 Ph   Ms    H                               Et        H    NO.sub.2 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    CF.sub.3 COOMe            Ms    H                               Et        H    CF.sub.3 COOEt            Ms    H                               Et        H    CF.sub.3 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    CF.sub.3 CONMe.sub.2      Ms    H                               Et        H    CF.sub.3 CONEt.sub.2      Ms    H                               Et        H    CF.sub.3 COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    CF.sub.3 Y1               Ms    H                               Et        H    CF.sub.3 Y2               Ms    H                               Et        H    CF.sub.3 Y3               Ms    H                               Et        H    CF.sub.3 COOPh            Ms    H                               Et        H    CF.sub.3 COOCH.sub.2 Ph   Ms    H                               Et        H    CF.sub.3 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    CN       COOMe            Ms    H                               Et        H    CN       COOEt            Ms    H                               Et        H    CN       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    CN       CONMe.sub.2      Ms    H                               Et        H    CN       CONEt.sub.2      Ms    H                               Et        H    CN       COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    CN       Y1               Ms    H                               Et        H    CN       Y2               Ms    H                               Et        H    CN       Y3               Ms    H                               Et        H    CN       COOPh            Ms    H                               Et        H    CN       COOCH.sub.2 Ph   Ms    H                               Et        H    CN       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOMe            Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOEt            Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    CH.sub.2 OEt                                                                            CONMe.sub.2      Ms    H                               Et        H    CH.sub.2 OEt                                                                            CONEt.sub.2      Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    CH.sub.2 OEt                                                                            Y1               Ms    H                               Et        H    CH.sub.2 OEt                                                                            Y2               Ms    H                               Et        H    CH.sub.2 OEt                                                                            Y3               Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOPh            Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOCH.sub.2 Ph   Ms    H                               Et        H    CH.sub.2 OEt                                                                            COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    Et       COOMe            Ms    H                               Et        H    Et       COOEt            Ms    H                               Et        H    Et       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Et       CONMe.sub.2      Ms    H                               Et        H    Et       CONEt.sub.2      Ms    H                               Et        H    Et       COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    Et       Y1               Ms    H                               Et        H    Et       Y2               Ms    H                               Et        H    Et       Y3               Ms    H                               Et        H    Et       COOPh            Ms    H                               Et        H    Et       COOCH.sub.2 Ph   Ms    H                               Et        H    Et       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    i-Pr     COOMe            Ms    H                               Et        H    i-Pr     COOEt            Ms    H                               Et        H    i-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    i-Pr     CONMe.sub.2      Ms    H                               Et        H    i-Pr     CONEt.sub.2      Ms    H                               Et        H    i-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    i-Pr     Y1               Ms    H                               Et        H    i-Pr     Y2               Ms    H                               Et        H    i-Pr     Y3               Ms    H                               Et        H    i-Pr     COOPh            Ms    H                               Et        H    i-Pr     COOCH.sub.2 Ph   Ms    H                               Et        H    i-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    n-Pr     COOMe            Ms    H                               Et        H    n-Pr     COOEt            Ms    H                               Et        H    n-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    n-Pr     CONMe.sub.2      Ms    H                               Et        H    n-Pr     CONEt.sub.2      Ms    H                               Et        H    n-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    n-Pr     Y1               Ms    H                               Et        H    n-Pr     Y2               Ms    H                               Et        H    n-Pr     Y3               Ms    H                               Et        H    n-Pr     COOPh            Ms    H                               Et        H    n-Pr     COOCH.sub.2 Ph   Ms    H                               Et        H    n-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               Et        H    I        COOMe            Ms    H                               Et        H    I        COOEt            Ms    H                               Et        H    I        COOCH(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    I        CONMe.sub.2      Ms    H                               Et        H    I        CONEt.sub.2      Ms    H                               Et        H    I        COOC.sub.3 H.sub.7                                                                              Ms    H                               Et        H    I        Y1               Ms    H                               Et        H    I        Y2               Ms    H                               Et        H    I        Y3               Ms    H                               Et        H    I        COOPh            Ms    H                               Et        H    I        COOCH.sub.2 Ph   Ms    H                               Et        H    I        COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    NO.sub.2 COOMe            Ms    H                               i-Pr      H    NO.sub.2 COOEt            Ms    H                               i-Pr      H    NO.sub.2 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    NO.sub.2 CONMe.sub.2      Ms    H                               i-Pr      H    NO.sub.2 CONEt.sub.2      Ms    H                               i-Pr      H    NO.sub.2 COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    NO.sub.2 Y1               Ms    H                               i-Pr      H    NO.sub.2 Y2               Ms    H                               i-Pr      H    NO.sub.2 Y3               Ms    H                               i-Pr      H    NO.sub.2 COOPh            Ms    H                               i-Pr      H    NO.sub.2 COOCH.sub.2 Ph   Ms    H                               i-Pr      H    NO.sub.2 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    CF.sub.3 COOMe            Ms    H                               i-Pr      H    CF.sub.3 COOEt            Ms    H                               i-Pr      H    CF.sub.3 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    CF.sub.3 CONMe.sub.2      Ms    H                               i-Pr      H    CF.sub.3 CONEt.sub.2      Ms    H                               i-Pr      H    CF.sub.3 COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    CF.sub.3 Y1               Ms    H                               i-Pr      H    CF.sub.3 Y2               Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR37##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     i-Pr      H    CF.sub.3 Y3               Ms    H                               i-Pr      H    CF.sub.3 COOPh            Ms    H                               i-Pr      H    CF.sub.3 COOCH.sub.2 Ph   Ms    H                               i-Pr      H    CF.sub.3 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    CN       COOMe            Ms    H                               i-Pr      H    CN       COOEt            Ms    H                               i-Pr      H    CN       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    CN       CONMe.sub.2      Ms    H                               i-Pr      H    CN       CONEt.sub.2      Ms    H                               i-Pr      H    CN       COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    CN       Y1               Ms    H                               i-Pr      H    CN       Y2               Ms    H                               i-Pr      H    CN       Y3               Ms    H                               i-Pr      H    CN       COOPh            Ms    H                               i-Pr      H    CN       COOCH.sub.2 Ph   Ms    H                               i-Pr      H    CN       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOMe            Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOEt            Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            CONMe.sub.2      Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            CONEt.sub.2      Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            Y1               Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            Y2               Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            Y3               Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOPh            Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOCH.sub.2 Ph   Ms    H                               i-Pr      H    CH.sub.2 OEt                                                                            COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    Et       COOMe            Ms    H                               i-Pr      H    Et       COOEt            Ms    H                               i-Pr      H    Et       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Et       CONMe.sub.2      Ms    H                               i-Pr      H    Et       CONEt.sub.2      Ms    H                               i-Pr      H    Et       COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    Et       Y1               Ms    H                               i-Pr      H    Et       Y2               Ms    H                               i-Pr      H    Et       Y3               Ms    H                               i-Pr      H    Et       COOPh            Ms    H                               i-Pr      H    Et       COOCH.sub.2 Ph   Ms    H                               i-Pr      H    Et       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    i-Pr     COOMe            Ms    H                               i-Pr      H    i-Pr     COOEt            Ms    H                               i-Pr      H    i-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    i-Pr     CONMe.sub.2      Ms    H                               i-Pr      H    i-Pr     CONEt.sub.2      Ms    H                               i-Pr      H    i-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    i-Pr     Y1               Ms    H                               i-Pr      H    i-Pr     Y2               Ms    H                               i-Pr      H    i-Pr     Y3               Ms    H                               i-Pr      H    i-Pr     COOPh            Ms    H                               i-Pr      H    i-Pr     COOCH.sub.2 Ph   Ms    H                               i-Pr      H    i-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    n-Pr     COOMe            Ms    H                               i-Pr      H    n-Pr     COOEt            Ms    H                               i-Pr      H    n-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    n-Pr     CONMe.sub.2      Ms    H                               i-Pr      H    n-Pr     CONEt.sub.2      Ms    H                               i-Pr      H    n-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    n-Pr     Y1               Ms    H                               i-Pr      H    n-Pr     Y2               Ms    H                               i-Pr      H    n-Pr     Y3               Ms    H                               i-Pr      H    n-Pr     COOPh            Ms    H                               i-Pr      H    n-Pr     COOCH.sub.2 Ph   Ms    H                               i-Pr      H    n-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               i-Pr      H    I        COOMe            Ms    H                               i-Pr      H    I        COOEt            Ms    H                               i-Pr      H    I        COOCH(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    I        CONMe.sub.2      Ms    H                               i-Pr      H    I        CONEt.sub.2      Ms    H                               i-Pr      H    I        COOC.sub.3 H.sub.7                                                                              Ms    H                               i-Pr      H    I        Y1               Ms    H                               i-Pr      H    I        Y2               Ms    H                               i-Pr      H    I        Y3               Ms    H                               i-Pr      H    I        COOPh            Ms    H                               i-Pr      H    I        COOCH.sub.2 Ph   Ms    H                               i-Pr      H    I        COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    NO.sub.2 COOMe            Ms    H                               allyl     H    NO.sub.2 COOEt            Ms    H                               allyl     H    NO.sub.2 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    NO.sub.2 CONMe.sub.2      Ms    H                               allyl     H    NO.sub.2 CONEt.sub.2      Ms    H                               allyl     H    NO.sub.2 COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    NO.sub.2 Y1               Ms    H                               allyl     H    NO.sub.2 Y2               Ms    H                               allyl     H    NO.sub.2 Y3               Ms    H                               allyl     H    NO.sub.2 COOPh            Ms    H                               allyl     H    NO.sub.2 COOCH.sub.2 Ph   Ms    H                               allyl     H    NO.sub.2 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    CF.sub.3 COOMe            Ms    H                               allyl     H    CF.sub.3 COOEt            Ms    H                               allyl     H    CF.sub.3 COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    CF.sub.3 CONMe.sub.2      Ms    H                               allyl     H    CF.sub.3 CONEt.sub.2      Ms    H                               allyl     H    CF.sub.3 COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    CF.sub.3 Y1               Ms    H                               allyl     H    CF.sub.3 Y2               Ms    H                               allyl     H    CF.sub.3 Y3               Ms    H                               allyl     H    CF.sub.3 COOPh            Ms    H                               allyl     H    CF.sub.3 COOCH.sub.2 Ph   Ms    H                               allyl     H    CF.sub.3 COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    CN       COOMe            Ms    H                               allyl     H    CN       COOEt            Ms    H                               allyl     H    CN       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    CN       CONMe.sub.2      Ms    H                               allyl     H    CN       CONEt.sub.2      Ms    H                               allyl     H    CN       COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    CN       Y1               Ms    H                               allyl     H    CN       Y2               Ms    H                               allyl     H    CN       Y3               Ms    H                               allyl     H    CN       COOPh            Ms    H                               allyl     H    CN       COOCH.sub.2 Ph   Ms    H                               allyl     H    CN       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOMe            Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOEt            Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    CH.sub.2 OEt                                                                            CONMe.sub.2      Ms    H                               allyl     H    CH.sub.2 OEt                                                                            CONEt.sub.2      Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    CH.sub.2 OEt                                                                            Y1               Ms    H                               allyl     H    CH.sub.2 OEt                                                                            Y2               Ms    H                               allyl     H    CH.sub.2 OEt                                                                            Y3               Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOPh            Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOCH.sub.2 Ph   Ms    H                               allyl     H    CH.sub.2 OEt                                                                            COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    Et       COOMe            Ms    H                               allyl     H    Et       COOEt            Ms    H                               allyl     H    Et       COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    Et       CONMe.sub.2      Ms    H                               allyl     H    Et       CONEt.sub.2      Ms    H                               allyl     H    Et       COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    Et       Y1               Ms    H                               allyl     H    Et       Y2               Ms    H                               allyl     H    Et       Y3               Ms    H                               allyl     H    Et       COOPh            Ms    H                               allyl     H    Et       COOCH.sub.2 Ph   Ms    H                               allyl     H    Et       COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    i-Pr     COOMe            Ms    H                               allyl     H    i-Pr     COOEt            Ms    H                               allyl     H    i-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    i-Pr     CONMe.sub.2      Ms    H                               allyl     H    i-Pr     CONEt.sub.2      Ms    H                               allyl     H    i-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    i-Pr     Y1               Ms    H                               allyl     H    i-Pr     Y2               Ms    H                               allyl     H    i-Pr     Y3               Ms    H                               allyl     H    i-Pr     COOPh            Ms    H                               allyl     H    i-Pr     COOCH.sub. 2 Ph  Ms    H                               allyl     H    i-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    n-Pr     COOMe            Ms    H                               allyl     H    n-Pr     COOEt            Ms    H                               allyl     H    n-Pr     COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    n-Pr     CONMe.sub.2      Ms    H                               allyl     H    n-Pr     CONEt.sub.2      Ms    H                               allyl     H    n-Pr     COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    n-Pr     Y1               Ms    H                               allyl     H    n-Pr     Y2               Ms    H                               allyl     H    n-Pr     Y3               Ms    H                               allyl     H    n-Pr     COOPh            Ms    H                               allyl     H    n-Pr     COOCH.sub.2 Ph   Ms    H                               allyl     H    n-Pr     COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    I        COOMe            Ms    H                               allyl     H    I        COOEt            Ms    H                               allyl     H    I        COOCH(CH.sub.3).sub.2                                                                           Ms    H                               allyl     H    I        CONMe.sub.2      Ms    H                               allyl     H    I        CONEt.sub.2      Ms    H                               allyl     H    I        COOC.sub.3 H.sub.7                                                                              Ms    H                               allyl     H    I        Y1               Ms    H                               allyl     H    I        Y2               Ms    H                               allyl     H    I        Y3               Ms    H                               allyl     H    I        COOPh            Ms    H                               allyl     H    I        COOCH.sub.2 Ph   Ms    H                               allyl     H    I        COOCH.sub.2 CHCH.sub.2                                                                          Ms    H                               allyl     H    Me       COOH             Ms    H                               allyl     H    Cl       COOH             Ms    H                               Me        H    Me       COOH             Ms    H                               Me        H    Cl       COOH             Ms    H                               Et        H    Me       COOH             Ms    H                               Et        H    Cl       COOH             Ms    H                               i-Pr      H    Me       COOH             Ms    H                               i-Pr      H    Cl       COOH             Ms    H                               Me        H    COOMe    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    COOMe    CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    COOMe    SCH.sub.3        Ms    H                               Me        H    COOMe    CH.sub.2 OH      Ms    H                               Me        H    COOMe    CH.sub.2 SCH.sub.3                                                                              Ms    H                               Et        H    COOMe    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    COOMe    CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    COOMe    SCH.sub.3        Ms    H                               Et        H    COOMe    CH.sub.2 OH      Ms    H                               Et        H    COOMe    CH.sub.2 SCH.sub.3                                                                              Ms    H                               i-Pr      H    COOMe    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               i-Pr      H    COOMe    CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               i-Pr      H    COOMe    SCH.sub.3        Ms    H                               i-Pr      H    COOMe    CH.sub.2 OH      Ms    H                               i-Pr      H    COOMe    CH.sub.2 SCH.sub.3                                                                              Ms    H                               Me        H    COOEt    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    COOEt    CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    COOEt    SCH.sub.3        Ms    H                               Me        H    COOEt    CH.sub.2 OH      Ms    H                               Me        H    COOEt    CH.sub.2 SCH.sub.3                                                                              Ms    H                               Et        H    COOEt    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    COOEt    CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    COOEt    SCH.sub.3        Ms    H                               Et        H    COOEt    CH.sub.2 OH      Ms    H                               Et        H    COOEt    CH.sub.2 SCH.sub.3                                                                              Ms    H                               i-Pr      H    COOEt    CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               i-Pr      H    COOEt    CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               i-Pr      H    COOEt    SCH.sub.3        Ms    H                               i-Pr      H    COOEt    CH.sub.2 OH      Ms    H                               i-Pr      H    COOEt    CH.sub.2 SCH.sub.3                                                                              Ms    H                               Me        H    Me       COOY4            Ms    H                               Me        H    Me       COOY5            Ms    H                               Me        H    Me       COOY6            Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               Me        H    Me       COOCH.sub.2 CF.sub.3                                                                            Ms    H                               Me        H    Me       COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               Me        H    Me       COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               Me        H    Me       COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               Me        H    Me       COOY7            Ms    H                               Me        H    Me       COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               Me        H    Me       COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               Me        H    Me       COOCH(CH.sub.3)COOEt                                                                            Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               Me        H    Me       COOPh4-CH.sub.3  Ms    H                               Me        H    Me       COOPh4-Cl        Ms    H                               Me        H    Me       COOPh4-NO.sub.2  Ms    H                               Me        H    Me       COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               Me        H    Me       COOY8            Ms    H                               Me        H    Me       COOCH.sub.2 Y8   Ms    H                               Me        H    Me       COOY9            Ms    H                               Me        H    Me       COOY10           Ms    H                               Me        H    Me       CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               Me        H    Me       CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               Me        H    Cl       COOY4            Ms    H                               Me        H    Cl       COOY5            Ms    H                               Me        H    Cl       COOY6            Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               Me        H    Cl       COOCH.sub.2 CF.sub.3                                                                            Ms    H                               Me        H    Cl       COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               Me        H    Cl       COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               Me        H    Cl       COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               Me        H    Cl       COOY7            Ms    H                               Me        H    Cl       COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               Me        H    Cl       COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               Me        H    Cl       COOCH(CH.sub.3)COOEt                                                                            Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               Me        H    Cl       COOPh4-CH.sub.3  Ms    H                               Me        H    Cl       COOPh4-Cl        Ms    H                               Me        H    Cl       COOPh4-NO.sub.2  Ms    H                               Me        H    Cl       COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               Me        H    Cl       COOY8            Ms    H                               Me        H    Cl       COOCH.sub.2 Y8   Ms    H                               Me        H    Cl       COOY9            Ms    H                               Me        H    Cl       COOY10           Ms    H                               Me        H    Cl       CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               Me        H    Cl       CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               Me        H    OMe      COOY4            Ms    H                               Me        H    OMe      COOY5            Ms    H                               Me        H    OMe      COOY6            Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               Me        H    OMe      COOCH.sub.2 CF.sub.3                                                                            Ms    H                               Me        H    OMe      COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               Me        H    OMe      COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               Me        H    OMe      COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               Me        H    OMe      COOY7            Ms    H                               Me        H    OMe      COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               Me        H    OMe      COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               Me        H    OMe      COOCH(CH.sub.3)COOEt                                                                            Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               Me        H    OMe      COOPh4-CH.sub.3  Ms    H                               Me        H    OMe      COOPh4-Cl        Ms    H                               Me        H    OMe      COOPh4-NO.sub.2  Ms    H                               Me        H    OMe      COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               Me        H    OMe      COOY8            Ms    H                               Me        H    OMe      COOCH.sub.2 Y8   Ms    H                               Me        H    OMe      COOY9            Ms    H                               Me        H    OMe      COOY10           Ms    H                               Me        H    OMe      CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               Me        H    OMe      CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               Et        H    Me       COOY4            Ms    H                               Et        H    Me       COOY5            Ms    H                               Et        H    Me       COOY6            Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               Et        H    Me       COOCH.sub.2 CF.sub.3                                                                            Ms    H                               Et        H    Me       COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               Et        H    Me       COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               Et        H    Me       COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               Et        H    Me       COOY7            Ms    H                               Et        H    Me       COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               Et        H    Me       COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               Et        H    Me       COOCH(CH.sub.3)COOEt                                                                            Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               Et        H    Me       COOPh4-CH.sub.3  Ms    H                               Et        H    Me       COOPh4-Cl        Ms    H                               Et        H    Me       COOPh4-NO.sub.2  Ms    H                               Et        H    Me       COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               Et        H    Me       COOY8            Ms    H                               Et        H    Me       COOCH.sub.2 Y8   Ms    H                               Et        H    Me       COOY9            Ms    H                               Et        H    Me       COOY10           Ms    H                               Et        H    Me       CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               Et        H    Me       CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               Et        H    Cl       COOY4            Ms    H                               Et        H    Cl       COOY5            Ms    H                               Et        H    Cl       COOY6            Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               Et        H    Cl       COOCH.sub.2 CF.sub.3                                                                            Ms    H                               Et        H    Cl       COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               Et        H    Cl       COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               Et        H    Cl       COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               Et        H    Cl       COOY7            Ms    H                               Et        H    Cl       COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               Et        H    Cl       COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               Et        H    Cl       COOCH(CH.sub.3)COOEt                                                                            Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               Et        H    Cl       COOPh4-CH.sub.3  Ms    H                               Et        H    Cl       COOPh4-Cl        Ms    H                               Et        H    Cl       COOPh4-NO.sub.2  Ms    H                               Et        H    Cl       COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               Et        H    Cl       COOY8            Ms    H                               Et        H    Cl       COOCH.sub.2 Y8   Ms    H                               Et        H    Cl       COOY9            Ms    H                               Et        H    Cl       COOY10           Ms    H                               Et        H    Cl       CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               Et        H    Cl       CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               Et        H    OMe      COOY4            Ms    H                               Et        H    OMe      COOY5            Ms    H                               Et        H    OMe      COOY6            Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               Et        H    OMe      COOCH.sub.2 CF.sub.3                                                                            Ms    H                               Et        H    OMe      COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               Et        H    OMe      COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               Et        H    OMe      COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               Et        H    OMe      COOY7            Ms    H                               Et        H    OMe      COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               Et        H    OMe      COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               Et        H    OMe      COOCH(CH.sub.3)COOEt                                                                            Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               Et        H    OMe      COOPh4-CH.sub.3  Ms    H                               Et        H    OMe      COOPh4-Cl        Ms    H                               Et        H    OMe      COOPh4-NO.sub.2  Ms    H                               Et        H    OMe      COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               Et        H    OMe      COOY8            Ms    H                               Et        H    OMe      COOCH.sub.2 Y8   Ms    H                               Et        H    OMe      COOY9            Ms    H                               Et        H    OMe      COOY10           Ms    H                               Et        H    OMe      CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               Et        H    OMe      CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               i-Pr      H    Me       COOY4            Ms    H                               i-Pr      H    Me       COOY5            Ms    H                               i-Pr      H    Me       COOY6            Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               i-Pr      H    Me       COOCH.sub.2 CF.sub.3                                                                            Ms    H                               i-Pr      H    Me       COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               i-Pr      H    Me       COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               i-Pr      H    Me       COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               i-Pr      H    Me       COOY7            Ms    H                               i-Pr      H    Me       COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               i-Pr      H    Me       COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               i-Pr      H    Me       COOCH(CH.sub.3)COOEt                                                                            Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               i-Pr      H    Me       COOPh4-CH.sub.3  Ms    H                               i-Pr      H    Me       COOPh4-Cl        Ms    H                               i-Pr      H    Me       COOPh4-NO.sub.2  Ms    H                               i-Pr      H    Me       COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               i-Pr      H    Me       COOY8            Ms    H                               i-Pr      H    Me       COOCH.sub.2 Y8   Ms    H                               i-Pr      H    Me       COOY9            Ms    H                               i-Pr      H    Me       COOY10           Ms    H                               i-Pr      H    Me       CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               i-Pr      H    Me       CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               i-Pr      H    Cl       COOY4            Ms    H                               i-Pr      H    Cl       COOY5            Ms    H                               i-Pr      H    Cl       COOY6            Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CF.sub.3                                                                            Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               i-Pr      H    Cl       COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               i-Pr      H    Cl       COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 Ms                                                                         Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               i-Pr      H    Cl       COOY7            Ms    H                               i-Pr      H    Cl       COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               i-Pr      H    Cl       COOCH(CH.sub.3)COOEt                                                                            Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               i-Pr      H    Cl       COOPh4-CH.sub.3  Ms    H                               i-Pr      H    Cl       COOPh4-Cl        Ms    H                               i-Pr      H    Cl       COOPh4-NO.sub.2  Ms    H                               i-Pr      H    Cl       COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               i-Pr      H    Cl       COOY8            Ms    H                               i-Pr      H    Cl       COOCH.sub.2 Y8   Ms    H                               i-Pr      H    Cl       COOY9            Ms    H                               i-Pr      H    Cl       COOY10           Ms    H                               i-Pr      H    Cl       CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               i-Pr      H    Cl       CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               i-Pr      H    OMe      COOY4            Ms    H                               i-Pr      H    OMe      COOY5            Ms    H                               i-Pr      H    OMe      COOY6            Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 Cl                                                                         Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CF.sub.3                                                                            Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CClCH.sub.2                                                                         Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.3                                                                  Ms    H                               i-Pr      H    OMe      COOCH.sub.2 SCH.sub.3                                                                           Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                      Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMs                                                                        Ms    H                               i-Pr      H    OMe      COOCH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub. 2 Ms                                                                        Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 CN                                                                         Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 NHCH.sub.3                                                                 Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OH                                                                         Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 CH.sub.2 NO.sub.2                                                          Ms    H                               i-Pr      H    OMe      COOY7            Ms    H                               i-Pr      H    OMe      COOCH.sub.2 COCH.sub.3                                                                          Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CO.sub.2 CH.sub.3                                                                   Ms    H                               i-Pr      H    OMe      COOCH(CH.sub.3)COOEt                                                                            Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OPh                                                                        Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                               Ms    H                               i-Pr      H    OMe      COOPh4-CH.sub.3  Ms    H                               i-Pr      H    OMe      COOPh4-Cl        Ms    H                               i-Pr      H    OMe      COOPh4-NO.sub.2  Ms    H                               i-Pr      H    OMe      COOCH.sub.2 SiMe.sub.3                                                                          Ms    H                               i-Pr      H    OMe      COOY8            Ms    H                               i-Pr      H    OMe      COOCH.sub.2 Y8   Ms    H                               i-Pr      H    OMe      COOY9            Ms    H                               i-Pr      H    OMe      COOY10           Ms    H                               i-Pr      H    OMe      CONHSO.sub.2 CH.sub.3                                                                           Ms    H                               i-Pr      H    OMe      CONHSO.sub.2 CF.sub.3                                                                           Ms    H                               Me        H    Me       CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               Me        H    Me       CONHPh           Ms    H                               Me        H    Me       COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               Me        H    Me       COOCH.sub.2 COPh Ms    H                               Me        H    Me       COOSi(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    Me       COONC(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Me       COOY11           Ms    H                               Me        H    Me       COOY12           Ms    H                               Me        H    Me       COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               Me        H    Me       COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               Me        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               Me        H    OMe      CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               Me        H    OMe      CONHPh           Ms    H                               Me        H    OMe      COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               Me        H    OMe      COOCH.sub.2 COPh Ms    H                               Me        H    OMe      COOSi(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    OMe      COONC(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    OMe      COOY11           Ms    H                               Me        H    OMe      COOY12           Ms    H                               Me        H    OMe      COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               Me        H    OMe      COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               Me        H    Cl       CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               Me        H    Cl       CONHPh           Ms    H                               Me        H    Cl       COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               Me        H    Cl       COOCH.sub.2 COPh Ms    H                               Me        H    Cl       COOSi(CH.sub.3).sub.3                                                                           Ms    H                               Me        H    Cl       COONC(CH.sub.3).sub.2                                                                           Ms    H                               Me        H    Cl       COOY11           Ms    H                               Me        H    Cl       COOY12           Ms    H                               Me        H    Cl       COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               Me        H    Cl       COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               Et        H    Me       CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               Et        H    Me       CONHPh           Ms    H                               Et        H    Me       COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               Et        H    Me       COOCH.sub.2 COPh Ms    H                               Et        H    Me       COOSi(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    Me       COONC(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Me       COOY11           Ms    H                               Et        H    Me       COOY12           Ms    H                               Et        H    Me       COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               Et        H    Me       COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               Et        H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               Et        H    OMe      CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               Et        H    OMe      CONHPh           Ms    H                               Et        H    OMe      COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               Et        H    OMe      COOCH.sub.2 COPh Ms    H                               Et        H    OMe      COOSi(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    OMe      COONC(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    OMe      COOY11           Ms    H                               Et        H    OMe      COOY12           Ms    H                               Et        H    OMe      COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               Et        H    OMe      COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               Et        H    Cl       CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               Et        H    Cl       CONHPh           Ms    H                               Et        H    Cl       COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               Et        H    Cl       COOCH.sub.2 COPh Ms    H                               Et        H    Cl       COOSi(CH.sub.3).sub.3                                                                           Ms    H                               Et        H    Cl       COONC(CH.sub.3).sub.2                                                                           Ms    H                               Et        H    Cl       COOY11           Ms    H                               Et        H    Cl       COOY12           Ms    H                               Et        H    Cl       COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               Et        H    Cl       COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               i-Pr      H    Me       CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               i-Pr      H    Me       CONHPh           Ms    H                               i-Pr      H    Me       COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               i-Pr      H    Me       COOCH.sub.2 COPh Ms    H                               i-Pr      H    Me       COOSi(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    Me       COONC(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Me       COOY11           Ms    H                               i-Pr      H    Me       COOY12           Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR38##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     i-Pr      H    Me       COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               i-Pr      H    Me       COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               i-Pr      H    OMe      CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               i-Pr      H    OMe      CONHPh           Ms    H                               i-Pr      H    OMe      COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               i-Pr      H    OMe      COOCH.sub.2 COPh Ms    H                               i-Pr      H    OMe      COOSi(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    OMe      COONC(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    OMe      COOY11           Ms    H                               i-Pr      H    OMe      COOY12           Ms    H                               i-Pr      H    OMe      COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               i-Pr      H    OMe      COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               i-Pr      H    Cl       CON(CH.sub.3)OCH.sub.3                                                                          Ms    H                               i-Pr      H    Cl       CONHPh           Ms    H                               i-Pr      H    Cl       COOCH.sub.2 COC(CH.sub.3).sub.3                                                                 Ms    H                               i-Pr      H    Cl       COOCH.sub.2 COPh Ms    H                               i-Pr      H    Cl       COOSi(CH.sub.3).sub.3                                                                           Ms    H                               i-Pr      H    Cl       COONC(CH.sub.3).sub.2                                                                           Ms    H                               i-Pr      H    Cl       COOY11           Ms    H                               i-Pr      H    Cl       COOY12           Ms    H                               i-Pr      H    Cl       COOCH.sub.2 OCOC(CH.sub.3).sub.3                                                                Ms    H                               i-Pr      H    Cl       COOCH.sub.2 OCOCH.sub.3                                                                         Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CHCH.sub.2                                                       Ms    H                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OCH.sub.2 CCH                                                              Ms    H                               Me        H    Me       CH.sub.2 OH      Ms    H                               Me        H    Me       CH.sub.2 OMe     Ms    H                               Me        H    Me       CH.sub.2 OMe     Cl    H                               Me        H    Me       CH.sub.2 OMe     MeS   H                               Me        H    Me       CH.sub.2 OMe     MeSO  H                               Me        H    Me       CH.sub.2 OMe     Ms    Q1                              Me        H    Me       CH.sub.2 OMe     MeS   Q1                              Me        H    Me       CH.sub.2 OMe     MeSO  Q1                              Me        H    Me       CH.sub.2 OMe     Ms    Q2                              Me        H    Me       CH.sub.2 OMe     MeS   Q2                              Me        H    Me       CH.sub.2 OMe     MeSO  Q2                              Me        H    Me       CH.sub.2 OMe     Ms    Q3                              Me        H    Me       CH.sub.2 OMe     MeS   Q3                              Me        H    Me       CH.sub.2 OMe     MeSO  Q3                              Me        H    Me       CH.sub.2 OMe     Ms    Q4                              Me        H    Me       CH.sub.2 OMe     Ms    Q5                              Me        H    Me       CH.sub.2 OMe     Ms    Q6                              Me        H    Me       CH.sub.2 OMe     Ms    Q7                              Me        H    Me       CH.sub.2 OMe     Ms    Q8                              Me        H    Me       CH.sub.2 OMe     Ms    Q9                              Me        H    Me       CH.sub.2 OEt     Ms    H                               Me        H    Me       CH.sub.2 OEt     Cl    H                               Me        H    Me       CH.sub.2 OEt     MeS   H                               Me        H    Me       CH.sub.2 OEt     MeSO  H                               Me        H    Me       CH.sub.2 OEt     Ms    Q1                              Me        H    Me       CH.sub.2 OEt     MeS   Q1                              Me        H    Me       CH.sub.2 OEt     MeSO  Q1                              Me        H    Me       CH.sub.2 OEt     Ms    Q2                              Me        H    Me       CH.sub.2 OEt     MeS   Q2                              Me        H    Me       CH.sub.2 OEt     MeSO  Q2                              Me        H    Me       CH.sub.2 OEt     Ms    Q3                              Me        H    Me       CH.sub.2 OEt     MeS   Q3                              Me        H    Me       CH.sub.2 OEt     MeSO  Q3                              Me        H    Me       CH.sub.2 OEt     Ms    Q4                              Me        H    Me       CH.sub.2 OEt     Ms    Q5                              Me        H    Me       CH.sub.2 OEt     Ms    Q6                              Me        H    Me       CH.sub.2 OEt     Ms    Q7                              Me        H    Me       CH.sub.2 OEt     Ms    Q8                              Me        H    Me       CH.sub.2 OEt     Ms    Q9                              Me        H    Me       CH.sub.2 OPri    Ms    H                               Me        H    Me       CH.sub.2 OPri    Cl    H                               Me        H    Me       CH.sub.2 OPri    MeS   H                               Me        H    Me       CH.sub.2 OPri    MeSO  H                               Me        H    Me       CH.sub.2 OPri    Ms    Q1                              Me        H    Me       CH.sub.2 OPri    Ms    Q2                              Me        H    Me       CH.sub.2 OPri    Ms    Q3                              Me        H    Me       CH.sub.2 OPrn    Ms    H                               Me        H    Me       CH.sub.2 OPrn    Cl    H                               Me        H    Me       CH.sub.2 OPrn    MeS   H                               Me        H    Me       CH.sub.2 OPrn    MeSO  H                               Me        H    Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        H    Me       CH.sub.2 OCHCH.sub.2                                                                            Cl    H                               Me        H    Me       CH.sub.2 OCHCH.sub.2                                                                            MeS   H                               Me        H    Me       CH.sub.2 OCHCH.sub.2                                                                            MeSO  H                               Me        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS   H                               Me        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO  H                               Me        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Cl    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          MeS   H                               Me        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          MeSO  H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS   H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO  H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Br                                                                  Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 CN                                                                  Ms    H                               Me        H    Me       CH.sub.2 OAmn    Ms    H                               Me        H    Me       CH.sub.2 OY5     Ms    H                               Me        H    Me       CHMeOH           Ms    H                               Me        H    Me       CHMeOMe          Ms    H                               Me        H    Me       CHMeOMe          Cl    H                               Me        H    Me       CHMeOMe          MeS   H                               Me        H    Me       CHMeOMe          MeSO  H                               Me        H    Me       CHMeOMe          Ms    Q1                              Me        H    Me       CHMeOMe          Ms    Q2                              Me        H    Me       CHMeOMe          Ms    Q3                              Me        H    Me       CHMeOEt          Ms    H                               Me        H    Me       CHMeOEt          Cl    H                               Me        H    Me       CHMeOEt          MeS   H                               Me        H    Me       CHMeOEt          MeSO  H                               Me        H    Me       CHMeOEt          Ms    Q1                              Me        H    Me       CHMeOEt          Ms    Q2                              Me        H    Me       CHMeOEt          Ms    Q3                              Me        H    Me       CHMeOPri         Ms    H                               Me        H    Me       CHMeOPri         Cl    H                               Me        H    Me       CHMeOPri         MeS   H                               Me        H    Me       CHMeOPri         MeSO  H                               Me        H    Me       CHMeOPrn         Ms    H                               Me        H    Me       CHMeOCHCH.sub.2  Ms    H                               Me        H    Me       CHMeOCHCH.sub.2  Ms    H                               Me        H    Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        H    Me       CHMeOCH.sub.2 C CH                                                                              Ms    H                               Me        H    Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        H    Me       CHMeOY5          Ms    H                               Me        H    Me       CMe.sub.2 OH     Ms    H                               Me        H    Me       CMe.sub.2 OMe    Ms    H                               Me        H    Me       CMe.sub.2 OMe    Cl    H                               Me        H    Me       CMe.sub.2 OMe    MeS   H                               Me        H    Me       CMe.sub.2 OMe    MeSO  H                               Me        H    Me       CMe.sub.2 OEt    Ms    H                               Me        H    Me       CMe.sub.2 OEt    Cl    H                               Me        H    Me       CMe.sub.2 OEt    MeS   H                               Me        H    Me       CMe.sub.2 OEt    MeSO  H                               Me        H    Me       CMe.sub.2 OPri   Ms    H                               Me        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Cl    H                               Me        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           MeS   H                               Me        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           MeSO  H                               Me        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Cl    H                               Me        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           MeS   H                               Me        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           MeSO  H                               Me        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Me        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          Cl    H                               Me        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          MeS   H                               Me        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          MeSO  H                               Me        H    Me       CHEtOH           Ms    H                               Me        H    Me       CHEtOMe          Ms    H                               Me        H    Me       CHEtOMe          Cl    H                               Me        H    Me       CHEtOMe          MeS   H                               Me        H    Me       CHEtOMe          MeSO  H                               Me        H    Me       CHEtOEt          Ms    H                               Me        H    Me       CHEtOPri         Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Me        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Me        H    Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        H    Me       CH.sub.2 OY8     Ms    H                               Me        H    Me       CH.sub.2 OY9     Ms    H                               Me        H    Me       CH.sub.2 OY10    Ms    H                               Me        H    Me       CHMeOY8          Ms    H                               Me        H    Me       CHMeOY9          Ms    H                               Me        H    Me       CHMeOY10         Ms    H                               Me        H    Me       CH.sub.2 OY13    Ms    H                               Me        H    Me       CHMeOY13         Ms    H                               Me        H    Me       CH.sub.2 NHMe    Ms    H                               Me        H    Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        H    Me       CH.sub.2 NEtMe   Ms    H                               Me        H    Me       CH.sub.2 NEt.sub.2                                                                              Ms    H                               Me        H    Me       CH.sub.2Y14      Ms    H                               Me        H    Me       CHMeNMe.sub.2    Ms    H                               Me        H    Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        H    Me       CHMeOCH.sub.2 Ph Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        H    Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        H    Me       CH.sub.2 CN      Ms    H                               Me        H    Me       CHMeCN           Ms    H                               Me        H    Me       CH.sub.2 SMe     Ms    H                               Me        H    Me       CH.sub.2 SMe     Cl    H                               Me        H    Me       CH.sub.2 SMe     MeS   H                               Me        H    Me       CH.sub.2 SMe     MeSO  H                               Me        H    Me       CH.sub.2 SEt     Ms    H                               Me        H    Me       CH.sub.2 SEt     Cl    H                               Me        H    Me       CH.sub.2 SEt     MeS   H                               Me        H    Me       CH.sub.2 SEt     MeSO  H                               Me        H    Me       CH.sub.2 SOMe    Ms    H                               Me        H    Me       CH.sub.2 SOEt    Ms    H                               Me        H    Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    Me       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Me        H    Me       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Me        H    Me       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Me        H    Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        H    Me       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Me        H    Me       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Me        H    Me       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Me        H    Me       CHMeSMe          Ms    H                               Me        H    Me       CHMeSEt          Ms    H                               Me        H    Me       CHMeSO.sub.2 Me  Ms    H                               Me        H    Me       CHMeSO.sub.2 Et  Ms    H                               Me        H    Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    Me       CH.sub.2 OCOMe   Ms    H                               Me        H    Me       CH.sub.2 OCOEt   Ms    H                               Me        H    Me       CHMeOCOMe        Ms    H                               Me        H    Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        H    Me       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Me        H    Me       CHMeOSO.sub.2 Me Ms    H                               Et        H    Me       CH.sub.2 OH      Ms    H                               Et        H    Me       CH.sub.2 OMe     Ms    H                               Et        H    Me       CH.sub.2 OMe     Cl    H                               Et        H    Me       CH.sub.2 OMe     MeS   H                               Et        H    Me       CH.sub.2 OMe     MeSO  H                               Et        H    Me       CH.sub.2 OMe     Ms    Q1                              Et        H    Me       CH.sub.2 OMe     MeS   Q1                              Et        H    Me       CH.sub.2 OMe     MeSO  Q1                              Et        H    Me       CH.sub.2 OMe     Ms    Q2                              Et        H    Me       CH.sub.2 OMe     MeS   Q2                              Et        H    Me       CH.sub.2 OMe     MeSO  Q2                              Et        H    Me       CH.sub.2 OMe     Ms    Q3                              Et        H    Me       CH.sub.2 OMe     MeS   Q3                              Et        H    Me       CH.sub.2 OMe     MeSO  Q3                              Et        H    Me       CH.sub.2 OMe     Ms    Q4                              Et        H    Me       CH.sub.2 OMe     Ms    Q5                              Et        H    Me       CH.sub.2 OMe     Ms    Q6                              Et        H    Me       CH.sub.2 OMe     Ms    Q7                              Et        H    Me       CH.sub.2 OMe     Ms    Q8                              Et        H    Me       CH.sub.2 OMe     Ms    Q9                              Et        H    Me       CH.sub.2 OEt     Ms    H                               Et        H    Me       CH.sub.2 OEt     Cl    H                               Et        H    Me       CH.sub.2 OEt     MeS   H                               Et        H    Me       CH.sub.2 OEt     MeSO  H                               Et        H    Me       CH.sub.2 OEt     Ms    Q1                              Et        H    Me       CH.sub.2 OEt     MeS   Q1                              Et        H    Me       CH.sub.2 OEt     MeSO  Q1                              Et        H    Me       CH.sub.2 OEt     Ms    Q2                              Et        H    Me       CH.sub.2 OEt     MeS   Q2                              Et        H    Me       CH.sub.2 OEt     MeSO  Q2                              Et        H    Me       CH.sub.2 OEt     Ms    Q3                              Et        H    Me       CH.sub.2 OEt     MeS   Q3                              Et        H    Me       CH.sub.2 OEt     MeSO  Q3                              Et        H    Me       CH.sub.2 OEt     Ms    Q4                              Et        H    Me       CH.sub.2 OEt     Ms    Q5                              Et        H    Me       CH.sub.2 OEt     Ms    Q6                              Et        H    Me       CH.sub.2 OEt     Ms    Q7                              Et        H    Me       CH.sub.2 OEt     Ms    Q8                              Et        H    Me       CH.sub.2 OEt     Ms    Q9                              Et        H    Me       CH.sub.2 OPri    Ms    H                               Et        H    Me       CH.sub.2 OPri    Cl    H                               Et        H    Me       CH.sub.2 OPri    MeS   H                               Et        H    Me       CH.sub.2 OPri    MeSO  H                               Et        H    Me       CH.sub.2 OPri    Ms    Q1                              Et        H    Me       CH.sub.2 OPri    Ms    Q2                              Et        H    Me       CH.sub.2 OPri    Ms    Q3                              Et        H    Me       CH.sub.2 OPrn    Ms    H                               Et        H    Me       CH.sub.2 OPrn    Cl    H                               Et        H    Me       CH.sub.2 OPrn    MeS   H                               Et        H    Me       CH.sub.2 OPrn    MeSO  H                               Et        H    Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        H    Me       CH.sub.2 OCHCH.sub.2                                                                            Cl    H                               Et        H    Me       CH.sub.2 OCHCH.sub.2                                                                            MeS   H                               Et        H    Me       CH.sub.2 OCHCH.sub.2                                                                            MeSO  H                               Et        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS   H                               Et        H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO  H                               Et        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Cl    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          MeS   H                               Et        H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          MeSO  H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS   H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO  H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Br                                                                  Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 CN                                                                  Ms    H                               Et        H    Me       CH.sub.2 OAmn    Ms    H                               Et        H    Me       CH.sub.2 OY5     Ms    H                               Et        H    Me       CHMeOH           Ms    H                               Et        H    Me       CHMeOMe          Ms    H                               Et        H    Me       CHMeOMe          Cl    H                               Et        H    Me       CHMeOMe          MeS   H                               Et        H    Me       CHMeOMe          MeSO  H                               Et        H    Me       CHMeOMe          Ms    Q1                              Et        H    Me       CHMeOMe          Ms    Q2                              Et        H    Me       CHMeOMe          Ms    Q3                              Et        H    Me       CHMeOEt          Ms    H                               Et        H    Me       CHMeOEt          Cl    H                               Et        H    Me       CHMeOEt          MeS   H                               Et        H    Me       CHMeOEt          MeSO  H                               Et        H    Me       CHMeOEt          Ms    Q1                              Et        H    Me       CHMeOEt          Ms    Q2                              Et        H    Me       CHMeOEt          Ms    Q3                              Et        H    Me       CHMeOPri         Ms    H                               Et        H    Me       CHMeOPri         Cl    H                               Et        H    Me       CHMeOPri         MeS   H                               Et        H    Me       CHMeOPri         MeSO  H                               Et        H    Me       CHMeOPrn         Ms    H                               Et        H    Me       CHMeOCHCH.sub.2  Ms    H                               Et        H    Me       CHMeOCHCH.sub.2  Ms    H                               Et        H    Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        H    Me       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        H    Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        H    Me       CHMeOY5          Ms    H                               Et        H    Me       CMe.sub.2 OH     Ms    H                               Et        H    Me       CMe.sub.2 OMe    Ms    H                               Et        H    Me       CMe.sub.2 OMe    Cl    H                               Et        H    Me       CMe.sub.2 OMe    MeS   H                               Et        H    Me       CMe.sub.2 OMe    MeSO  H                               Et        H    Me       CMe.sub.2 OEt    Ms    H                               Et        H    Me       CMe.sub.2 OEt    Cl    H                               Et        H    Me       CMe.sub.2 OEt    MeS   H                               Et        H    Me       CMe.sub.2 OEt    MeSO  H                               Et        H    Me       CMe.sub.2 OPri   Ms    H                               Et        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Cl    H                               Et        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           MeS   H                               Et        H    Me       CH.sub.2 CH.sub.2 OMe                                                                           MeSO  H                               Et        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Cl    H                               Et        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           MeS   H                               Et        H    Me       CH.sub.2 CH.sub.2 OEt                                                                           MeSO  H                               Et        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Et        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          Cl    H                               Et        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          MeS   H                               Et        H    Me       CH.sub.2 CH.sub.2 OPri                                                                          MeSO  H                               Et        H    Me       CHEtOH           Ms    H                               Et        H    Me       CHEtOMe          Ms    H                               Et        H    Me       CHEtOMe          Cl    H                               Et        H    Me       CHEtOMe          MeS   H                               Et        H    Me       CHEtOMe          MeSO  H                               Et        H    Me       CHEtOEt          Ms    H                               Et        H    Me       CHEtOPri         Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Et        H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Et        H    Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        H    Me       CH.sub.2 OY8     Ms    H                               Et        H    Me       CH.sub.2 OY9     Ms    H                               Et        H    Me       CH.sub.2 OY10    Ms    H                               Et        H    Me       CHMeOY8          Ms    H                               Et        H    Me       CHMeOY9          Ms    H                               Et        H    Me       CHMeOY10         Ms    H                               Et        H    Me       CH.sub.2 OY13    Ms    H                               Et        H    Me       CHMeOY13         Ms    H                               Et        H    Me       CH.sub.2 NHMe    Ms    H                               Et        H    Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        H    Me       CH.sub.2 NEtMe   Ms    H                               Et        H    Me       CH.sub.2 NEt.sub.2                                                                              Ms    H                               Et        H    Me       CH.sub.2Y14      Ms    H                               Et        H    Me       CHMeNMe.sub.2    Ms    H                               Et        H    Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        H    Me       CHMeOCH.sub.2 Ph Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        H    Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        H    Me       CH.sub.2 CN      Ms    H                               Et        H    Me       CHMeCN           Ms    H                               Et        H    Me       CH.sub.2 SMe     Ms    H                               Et        H    Me       CH.sub.2 SMe     Cl    H                               Et        H    Me       CH.sub.2 SMe     MeS   H                               Et        H    Me       CH.sub.2 SMe     MeSO  H                               Et        H    Me       CH.sub.2 SEt     Ms    H                               Et        H    Me       CH.sub.2 SEt     Cl    H                               Et        H    Me       CH.sub.2 SEt     MeS   H                               Et        H    Me       CH.sub.2 SEt     MeSO  H                               Et        H    Me       CH.sub.2 SOMe    Ms    H                               Et        H    Me       CH.sub.2 SOEt    Ms    H                               Et        H    Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    Me       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Et        H    Me       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Et        H    Me       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Et        H    Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        H    Me       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Et        H    Me       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Et        H    Me       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Et        H    Me       CHMeSMe          Ms    H                               Et        H    Me       CHMeSEt          Ms    H                               Et        H    Me       CHMeSO.sub.2 Me  Ms    H                               Et        H    Me       CHMeSO.sub.2 Et  Ms    H                               Et        H    Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    Me       CH.sub.2 OCOMe   Ms    H                               Et        H    Me       CH.sub.2 OCOEt   Ms    H                               Et        H    Me       CHMeOCOMe        Ms    H                               Et        H    Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    Me       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Et        H    Me       CHMeOSO.sub.2 Me Ms    H                               Pri       H    Me       CH.sub.2 OH      Ms    H                               Pri       H    Me       CH.sub.2 OMe     Ms    H                               Pri       H    Me       CH.sub.2 OMe     Cl    H                               Pri       H    Me       CH.sub.2 OMe     MeS   H                               Pri       H    Me       CH.sub.2 OMe     MeSO  H                               Pri       H    Me       CH.sub.2 OMe     Ms    Q1                              Pri       H    Me       CH.sub.2 OMe     MeS   Q1                              Pri       H    Me       CH.sub.2 OMe     MeSO  Q1                              Pri       H    Me       CH.sub.2 OMe     Ms    Q2                              Pri       H    Me       CH.sub.2 OMe     MeS   Q2                              Pri       H    Me       CH.sub.2 OMe     MeSO  Q2                              Pri       H    Me       CH.sub.2 OMe     Ms    Q3                              Pri       H    Me       CH.sub.2 OMe     MeS   Q3                              Pri       H    Me       CH.sub.2 OMe     MeSO  Q3                              Pri       H    Me       CH.sub.2 OMe     Ms    Q4                              Pri       H    Me       CH.sub.2 OMe     Ms    Q5                              Pri       H    Me       CH.sub.2 OMe     Ms    Q6                              Pri       H    Me       CH.sub.2 OMe     Ms    Q7                              Pri       H    Me       CH.sub.2 OMe     Ms    Q8                              Pri       H    Me       CH.sub.2 OMe     Ms    Q9                              Pri       H    Me       CH.sub.2 OEt     Ms    H                               Pri       H    Me       CH.sub.2 OEt     Cl    H                               Pri       H    Me       CH.sub.2 OEt     MeS   H                               Pri       H    Me       CH.sub.2 OEt     MeSO  H                               Pri       H    Me       CH.sub.2 OEt     Ms    Q1                              Pri       H    Me       CH.sub.2 OEt     MeS   Q1                              Pri       H    Me       CH.sub.2 OEt     MeSO  Q1                              Pri       H    Me       CH.sub.2 OEt     Ms    Q2                              Pri       H    Me       CH.sub.2 OEt     MeS   Q2                              Pri       H    Me       CH.sub.2 OEt     MeSO  Q2                              Pri       H    Me       CH.sub.2 OEt     Ms    Q3                              Pri       H    Me       CH.sub.2 OEt     MeS   Q3                              Pri       H    Me       CH.sub.2 OEt     MeSO  Q3                              Pri       H    Me       CH.sub.2 OEt     Ms    Q4                              Pri       H    Me       CH.sub.2 OEt     Ms    Q5                              Pri       H    Me       CH.sub.2 OEt     Ms    Q6                              Pri       H    Me       CH.sub.2 OEt     Ms    Q7                              Pri       H    Me       CH.sub.2 OEt     Ms    Q8                              Pri       H    Me       CH.sub.2 OEt     Ms    Q9                              Pri       H    Me       CH.sub.2 OPri    Ms    H                               Pri       H    Me       CH.sub.2 OPri    Cl    H                               Pri       H    Me       CH.sub.2 OPri    MeS   H                               Pri       H    Me       CH.sub.2 OPri    MeSO  H                               Pri       H    Me       CH.sub.2 OPri    Ms    Q1                              Pri       H    Me       CH.sub.2 OPri    Ms    Q2                              Pri       H    Me       CH.sub.2 OPri    Ms    Q3                              Pri       H    Me       CH.sub.2 OPrn    Ms    H                               Pri       H    Me       CH.sub.2 OPrn    Cl    H                               Pri       H    Me       CH.sub.2 OPrn    MeS   H                               Pri       H    Me       CH.sub.2 OPrn    MeSO  H                               Pri       H    Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       H    Me       CH.sub.2 OCHCH.sub.2                                                                            Cl    H                               Pri       H    Me       CH.sub.2 OCHCH.sub.2                                                                            MeS   H                               Pri       H    Me       CH.sub.2 OCHCH.sub.2                                                                            MeSO  H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS   H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO  H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Cl    H                               Pr i      H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          MeS   H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          MeSO  H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS   H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO  H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Br                                                                  Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 CN                                                                  Ms    H                               Pri       H    Me       CH.sub.2 OAmn    Ms    H                               Pri       H    Me       CH.sub.2 OY5     Ms    H                               Pri       H    Me       CHMeOH           Ms    H                               Pri       H    Me       CHMeOMe          Ms    H                               Pri       H    Me       CHMeOMe          Cl    H                               Pri       H    Me       CHMeOMe          MeS   H                               Pri       H    Me       CHMeOMe          MeSO  H                               Pri       H    Me       CHMeOMe          Ms    Q1                              Pri       H    Me       CHMeOMe          Ms    Q2                              Pri       H    Me       CHMeOMe          Ms    Q3                              Pri       H    Me       CHMeOEt          Ms    H                               Pri       H    Me       CHMeOEt          Cl    H                               Pri       H    Me       CHMeOEt          MeS   H                               Pri       H    Me       CHMeOEt          MeSO  H                               Pri       H    Me       CHMeOEt          Ms    Q1                              Pri       H    Me       CHMeOEt          Ms    Q2                              Pri       H    Me       CHMeOEt          Ms    Q3                              Pri       H    Me       CHMeOPri         Ms    H                               Pri       H    Me       CHMeOPri         Cl    H                               Pri       H    Me       CHMeOPri         MeS   H                               Pri       H    Me       CHMeOPri         MeSO  H                               Pri       H    Me       CHMeOPrn         Ms    H                               Pri       H    Me       CHMeOCHCH.sub.2  Ms    H                               Pri       H    Me       CHMeOCHCH.sub.2  Ms    H                               Pri       H    Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       H    Me       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Pri       H    Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       H    Me       CHMeOY5          Ms    H                               Pri       H    Me       CMe.sub.2 OH     Ms    H                               Pri       H    Me       CMe.sub.2 OMe    Ms    H                               Pri       H    Me       CMe.sub.2 OMe    Cl    H                               Pri       H    Me       CMe.sub.2 OMe    MeS   H                               Pri       H    Me       CMe.sub.2 OMe    MeSO  H                               Pri       H    Me       CMe.sub.2 OEt    Ms    H                               Pri       H    Me       CMe.sub.2 OEt    Cl    H                               Pri       H    Me       CMe.sub.2 OEt    MeS   H                               Pri       H    Me       CMe.sub.2 OEt    MeSO  H                               Pri       H    Me       CMe.sub.2 OPri   Ms    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Cl    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OMe                                                                           MeS   H                               Pri       H    Me       CH.sub.2 CH.sub.2 OMe                                                                           MeSO  H                               Pri       H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Cl    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OEt                                                                           MeS   H                               Pri       H    Me       CH.sub.2 CH.sub.2 OEt                                                                           MeSO  H                               Pri       H    Me       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OPri                                                                          Cl    H                               Pri       H    Me       CH.sub.2 CH.sub.2 OPri                                                                          MeS   H                               Pri       H    Me       CH.sub.2 CH.sub.2 OPri                                                                          MeSO  H                               Pri       H    Me       CHEtOH           Ms    H                               Pri       H    Me       CHEtOMe          Ms    H                               Pri       H    Me       CHEtOMe          Cl    H                               Pr i      H    Me       CHEtOMe          MeS   H                               Pri       H    Me       CHEtOMe          MeSO  H                               Pri       H    Me       CHEtOEt          Ms    H                               Pri       H    Me       CHEtOPri         Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Pri       H    Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       H    Me       CH.sub.2 OY8     Ms    H                               Pri       H    Me       CH.sub.2 OY9     Ms    H                               Pri       H    Me       CH.sub.2 OY10    Ms    H                               Pri       H    Me       CHMeOY8          Ms    H                               Pri       H    Me       CHMeOY9          Ms    H                               Pri       H    Me       CHMeOY10         Ms    H                               Pri       H    Me       CH.sub.2 OY13    Ms    H                               Pri       H    Me       CHMeOY13         Ms    H                               Pri       H    Me       CH.sub.2 NHMe    Ms    H                               Pri       H    Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       H    Me       CH.sub. 2 NEtMe  Ms    H                               Pri       H    Me       CH.sub.2 NEt.sub.2                                                                              Ms    H                               Pri       H    Me       CH.sub.2Y14      Ms    H                               Pri       H    Me       CHMeNMe.sub.2    Ms    H                               Pri       H    Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       H    Me       CHMeOCH.sub.2 Ph Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       H    Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       H    Me       CH.sub.2 CN      Ms    H                               Pri       H    Me       CHMeCN           Ms    H                               Pri       H    Me       CH.sub.2 SMe     Ms    H                               Pri       H    Me       CH.sub.2 SMe     Cl    H                               Pri       H    Me       CH.sub.2 SMe     MeS   H                               Pri       H    Me       CH.sub.2 SMe     MeSO  H                               Pri       H    Me       CH.sub.2 SEt     Ms    H                               Pri       H    Me       CH.sub.2 SEt     Cl    H                               Pri       H    Me       CH.sub.2 SEt     MeS   H                               Pri       H    Me       CH.sub.2 SEt     MeSO  H                               Pri       H    Me       CH.sub.2 SOMe    Ms    H                               Pri       H    Me       CH.sub.2 SOEt    Ms    H                               Pri       H    Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       H    Me       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Pri       H    Me       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Pri       H    Me       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Pri       H    Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       H    Me       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Pri       H    Me       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Pri       H    Me       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Pri       H    Me       CHMeSMe          Ms    H                               Pri       H    Me       CHMeSEt          Ms    H                               Pri       H    Me       CHMeSO.sub.2 Me  Ms    H                               Pri       H    Me       CHMeSO.sub.2 Et  Ms    H                               Pri       H    Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    Me       CH.sub.2 OCOMe   Ms    H                               Pri       H    Me       CH.sub.2 OCOEt   Ms    H                               Pri       H    Me       CHMeOCOMe        Ms    H                               Pri       H    Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       H    Me       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Pri       H    Me       CHMeOSO.sub.2 Me Ms    H                               __________________________________________________________________________

                                      TABLE 5                                      __________________________________________________________________________      ##STR39##                                                                     A         B    X        Y                Z      Q                              __________________________________________________________________________     Me        H    Cl       CH.sub.2 OH      Ms     H                              Me        H    Cl       CH.sub.2 OMe     Ms     H                              Me        H    Cl       CH.sub.2 OMe     Cl     H                              Me        H    Cl       CH.sub.2 OMe     MeS    H                              Me        H    Cl       CH.sub.2 OMe     MeSO   H                              Me        H    Cl       CH.sub.2 OMe     Ms     Q1                             Me        H    Cl       CH.sub.2 OMe     MeS    Q1                             Me        H    Cl       CH.sub.2 OMe     MeSO   Q1                             Me        H    Cl       CH.sub.2 OMe     Ms     Q2                             Me        H    Cl       CH.sub.2 OMe     MeS    Q2                             Me        H    Cl       CH.sub.2 OMe     MeSO   Q2                             Me        H    Cl       CH.sub.2 OMe     Ms     Q3                             Me        H    Cl       CH.sub.2 OMe     MeS    Q3                             Me        H    Cl       CH.sub.2 OMe     MeSO   Q3                             Me        H    Cl       CH.sub.2 OMe     Ms     Q4                             Me        H    Cl       CH.sub. 2 OMe    Ms     Q5                             Me        H    Cl       CH.sub.2 OMe     Ms     Q6                             Me        H    Cl       CH.sub.2 OMe     Ms     Q7                             Me        H    Cl       CH.sub.2 OMe     Ms     Q8                             Me        H    Cl       CH.sub.2 OMe     Ms     Q9                             Me        H    Cl       CH.sub.2 OEt     Ms     H                              Me        H    Cl       CH.sub.2 OEt     Cl     H                              Me        H    Cl       CH.sub.2 OEt     MeS    H                              Me        H    Cl       CH.sub.2 OEt     MeSO   H                              Me        H    Cl       CH.sub.2 OEt     Ms     Q1                             Me        H    Cl       CH.sub.2 OEt     MeS    Q1                             Me        H    Cl       CH.sub.2 OEt     MeSO   Q1                             Me        H    Cl       CH.sub.2 OEt     Ms     Q2                             Me        H    Cl       CH.sub.2 OEt     MeS    Q2                             Me        H    Cl       CH.sub.2 OEt     MeSO   Q2                             Me        H    Cl       CH.sub.2 OEt     Ms     Q3                             Me        H    Cl       CH.sub.2 OEt     MeS    Q3                             Me        H    Cl       CH.sub.2 OEt     MeSO   Q3                             Me        H    Cl       CH.sub.2 OEt     Ms     Q4                             Me        H    Cl       CH.sub.2 OEt     Ms     Q5                             Me        H    Cl       CH.sub.2 OEt     Ms     Q6                             Me        H    Cl       CH.sub.2 OEt     Ms     Q7                             Me        H    Cl       CH.sub.2 OEt     Ms     Q8                             Me        H    Cl       CH.sub.2 OEt     Ms     Q9                             Me        H    Cl       CH.sub.2 OPri    Ms     H                              Me        H    Cl       CH.sub.2 OPri    Cl     H                              Me        H    Cl       CH.sub.2 OPri    MeS    H                              Me        H    Cl       CH.sub.2 OPri    MeSO   H                              Me        H    Cl       CH.sub.2 OPri    Ms     Q1                             Me        H    Cl       CH.sub.2 OPri    Ms     Q2                             Me        H    Cl       CH.sub.2 OPri    Ms     Q3                             Me        H    Cl       CH.sub.2 OPrn    Ms     H                              Me        H    Cl       CH.sub.2 OPrn    Cl     H                              Me        H    Cl       CH.sub.2 OPrn    MeS    H                              Me        H    Cl       CH.sub.2 OPrn    MeSO   H                              Me        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms     H                              Me        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Cl     H                              Me        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            MeS    H                              Me        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            MeSO   H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS    H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO   H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Cl     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          MeS    H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          MeSO   H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS    H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO   H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Br                                                                  Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 CN                                                                  Ms     H                              Me        H    Cl       CH.sub.2 OAmn    Ms     H                              Me        H    Cl       CH.sub.2 OY5     Ms     H                              Me        H    Cl       CHMeOH           Ms     H                              Me        H    Cl       CHMeOMe          Ms     H                              Me        H    Cl       CHMeOMe          Cl     H                              Me        H    Cl       CHMeOMe          MeS    H                              Me        H    Cl       CHMeOMe          MeSO   H                              Me        H    Cl       CHMeOMe          Ms     Q1                             Me        H    Cl       CHMeOMe          Ms     Q2                             Me        H    Cl       CHMeOMe          Ms     Q3                             Me        H    Cl       CHMeOEt          Ms     H                              Me        H    Cl       CHMeOEt          Cl     H                              Me        H    Cl       CHMeOEt          MeS    H                              Me        H    Cl       CHMeOEt          MeSO   H                              Me        H    Cl       CHMeOEt          Ms     Q1                             Me        H    Cl       CHMeOEt          Ms     Q2                             Me        H    Cl       CHMeOEt          Ms     Q3                             Me        H    Cl       CHMeOPri         Ms     H                              Me        H    Cl       CHMeOPri         Cl     H                              Me        H    Cl       CHMeOPri         MeS    H                              Me        H    Cl       CHMeOPri         MeSO   H                              Me        H    Cl       CHMeOPrn         Ms     H                              Me        H    Cl       CHMeOCHCH.sub.2  Ms     H                              Me        H    Cl       CHMeOCHCH.sub.2  Ms     H                              Me        H    Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms     H                              Me        H    Cl       CHMeOCH.sub.2 CCH                                                                               Ms     H                              Me        H    Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms     H                              Me        H    Cl       CHMeOY5          Ms     H                              Me        H    Cl       CHMe.sub.2 OH    Ms     H                              Me        H    Cl       CHMe.sub.2 OMe   Ms     H                              Me        H    Cl       CHMe.sub.2 OMe   Cl     H                              Me        H    Cl       CHMe.sub.2 OMe   MeS    H                              Me        H    Cl       CHMe.sub.2 OMe   MeSO   H                              Me        H    Cl       CHMe.sub.2 OEt   Ms     H                              Me        H    Cl       CHMe.sub.2 OEt   Cl     H                              Me        H    Cl       CHMe.sub.2 OEt   MeS    H                              Me        H    Cl       CHMe.sub.2 OEt   MeSO   H                              Me        H    Cl       CHMe.sub.2 OPri  Ms     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Cl     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           MeS    H                              Me        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           MeSO   H                              Me        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Cl     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           MeS    H                              Me        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           MeSO   H                              Me        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          Ms     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          Cl     H                              Me        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          MeS    H                              Me        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          MeSO   H                              Me        H    Cl       CHEtOH           Ms     H                              Me        H    Cl       CHEtOMe          Ms     H                              Me        H    Cl       CHEtOMe          Cl     H                              Me        H    Cl       CHEtOMe          MeS    H                              Me        H    Cl       CHEtOMe          MeSO   H                              Me        H    Cl       CHEtOEt          Ms     H                              Me        H    Cl       CHEtOPri         Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS    H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO   H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms     H                              Me        H    Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms     H                              Me        H    Cl       CH.sub.2 OY8     Ms     H                              Me        H    Cl       CH.sub.2 OY9     Ms     H                              Me        H    Cl       CH.sub.2 OY10    Ms     H                              Me        H    Cl       CHMeOY8          Ms     H                              Me        H    Cl       CHMeOY9          Ms     H                              Me        H    Cl       CHMeOY10         Ms     H                              Me        H    Cl       CH.sub.2 OY13    Ms     H                              Me        H    Cl       CHMeOY13         Ms     H                              Me        H    Cl       CH.sub.2 NHMe    Ms     H                              Me        H    Cl       CH.sub.2 NMe.sub.2                                                                              Ms     H                              Me        H    Cl       CH.sub.2 NEtMe   Ms     H                              Me        H    Cl       CH.sub.2 NEt.sub.2                                                                              Ms     H                              Me        H    Cl       CH.sub.2Y14      Ms     H                              Me        H    Cl       CHMeNMe.sub.2    Ms     H                              Me        H    Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms     H                              Me        H    Cl       CHMeOCH.sub.2 Ph Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms     H                              Me        H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms     H                              Me        H    Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms     H                              Me        H    Cl       CH.sub.2 CN      Ms     H                              Me        H    Cl       CHMeCN           Ms     H                              Me        H    Cl       CH.sub.2 SMe     Ms     H                              Me        H    Cl       CH.sub.2 SMe     Cl     H                              Me        H    Cl       CH.sub.2 SMe     MeS    H                              Me        H    Cl       CH.sub.2 SMe     MeSO   H                              Me        H    Cl       CH.sub.2 SEt     Ms     H                              Me        H    Cl       CH.sub.2 SEt     Cl     H                              Me        H    Cl       CH.sub.2 SEt     MeS    H                              Me        H    Cl       CH.sub.2 SEt     MeSO   H                              Me        H    Cl       CH.sub.2 SOMe    Ms     H                              Me        H    Cl       CH.sub.2 SOEt    Ms     H                              Me        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms     H                              Me        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Cl     H                              Me        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            MeS    H                              Me        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            MeSO   H                              Me        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms     H                              Me        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Cl     H                              Me        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            MeS    H                              Me        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            MeSO   H                              Me        H    Cl       CHMeSMe          Ms     H                              Me        H    Cl       CHMeSEt          Ms     H                              Me        H    Cl       CHMeSO.sub.2 Me  Ms     H                              Me        H    Cl       CHMeSO.sub.2 Et  Ms     H                              Me        H    Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms     H                              Me        H    Cl       CH.sub.2 OCOMe   Ms     H                              Me        H    Cl       CH.sub.2 OCOEt   Ms     H                              Me        H    Cl       CHMeOCOMe        Ms     H                              Me        H    Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms     H                              Me        H    Cl       CH.sub.2 OSO.sub.2 Et                                                                           Ms     H                              Me        H    Cl       CHMeOSO.sub.2 Me Ms     H                              Et        H    Cl       CH.sub.2 OH      Ms     H                              Et        H    Cl       CH.sub.2 OMe     Ms     H                              Et        H    Cl       CH.sub.2 OMe     Cl     H                              Et        H    Cl       CH.sub.2 OMe     MeS    H                              Et        H    Cl       CH.sub.2 OMe     MeSO   H                              Et        H    Cl       CH.sub.2 OMe     Ms     Q1                             Et        H    Cl       CH.sub.2 OMe     MeS    Q1                             Et        H    Cl       CH.sub.2 OMe     MeSO   Q1                             Et        H    Cl       CH.sub.2 OMe     Ms     Q2                             Et        H    Cl       CH.sub.2 OMe     MeS    Q2                             Et        H    Cl       CH.sub.2 OMe     MeSO   Q2                             Et        H    Cl       CH.sub.2 OMe     Ms     Q3                             Et        H    Cl       CH.sub.2 OMe     MeS    Q3                             Et        H    Cl       CH.sub.2 OMe     MeSO   Q3                             Et        H    Cl       CH.sub.2 OMe     Ms     Q4                             Et        H    Cl       CH.sub.2 OMe     Ms     Q5                             Et        H    Cl       CH.sub.2 OMe     Ms     Q6                             Et        H    Cl       CH.sub.2 OMe     Ms     Q7                             Et        H    Cl       CH.sub.2 OMe     Ms     Q8                             Et        H    Cl       CH.sub.2 OMe     Ms     Q9                             Et        H    Cl       CH.sub.2 OEt     Ms     H                              Et        H    Cl       CH.sub.2 OEt     Cl     H                              Et        H    Cl       CH.sub.2 OEt     MeS    H                              Et        H    Cl       CH.sub.2 OEt     MeSO   H                              Et        H    Cl       CH.sub.2 OEt     Ms     Q1                             Et        H    Cl       CH.sub.2 OEt     MeS    Q1                             Et        H    Cl       CH.sub.2 OEt     MeSO   Q1                             Et        H    Cl       CH.sub.2 OEt     Ms     Q2                             Et        H    Cl       CH.sub.2 OEt     MeS    Q2                             Et        H    Cl       CH.sub.2 OEt     MeSO   Q2                             Et        H    Cl       CH.sub.2 OEt     Ms     Q3                             Et        H    Cl       CH.sub.2 OEt     MeS    Q3                             Et        H    Cl       CH.sub.2 OEt     MeSO   Q3                             Et        H    Cl       CH.sub.2 OEt     Ms     Q4                             Et        H    Cl       CH.sub.2 OEt     Ms     Q5                             Et        H    Cl       CH.sub.2 OEt     Ms     Q6                             Et        H    Cl       CH.sub.2 OEt     Ms     Q7                             Et        H    Cl       CH.sub.2 OEt     Ms     Q8                             Et        H    Cl       CH.sub.2 OEt     Ms     Q9                             Et        H    Cl       CH.sub.2 OPri    Ms     H                              Et        H    Cl       CH.sub.2 OPri    Cl     H                              Et        H    Cl       CH.sub.2 OPri    MeS    H                              Et        H    Cl       CH.sub.2 OPri    MeSO   H                              Et        H    Cl       CH.sub.2 OPri    Ms     Q1                             Et        H    Cl       CH.sub.2 OPri    Ms     Q2                             Et        H    Cl       CH.sub.2 OPri    Ms     Q3                             Et        H    Cl       CH.sub.2 OPrn    Ms     H                              Et        H    Cl       CH.sub.2 OPrn    Cl     H                              Et        H    Cl       CH.sub.2 OPrn    MeS    H                              Et        H    Cl       CH.sub.2 OPrn    MeSO   H                              Et        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms     H                              Et        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Cl     H                              Et        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            MeS    H                              Et        H    Cl       CH.sub.2 OCHCH.sub.2                                                                            MeSO   H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS    H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO   H                              Et        H    Cl       CH.sub.2 OCH.sub.2 C CH                                                                         Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Cl     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          MeS    H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          MeSO   H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS    H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO   H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Br                                                                  Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 CN                                                                  Ms     H                              Et        H    Cl       CH.sub.2 OAmn    Ms     H                              Et        H    Cl       CH.sub.2 OY5     Ms     H                              Et        H    Cl       CHMeOH           Ms     H                              Et        H    Cl       CHMeOMe          Ms     H                              Et        H    Cl       CHMeOMe          Cl     H                              Et        H    Cl       CHMeOMe          MeS    H                              Et        H    Cl       CHMeOMe          MeSO   H                              Et        H    Cl       CHMeOMe          Ms     Q1                             Et        H    Cl       CHMeOMe          Ms     Q2                             Et        H    Cl       CHMeOMe          Ms     Q3                             Et        H    Cl       CHMeOEt          Ms     H                              Et        H    Cl       CHMeOEt          Cl     H                              Et        H    Cl       CHMeOEt          MeS    H                              Et        H    Cl       CHMeOEt          MeSO   H                              Et        H    Cl       CHMeOEt          Ms     Q1                             Et        H    Cl       CHMeOEt          Ms     Q2                             Et        H    Cl       CHMeOEt          Ms     Q3                             Et        H    Cl       CHMeOPri         Ms     H                              Et        H    Cl       CHMeOPri         Cl     H                              Et        H    Cl       CHMeOPri         MeS    H                              Et        H    Cl       CHMeOPri         MeSO   H                              Et        H    Cl       CHMeOPrn         Ms     H                              Et        H    Cl       CHMeOCHCH.sub.2  Ms     H                              Et        H    Cl       CHMeOCHCH.sub.2  Ms     H                              Et        H    Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms     H                              Et        H    Cl       CHMeOCH.sub.2 CCH                                                                               Ms     H                              Et        H    Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms     H                              Et        H    Cl       CHMeOY5          Ms     H                              Et        H    Cl       CMe.sub.2 OH     Ms     H                              Et        H    Cl       CMe.sub.2 OMe    Ms     H                              Et        H    Cl       CMe.sub.2 OMe    Cl     H                              Et        H    Cl       CMe.sub.2 OMe    MeS    H                              Et        H    Cl       CMe.sub.2 OMe    MeSO   H                              Et        H    Cl       CMe.sub.2 OEt    Ms     H                              Et        H    Cl       CMe.sub.2 OEt    Cl     H                              Et        H    Cl       CMe.sub.2 OEt    MeS    H                              Et        H    Cl       CMe.sub.2 OEt    MeSO   H                              Et        H    Cl       CMe.sub.2 OPri   Ms     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Cl     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           MeS    H                              Et        H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           MeSO   H                              Et        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Cl     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           MeS    H                              Et        H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           MeSO   H                              Et        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          Ms     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          Cl     H                              Et        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          MeS    H                              Et        H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          MeSO   H                              Et        H    Cl       CHEtOH           Ms     H                              Et        H    Cl       CHEtOMe          Ms     H                              Et        H    Cl       CHEtOMe          Cl     H                              Et        H    Cl       CHEtOMe          MeS    H                              Et        H    Cl       CHEtOMe          MeSO   H                              Et        H    Cl       CHEtOEt          Ms     H                              Et        H    Cl       CHEtOPri         Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub. 2 OMe                                                                Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS    H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO   H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms     H                              Et        H    Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms     H                              Et        H    Cl       CH.sub.2 OY8     Ms     H                              Et        H    Cl       CH.sub.2 OY9     Ms     H                              Et        H    Cl       CH.sub.2 OY10    Ms     H                              Et        H    Cl       CHMeOY8          Ms     H                              Et        H    Cl       CHMeOY9          Ms     H                              Et        H    Cl       CHMeOY10         Ms     H                              Et        H    Cl       CH.sub.2 OY13    Ms     H                              Et        H    Cl       CHMeOY13         Ms     H                              Et        H    Cl       CH.sub.2 NHMe    Ms     H                              Et        H    Cl       CH.sub.2 NMe.sub.2                                                                              Ms     H                              Et        H    Cl       CH.sub.2 NEtMe   Ms     H                              Et        H    Cl       CH.sub.2 NEt.sub.2                                                                              Ms     H                              Et        H    Cl       CH.sub.2Y14      Ms     H                              Et        H    Cl       CHMeNMe.sub.2    Ms     H                              Et        H    Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms     H                              Et        H    Cl       CHMeOCH.sub. 2 Ph                                                                               Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms     H                              Et        H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms     H                              Et        H    Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms     H                              Et        H    Cl       CH.sub.2 CN      Ms     H                              Et        H    Cl       CHMeCN           Ms     H                              Et        H    Cl       CH.sub.2 SMe     Ms     H                              Et        H    Cl       CH.sub.2 SMe     Cl     H                              Et        H    Cl       CH.sub.2 SMe     MeS    H                              Et        H    Cl       CH.sub.2 SMe     MeSO   H                              Et        H    Cl       CH.sub.2 SEt     Ms     H                              Et        H    Cl       CH.sub.2 SEt     Cl     H                              Et        H    Cl       CH.sub.2 SEt     MeS    H                              Et        H    Cl       CH.sub.2 SEt     MeSO   H                              Et        H    Cl       CH.sub.2 SOMe    Ms     H                              Et        H    Cl       CH.sub.2 SOEt    Ms     H                              Et        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms     H                              Et        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Cl     H                              Et        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            MeS    H                              Et        H    Cl       CH.sub.2 SO.sub.2 Me                                                                            MeSO   H                              Et        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms     H                              Et        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Cl     H                              Et        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            MeS    H                              Et        H    Cl       CH.sub.2 SO.sub.2 Et                                                                            MeSO   H                              Et        H    Cl       CHMeSMe          Ms     H                              Et        H    Cl       CHMeSEt          Ms     H                              Et        H    Cl       CHMeSO.sub.2 Me  Ms     H                              Et        H    Cl       CHMeSO.sub.2 Et  Ms     H                              Et        H    Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms     H                              Et        H    Cl       CH.sub.2 OCOMe   Ms     H                              Et        H    Cl       CH.sub.2 OCOEt   Ms     H                              Et        H    Cl       CHMeOCOMe        Ms     H                              Et        H    Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms     H                              Et        H    Cl       CH.sub.2 OSO.sub.2 Et                                                                           Ms     H                              Et        H    Cl       CHMeOSO.sub.2 Me Ms     H                              Pri       H    Cl       CH.sub.2 OH      Ms     H                              Pri       H    Cl       CH.sub.2 OMe     Ms     H                              Pri       H    Cl       CH.sub.2 OMe     Cl     H                              Pri       H    Cl       CH.sub.2 OMe     MeS    H                              Pri       H    Cl       CH.sub.2 OMe     MeSO   H                              Pri       H    Cl       CH.sub.2 OMe     Ms     Q1                             Pri       H    Cl       CH.sub.2 OMe     MeS    Q1                             Pri       H    Cl       CH.sub.2 OMe     MeSO   Q1                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q2                             Pri       H    Cl       CH.sub.2 OMe     MeS    Q2                             Pri       H    Cl       CH.sub.2 OMe     MeSO   Q2                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q3                             Pri       H    Cl       CH.sub.2 OMe     MeS    Q3                             Pri       H    Cl       CH.sub.2 OMe     MeSO   Q3                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q4                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q5                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q6                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q7                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q8                             Pri       H    Cl       CH.sub.2 OMe     Ms     Q9                             Pri       H    Cl       CH.sub.2 OEt     Ms     H                              Pri       H    Cl       CH.sub.2 OEt     Cl     H                              Pri       H    Cl       CH.sub.2 OEt     MeS    H                              Pri       H    Cl       CH.sub.2 OEt     MeSO   H                              Pri       H    Cl       CH.sub.2 OEt     Ms     Q1                             Pri       H    Cl       CH.sub.2 OEt     MeS    Q1                             Pri       H    Cl       CH.sub.2 OEt     MeSO   Q1                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q2                             Pri       H    Cl       CH.sub.2 OEt     MeS    Q2                             Pri       H    Cl       CH.sub.2 OEt     MeSO   Q2                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q3                             Pri       H    Cl       CH.sub.2 OEt     MeS    Q3                             Pri       H    Cl       CH.sub.2 OEt     MeSO   Q3                             Pr i      H    Cl       CH.sub.2 OEt     Ms     Q4                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q5                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q6                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q7                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q8                             Pri       H    Cl       CH.sub.2 OEt     Ms     Q9                             Pri       H    Cl       CH.sub.2 OPri    Ms     H                              Pri       H    Cl       CH.sub.2 OPri    Cl     H                              Pri       H    Cl       CH.sub.2 OPri    MeS    H                              Pri       H    Cl       CH.sub.2 OPri    MeSO   H                              Pri       H    Cl       CH.sub.2 OPri    Ms     Q1                             Pri       H    Cl       CH.sub.2 OPri    Ms     Q2                             Pri       H    Cl       CH.sub.2 OPri    Ms     Q3                             Pri       H    Cl       CH.sub.2 OPrn    Ms     H                              Pri       H    Cl       CH.sub.2 OPrn    Cl     H                              Pri       H    Cl       CH.sub.2 OPrn    MeS    H                              Pri       H    Cl       CH.sub.2 OPrn    MeSO   H                              Pri       H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms     H                              Pri       H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Cl     H                              Pri       H    Cl       CH.sub.2 OCHCH.sub.2                                                                            MeS    H                              Pri       H    Cl       CH.sub.2 OCHCH.sub.2                                                                            MeSO   H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS    H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO   H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Cl     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          MeS    H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          MeSO   H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS    H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO   H                              Pri       H    Cl       CH.sub. 2 OCH.sub.2 CH.sub.2 Br                                                                 Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 CN                                                                  Ms     H                              Pri       H    Cl       CH.sub.2 OAmn    Ms     H                              Pri       H    Cl       CH.sub.2 OY5     Ms     H                              Pri       H    Cl       CHMeOH           Ms     H                              Pri       H    Cl       CHMeOMe          Ms     H                              Pri       H    Cl       CHMeOMe          Cl     H                              Pri       H    Cl       CHMeOMe          MeS    H                              Pri       H    Cl       CHMeOMe          MeSO   H                              Pri       H    Cl       CHMeOMe          Ms     Q1                             Pri       H    Cl       CHMeOMe          Ms     Q2                             Pri       H    Cl       CHMeOMe          Ms     Q3                             Pri       H    Cl       CHMeOEt          Ms     H                              Pri       H    Cl       CHMeOEt          Cl     H                              Pri       H    Cl       CHMeOEt          MeS    H                              Pri       H    Cl       CHMeOEt          MeSO   H                              Pri       H    Cl       CHMeOEt          Ms     Q1                             Pri       H    Cl       CHMeOEt          Ms     Q2                             Pri       H    Cl       CHMeOEt          Ms     Q3                             Pri       H    Cl       CHMeOPri         Ms     H                              Pri       H    Cl       CHMeOPri         Cl     H                              Pri       H    Cl       CHMeOPri         MeS    H                              Pri       H    Cl       CHMeOPri         MeSO   H                              Pri       H    Cl       CHMeOPrn         Ms     H                              Pri       H    Cl       CHMeOCHCH.sub.2  Ms     H                              Pri       H    Cl       CHMeOCH CH.sub.2 Ms     H                              Pri       H    Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms     H                              Pri       H    Cl       CHMeOCH.sub.2 CCH                                                                               Ms     H                              Pri       H    Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms     H                              Pri       H    Cl       CHMeOY5          Ms     H                              Pri       H    Cl       CMe.sub.2 OH     Ms     H                              Pri       H    Cl       CMe.sub.2 OMe    Ms     H                              Pri       H    Cl       CMe.sub.2 OMe    Cl     H                              Pri       H    Cl       CMe.sub.2 OMe    MeS    H                              Pri       H    Cl       CMe.sub.2 OMe    MeSO   H                              Pri       H    Cl       CMe.sub.2 OEt    Ms     H                              Pri       H    Cl       CMe.sub.2 OEt    Cl     H                              Pri       H    Cl       CMe.sub.2 OEt    MeS    H                              Pri       H    Cl       CMe.sub.2 OEt    MeSO   H                              Pri       H    Cl       CMe.sub.2 OPri   Ms     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Cl     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           MeS    H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           MeSO   H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms     H                              Pr i      H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Cl     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           MeS    H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           MeSO   H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          Ms     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          Cl     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          MeS    H                              Pri       H    Cl       CH.sub.2 CH.sub.2 OPri                                                                          MeSO   H                              Pri       H    Cl       CHEtOH           Ms     H                              Pri       H    Cl       CHEtOMe          Ms     H                              Pri       H    Cl       CHEtOMe          Cl     H                              Pri       H    Cl       CHEtOMe          MeS    H                              Pri       H    Cl       CHEtOMe          MeSO   H                              Pri       H    Cl       CHEtOEt          Ms     H                              Pri       H    Cl       CHEtOPri         Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS    H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO   H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms     H                              Pri       H    Cl       CHMeOCH.sub. 2 CH.sub.2 OMe                                                                     Ms     H                              Pri       H    Cl       CH.sub.2 OY8     Ms     H                              Pri       H    Cl       CH.sub.2 OY9     Ms     H                              Pri       H    Cl       CH.sub.2 OY10    Ms     H                              Pri       H    Cl       CHMeOY8          Ms     H                              Pri       H    Cl       CHMeOY9          Ms     H                              Pri       H    Cl       CHMeOY10         Ms     H                              Pri       H    Cl       CH.sub.2 OY13    Ms     H                              Pri       H    Cl       CHMeOY13         Ms     H                              Pri       H    Cl       CH.sub.2 NHMe    Ms     H                              Pri       H    Cl       CH.sub.2 NMe.sub.2                                                                              Ms     H                              Pri       H    Cl       CH.sub.2 NEtMe   Ms     H                              Pri       H    Cl       CH.sub.2 NEt.sub.2                                                                              Ms     H                              Pri       H    Cl       CH.sub.2Y14      Ms     H                              Pri       H    Cl       CHMeNMe.sub.2    Ms     H                              Pri       H    Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms     H                              Pri       H    Cl       CHMeOCH.sub.2 Ph Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms     H                              Pri       H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms     H                              Pri       H    Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms     H                              Pri       H    Cl       CH.sub.2 CN      Ms     H                              Pri       H    Cl       CHMeCN           Ms     H                              Pri       H    Cl       CH.sub.2 SMe     Ms     H                              Pri       H    Cl       CH.sub.2 SMe     Cl     H                              Pri       H    Cl       CH.sub.2 SMe     MeS    H                              Pri       H    Cl       CH.sub.2 SMe     MeSO   H                              Pri       H    Cl       CH.sub.2 SEt     Ms     H                              Pri       H    Cl       CH.sub.2 SEt     Cl     H                              Pri       H    Cl       CH.sub.2 SEt     MeS    H                              Pri       H    Cl       CH.sub.2 SEt     MeSO   H                              Pri       H    Cl       CH.sub.2 SOMe    Ms     H                              Pri       H    Cl       CH.sub.2 SOEt    Ms     H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms     H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Cl     H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Me                                                                            MeS    H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Me                                                                            MeSO   H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms     H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Cl     H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Et                                                                            MeS    H                              Pri       H    Cl       CH.sub.2 SO.sub.2 Et                                                                            MeSO   H                              Pri       H    Cl       CHMeSMe          Ms     H                              Pri       H    Cl       CHMeSEt          Ms     H                              Pri       H    Cl       CHMeSO.sub.2 Me  Ms     H                              Pri       H    Cl       CHMeSO.sub.2 Et  Ms     H                              Pri       H    Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms     H                              Pri       H    Cl       CH.sub.2 OCOMe   Ms     H                              Pri       H    Cl       CH.sub.2 OCOEt   Ms     H                              Pri       H    Cl       CHMeOCOMe        Ms     H                              Pri       H    Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms     H                              Pri       H    Cl       CH.sub.2 OSO.sub.2 Et                                                                           Ms     H                              Pri       H    Cl       CHMeOSO.sub.2 Me Ms     H                              Me        H    MeO      CH.sub.2 OH      Ms     H                              Me        H    MeO      CH.sub.2 OMe     Ms     H                              Me        H    MeO      CH.sub.2 OMe     Cl     H                              Me        H    MeO      CH.sub.2 OMe     MeS    H                              Me        H    MeO      CH.sub.2 OMe     MeSO   H                              Me        H    MeO      CH.sub.2 OMe     Ms     Q1                             Me        H    MeO      CH.sub.2 OMe     MeS    Q1                             Me        H    MeO      CH.sub.2 OMe     MeSO   Q1                             Me        H    MeO      CH.sub.2 OMe     Ms     Q2                             Me        H    MeO      CH.sub.2 OMe     MeS    Q2                             Me        H    MeO      CH.sub.2 OMe     MeSO   Q2                             Me        H    MeO      CH.sub.2 OMe     Ms     Q3                             Me        H    MeO      CH.sub.2 OMe     MeS    Q3                             Me        H    MeO      CH.sub.2 OMe     MeSO   Q3                             Me        H    MeO      CH.sub.2 OMe     Ms     Q4                             Me        H    MeO      CH.sub.2 OMe     Ms     Q5                             Me        H    MeO      CH.sub.2 OMe     Ms     Q6                             Me        H    MeO      CH.sub.2 OMe     Ms     Q7                             Me        H    MeO      CH.sub.2 OMe     Ms     Q8                             Me        H    MeO      CH.sub.2 OMe     Ms     Q9                             Me        H    MeO      CH.sub.2 OEt     Ms     H                              Me        H    MeO      CH.sub.2 OEt     Cl     H                              Me        H    MeO      CH.sub.2 OEt     MeS    H                              Me        H    MeO      CH.sub.2 OEt     MeSO   H                              Me        H    MeO      CH.sub.2 OEt     Ms     Q1                             Me        H    MeO      CH.sub.2 OEt     MeS    Q1                             Me        H    MeO      CH.sub.2 OEt     MeSO   Q1                             Me        H    MeO      CH.sub.2 OEt     Ms     Q2                             Me        H    MeO      CH.sub.2 OEt     MeS    Q2                             Me        H    MeO      CH.sub.2 OEt     MeSO   Q2                             Me        H    MeO      CH.sub.2 OEt     Ms     Q3                             Me        H    MeO      CH.sub.2 OEt     MeS    Q3                             Me        H    MeO      CH.sub.2 OEt     MeSO   Q3                             Me        H    MeO      CH.sub.2 OEt     Ms     Q4                             Me        H    MeO      CH.sub.2 OEt     Ms     Q5                             Me        H    MeO      CH.sub.2 OEt     Ms     Q6                             Me        H    MeO      CH.sub.2 OEt     Ms     Q7                             Me        H    MeO      CH.sub.2 OEt     Ms     Q8                             Me        H    MeO      CH.sub.2 OEt     Ms     Q9                             Me        H    MeO      CH.sub.2 OPri    Ms     H                              __________________________________________________________________________

                                      TABLE 5                                      __________________________________________________________________________      ##STR40##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Me        H    MeO      CH.sub.2 OPri    Cl    H                               Me        H    MeO      CH.sub.2 OPri    MeS   H                               Me        H    MeO      CH.sub.2 OPri    MeSO  H                               Me        H    MeO      CH.sub.2 OPri    Ms    Q1                              Me        H    MeO      CH.sub.2 OPri    Ms    Q2                              Me        H    MeO      CH.sub.2 OPri    Ms    Q3                              Me        H    MeO      CH.sub.2 OPrn    Ms    H                               Me        H    MeO      CH.sub.2 OPrn    Cl    H                               Me        H    MeO      CH.sub.2 OPrn    MeS   H                               Me        H    MeO      CH.sub.2 OPrn    MeSO  H                               Me        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Cl    H                               Me        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            MeS   H                               Me        H    MeO      CH.sub. 2 OCHCH.sub.2                                                                           MeSO  H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS   H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO  H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Cl    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          MeS   H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          MeSO  H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS   H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO  H                               Me        H    MeO      CH.sub.2 OY5     Ms    H                               Me        H    MeO      CHMeOH           Ms    H                               Me        H    MeO      CHMeOMe          Ms    H                               Me        H    MeO      CHMeOMe          Cl    H                               Me        H    MeO      CHMeOMe          MeS   H                               Me        H    MeO      CHMeOMe          MeSO  H                               Me        H    MeO      CHMeOMe          Ms    Q1                              Me        H    MeO      CHMeOMe          Ms    Q2                              Me        H    MeO      CHMeOMe          Ms    Q3                              Me        H    MeO      CHMeOEt          Ms    H                               Me        H    MeO      CHMeOEt          Cl    H                               Me        H    MeO      CHMeOEt          MeS   H                               Me        H    MeO      CHMeOEt          MeSO  H                               Me        H    MeO      CHMeOEt          Ms    Q1                              Me        H    MeO      CHMeOEt          Ms    Q2                              Me        H    MeO      CHMeOEt          Ms    Q3                              Me        H    MeO      CHMeOPri         Ms    H                               Me        H    MeO      CHMeOPri         Cl    H                               Me        H    MeO      CHMeOPri         MeS   H                               Me        H    MeO      CHMeOPri         MeSO  H                               Me        H    MeO      CHMeOPrn         Ms    H                               Me        H    MeO      CHMeOCHCH.sub.2  Ms    H                               Me        H    MeO      CHMeOCHCH.sub.2  Ms    H                               Me        H    MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        H    MeO      CHMeOCH.sub.2 CCH                                                                               Ms    H                               Me        H    MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        H    MeO      CHMeOY5          Ms    H                               Me        H    MeO      CMe.sub.2 OH     Ms    H                               Me        H    MeO      CMe.sub.2 OMe    Ms    H                               Me        H    MeO      CMe.sub.2 OMe    Cl    H                               Me        H    MeO      CMe.sub.2 OMe    MeS   H                               Me        H    MeO      CMe.sub.2 OMe    MeSO  H                               Me        H    MeO      CMe.sub.2 OEt    Ms    H                               Me        H    MeO      CMe.sub.2 OEt    Cl    H                               Me        H    MeO      CMe.sub.2 OEt    MeS   H                               Me        H    MeO      CMe.sub.2 OEt    MeSO  H                               Me        H    MeO      CMe.sub.2 OPri   Ms    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Cl    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           MeS   H                               Me        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           MeSO  H                               Me        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Cl    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           MeS   H                               Me        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           MeSO  H                               Me        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          Cl    H                               Me        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          MeS   H                               Me        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          MeSO  H                               Me        H    MeO      CHEtOH           Ms    H                               Me        H    MeO      CHEtOMe          Ms    H                               Me        H    MeO      CHEtOMe          Cl    H                               Me        H    MeO      CHEtOMe          MeS   H                               Me        H    MeO      CHEtOMe          MeSO  H                               Me        H    MeO      CHEtOEt          Ms    H                               Me        H    MeO      CHEtOPri         Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Me        H    MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        H    MeO      CH.sub.2 OY8     Ms    H                               Me        H    MeO      CH.sub.2 OY9     Ms    H                               Me        H    MeO      CH.sub.2 OY10    Ms    H                               Me        H    MeO      CHMeOY8          Ms    H                               Me        H    MeO      CHMeOY9          Ms    H                               Me        H    MeO      CHMeOY10         Ms    H                               Me        H    MeO      CH.sub.2 OY13    Ms    H                               Me        H    MeO      CHMeOY13         Ms    H                               Me        H    MeO      CH.sub.2 NHMe    Ms    H                               Me        H    MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        H    MeO      CH.sub.2 NEtMe   Ms    H                               Me        H    MeO      CH.sub.2 NEt.sub.2                                                                              Ms    H                               Me        H    MeO      CH.sub.2Y14      Ms    H                               Me        H    MeO      CHMeNMe.sub.2    Ms    H                               Me        H    MeO      CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        H    MeO      CHMeOCH.sub.2 Ph Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        H    MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        H    MeO      CH.sub.2 CN      Ms    H                               Me        H    MeO      CHMeCN           Ms    H                               Me        H    MeO      CH.sub.2 SMe     Ms    H                               Me        H    MeO      CH.sub.2 SMe     Cl    H                               Me        H    MeO      CH.sub.2 SMe     MeS   H                               Me        H    MeO      CH.sub.2 SMe     MeSO  H                               Me        H    MeO      CH.sub.2 SEt     Ms    H                               Me        H    MeO      CH.sub.2 SEt     Cl    H                               Me        H    MeO      CH.sub.2 SEt     MeS   H                               Me        H    MeO      CH.sub.2 SEt     MeSO  H                               Me        H    MeO      CH.sub.2 SOMe    Ms    H                               Me        H    MeO      CH.sub.2 SOEt    Ms    H                               Me        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Me        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Me        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Me        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Me        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Me        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Me        H    MeO      CHMeSMe          Ms    H                               Me        H    MeO      CHMeSEt          Ms    H                               Me        H    MeO      CHMeSO.sub.2 Me  Ms    H                               Me        H    MeO      CHMeSO.sub.2 Et  Ms    H                               Me        H    MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    MeO      CH.sub.2 OCOMe   Ms    H                               Me        H    MeO      CH.sub.2 OCOEt   Ms    H                               Me        H    MeO      CHMeOCOMe        Ms    H                               Me        H    MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        H    MeO      CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Me        H    MeO      CHMeOSO.sub.2 Me Ms    H                               Et        H    MeO      CH.sub.2 OH      Ms    H                               Et        H    MeO      CH.sub.2 OMe     Ms    H                               Et        H    MeO      CH.sub.2 OMe     Cl    H                               Et        H    MeO      CH.sub.2 OMe     MeS   H                               Et        H    MeO      CH.sub.2 OMe     MeSO  H                               Et        H    MeO      CH.sub.2 OMe     Ms    Q1                              Et        H    MeO      CH.sub.2 OMe     MeS   Q1                              Et        H    MeO      CH.sub.2 OMe     MeSO  Q1                              Et        H    MeO      CH.sub.2 OMe     Ms    Q2                              Et        H    MeO      CH.sub.2 OMe     MeS   Q2                              Et        H    MeO      CH.sub.2 OMe     MeSO  Q2                              Et        H    MeO      CH.sub.2 OMe     Ms    Q3                              Et        H    MeO      CH.sub.2 OMe     MeS   Q3                              Et        H    MeO      CH.sub.2 OMe     MeSO  Q3                              Et        H    MeO      CH.sub.2 OMe     Ms    Q4                              Et        H    MeO      CH.sub.2 OMe     Ms    Q5                              Et        H    MeO      CH.sub.2 OMe     Ms    Q6                              Et        H    MeO      CH.sub.2 OMe     Ms    Q7                              Et        H    MeO      CH.sub.2 OMe     Ms    Q8                              Et        H    MeO      CH.sub.2 OMe     Ms    Q9                              Et        H    MeO      CH.sub.2 OEt     Ms    H                               Et        H    MeO      CH.sub.2 OEt     Cl    H                               Et        H    MeO      CH.sub.2 OEt     MeS   H                               Et        H    MeO      CH.sub.2 OEt     MeSO  H                               Et        H    MeO      CH.sub.2 OEt     Ms    Q1                              Et        H    MeO      CH.sub.2 OEt     MeS   Q1                              Et        H    MeO      CH.sub.2 OEt     MeSO  Q1                              Et        H    MeO      CH.sub.2 OEt     Ms    Q2                              Et        H    MeO      CH.sub.2 OEt     MeS   Q2                              Et        H    MeO      CH.sub.2 OEt     MeSO  Q2                              Et        H    MeO      CH.sub.2 OEt     Ms    Q3                              Et        H    MeO      CH.sub.2 OEt     MeS   Q3                              Et        H    MeO      CH.sub.2 OEt     MeSO  Q3                              Et        H    MeO      CH.sub.2 OEt     Ms    Q4                              Et        H    MeO      CH.sub.2 OEt     Ms    Q5                              Et        H    MeO      CH.sub.2 OEt     Ms    Q6                              Et        H    MeO      CH.sub.2 OEt     MS    Q7                              Et        H    MeO      CH.sub.2 OEt     Ms    Q8                              Et        H    MeO      CH.sub.2 OEt     Ms    Q9                              Et        H    MeO      CH.sub.2 OPri    Ms    H                               Et        H    MeO      CH.sub.2 OPri    Cl    H                               Et        H    MeO      CH.sub.2 OPri    MeS   H                               Et        H    MeO      CH.sub.2 OPri    MeSO  H                               Et        H    MeO      CH.sub.2 OPri    Ms    Q1                              Et        H    MeO      CH.sub.2 OPri    Ms    Q2                              Et        H    MeO      CH.sub.2 OPri    Ms    Q3                              Et        H    MeO      CH.sub.2 OPrn    Ms    H                               Et        H    MeO      CH.sub.2 OPrn    Cl    H                               Et        H    MeO      CH.sub.2 OPrn    MeS   H                               Et        H    MeO      CH.sub.2 OPrn    MeSO  H                               Et        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Cl    H                               Et        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            MeS   H                               Et        H    MeO      CH.sub.2 OCHCH.sub.2                                                                            MeSO  H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS   H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO  H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Cl    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          MeS   H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          MeSO  H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS   H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeSO  H                               Et        H    MeO      CH.sub.2 OY5     Ms    H                               Et        H    MeO      CHMeOH           Ms    H                               Et        H    MeO      CHMeOMe          Ms    H                               Et        H    MeO      CHMeOMe          Cl    H                               Et        H    MeO      CHMeOMe          MeS   H                               Et        H    MeO      CHMeOMe          MeSO  H                               Et        H    MeO      CHMeOMe          Ms    Q1                              Et        H    MeO      CHMeOMe          Ms    Q2                              Et        H    MeO      CHMeOMe          Ms    Q3                              Et        H    MeO      CHMeOEt          Ms    H                               Et        H    MeO      CHMeOEt          Cl    H                               Et        H    MeO      CHMeOEt          MeS   H                               Et        H    MeO      CHMeOEt          MeSO  H                               Et        H    MeO      CHMeOEt          Ms    Q1                              Et        H    MeO      CHMeOEt          Ms    Q2                              Et        H    MeO      CHMeOEt          Ms    Q3                              Et        H    MeO      CHMeOPri         Ms    H                               Et        H    MeO      CHMeOPri         Cl    H                               Et        H    MeO      CHMeOPri         MeS   H                               Et        H    MeO      CHMeOPri         MeSO  H                               Et        H    MeO      CHMeOPrn         Ms    H                               Et        H    MeO      CHMeOCHCH.sub.2  Ms    H                               Et        H    MeO      CHMeOCHCH.sub.2  Ms    H                               Et        H    MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        H    MeO      CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        H    MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        H    MeO      CHMeOY5          Ms    H                               Et        H    MeO      CMe.sub.2 OH     Ms    H                               Et        H    MeO      CMe.sub.2 OMe    Ms    H                               Et        H    MeO      CMe.sub.2 OMe    Cl    H                               Et        H    MeO      CMe.sub.2 OMe    MeS   H                               Et        H    MeO      CMe.sub.2 OMe    MeSO  H                               Et        H    MeO      CMe.sub.2 OEt    Ms    H                               Et        H    MeO      CMe.sub.2 OEt    Cl    H                               Et        H    MeO      CMe.sub.2 OEt    MeS   H                               Et        H    MeO      CMe.sub.2 OEt    MeSO  H                               Et        H    MeO      CMe.sub.2 OPri   Ms    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Cl    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           MeS   H                               Et        H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           MeSO  H                               Et        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Cl    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           MeS   H                               Et        H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           MeSO  H                               Et        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          Cl    H                               Et        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          MeS   H                               Et        H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          MeSO  H                               Et        H    MeO      CHEtOH           Ms    H                               Et        H    MeO      CHEtOMe          Ms    H                               Et        H    MeO      CHEtOMe          Cl    H                               Et        H    MeO      CHEtOMe          MeS   H                               Et        H    MeO      CHEtOMe          MeSO  H                               Et        H    MeO      CHEtOEt          Ms    H                               Et        H    MeO      CHEtOPri         Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Et        H    MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        H    MeO      CH.sub.2 OY8     Ms    H                               Et        H    MeO      CH.sub.2 OY9     Ms    H                               Et        H    MeO      CH.sub.2 OY10    Ms    H                               Et        H    MeO      CHMeOY8          Ms    H                               Et        H    MeO      CHMeOY9          Ms    H                               Et        H    MeO      CHMeOY10         Ms    H                               Et        H    MeO      CH.sub.2 OY13    Ms    H                               Et        H    MeO      CHMeOY13         Ms    H                               Et        H    MeO      CH.sub.2 NHMe    Ms    H                               Et        H    MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        H    MeO      CH.sub.2 NEtMe   Ms    H                               Et        H    MeO      CH.sub.2 NEt.sub.2                                                                              Ms    H                               Et        H    MeO      CH.sub.2Y14      Ms    H                               Et        H    MeO      CHMeNMe.sub.2    Ms    H                               Et        H    MeO      CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        H    MeO      CHMeOCH.sub.2 Ph Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        H    MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        H    MeO      CH.sub.2 CN      Ms    H                               Et        H    MeO      CHMeCN           Ms    H                               Et        H    MeO      CH.sub.2 SMe     Ms    H                               Et        H    MeO      CH.sub.2 SMe     Cl    H                               Et        H    MeO      CH.sub.2 SMe     MeS   H                               Et        H    MeO      CH.sub.2 SMe     MeSO  H                               Et        H    MeO      CH.sub.2 SEt     Ms    H                               Et        H    MeO      CH.sub.2 SEt     Cl    H                               Et        H    MeO      CH.sub.2 SEt     MeS   H                               Et        H    MeO      CH.sub.2 SEt     MeSO  H                               Et        H    MeO      CH.sub.2 SOMe    Ms    H                               Et        H    MeO      CH.sub.2 SOEt    Ms    H                               Et        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Et        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Et        H    MeO      CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Et        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Et        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Et        H    MeO      CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Et        H    MeO      CHMeSMe          Ms    H                               Et        H    MeO      CHMeSEt          Ms    H                               Et        H    MeO      CHMeSO.sub.2 Me  Ms    H                               Et        H    MeO      CHMeSO.sub.2 Et  Ms    H                               Et        H    MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    MeO      CH.sub.2 OCOMe   Ms    H                               Et        H    MeO      CH.sub.2 OCOEt   Ms    H                               Et        H    MeO      CHMeOCOMe        Ms    H                               Et        H    MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    MeO      CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Et        H    MeO      CHMeOSO.sub.2 Me Ms    H                               Pri       H    MeO      CH.sub.2 OH      Ms    H                               Pri       H    MeO      CH.sub.2 OMe     Ms    H                               Pri       H    MeO      CH.sub.2 OMe     Cl    H                               Pri       H    MeO      CH.sub.2 OMe     MeS   H                               Pri       H    MeO      CH.sub.2 OMe     MeSO  H                               Pri       H    MeO      CH.sub.2 OMe     Ms    Q1                              Pri       H    MeO      CH.sub.2 OMe     MeS   Q1                              Pri       H    MeO      CH.sub.2 OMe     MeSO  Q1                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q2                              Pri       H    MeO      CH.sub.2 OMe     MeS   Q2                              Pri       H    MeO      CH.sub.2 OMe     MeSO  Q2                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q3                              Pri       H    MeO      CH.sub.2 OMe     MeS   Q3                              Pri       H    MeO      CH.sub.2 OMe     MeSO  Q3                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q4                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q5                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q6                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q7                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q8                              Pri       H    MeO      CH.sub.2 OMe     Ms    Q9                              Pri       H    MeO      CH.sub.2 OEt     Ms    H                               Pri       H    MeO      CH.sub.2 OEt     Cl    H                               Pri       H    MeO      CH.sub.2 OEt     MeS   H                               Pri       H    MeO      CH.sub.2 OEt     MeSO  H                               Pri       H    MeO      CH.sub.2 OEt     Ms    Q1                              Pri       H    MeO      CH.sub.2 OEt     MeS   Q1                              Pri       H    MeO      CH.sub.2 OEt     MeSO  Q1                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q2                              Pri       H    MeO      CH.sub.2 OEt     MeS   Q2                              Pri       H    MeO      CH.sub.2 OEt     MeSO  Q2                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q3                              Pri       H    MeO      CH.sub.2 OEt     MeS   Q3                              Pri       H    MeO      CH.sub.2 OEt     MeSO  Q3                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q4                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q5                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q6                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q7                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q8                              Pri       H    MeO      CH.sub.2 OEt     Ms    Q9                              Pri       H    MeO      CH.sub.2 OPri    Ms    H                               Pri       H    MeO      CH.sub.2 OPri    Cl    H                               Pri       H    MeO      CH.sub.2 OPri    MeS   H                               Pri       H    MeO      CH.sub.2 OPri    MeSO  H                               Pri       H    MeO      CH.sub.2 OPri    Ms    Q1                              Pri       H    MeO      CH.sub.2 OPri    Ms    Q2                              Pri       H    MeO      CH.sub.2 OPri    Ms    Q3                              Pri       H    MeO      CH.sub.2 OPrn    Ms    H                               Pri       H    MeO      CH.sub.2 OPrn    Cl    H                               Pri       H    MeO      CH.sub.2 OPrn    MeS   H                               Pri       H    MeO      CH.sub.2 OPrn    MeSO  H                               Pri       H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Cl    H                               Pri       H    MeO      CH.sub.2 OCHCH.sub.2                                                                            MeS   H                               Pri       H    MeO      CH.sub.2 OCHCH.sub.2                                                                            MeSO  H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Cl    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeS   H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   MeSO  H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Cl    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          MeS   H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          MeSO  H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Cl    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  MeS   H                               Pri       H    MeO      CH.sub. 2 OCH.sub.2 CH.sub.2 Cl                                                                 MeSO  H                               Pri       H    MeO      CH.sub.2 OY5     Ms    H                               Pri       H    MeO      CHMeOH           Ms    H                               Pri       H    MeO      CHMeOMe          Ms    H                               Pri       H    MeO      CHMeOMe          Cl    H                               Pri       H    MeO      CHMeOMe          MeS   H                               Pri       H    MeO      CHMeOMe          MeSO  H                               Pri       H    MeO      CHMeOMe          Ms    Q1                              Pri       H    MeO      CHMeOMe          Ms    Q2                              Pri       H    MeO      CHMeOMe          Ms    Q3                              Pri       H    MeO      CHMeOEt          Ms    H                               Pri       H    MeO      CHMeOEt          Cl    H                               Pri       H    MeO      CHMeOEt          MeS   H                               Pri       H    MeO      CHMeOEt          MeSO  H                               Pri       H    MeO      CHMeOEt          Ms    Q1                              Pri       H    MeO      CHMeOEt          Ms    Q2                              Pri       H    MeO      CHMeOEt          Ms    Q3                              Pri       H    MeO      CHMeOPri         Ms    H                               Pri       H    MeO      CHMeOPri         Cl    H                               Pri       H    MeO      CHMeOPri         MeS   H                               Pri       H    MeO      CHMeOPri         MeSO  H                               Pri       H    MeO      CHMeOPrn         Ms    H                               Pri       H    MeO      CHMeOCHCH.sub.2  Ms    H                               Pri       H    MeO      CHMeOCHCH.sub.2  Ms    H                               Pri       H    MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       H    MeO      CHMeOCH.sub.2 C CH                                                                              Ms    H                               Pri       H    MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       H    MeO      CHMeOY5          Ms    H                               Pri       H    MeO      CMe.sub.2 OH     Ms    H                               Pri       H    MeO      CMe.sub.2 OMe    Ms    H                               Pri       H    MeO      CMe.sub.2 OMe    Cl    H                               Pri       H    MeO      CMe.sub.2 OMe    MeS   H                               Pri       H    MeO      CMe.sub.2 OMe    MeSO  H                               Pri       H    MeO      CMe.sub.2 OEt    Ms    H                               Pri       H    MeO      CMe.sub.2 OEt    Cl    H                               Pri       H    MeO      CMe.sub.2 OEt    MeS   H                               Pri       H    MeO      CMe.sub.2 OEt    MeSO  H                               Pri       H    MeO      CMe.sub.2 OPri   Ms    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Cl    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           MeS   H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           MeSO  H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Cl    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           MeS   H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           MeSO  H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          Cl    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          MeS   H                               Pri       H    MeO      CH.sub.2 CH.sub.2 OPri                                                                          MeSO  H                               Pri       H    MeO      CHEtOH           Ms    H                               Pri       H    MeO      CHEtOMe          Ms    H                               Pri       H    MeO      CHEtOMe          Cl    H                               Pri       H    MeO      CHEtOMe          MeS   H                               Pri       H    MeO      CHEtOMe          MeSO  H                               Pri       H    MeO      CHEtOEt          Ms    H                               Pri       H    MeO      CHEtOPri         Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Pri       H    MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       H    MeO      CH.sub.2 OY8     Ms    H                               Pri       H    MeO      CH.sub.2 O Y9    Ms    H                               Pri       H    MeO      CH.sub.2 OY10    Ms    H                               Pri       H    MeO      CHMeOY8          Ms    H                               Pri       H    MeO      CHMeOY9          Ms    H                               Pri       H    MeO      CHMeOY10         Ms    H                               Pri       H    MeO      CH.sub.2 OY13    Ms    H                               Pri       H    MeO      CHMeOY13         Ms    H                               Pri       H    MeO      CH.sub.2 NHMe    Ms    H                               Pri       H    MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       H    MeO      CH.sub.2 NEtMe   Ms    H                               Pri       H    MeO      CH.sub.2 NEt.sub.2                                                                              Ms    H                               Pri       H    MeO      CH.sub.2Y14      Ms    H                               Pri       H    MeO      CHMeNMe.sub.2    Ms    H                               Pri       H    MeO      CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       H    MeO      CHMeOCH.sub.2 Ph Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       H    MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       H    MeO      CH.sub.2 CN      Ms    H                               Pri       H    MeO      CHMeCN           Ms    H                               Pri       H    MeO      CH.sub. 2 SMe    Ms    H                               Pri       H    MeO      CH.sub.2 SMe     Cl    H                               Pri       H    MeO      CH.sub.2 SMe     MeS   H                               Pri       H    MeO      CH.sub.2 SMe     MeSO  H                               Pri       H    MeO      CH.sub.2 SEt     Ms    H                               Pri       H    MeO      CH.sub.2 SEt     Cl    H                               Pri       H    MeO      CH.sub.2 SEt     MeS   H                               Pri       H    MeO      CH.sub.2 SEt     MeSO  H                               Pri       H    MeO      CH.sub.2 SOMe    Ms    H                               Pri       H    MeO      CH.sub.2 SOEt    Ms    H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Pri       H    MeO      CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Pri       H    MeO      CHMeSMe          Ms    H                               Pri       H    MeO      CHMeSEt          Ms    H                               Pri       H    MeO      CHMeSO.sub.2 Me  Ms    H                               Pri       H    MeO      CHMeSO.sub.2 Et  Ms    H                               Pri       H    MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    MeO      CH.sub.2 OCOMe   Ms    H                               Pri       H    MeO      CH.sub.2 OCOEt   Ms    H                               Pri       H    MeO      CHMeOCOMe        Ms    H                               Pri       H    MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       H    MeO      CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Pri       H    MeO      CHMeOSO.sub.2 Me Ms    H                               Me        Me   Me       CH.sub.2 OH      Ms    H                               Me        Me   Me       CH.sub.2 OMe     Ms    H                               Me        Me   Me       CH.sub.2 OMe     Cl    H                               Me        Me   Me       CH.sub.2 OMe     MeS   H                               Me        Me   Me       CH.sub.2 OMe     MeSO  H                               Me        Me   Me       CH.sub.2 OMe     Ms    Q1                              Me        Me   Me       CH.sub.2 OMe     Cl    Q1                              Me        Me   Me       CH.sub.2 OMe     MeS   Q1                              Me        Me   Me       CH.sub.2 OMe     MeSO  Q2                              Me        Me   Me       CH.sub.2 OMe     MeS   Q2                              Me        Me   Me       CH.sub.2 OMe     MeSO  Q2                              Me        Me   Me       CH.sub.2 OMe     Ms    Q3                              Me        Me   Me       CH.sub.2 OMe     MeS   Q3                              Me        Me   Me       CH.sub.2 OMe     MeSO  Q3                              Me        Me   Me       CH.sub.2 OEt     Ms    H                               Me        Me   Me       CH.sub.2 OEt     Cl    H                               Me        Me   Me       CH.sub.2 OEt     MeS   H                               Me        Me   Me       CH.sub.2 OEt     MeSO  H                               Me        Me   Me       CH.sub.2 OEt     Ms    Q1                              Me        Me   Me       CH.sub.2 OEt     MeS   Q1                              Me        Me   Me       CH.sub.2 OEt     MeSO  Q1                              Me        Me   Me       CH.sub.2 OEt     Ms    Q2                              Me        Me   Me       CH.sub.2 OEt     MeS   Q2                              Me        Me   Me       CH.sub.2 OEt     MeSO  Q2                              Me        Me   Me       CH.sub.2 OEt     Ms    Q3                              Me        Me   Me       CH.sub.2 OEt     MeS   Q3                              Me        Me   Me       CH.sub.2 OEt     MeSO  Q3                              Me        Me   Me       CH.sub.2 OPri    Ms    H                               Me        Me   Me       CH.sub.2 OPri    Cl    H                               Me        Me   Me       CH.sub.2 OPri    MeS   H                               Me        Me   Me       CH.sub.2 OPri    MeSO  H                               Me        Me   Me       CH.sub.2 OPri    Ms    Q1                              Me        Me   Me       CH.sub.2 OPri    Ms    Q2                              Me        Me   Me       CH.sub.2 OPri    Ms    Q3                              Me        Me   Me       CH.sub.2 OPrn    Ms    H                               Me        Me   Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 C CH                                                                         Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   Me       CH.sub.2 OY5     Ms    H                               Me        Me   Me       CHMeOH           Ms    H                               Me        Me   Me       CHMeOMe          Ms    H                               Me        Me   Me       CHMeOMe          Cl    H                               Me        Me   Me       CHMeOMe          MeS   H                               Me        Me   Me       CHMeOMe          MeSO  H                               Me        Me   Me       CHMeOMe          Ms    Q1                              Me        Me   Me       CHMeOMe          Ms    Q2                              Me        Me   Me       CHMeOMe          Ms    Q3                              Me        Me   Me       CHMeOEt          Ms    H                               Me        Me   Me       CHMeOEt          Cl    H                               Me        Me   Me       CHMeOEt          MeS   H                               Me        Me   Me       CHMeOEt          MeSO  H                               Me        Me   Me       CHMeOEt          Ms    Q1                              Me        Me   Me       CHMeOEt          Ms    Q2                              Me        Me   Me       CHMeOEt          Ms    Q3                              Me        Me   Me       CHMeOPri         Ms    H                               Me        Me   Me       CHMeOPri         Cl    H                               Me        Me   Me       CHMeOPri         MeS   H                               Me        Me   Me       CHMeOPri         MeSO  H                               Me        Me   Me       CHMeOPrn         Ms    H                               Me        Me   Me       CHMeOCHCH.sub.2  Ms    H                               Me        Me   Me       CHMeOCHCH.sub.2  Ms    H                               Me        Me   Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        Me   Me       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Me        Me   Me       CHMeOCH.sub.2 CH.sub. 2 Cl                                                                      Ms    H                               Me        Me   Me       CHMeOY5          Ms    H                               Me        Me   Me       CMe.sub.2 OH     Ms    H                               Me        Me   Me       CMe.sub.2 OMe    Ms    H                               Me        Me   Me       CMe.sub.2 OEt    Ms    H                               Me        Me   Me       CMe.sub.2 OPri   Ms    H                               Me        Me   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   Me       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Me        Me   Me       CHEtOH           Ms    H                               Me        Me   Me       CHEtOMe          Ms    H                               Me        Me   Me       CHEtOMe          Cl    H                               Me        Me   Me       CHEtOMe          MeS   H                               Me        Me   Me       CHEtOMe          MeSO  H                               Me        Me   Me       CHEtOEt          Ms    H                               Me        Me   Me       CHEtOPri         Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR41##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Me        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Me        Me   Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        Me   Me       CH.sub.2 OY8     Ms    H                               Me        Me   Me       CH.sub.2 OY9     Ms    H                               Me        Me   Me       CH.sub.2 OY10    Ms    H                               Me        Me   Me       CHMeOY8          Ms    H                               Me        Me   Me       CHMeOY9          Ms    H                               Me        Me   Me       CHMeOY10         Ms    H                               Me        Me   Me       CH.sub.2 O Y13   Ms    H                               Me        Me   Me       CHMeOY13         Ms    H                               Me        Me   Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   Me       CH.sub.2Y14      Ms    H                               Me        Me   Me       CHMeNMe.sub.2    Ms    H                               Me        Me   Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   Me       CHMeOCH.sub.2 Ph Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   Me       CH.sub.2 CN      Ms    H                               Me        Me   Me       CHMeCN           Ms    H                               Me        Me   Me       CH.sub.2 SMe     Ms    H                               Me        Me   Me       CH.sub.2 SMe     Cl    H                               Me        Me   Me       CH.sub.2 SMe     MeS   H                               Me        Me   Me       CH.sub.2 SMe     MeSO  H                               Me        Me   Me       CH.sub.2 SEt     Ms    H                               Me        Me   Me       CH.sub.2 SEt     Cl    H                               Me        Me   Me       CH.sub.2 SEt     MeS   H                               Me        Me   Me       CH.sub.2 SEt     MeSO  H                               Me        Me   Me       CH.sub.2 SOMe    Ms    H                               Me        Me   Me       CH.sub.2 SOEt    Ms    H                               Me        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Me        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Me        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Me        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            CL    H                               Me        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Me        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Me        Me   Me       CHMeSMe          Ms    H                               Me        Me   Me       CHMeSEt          Ms    H                               Me        Me   Me       CHMeSO.sub.2 Me  Ms    H                               Me        Me   Me       CHMeSO.sub.2 Et  Ms    H                               Me        Me   Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Me       CH.sub.2 OCOMe   Ms    H                               Me        Me   Me       CH.sub.2 OCOEt   Ms    H                               Me        Me   Me       CHMeOCOMe        Ms    H                               Me        Me   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   Me       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Me        Me   Me       CHMeOSO.sub.2 Me Ms    H                               Et        Me   Me       CH.sub.2 OH      Ms    H                               Et        Me   Me       CH.sub.2 OMe     Ms    H                               Et        Me   Me       CH.sub.2 OMe     Cl    H                               Et        Me   Me       CH.sub.2 OMe     MeS   H                               Et        Me   Me       CH.sub.2 OMe     MeSO  H                               Et        Me   Me       CH.sub.2 OMe     Ms    Q1                              Et        Me   Me       CH.sub.2 OMe     Cl    Q1                              Et        Me   Me       CH.sub.2 OMe     MeS   Q1                              Et        Me   Me       CH.sub.2 OMe     MeSO  Q2                              Et        Me   Me       CH.sub.2 OMe     MeS   Q2                              Et        Me   Me       CH.sub.2 OMe     MeSO  Q2                              Et        Me   Me       CH.sub.2 OMe     Ms    Q3                              Et        Me   Me       CH.sub.2 OMe     MeS   Q3                              Et        Me   Me       CH.sub.2 OMe     MeSO  Q3                              Et        Me   Me       CH.sub.2 OEt     Ms    H                               Et        Me   Me       CH.sub.2 OEt     Cl    H                               Et        Me   Me       CH.sub.2 OEt     MeS   H                               Et        Me   Me       CH.sub.2 OEt     MeSO  H                               Et        Me   Me       CH.sub.2 OEt     Ms    Q1                              Et        Me   Me       CH.sub.2 OEt     MeS   Q1                              Et        Me   Me       CH.sub.2 OEt     MeSO  Q1                              Et        Me   Me       CH.sub.2 OEt     Ms    Q2                              Et        Me   Me       CH.sub.2 OEt     MeS   Q2                              Et        Me   Me       CH.sub.2 OEt     MeSO  Q2                              Et        Me   Me       CH.sub.2 OEt     Ms    Q3                              Et        Me   Me       CH.sub.2 OEt     MeS   Q3                              Et        Me   Me       CH.sub.2 OEt     MeSO  Q3                              Et        Me   Me       CH.sub.2 OEt     MeSO  Q3                              Et        Me   Me       CH.sub.2 OPri    Ms    H                               Et        Me   Me       CH.sub.2 OPr i   Cl    H                               Et        Me   Me       CH.sub.2 OPri    MeS   H                               Et        Me   Me       CH.sub.2 OPri    MeSO  H                               Et        Me   Me       CH.sub.2 OPri    Ms    Q1                              Et        Me   Me       CH.sub.2 OPri    Ms    Q2                              Et        Me   Me       CH.sub.2 OPri    Ms    Q3                              Et        Me   Me       CH.sub.2 OPrn    Ms    H                               Et        Me   Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   Me       CH.sub.2 OY5     Ms    H                               Et        Me   Me       CHMeOH           Ms    H                               Et        Me   Me       CHMeOMe          Ms    H                               Et        Me   Me       CHMeOMe          Cl    H                               Et        Me   Me       CHMeOMe          MeS   H                               Et        Me   Me       CHMeOMe          MeSO  H                               Et        Me   Me       CHMeOMe          Ms    Q1                              Et        Me   Me       CHMeOMe          Ms    Q2                              Et        Me   Me       CHMeOMe          Ms    Q3                              Et        Me   Me       CHMeOEt          Ms    H                               Et        Me   Me       CHMeOEt          Cl    H                               Et        Me   Me       CHMeOEt          MeS   H                               Et        Me   Me       CHMeOEt          MeSO  H                               Et        Me   Me       CHMeOEt          Ms    Q1                              Et        Me   Me       CHMeOEt          Ms    Q2                              Et        Me   Me       CHMeOEt          Ms    Q3                              Et        Me   Me       CHMeOPri         Ms    H                               Et        Me   Me       CHMeOPri         Cl    H                               Et        Me   Me       CHMeOPri         MeS   H                               Et        Me   Me       CHMeOPri         MeSO  H                               Et        Me   Me       CHMeOPrn         Ms    H                               Et        Me   Me       CHMeOCHCH.sub.2  Ms    H                               Et        Me   Me       CHMeOCHCH.sub.2  Ms    H                               Et        Me   Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        Me   Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        Me   Me       CHMeOY5          Ms    H                               Et        Me   Me       CMe.sub.2 OH     Ms    H                               Et        Me   Me       CMe.sub.2 OMe    Ms    H                               Et        Me   Me       CMe.sub.2 OEt    Ms    H                               Et        Me   Me       CMe.sub.2 OPri   Ms    H                               Et        Me   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   Me       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Et        Me   Me       CHEtOH           Ms    H                               Et        Me   Me       CHEtOMe          Ms    H                               Et        Me   Me       CHEtOMe          Cl    H                               Et        Me   Me       CHEtOMe          MeS   H                               Et        Me   Me       CHEtOMe          MeSO  H                               Et        Me   Me       CHEtOEt          Ms    H                               Et        Me   Me       CHEtOPri         Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Et        Me   Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        Me   Me       CH.sub.2 OY8     Ms    H                               Et        Me   Me       CH.sub.2 OY9     Ms    H                               Et        Me   Me       CH.sub.2 OY10    Ms    H                               Et        Me   Me       CHMeOY8          Ms    H                               Et        Me   Me       CHMeOY9          Ms    H                               Et        Me   Me       CHMeOYJ10        Ms    H                               Et        Me   Me       CH.sub.2 OY13    Ms    H                               Et        Me   Me       CHMeOY13         Ms    H                               Et        Me   Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        Me   Me       CH.sub.2Y14      Ms    H                               Et        Me   Me       CHMeNMe.sub.2    Ms    H                               Et        Me   Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        Me   Me       CHMeOCH.sub.2 Ph Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        Me   Me       CH.sub.2 CN      Ms    H                               Et        Me   Me       CHMeCN           Ms    H                               Et        Me   Me       CH.sub.2 SMe     Ms    H                               Et        Me   Me       CH.sub.2 SMe     Cl    H                               Et        Me   Me       CH.sub.2 SMe     MeS   H                               Et        Me   Me       CH.sub.2 SMe     MeSO  H                               Et        Me   Me       CH.sub.2 SEt     Ms    H                               Et        Me   Me       CH.sub.2 SEt     Cl    H                               Et        Me   Me       CH.sub.2 SEt     MeS   H                               Et        Me   Me       CH.sub.2 SEt     MeSO  H                               Et        Me   Me       CH.sub.2 SOMe    Ms    H                               Et        Me   Me       CH.sub.2 SOEt    Ms    H                               Et        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Et        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Et        Me   Me       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Et        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Et        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Et        Me   Me       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Et        Me   Me       CHMeSMe          Ms    H                               Et        Me   Me       CHMeSEt          Ms    H                               Et        Me   Me       CHMeSO.sub.2 Me  Ms    H                               Et        Me   Me       CHMeSO.sub.2 Et  Ms    H                               Et        Me   Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Me       CH.sub.2 OCOMe   Ms    H                               Et        Me   Me       CH.sub.2 OCOEt   Ms    H                               Et        Me   Me       CHMeOCOMe        Ms    H                               Et        Me   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   Me       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Et        Me   Me       CHMeOSO.sub.2 Me Ms    H                               Pri       Me   Me       CH.sub.2 OH      Ms    H                               Pri       Me   Me       CH.sub.2 OMe     Ms    H                               Pri       Me   Me       CH.sub.2 OMe     Cl    H                               Pri       Me   Me       CH.sub.2 OMe     MeS   H                               Pri       Me   Me       CH.sub.2 OMe     MeSO  H                               Pri       Me   Me       CH.sub.2 OMe     Ms    Q1                              Pri       Me   Me       CH.sub.2 OMe     Cl    Q1                              Pri       Me   Me       CH.sub.2 OMe     MeS   Q1                              Pri       Me   Me       CH.sub.2 OMe     MeSO  Q2                              Pri       Me   Me       CH.sub.2 OMe     MeS   Q2                              Pri       Me   Me       CH.sub.2 OMe     MeSO  Q2                              Pri       Me   Me       CH.sub.2 OMe     Ms    Q3                              Pri       Me   Me       CH.sub.2 OMe     MeS   Q3                              Pri       Me   Me       CH.sub.2 OMe     MeSO  Q3                              Pri       Me   Me       CH.sub.2 OEt     Ms    H                               Pri       Me   Me       CH.sub.2 OEt     Cl    H                               Pri       Me   Me       CH.sub.2 OEt     MeS   H                               Pri       Me   Me       CH.sub.2 OEt     MeSO  H                               Pri       Me   Me       CH.sub.2 OEt     Ms    Q1                              Pri       Me   Me       CH.sub.2 OEt     MeS   Q1                              Pri       Me   Me       CH.sub.2 OEt     MeSO  Q1                              Pri       Me   Me       CH.sub.2 OEt     Ms    Q2                              Pri       Me   Me       CH.sub.2 OEt     MeS   Q2                              Pri       Me   Me       CH.sub.2 OEt     MeSO  Q2                              Pri       Me   Me       CH.sub.2 OEt     Ms    Q3                              Pri       Me   Me       CH.sub.2 OEt     MeS   Q3                              Pri       Me   Me       CH.sub.2 OEt     MeSO  Q3                              Pri       Me   Me       CH.sub.2 OPri    Ms    H                               Pri       Me   Me       CH.sub.2 OPri    Cl    H                               Pri       Me   Me       CH.sub.2 OPri    MeS   H                               Pri       Me   Me       CH.sub.2 OPri    MeSO  H                               Pri       Me   Me       CH.sub.2 OPri    Ms    Q1                              Pri       Me   Me       CH.sub.2 OPri    Ms    Q2                              Pri       Me   Me       CH.sub.2 OPri    Ms    Q3                              Pri       Me   Me       CH.sub.2 OPrn    Ms    H                               Pri       Me   Me       CH.sub. 2 OCHCH.sub.2                                                                           Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH2                                                                          Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   Me       CH.sub.2 OY5     Ms    H                               Pri       Me   Me       CHMeOH           Ms    H                               Pri       Me   Me       CHMeOMe          Ms    H                               Pri       Me   Me       CHMeOMe          Cl    H                               Pri       Me   Me       CHMeOMe          MeS   H                               Pri       Me   Me       CHMeOMe          MeSO  H                               Pri       Me   Me       CHMeOMe          Ms    Q1                              Pri       Me   Me       CHMeOMe          Ms    Q2                              Pri       Me   Me       CHMeOMe          Ms    Q3                              Pri       Me   Me       CHMeOEt          Ms    H                               Pri       Me   Me       CHMeOEt          Cl    H                               Pri       Me   Me       CHMeOEt          MeS   H                               Pri       Me   Me       CHMeOEt          MeSO  H                               Pri       Me   Me       CHMeOEt          Ms    Q1                              Pri       Me   Me       CHMeOEt          Ms    Q2                              Pri       Me   Me       CHMeOEt          Ms    Q3                              Pri       Me   Me       CHMeOPri         Ms    H                               Pri       Me   Me       CHMeOPri         Cl    H                               Pri       Me   Me       CHMeOPri         MeS   H                               Pri       Me   Me       CHMeOPri         MeSO  H                               Pr i      Me   Me       CHMeOPrn         Ms    H                               Pri       Me   Me       CHMeOCHCH.sub.2  Ms    H                               Pri       Me   Me       CHMeOCHCH.sub.2  Ms    H                               Pri       Me   Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       Me   Me       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Pri       Me   Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       Me   Me       CMe.sub.2 OH     Ms    H                               Pri       Me   Me       CMe.sub.2 OMe    Ms    H                               Pri       Me   Me       CMe.sub.2 OEt    Ms    H                               Pri       Me   Me       CMe.sub.2 OPri   Ms    H                               Pri       Me   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Me   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Me   Me       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Pri       Me   Me       CHEtOH           Ms    H                               Pri       Me   Me       CHEtOMe          Ms    H                               Pri       Me   Me       CHEtOMe          Cl    H                               Pri       Me   Me       CHEtOMe          MeS   H                               Pri       Me   Me       CHEtOMe          MeSO  H                               Pri       Me   Me       CHEtOEt          Ms    H                               Pri       Me   Me       CHEtOPri         Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Pri       Me   Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       Me   Me       CH.sub.2 OY8     Ms    H                               Pri       Me   Me       CH.sub.2 OY9     Ms    H                               Pri       Me   Me       CH.sub.2 OY10    Ms    H                               Pri       Me   Me       CHMeOY8          Ms    H                               Pri       Me   Me       CHMeOY9          Ms    H                               Pri       Me   Me       CHMeOY10         Ms    H                               Pri       Me   Me       CH.sub.2 OY13    Ms    H                               Pri       Me   Me       CHMeOY13         Ms    H                               Pri       Me   Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       Me   Me       CH.sub.2Y14      Ms    H                               Pri       Me   Me       CHMeNMe.sub.2    Ms    H                               Pri       Me   Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       Me   Me       CHMeOCH.sub.2 Ph Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       Me   Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       Me   Me       CH.sub.2 CN      Ms    H                               Pri       Me   Me       CHMeCN           Ms    H                               Pri       Me   Me       CH.sub.2 SMe     Ms    H                               Pri       Me   Me       CH.sub.2 SMe     Cl    H                               Pri       Me   Me       CH.sub.2 SMe     MeS   H                               Pri       Me   Me       CH.sub.2 SMe     MeSO  H                               Pri       Me   Me       CH.sub.2 SEt     Ms    H                               Pri       Me   Me       CH.sub.2 SEt     Cl    H                               Pri       Me   Me       CH.sub.2 SEt     MeS   H                               Pri       Me   Me       CH.sub.2 SEt     MeSO  H                               Pri       Me   Me       CH.sub.2 SOMe    Ms    H                               Pri       Me   Me       CH.sub.2 SOEt    Ms    H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Pri       Me   Me       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Pri       Me   Me       CHMeSMe          Ms    H                               Pri       Me   Me       CHMeSEt          Ms    H                               Pri       Me   Me       CHMeSO.sub.2 Me  Ms    H                               Pri       Me   Me       CHMeSO.sub.2 Et  Ms    H                               Pri       Me   Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Me       CH.sub.2 OCOMe   Ms    H                               Pri       Me   Me       CH.sub.2 OCOEt   Ms    H                               Pri       Me   Me       CHMeOCOMe        Ms    H                               Pri       Me   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Me   Me       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Pri       Me   Me       CHMeOSO.sub.2 Me Ms    H                               Me        Me   Cl       CH.sub.2 OH      Ms    H                               Me        Me   Cl       CH.sub.2 OMe     Ms    H                               Me        Me   Cl       CH.sub.2 OMe     Cl    H                               Me        Me   Cl       CH.sub.2 OMe     MeS   H                               Me        Me   Cl       CH.sub.2 OMe     MeSO  H                               Me        Me   Cl       CH.sub.2 OMe     Ms    Q1                              Me        Me   Cl       CH.sub.2 OMe     Cl    Q1                              Me        Me   Cl       CH.sub.2 OMe     MeS   Q1                              Me        Me   Cl       CH.sub.2 OMe     MeSO  Q2                              Me        Me   Cl       CH.sub.2 OMe     MeS   Q2                              Me        Me   Cl       CH.sub.2 OMe     MeSO  Q2                              Me        Me   Cl       CH.sub.2 OMe     Ms    Q3                              Me        Me   Cl       CH.sub.2 OMe     MeS   Q3                              Me        Me   Cl       CH.sub.2 OMe     MeSO  Q3                              Me        Me   Cl       CH.sub.2 OEt     Ms    H                               Me        Me   Cl       CH.sub.2 OEt     Cl    H                               Me        Me   Cl       CH.sub.2 OEt     MeS   H                               Me        Me   Cl       CH.sub.2 OEt     MeSO  H                               Me        Me   Cl       CH.sub.2 OEt     Ms    Q1                              Me        Me   Cl       CH.sub.2 OEt     MeS   Q1                              Me        Me   Cl       CH.sub.2 OEt     MeSO  Q1                              Me        Me   Cl       CH.sub.2 OEt     Ms    Q2                              Me        Me   Cl       CH.sub.2 OEt     MeS   Q2                              Me        Me   Cl       CH.sub.2 OEt     MeSO  Q2                              Me        Me   Cl       CH.sub.2 OEt     Ms    Q3                              Me        Me   Cl       CH.sub.2 OEt     MeS   Q3                              Me        Me   Cl       CH.sub.2 OEt     MeSO  Q3                              Me        Me   Cl       CH.sub.2 OPri    Ms    H                               Me        Me   Cl       CH.sub.2 OPri    Cl    H                               Me        Me   Cl       CH.sub.2 OPri    MeS   H                               Me        Me   Cl       CH.sub.2 OPri    MeSO  H                               Me        Me   Cl       CH.sub.2 OPri    Ms    Q1                              Me        Me   Cl       CH.sub.2 OPri    Ms    Q2                              Me        Me   Cl       CH.sub. 2 OPri   Ms    Q3                              Me        Me   Cl       CH.sub.2 OPrn    Ms    H                               Me        Me   Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   Cl       CH.sub.2 OY5     Ms    H                               Me        Me   Cl       CHMeOH           Ms    H                               Me        Me   Cl       CHMeOMe          Ms    H                               Me        Me   Cl       CHMeOMe          Cl    H                               Me        Me   Cl       CHMeOMe          MeS   H                               Me        Me   Cl       CHMeOMe          MeSO  H                               Me        Me   Cl       CHMeOMe          Ms    Q1                              Me        Me   Cl       CHMeOMe          Ms    Q2                              Me        Me   Cl       CHMeOMe          Ms    Q3                              Me        Me   Cl       CHMeOEt          Ms    H                               Me        Me   Cl       CHMeOEt          Ms    H                               Me        Me   Cl       CHMeOEt          Cl    H                               Me        Me   Cl       CHMeOEt          MeS   H                               Me        Me   Cl       CHMeOEt          MeSO  H                               Me        Me   Cl       CHMeOEt          Ms    Q1                              Me        Me   Cl       CHMeOEt          Ms    Q2                              Me        Me   Cl       CHMeOEt          Ms    Q3                              Me        Me   Cl       CHMeOPri         Ms    H                               Me        Me   Cl       CHMeOPri         Cl    H                               Me        Me   Cl       CHMeOPri         MeS   H                               Me        Me   Cl       CHMeOPri         MeSO  H                               Me        Me   Cl       CHMeOPrn         Ms    H                               Me        Me   Cl       CHMeOCHCH.sub.2  Ms    H                               Me        Me   Cl       CHMeOCHCH.sub.2  Ms    H                               Me        Me   Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        Me   Cl       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Me        Me   Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        Me   Cl       CHMeOY5          Ms    H                               Me        Me   Cl       CME.sub.2 OH     Ms    H                               Me        Me   Cl       CMe.sub.2 OMe    Ms    H                               Me        Me   Cl       CMe.sub.2 OEt    Ms    H                               Me        Me   Cl       CMe.sub.2 OPri   Ms    H                               Me        Me   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   Cl       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Me        Me   Cl       CHEtOH           Ms    H                               Me        Me   Cl       CHEtOMe          Ms    H                               Me        Me   Cl       CHEtOMe          Cl    H                               Me        Me   Cl       CHEtOMe          MeS   H                               Me        Me   Cl       CHEtOMe          MeSO  H                               Me        Me   Cl       CHEtOEt          Ms    H                               Me        Me   Cl       CHEtOPri         Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Me        Me   Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        Me   Cl       CH.sub.2 OY8     Ms    H                               Me        Me   Cl       CH.sub.2 OY9     Ms    H                               Me        Me   Cl       CH.sub.2 OY10    Ms    H                               Me        Me   Cl       CHMeOY8          Ms    H                               Me        Me   Cl       CHMeOY9          Ms    H                               Me        Me   Cl       CHMeOY10         Ms    H                               Me        Me   Cl       CH.sub.2 OY13    Ms    H                               Me        Me   Cl       CHMeOY13         Ms    H                               Me        Me   Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   Cl       CH.sub.2Y14      Ms    H                               Me        Me   Cl       CHMeNMe.sub.2    Ms    H                               Me        Me   Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   Cl       CHMeOCH.sub.2 Ph Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   Cl       CH.sub.2 CN      Ms    H                               Me        Me   Cl       CHMeCN           Ms    H                               Me        Me   Cl       CH.sub.2 SMe     Ms    H                               Me        Me   Cl       CH.sub.2 SMe     Cl    H                               Me        Me   Cl       CH.sub.2 SMe     MeS   H                               Me        Me   Cl       CH.sub.2 SMe     MeSO  H                               Me        Me   Cl       CH.sub.2 SEt     Ms    H                               Me        Me   Cl       CH.sub.2 SEt     Cl    H                               Me        Me   Cl       CH.sub.2 SEt     MeS   H                               Me        Me   Cl       CH.sub.2 SEt     MeSO  H                               Me        Me   Cl       CH.sub.2 SOMe    Ms    H                               Me        Me   Cl       CH.sub.2 SOEt    Ms    H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Me        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Me        Me   Cl       CHMeSMe          Ms    H                               Me        Me   Cl       CHMeSEt          Ms    H                               Me        Me   Cl       CHMeSO.sub.2 Me  Ms    H                               Me        Me   Cl       CHMeSO.sub.2 Et  Ms    H                               Me        Me   Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Cl       CH.sub.2 OCOMe   Ms    H                               Me        Me   Cl       CH.sub.2 OCOEt   Ms    H                               Me        Me   Cl       CHMeOCOMe        Ms    H                               Me        Me   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   Cl       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Me        Me   Cl       CHMeOSO.sub.2 Me Ms    H                               Et        Me   Cl       CH.sub.2 OH      Ms    H                               Et        Me   Cl       CH.sub.2 OMe     Ms    H                               Et        Me   Cl       CH.sub.2 OMe     Cl    H                               Et        Me   Cl       CH.sub.2 OMe     MeS   H                               Et        Me   Cl       CH.sub.2 OMe     MeSO  H                               Et        Me   Cl       CH.sub.2 OMe     Ms    Q1                              Et        Me   Cl       CH.sub.2 OMe     Cl    Q1                              Et        Me   Cl       CH.sub.2 OMe     MeS   Q1                              Et        Me   Cl       CH.sub.2 OMe     MeSO  Q2                              Et        Me   Cl       CH.sub.2 OMe     MeS   Q2                              Et        Me   Cl       CH.sub.2 OMe     MeSO  Q2                              Et        Me   Cl       CH.sub.2 OMe     Ms    Q3                              Et        Me   Cl       CH.sub.2 OMe     MeS   Q3                              Et        Me   Cl       CH.sub.2 OMe     MeSO  Q3                              Et        Me   Cl       CH.sub.2 OEt     Ms    H                               Et        Me   Cl       CH.sub.2 OEt     Cl    H                               Et        Me   Cl       CH.sub.2 OEt     MeS   H                               Et        Me   Cl       CH.sub.2 OEt     MeSO  H                               Et        Me   Cl       CH.sub.2 OEt     Ms    Q1                              Et        Me   Cl       CH.sub.2 OEt     MeS   Q1                              Et        Me   Cl       CH.sub.2 OEt     MeSO  Q1                              Et        Me   Cl       CH.sub.2 OEt     Ms    Q2                              Et        Me   Cl       CH.sub.2 OEt     MeS   Q2                              Et        Me   Cl       CH.sub.2 OEt     MeSO  Q2                              Et        Me   Cl       CH.sub.2 OEt     Ms    Q3                              Et        Me   Cl       CH.sub.2 OEt     MeS   Q3                              Et        Me   Cl       CH.sub.2 OEt     MeSO  Q3                              Et        Me   Cl       CH.sub.2 OPri    Ms    H                               Et        Me   Cl       CH.sub.2 OPri    Cl    H                               Et        Me   Cl       CH.sub.2 OPri    MeS   H                               Et        Me   Cl       CH.sub.2 OPri    MeSO  H                               Et        Me   Cl       CH.sub.2 OPri    Ms    Q1                              Et        Me   Cl       CH.sub.2 OPri    Ms    Q2                              Et        Me   Cl       CH.sub.2 OPri    Ms    Q3                              Et        Me   Cl       CH.sub.2 OPrn    Ms    H                               Et        Me   Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   Cl       CH.sub.2 OY5     Ms    H                               Et        Me   Cl       CHMeOH           Ms    H                               Et        Me   Cl       CHMeOMe          Ms    H                               Et        Me   Cl       CHMeOMe          Cl    H                               Et        Me   Cl       CHMeOMe          MeS   H                               Et        Me   Cl       CHMeOMe          MeSO  H                               Et        Me   Cl       CHMeOMe          Ms    Q1                              Et        Me   Cl       CHMeOMe          Ms    Q2                              Et        Me   Cl       CHMeOMe          Ms    Q3                              Et        Me   Cl       CHMeOEt          Ms    H                               Et        Me   Cl       CHMeOEt          Cl    H                               Et        Me   Cl       CHMeOEt          MeS   H                               Et        Me   Cl       CHMeOEt          MeSO  H                               Et        Me   Cl       CHMeOEt          Ms    Q1                              Et        Me   Cl       CHMeOEt          Ms    Q2                              Et        Me   Cl       CHMeOEt          Ms    Q3                              Et        Me   Cl       CHMeOPri         Ms    H                               Et        Me   Cl       CHMeOPri         Cl    H                               Et        Me   Cl       CHMeOPri         MeS   H                               Et        Me   Cl       CHMeOPri         MeSO  H                               Et        Me   Cl       CHMeOPrn         Ms    H                               Et        Me   Cl       CHMeOCHCH.sub.2  Ms    H                               Et        Me   Cl       CHMeOCHCH.sub.2  Ms    H                               Et        Me   Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        Me   Cl       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        Me   Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        Me   Cl       CHMeOY5          Ms    H                               Et        Me   Cl       CMe.sub.2 OH     Ms    H                               Et        Me   Cl       CMe.sub.2 OMe    Ms    H                               Et        Me   Cl       CMe.sub.2 OEt    Ms    H                               Et        Me   Cl       CMe.sub.2 OPri   Ms    H                               Et        Me   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   Cl       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Et        Me   Cl       CHEtOH           Ms    H                               Et        Me   Cl       CHEtOMe          Ms    H                               Et        Me   Cl       CHEtOMe          Cl    H                               Et        Me   Cl       CHEtOMe          MeS   H                               Et        Me   Cl       CHEtOEt          Ms    H                               Et        Me   Cl       CHEtOPri         Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Et        Me   Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        Me   Cl       CH.sub.2 OY8     Ms    H                               Et        Me   Cl       CH.sub.2 OY9     Ms    H                               Et        Me   Cl       CH.sub.2 OY10    Ms    H                               Et        Me   Cl       CHMeO Y8         Ms    H                               Et        Me   Cl       CHMeOY9          Ms    H                               Et        Me   Cl       CHMeOY10         Ms    H                               Et        Me   Cl       CH.sub.2 OY13    Ms    H                               Et        Me   Cl       CHMeOY13         Ms    H                               Et        Me   Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        Me   Cl       CH.sub.2Y14      Ms    H                               Et        Me   Cl       CHMeNMe.sub.2    Ms    H                               Et        Me   Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        Me   Cl       CHMeOCH.sub.2 Ph Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        Me   Cl       CH.sub.2 CN      Ms    H                               Et        Me   Cl       CHMeCN           Ms    H                               Et        Me   Cl       CH.sub.2 SMe     Ms    H                               Et        Me   Cl       CH.sub.2 SMe     Cl    H                               Et        Me   Cl       CH.sub.2 SMe     MeS   H                               Et        Me   Cl       CH.sub.2 SMe     MeSO  H                               Et        Me   Cl       CH.sub.2 SEt     Ms    H                               Et        Me   Cl       CH.sub.2 SEt     Cl    H                               Et        Me   Cl       CH.sub.2 SEt     MeS   H                               Et        Me   Cl       CH.sub.2 SEt     MeSO  H                               Et        Me   Cl       CH.sub.2 SOMe    Ms    H                               Et        Me   Cl       CH.sub.2 SOEt    Ms    H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Et        Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Et        Me   Cl       CHMeSMe          Ms    H                               Et        Me   Cl       CHMeSEt          Ms    H                               Et        Me   Cl       CHMeSO.sub.2 Me  Ms    H                               Et        Me   Cl       CHMeSO.sub.2 Et  Ms    H                               Et        Me   Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Cl       CH.sub.2 OCOMe   Ms    H                               Et        Me   Cl       CH.sub.2 OCOEt   Ms    H                               Et        Me   Cl       CHMeOCOMe        Ms    H                               Et        Me   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   Cl       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Et        Me   Cl       CHMeOSO.sub.2 Me Ms    H                               Pri       Me   Cl       CH.sub.2 OH      Ms    H                               Pri       Me   Cl       CH.sub.2 OMe     Ms    H                               Pri       Me   Cl       CH.sub.2 OMe     Cl    H                               Pri       Me   Cl       CH.sub.2 OMe     MeS   H                               Pri       Me   Cl       CH.sub.2 OMe     MeSO  H                               Pri       Me   Cl       CH.sub.2 OMe     Ms    Q1                              Pri       Me   Cl       CH.sub.2 OMe     Cl    Q1                              Pri       Me   Cl       CH.sub.2 OMe     MeS   Q1                              Pri       Me   Cl       CH.sub.2 OMe     MeSO  Q2                              Pri       Me   Cl       CH.sub.2 OMe     MeS   Q2                              Pri       Me   Cl       CH.sub.2 OMe     MeSO  Q2                              Pri       Me   Cl       CH.sub.2 OMe     Ms    Q3                         

                                      TABLE 5                                      __________________________________________________________________________      ##STR42##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Pri       Me   Cl       CH.sub.2 OMe     MeS   Q3                              Pri       Me   Cl       CH.sub.2 OMe     MeSO  Q3                              Pri       Me   Cl       CH.sub.2 OEt     Ms    H                               Pri       Me   Cl       CH.sub.2 OEt     Cl    H                               Pri       Me   Cl       CH.sub.2 OEt     MeS   H                               Pri       Me   Cl       CH.sub.2 OEt     MeSO  H                               Pri       Me   Cl       CH.sub.2 OEt     Ms    Q1                              Pri       Me   Cl       CH.sub.2 OEt     MeS   Q1                              Pri       Me   Cl       CH.sub.2 OEt     MeSO  Q1                              Pri       Me   Cl       CH.sub.2 OEt     Ms    Q2                              Pri       Me   Cl       CH.sub.2 OEt     MeS   Q2                              Pri       Me   Cl       CH.sub.2 OEt     MeSO  Q2                              Pri       Me   Cl       CH.sub.2 OEt     Ms    Q3                              Pri       Me   Cl       CH.sub.2 OEt     MeS   Q3                              Pri       Me   Cl       CH.sub.2 OEt     MeSO  Q3                              Pri       Me   Cl       CH.sub.2 OPri    Ms    H                               Pri       Me   Cl       CH.sub.2 OPri    Cl    H                               Pri       Me   Cl       CH.sub.2 OPri    MeS   H                               Pri       Me   Cl       CH.sub.2 OPri    MeSO  H                               Pri       Me   Cl       CH.sub.2 OPri    Ms    Q1                              Pri       Me   Cl       CH.sub.2 OPri    Ms    Q2                              Pri       Me   Cl       CH.sub.2 OPri    Ms    Q3                              Pri       Me   Cl       CH.sub.2 OPrn    Ms    H                               Pri       Me   Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   Cl       CH.sub.2 OY5     Ms    H                               Pri       Me   Cl       CHMeOH           Ms    H                               Pri       Me   Cl       CHMeOMe          Ms    H                               Pri       Me   Cl       CHMeOMe          Cl    H                               Pri       Me   Cl       CHMeOMe          MeS   H                               Pri       Me   Cl       CHMeOMe          MeSO  H                               Pri       Me   Cl       CHMeOMe          Ms    Q1                              Pri       Me   Cl       CHMeOMe          Ms    Q2                              Pri       Me   Cl       CHMeOMe          Ms    Q3                              Pri       Me   Cl       CHMeOEt          Ms    H                               Pri       Me   Cl       CHMeOEt          Ms    H                               Pri       Me   Cl       CHMeOEt          Cl    H                               Pri       Me   Cl       CHMeOEt          MeS   H                               Pri       Me   Cl       CHMeOEt          MeSO  H                               Pri       Me   Cl       CHMeOEt          Ms    Q1                              Pri       Me   Cl       CHMeOEt          Ms    Q2                              Pri       Me   Cl       CHMeOEt          Ms    Q3                              Pri       Me   Cl       CHMeOPri         Ms    H                               Pri       Me   Cl       CHMeOPri         Cl    H                               Pri       Me   Cl       CHMeOPri         MeS   H                               Pri       Me   Cl       CHMeOPri         MeSO  H                               Pri       Me   Cl       CHMeOPrn         Ms    H                               Pri       Me   Cl       CHMeOCHCH.sub.2  Ms    H                               Pri       Me   Cl       CHMeOCHCH.sub.2  Ms    H                               Pri       Me   Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       Me   Cl       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Pri       Me   Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       Me   Cl       CHMeOY5          Ms    H                               Pri       Me   Cl       CMe.sub.2 OH     Ms    H                               Pri       Me   Cl       CMe.sub.2 OMe    Ms    H                               Pri       Me   Cl       CMe.sub.2 OEt    Ms    H                               Pri       Me   Cl       CMe.sub.2 OPri   Ms    H                               Pri       Me   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Me   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Me   Cl       CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Pri       Me   Cl       CHEtOH           Ms    H                               Pri       Me   Cl       CHEtOMe          Ms    H                               Pri       Me   Cl       CHEtOMe          Cl    H                               Pri       Me   Cl       CHEtOMe          MeS   H                               Pri       Me   Cl       CHEtOMe          MeSO  H                               Pri       Me   Cl       CHEtOEt          Ms    H                               Pri       Me   Cl       CHEtOPri         Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Pri       Me   Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       Me   Cl       CH.sub.2 OY8     Ms    H                               Pri       Me   Cl       CH.sub.2 OY9     Ms    H                               Pri       Me   Cl       CH.sub. 2 OY10   Ms    H                               Pri       Me   Cl       CHMeOY8          Ms    H                               Pri       Me   Cl       CHMeOY9          Ms    H                               Pri       Me   Cl       CHMeOY10         Ms    H                               Pri       Me   Cl       CH.sub.2 OY13    Ms    H                               Pri       Me   Cl       CHMeOY13         Ms    H                               Pri       Me   Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       Me   Cl       CH.sub.2Y14      Ms    H                               Pri       Me   Cl       CHMeNMe.sub.2    Ms    H                               Pri       Me   Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       Me   Cl       CHMeOCH.sub.2 Ph Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       Me   Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       Me   Cl       CH.sub.2 CN      Ms    H                               Pri       Me   Cl       CHMeCN           Ms    H                               Pri       Me   Cl       CH.sub.2 SMe     Ms    H                               Pri       Me   Cl       CH.sub.2 SMe     Cl    H                               Pri       Me   Cl       CH.sub.2 SMe     MeS   H                               Pri       Me   Cl       CH.sub.2 SMe     MeSO  H                               Pri       Me   Cl       CH.sub. 2 SEt    Ms    H                               Pri       Me   Cl       CH.sub.2 SEt     Cl    H                               Pri       Me   Cl       CH.sub.2 SEt     MeS   H                               Pri       Me   Cl       CH.sub.2 SEt     MeSO  H                               Pri       Me   Cl       CH.sub.2 SOMe    Ms    H                               Pri       Me   Cl       CH.sub.2 SOEt    Ms    H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Pri       Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Pri       Me   Cl       CHMeSMe          Ms    H                               Pri       Me   Cl       CHMeSEt          Ms    H                               Pri       Me   Cl       CHMeSO.sub.2 Me  Ms    H                               Pri       Me   Cl       CHMeSO.sub.2 Et  Ms    H                               Pri       Me   Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Cl       CH.sub.2 OCOMe   Ms    H                               Pri       Me   Cl       CH.sub.2 OCOEt   Ms    H                               Pri       Me   Cl       CHMeOCOMe        Ms    H                               Pri       Me   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Me   Cl       CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Pri       Me   Cl       CHMeOSO.sub.2 Me Ms    H                               Me        Me   MeO      CH.sub.2 OH      Ms    H                               Me        Me   MeO      CH.sub.2 OMe     Ms    H                               Me        Me   MeO      CH.sub.2 OMe     Cl    H                               Me        Me   MeO      CH.sub.2 OMe     MeS   H                               Me        Me   MeO      CH.sub.2 OMe     MeSO  H                               Me        Me   MeO      CH.sub.2 OMe     Ms    Q1                              Me        Me   MeO      CH.sub.2 OMe     Cl    Q1                              Me        Me   MeO      CH.sub.2 OMe     MeS   Q1                              Me        Me   MeO      CH.sub.2 OMe     MeSO  Q2                              Me        Me   MeO      CH.sub.2 OMe     MeS   Q2                              Me        Me   MeO      CH.sub.2 OMe     MeSO  Q2                              Me        Me   MeO      CH.sub.2 OMe     Ms    Q3                              Me        Me   MeO      CH.sub.2 OMe     MeS   Q3                              Me        Me   MeO      CH.sub.2 OMe     MeSO  Q3                              Me        Me   MeO      CH.sub.2 OEt     Ms    H                               Me        Me   MeO      CH.sub.2 OEt     Cl    H                               Me        Me   MeO      CH.sub.2 OEt     MeS   H                               Me        Me   MeO      CH.sub.2 OEt     MeSO  H                               Me        Me   MeO      CH.sub.2 OEt     Ms    Q1                              Me        Me   MeO      CH.sub.2 OEt     MeS   Q1                              Me        Me   MeO      CH.sub.2 OEt     MeSO  Q1                              Me        Me   MeO      CH.sub.2 OEt     Ms    Q2                              Me        Me   MeO      CH.sub.2 OEt     MeS   Q2                              Me        Me   MeO      CH.sub.2 OEt     MeSO  Q2                              Me        Me   MeO      CH.sub.2 OEt     Ms    Q3                              Me        Me   MeO      CH.sub.2 OEt     MeS   Q3                              Me        Me   MeO      CH.sub.2 OEt     MeSO  Q3                              Me        Me   MeO      CH.sub.2 OPri    Ms    H                               Me        Me   MeO      CH.sub.2 OPri    Cl    H                               Me        Me   MeO      CH.sub.2 OPri    MeS   H                               Me        Me   MeO      CH.sub.2 OPri    MeSO  H                               Me        Me   MeO      CH.sub.2 OPri    Ms    Q1                              Me        Me   MeO      CH.sub.2 OPri    Ms    Q2                              Me        Me   MeO      CH.sub.2 OPri    Ms    Q3                              Me        Me   MeO      CH.sub.2 OPrn    Ms    H                               Me        Me   MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   MeO      CH.sub.2 OY5     Ms    H                               Me        Me   MeO      CHMeOH           Ms    H                               Me        Me   MeO      CHMeOMe          Ms    H                               Me        Me   MeO      CHMeOMe          Cl    H                               Me        Me   MeO      CHMeOMe          MeS   H                               Me        Me   MeO      CHMeOMe          MeSO  H                               Me        Me   MeO      CHMeOMe          Ms    Q1                              Me        Me   MeO      CHMeOMe          Ms    Q2                              Me        Me   MeO      CHMeOMe          Ms    Q3                              Me        Me   MeO      CHMeOEt          Ms    H                               Me        Me   MeO      CHMeOEt          Cl    H                               Me        Me   MeO      CHMeOEt          MeS   H                               Me        Me   MeO      CHMeOEt          MeSO  H                               Me        Me   MeO      CHMeOEt          Ms    Q1                              Me        Me   MeO      CHMeOEt          Ms    Q2                              Me        Me   MeO      CHMeOEt          Ms    Q3                              Me        Me   MeO      CHMeOPri         Ms    H                               Me        Me   MeO      CHMeOPri         Cl    H                               Me        Me   MeO      CHMeOPri         MeS   H                               Me        Me   MeO      CHMeOPri         MeSO  H                               Me        Me   MeO      CHMeOPrn         Ms    H                               Me        Me   MeO      CHMeOCHCH.sub.2  Ms    H                               Me        Me   MeO      CHMeOCHCH.sub.2  Ms    H                               Me        Me   MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        Me   MeO      CHMeOCH.sub.2 CCH                                                                               Ms    H                               Me        Me   MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        Me   MeO      CHMeOY5          Ms    H                               Me        Me   MeO      CMe.sub.2 OH     Ms    H                               Me        Me   MeO      CMe.sub.2 OMe    Ms    H                               Me        Me   MeO      CMe.sub.2 OEt    Ms    H                               Me        Me   MeO      CMe.sub.2 OPri   Ms    H                               Me        Me   MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   MeO      CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Me        Me   MeO      CHEtOH           Ms    H                               Me        Me   MeO      CHEtOMe          Ms    H                               Me        Me   MeO      CHEtOMe          Cl    H                               Me        Me   MeO      CHEtOMe          MeS   H                               Me        Me   MeO      CHEtOMe          MeSO  H                               Me        Me   MeO      CHEtOEt          Ms    H                               Me        Me   MeO      CHEtOPri         Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Me        Me   MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        Me   MeO      CH.sub.2 OY8     Ms    H                               Me        Me   MeO      CH.sub.2 OY9     Ms    H                               Me        Me   MeO      CH.sub.2 OY10    Ms    H                               Me        Me   MeO      CHMeOY8          Ms    H                               Me        Me   MeO      CHMeOY9          Ms    H                               Me        Me   MeO      CHMeOY10         Ms    H                               Me        Me   MeO      CH.sub.2 OY13    Ms    H                               Me        Me   MeO      CHMeOY13         Ms    H                               Me        Me   MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   MeO      CH.sub.2Y14      Ms    H                               Me        Me   MeO      CHMeNMe.sub.2    Ms    H                               Me        Me   MeO      CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   MeO      CHMeOCH.sub.2 Ph Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   MeO      CH.sub.2 CN      Ms    H                               Me        Me   MeO      CHMeCN           Ms    H                               Me        Me   MeO      CH.sub.2 SMe     Ms    H                               Me        Me   MeO      CH.sub.2 SMe     Cl    H                               Me        Me   MeO      CH.sub.2 SMe     MeS   H                               Me        Me   MeO      CH.sub.2 SMe     MeSO  H                               Me        Me   MeO      CH.sub.2 SEt     Ms    H                               Me        Me   MeO      CH.sub.2 SEt     Cl    H                               Me        Me   MeO      CH.sub.2 SEt     MeS   H                               Me        Me   MeO      CH.sub.2 SEt     MeSO  H                               Me        Me   MeO      CH.sub.2 SOMe    Ms    H                               Me        Me   MeO      CH.sub.2 SOEt    Ms    H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Me                                                                            Cl    H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Me                                                                            MeS   H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Me                                                                            MeSO  H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Et                                                                            Cl    H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Et                                                                            MeS   H                               Me        Me   MeO      CH.sub.2 SO.sub.2 Et                                                                            MeSO  H                               Me        Me   MeO      CHMeSMe          Ms    H                               Me        Me   MeO      CHMeSEt          Ms    H                               Me        Me   MeO      CHMeSO.sub.2 Me  Ms    H                               Me        Me   MeO      CHMeSO.sub.2 Et  Ms    H                               Me        Me   MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   MeO      CH.sub.2 OCOMe   Ms    H                               Me        Me   MeO      CH.sub.2 OCOEt   Ms    H                               Me        Me   MeO      CHMeOCOMe        Ms    H                               Me        Me   MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   MeO      CH.sub.2 OSO.sub.2 Et                                                                           Ms    H                               Me        Me   MeO      CHMeOSO.sub.2 Me Ms    H                               Et        Me   MeO      CH.sub.2 OH      Ms    H                               Et        Me   MeO      CH.sub.2 OMe     Ms    H                               Et        Me   MeO      CH.sub.2 OMe     Cl    H                               Et        Me   MeO      CH.sub.2 OMe     MeS   H                               Et        Me   MeO      CH.sub.2 OMe     MeSO  H                               Et        Me   MeO      CH.sub.2 OMe     Ms    Q1                              Et        Me   MeO      CH.sub.2 OMe     Cl    Q1                              Et        Me   MeO      CH.sub.2 OMe     MeS   Q1                              Et        Me   MeO      CH.sub.2 OMe     MeSO  Q2                              Et        Me   MeO      CH.sub.2 OMe     MeS   Q2                              Et        Me   MeO      CH.sub.2 OMe     MeSO  Q2                              Et        Me   MeO      CH.sub.2 OMe     Ms    Q3                              Et        Me   MeO      CH.sub.2 OMe     MeS   Q3                              Et        Me   MeO      CH.sub.2 OMe     MeSO  Q3  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  Et        Me   MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   MeO      CH.sub.2 OY5     Ms    H                               Et        Me   MeO      CHMeOH           Ms    H                               Et        Me   MeO      CHMeOMe          Ms    H                               Et        Me   MeO      CHMeOMe          Cl    H                               Et        Me   MeO      CHMeOMe          MeS   H                               Et        Me   MeO      CHMeOMe          MeSO  H                               Et        Me   MeO      CHMeOMe          Ms    Q1                              Et        Me   MeO      CHMeOMe          Ms    Q2                              Et        Me   MeO      CHMeOMe          Ms    Q3  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CHMeOCHCH.sub.2  Ms    H                               Et        Me   MeO      CHMeOCHCH.sub.2  Ms    H                               Et        Me   MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        Me   MeO      CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        Me   MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        Me   MeO      CHMeOY5          Ms    H                               Et        Me   MeO      CMe.sub.2 OH     Ms    H                               Et        Me   MeO      CMe.sub.2 OMe    Ms    H                               Et        Me   MeO      CMe.sub.2 OEt    Ms    H                               Et        Me   MeO      CMe.sub.2 OPri   Ms    H                               Et        Me   MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   MeO      CH.sub.2 CH.sub.2 OPri                                                                          Ms    H                               Et        Me   MeO      CHEtOH           Ms    H                               Et        Me   MeO      CHEtOMe          Ms    H                               Et        Me   MeO      CHEtOMe          Cl    H                               Et        Me   MeO      CHEtOMe          MeS   H                               Et        Me   MeO      CHEtOMe          MeSO  H                               Et        Me   MeO      CHEtOEt          Ms    H                               Et        Me   MeO      CHEtOPri         Ms    H                               Et        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Cl    H                               Et        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeS   H                               Et        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 MeSO  H                               Et        Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OEt                                                                 Ms    H                               Et        Me   MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        Me   MeO      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 Et        Me   MeO      CHMeSMe          Ms    H                               Et        Me   MeO      CHMeSEt          Ms    H                               Et        Me   MeO      CHMeSO.sub.2 Me  Ms    H                               Et        Me   MeO      CHMeSO.sub.2 Et  Ms    H                               Et        Me   MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   MeO      CH.sub.2 OCOMe   Ms    H                               Et        Me   MeO      CH.sub.2 OCOEt   Ms    H                               Et        Me   MeO      CHMeOCOMe        Ms    H                               Et        Me   MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   MeO      CH.sub.2 OSO.sub.2 Et                                                                           Ms    H    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                            Pri       Me   MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       Me   MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   MeO      CH.sub.2 OY5     Ms    H                               Pri       Me   MeO      CHMeOH           Ms    H                               Pri       Me   MeO      CHMeOMe          Ms    H                               Pri       Me   MeO      CHMeOMe          Cl    H                               Pri       Me   MeO      CHMeOMe          MeS   H                               Pri       Me   MeO      CHMeOMe          MeSO  H                               Pri       Me   MeO      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CMe.sub.2 OMe    Ms    H                               Me        H    Br       CMe.sub.2 OEt    Ms    H                               Me        H    Br       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        H    Br       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        H    Br       CHEtOH           Ms    H                               Me        H    Br       CHEtOMe          Ms    H                               Me        H    Br       CHEtOEt          Ms    H                               Me        H    Br       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    Br       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                             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                Ms    H                               Me        H    Br       CH.sub.2 OCOMe   Ms    H                               Me        H    Br       CHMeOCOMe        Ms    H                               Me        H    Br       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        H    Br       CHMeOSO.sub.2 Me Ms    H                               Et        H    Br       CH.sub.2 OH      Ms    H                               Et        H    Br       CH.sub.2 OMe     Ms    H                               Et        H    Br       CH.sub.2 OMe     Cl    H                               Et        H    Br       CH.sub.2 OMe     MeS   H                               Et        H    Br       CH.sub.2 OMe     MeSO  H                               Et        H    Br       CH.sub.2 OEt     Ms    H                               Et        H    Br       CH.sub.2 OEt     Cl    H                               Et        H    Br       CH.sub.2 OEt     MeS   H                               Et        H    Br       CH.sub.2 OEt     MeSO  H                               Et        H    Br       CH.sub.2 OPri    Ms    H                               Et        H    Br       CH.sub.2 OPrn    Ms    H                               Et        H    Br       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        H    Br       CHMeOH           Ms    H                               Et        H    Br       CHMeOMe          Ms    H                               Et        H    Br       CHMeOMe          Cl    H                               Et        H    Br       CHMeOMe          MeS   H                               Et        H    Br       CHMeOMe          MeSO  H                               Et        H    Br       CHMeOEt          Ms    H                               Et        H    Br       CHMeOCHCH.sub.2  Ms    H                               Et        H    Br       CHMeOCHCH.sub.2  Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR43##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Et        H    Br       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        H    Br       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        H    Br       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        H    Br       CMe.sub.2 OH     Ms    H                               Et        H    Br       CMe.sub.2 OMe    Ms    H                               Et        H    Br       CMe.sub.2 OEt    Ms    H                               Et        H    Br       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        H    Br       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        H    Br       CHEtOH           Ms    H                               Et        H    Br       CHEtOMe          Ms    H                               Et        H    Br       CHEtOEt          Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    Br       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        H    Br       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        H    Br       CHMeNMe.sub.2    Ms    H                               Et        H    Br       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        H    Br       CHMeOCH.sub.2 Ph Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        H    Br       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        H    Br       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        H    Br       CH.sub.2 CN      Ms    H                               Et        H    Br       CH.sub.2 SMe     Ms    H                               Et        H    Br       CH.sub.2 SEt     Ms    H                               Et        H    Br       CH.sub.2 SOMe    Ms    H                               Et        H    Br       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    Br       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        H    Br       CHMeSMe          Ms    H                               Et        H    Br       CHMeSO.sub.2 Me  Ms    H                               Et        H    Br       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    Br       CH.sub.2 OCOMe   Ms    H                               Et        H    Br       CHMeOCOMe        Ms    H                               Et        H    Br       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    Br       CHMeOSO.sub.2 Me Ms    H                               Pri       H    Br       CH.sub.2 OH      Ms    H                               Pri       H    Br       CH.sub.2 OMe     Ms    H                               Pri       H    Br       CH.sub.2 OMe     Cl    H                               Pri       H    Br       CH.sub.2 OMe     MeS   H                               Pri       H    Br       CH.sub.2 OMe     MeSO  H                               Pri       H    Br       CH.sub.2 OEt     Ms    H                               Pri       H    Br       CH.sub.2 OEt     Cl    H                               Pri       H    Br       CH.sub.2 OEt     MeS   H                               Pri       H    Br       CH.sub.2 OEt     MeSO  H                               Pri       H    Br       CH.sub.2 OPri    Ms    H                               Pri       H    Br       CH.sub.2 OPrn    Ms    H                               Pri       H    Br       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       H    Br       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       H    Br       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       H    Br       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       H    Br       CH.sub.2 CHMeOH  Ms    H                               Pri       H    Br       CH.sub.2 CHMeOMe Ms    H                               Pri       H    Br       CH.sub.2 CHMeOMe Cl    H                               Pri       H    Br       CH.sub.2 CHMeOMe MeS   H                               Pri       H    Br       CH.sub.2 CHMeOMe MeSO  H                               Pri       H    Br       CH.sub.2 CHMeOEt Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCHCH.sub.2                                                                        Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCHCH.sub.2                                                                        Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCH.sub.2 CHCH.sub.2                                                               Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCH.sub.2 CCH                                                                      Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCH.sub.2 CH.sub.2 Cl                                                              Ms    H                               Pri       H    Br       CH.sub.2 CMe.sub.2 OH                                                                           Ms    H                               Pri       H    Br       CH.sub.2 CMe.sub.2 OMe                                                                          Ms    H                               Pri       H    Br       CH.sub.2 CMe.sub.2 OEt                                                                          Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 CH.sub.2 OMe                                                                  Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 CH.sub.2 OEt                                                                  Ms    H                               Pri       H    Br       CH.sub.2 CHEtOH  Ms    H                               Pri       H    Br       CH.sub.2 CHEtOMe Ms    H                               Pri       H    Br       CH.sub.2 CHEtOEt Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                        Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCH.sub.2 CH.sub.2 OMe                                                             Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       H    Br       CH.sub. 2 CHMeNMe.sub.2                                                                         Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 CH.sub.2 NMe.sub.2                                                            Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OCH.sub.2 Ph                                                                  Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCH.sub.2 Ph                                                                       Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                         Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                         Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OCHMeCO.sub.2 Me                                                              Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 CN                                                                            Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 SMe                                                                           Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 SEt                                                                           Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 SOMe                                                                          Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 SO.sub.2 Me                                                                   Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 SO.sub.2 Et                                                                   Ms    H                               Pri       H    Br       CH.sub.2 CHMeSMe Ms    H                               Pri       H    Br       CH.sub.2 CHMeSO.sub.2 Me                                                                        Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                        Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OCOMe                                                                         Ms    H                               Pri       H    Br       CH.sub.2 CHMeOCOMe                                                                              Ms    H                               Pri       H    Br       CH.sub.2 CH.sub.2 OSO.sub.2 Me                                                                  Ms    H                               Pri       H    Br       CH.sub.2 CHMeOSO.sub.2 Me                                                                       Ms    H                               Me        H    I        CH.sub.2 OH      Ms    H                               Me        H    I        CH.sub.2 OMe     Ms    H                               Me        H    I        CH.sub.2 OMe     Cl    H                               Me        H    I        CH.sub.2 OMe     MeS   H                               Me        H    I        CH.sub.2 OMe     MeSO  H                               Me        H    I        CH.sub.2 OEt     Ms    H                               Me        H    I        CH.sub.2 OEt     Cl    H                               Me        H    I        CH.sub.2 OEt     MeS   H                               Me        H    I        CH.sub.2 OEt     MeSO  H                               Me        H    I        CH.sub.2 OPri    Ms    H                               Me        H    I        CH.sub.2 OPrn    Ms    H                               Me        H    I        CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        H    I        CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    I        CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    I        CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        H    I        CHMeOH           Ms    H                               Me        H    I        CHMeOMe          Ms    H                               Me        H    I        CHMeOMe          Cl    H                               Me        H    I        CHMeOMe          MeS   H                               Me        H    I        CHMeOMe          MeSO  H                               Me        H    I        CHMeOEt          Ms    H                               Me        H    I        CHMeOCHCH.sub.2  Ms    H                               Me        H    I        CHMeOCHCH.sub.2  Ms    H                               Me        H    I        CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        H    I        CHMeOCH.sub.2 CCH                                                                               Ms    H                               Me        H    I        CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        H    I        CMe.sub.2 OH     Ms    H                               Me        H    I        CH.sub.2 CMe.sub.2 OMe                                                                          Ms    H                               Me        H    I        CH.sub.2 CMe.sub.2 OEt                                                                          Ms    H                               Me        H    I        CH.sub.2 CH.sub.2 CH.sub.2 OMe                                                                  Ms    H                               Me        H    I        CH.sub.2 CH.sub.2 CH.sub.2 OEt                                                                  Ms    H                               Me        H    I        CH.sub.2 CHEtOH  Ms    H                               Me        H    I        CH.sub.2 CHEtOMe Ms    H                               Me        H    I        CH.sub.2 CHEtOEt Ms    H                               Me        H    I        CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                        Ms    H                               Me        H    I        CH.sub.2 CHMeOCH.sub.2 CH.sub.2 OMe                                                             Ms    H                               Me        H    I        CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        H    I        CH.sub.2 CHMeNMe.sub.2                                                                          Ms    H                               Me        H    I        CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        H    I        CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        H    I        CH.sub.2 CHMeOCH.sub.2 Ph                                                                       Ms    H                               Me        H    I        CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        H    I        CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        H    I        CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        H    I        CH.sub.2 CN      Ms    H                               Me        H    I        CH.sub.2 SMe     Ms    H                               Me        H    I        CH.sub.2 SEt     Ms    H                               Me        H    I        CH.sub.2 SOMe    Ms    H                               Me        H    I        CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    I        CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        H    I        CH.sub.2 CHMeSMe Ms    H                               Me        H    I        CH.sub.2 CHMeSO.sub.2 Me                                                                        Ms    H                               Me        H    I        CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    I        CH.sub.2 OCOMe   Ms    H                               Me        H    I        CH.sub.2 CHMeOCOMe                                                                              Ms    H                               Me        H    I        CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        H    I        CH.sub.2 CHMeOSO.sub.2 Me                                                                       Ms    H                               Et        H    I        CH.sub.2 OH      Ms    H                               Et        H    I        CH.sub.2 OMe     Ms    H                               Et        H    I        CH.sub.2 OMe     Cl    H                               Et        H    I        CH.sub. 2 OMe    MeS   H                               Et        H    I        CH.sub.2 OMe     MeSO  H                               Et        H    I        CH.sub.2 OEt     Ms    H                               Et        H    I        CH.sub.2 OEt     Cl    H                               Et        H    I        CH.sub.2 OEt     MeS   H                               Et        H    I        CH.sub.2 OEt     MeSO  H                               Et        H    I        CH.sub.2 OPri    Ms    H                               Et        H    I        CH.sub.2 OPrn    Ms    H                               Et        H    I        CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        H    I        CH.sub.2 CHMeOH  Ms    H                               Et        H    I        CH.sub.2 CHMeOMe Ms    H                               Et        H    I        CH.sub.2 CHMeOMe Cl    H                               Et        H    I        CH.sub.2 CHMeOMe MeS   H                               Et        H    I        CH.sub.2 CHMeOMe MeSO  H                               Et        H    I        CH.sub.2 CHMeOEt Ms    H                               Et        H    I        CH.sub.2 CHMeOCHCH.sub.2                                                                        Ms    H                               Et        H    I        CH.sub.2 CHMeOCHCH.sub.2                                                                        Ms    H                               Et        H    I        CH.sub.2 CHMeOCHCH.sub.2                                                                        Ms    H                               Et        H    I        CH.sub.2 CHMeOCH.sub. 2 CCH                                                                     Ms    H                               Et        H    I        CH.sub.2 CHMeOCH.sub.2 CH.sub.2 Cl                                                              Ms    H                               Et        H    I        CH.sub.2 CMe.sub.2 OH                                                                           Ms    H                               Et        H    I        CH.sub.2 CMe.sub.2 OMe                                                                          Ms    H                               Et        H    I        CH.sub.2 CMe.sub.2 OEt                                                                          Ms    H                               Et        H    I        CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        H    I        CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        H    I        CH.sub.2 CHEtOH  Ms    H                               Et        H    I        CH.sub.2 CHEtOMe Ms    H                               Et        H    I        CH.sub.2 CHEtOEt Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    I        CH.sub.2 CHMeOCH.sub.2 CH.sub.2 OMe                                                             Ms    H                               Et        H    I        CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        H    I        CH.sub.2 CHMeNMe.sub.2                                                                          Ms    H                               Et        H    I        CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        H    I        CH.sub.2 CHMeOCH.sub.2 Ph                                                                       Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        H    I        CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        H    I        CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        H    I        CH.sub.2 CN      Ms    H                               Et        H    I        CH.sub.2 SMe     Ms    H                               Et        H    I        CH.sub.2 SEt     Ms    H                               Et        H    I        CH.sub.2 SOMe    Ms    H                               Et        H    I        CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    I        CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        H    I        CH.sub.2 CHMeSMe Ms    H                               Et        H    I        CH.sub.2 CHMeSO.sub.2 Me                                                                        Ms    H                               Et        H    I        CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    I        CH.sub.2 OCOMe   Ms    H                               Et        H    I        CHMeOCOMe        Ms    H                               Et        H    I        CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    I        CHMeOSO.sub.2 Me Ms    H                               Pri       H    I        CH.sub.2 OH      Ms    H                               Pri       H    I        CH.sub.2 OMe     Ms    H                               Pri       H    I        CH.sub.2 OMe     Cl    H                               Pri       H    I        CH.sub.2 OMe     MeS   H                               Pri       H    I        CH.sub.2 OMe     MeSO  H                               Pri       H    I        CH.sub.2 OEt     Ms    H                               Pri       H    I        CH.sub.2 OEt     Cl    H                               Pri       H    I        CH.sub.2 OEt     MeS   H                               Pri       H    I        CH.sub.2 OEt     MeSO  H                               Pri       H    I        CH.sub.2 OPri    Ms    H                               Pri       H    I        CH.sub.2 OPrn    Ms    H                               Pri       H    I        CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       H    I        CHMeOH           Ms    H                               Pri       H    I        CHMeOMe          Ms    H                               Pri       H    I        CHMeOMe          Cl    H                               Pri       H    I        CHMeOMe          MeS   H                               Pri       H    I        CHMeOMe          MeSO  H                               Pri       H    I        CHMeOEt          Ms    H                               Pri       H    I        CHMeOCHCH.sub.2  Ms    H                               Pri       H    I        CHMeOCHCH.sub.2  Ms    H                               Pri       H    I        CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       H    I        CHMeOCH.sub.2 CCH                                                                               Ms    H                               Pri       H    I        CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       H    I        CMe.sub.2 OH     Ms    H                               Pri       H    I        CMe.sub.2 OMe    Ms    H                               Pr i      H    I        CMe.sub.2 OEt    Ms    H                               Pri       H    I        CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       H    I        CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       H    I        CHEtOH           Ms    H                               Pri       H    I        CHEtOMe          Ms    H                               Pri       H    I        CHEtOEt          Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    I        CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       H    I        CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       H    I        CHMeNMe.sub.2    Ms    H                               Pri       H    I        CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       H    I        CHMeOCH.sub.2 Ph Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       H    I        CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       H    I        CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       H    I        CH.sub.2 CN      Ms    H                               Pri       H    I        CH.sub.2 SMe     Ms    H                               Pri       H    I        CH.sub.2 SEt     Ms    H                               Pri       H    I        CH.sub.2 SOMe    Ms    H                               Pri       H    I        CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       H    I        CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       H    I        CHMeSMe          Ms    H                               Pri       H    I        CHMeSO.sub.2 Me  Ms    H                               Pri       H    I        CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    I        CH.sub.2 OCOMe   Ms    H                               Pri       H    I        CHMeOCOMe        Ms    H                               Pri       H    I        CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       H    I        CHMeOSO.sub.2 Me Ms    H                               Me        H    Et       CH.sub.2 OH      Ms    H                               Me        H    Et       CH.sub.2 OMe     Ms    H                               Me        H    Et       CH.sub.2 OMe     Cl    H                               Me        H    Et       CH.sub.2 OMe     MeS   H                               Me        H    Et       CH.sub.2 OMe     MeSO  H                               Me        H    Et       CH.sub.2 OEt     Ms    H                               Me        H    Et       CH.sub.2 OEt     Cl    H                               Me        H    Et       CH.sub.2 OEt     MeS   H                               Me        H    Et       CH.sub.2 OEt     MeSO  H                               Me        H    Et       CH.sub.2 OPri    Ms    H                               Me        H    Et       CH.sub.2 OPrn    Ms    H                               Me        H    Et       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        H    Et       CHMeOH           Ms    H                               Me        H    Et       CHMeOMe          Ms    H                               Me        H    Et       CHMeOMe          Cl    H                               Me        H    Et       CHMeOMe          MeS   H                               Me        H    Et       CHMeOMe          MeSO  H                               Me        H    Et       CHMeOEt          Ms    H                               Me        H    Et       CHMeOCHCH.sub.2  Ms    H                               Me        H    Et       CHMeOCHCH.sub.2  Ms    H                               Me        H    Et       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        H    Et       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Me        H    Et       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        H    Et       CMe.sub.2 OH     Ms    H                               Me        H    Et       CMe.sub.2 OMe    Ms    H                               Me        H    Et       CMe.sub.2 OEt    Ms    H                               Me        H    Et       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        H    Et       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        H    Et       CHEtOH           Ms    H                               Me        H    Et       CHEtOMe          Ms    H                               Me        H    Et       CHEtOEt          Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    Et       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        H    Et       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        H    Et       CHMeNMe.sub.2    Ms    H                               Me        H    Et       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        H    Et       CHMeOCH.sub.2 Ph Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        H    Et       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        H    Et       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        H    Et       CH.sub.2 CN      Ms    H                               Me        H    Et       CH.sub.2 SMe     Ms    H                               Me        H    Et       CH.sub.2 SEt     Ms    H                               Me        H    Et       CH.sub.2 SOMe    Ms    H                               Me        H    Et       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    Et       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        H    Et       CHMeSMe          Ms    H                               Me        H    Et       CHMeSO.sub.2 Me  Ms    H                               Me        H    Et       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    Et       CH.sub.2 OCOMe   Ms    H                               Me        H    Et       CHMeOCOMe        Ms    H                               Me        H    Et       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        H    Et       CHMeOSO.sub.2 Me Ms    H                               Et        H    Et       CH.sub.2 OH      Ms    H                               Et        H    Et       CH.sub.2 OMe     Ms    H                               Et        H    Et       CH.sub.2 OMe     Cl    H                               Et        H    Et       CH.sub.2 OMe     MeS   H                               Et        H    Et       CH.sub.2 OMe     MeSO  H                               Et        H    Et       CH.sub.2 OEt     Ms    H                               Et        H    Et       CH.sub.2 OEt     Cl    H                               Et        H    Et       CH.sub.2 OEt     MeS   H                               Et        H    Et       CH.sub.2 OEt     MeSO  H                               Et        H    Et       CH.sub.2 OPri    Ms    H                               Et        H    Et       CH.sub.2 OPrn    Ms    H                               Et        H    Et       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        H    Et       CHMeOH           Ms    H                               Et        H    Et       CHMeOMe          Ms    H                               Et        H    Et       CHMeOMe          Cl    H                               Et        H    Et       CHMeOMe          MeS   H                               Et        H    Et       CHMeOMe          MeSO  H                               Et        H    Et       CHMeOEt          Ms    H                               Et        H    Et       CHMeOCHCH.sub.2  Ms    H                               Et        H    Et       CHMeOCHCH.sub.2  Ms    H                               Et        H    Et       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Et        H    Et       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        H    Et       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        H    Et       CMe.sub.2 OH     Ms    H                               Et        H    Et       CMe.sub.2 OMe    Ms    H                               Et        H    Et       CMe.sub.2 OEt    Ms    H                               Et        H    Et       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        H    Et       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        H    Et       CHEtOH           Ms    H                               Et        H    Et       CHEtOMe          Ms    H                               Et        H    Et       CHEtOEt          Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    Et       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        H    Et       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        H    Et       CHMeNMe.sub.2    Ms    H                               Et        H    Et       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        H    Et       CHMeOCH.sub.2 Ph Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        H    Et       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        H    Et       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        H    Et       CH.sub.2 CN      Ms    H                               Et        H    Et       CH.sub.2 SMe     Ms    H                               Et        H    Et       CH.sub.2 SEt     Ms    H                               Et        H    Et       CH.sub.2 SOMe    Ms    H                               Et        H    Et       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    Et       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        H    Et       CHMeSMe          Ms    H                               Et        H    Et       CHMeSO.sub.2 Me  Ms    H                               Et        H    Et       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    Et       CH.sub.2 OCOMe   Ms    H                               Et        H    Et       CHMeOCOMe        Ms    H                               Et        H    Et       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    Et       CHMeOSO.sub.2 Me Ms    H                               Pri       H    Et       CH.sub.2 OH      Ms    H                               Pri       H    Et       CH.sub.2 OMe     Ms    H                               Pri       H    Et       CH.sub.2 OMe     Cl    H                               Pri       H    Et       CH.sub.2 OMe     MeS   H                               Pri       H    Et       CH.sub.2 OMe     MeSO  H                               Pri       H    Et       CH.sub.2 OEt     Ms    H                               Pri       H    Et       CH.sub.2 OEt     Cl    H                               Pri       H    Et       CH.sub.2 OEt     MeS   H                               Pri       H    Et       CH.sub.2 OEt     MeSO  H                               Pri       H    Et       CH.sub.2 OPri    Ms    H                               Pri       H    Et       CH.sub.2 OPrn    Ms    H                               Pri       H    Et       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       H    Et       CHMeOH           Ms    H                               Pri       H    Et       CHMeOMe          Ms    H                               Pri       H    Et       CHMeOMe          Cl    H                               Pri       H    Et       CHMeOMe          MeS   H                               Pri       H    Et       CHMeOMe          MeSO  H                               Pri       H    Et       CHMeOEt          Ms    H                               Pri       H    Et       CHMeOCHCH.sub.2  Ms    H                               Pri       H    Et       CHMeOCHCH.sub.2  Ms    H                               Pri       H    Et       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       H    Et       CHMeOCH.sub.2 CCH                                                                               Ms    H                               Pri       H    Et       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       H    Et       CMe.sub.2 OH     Ms    H                               Pri       H    Et       CMe.sub.2 OMe    Ms    H                               Pri       H    Et       CMe.sub.2 OEt    Ms    H                               Pri       H    Et       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       H    Et       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       H    Et       CHEtOH           Ms    H                               Pri       H    Et       CHEtOMe          Ms    H                               Pri       H    Et       CHEtOEt          Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    Et       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       H    Et       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       H    Et       CHMeNMe.sub.2    Ms    H                               Pri       H    Et       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       H    Et       CHMeOCH.sub.2 Ph Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       H    Et       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       H    Et       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       H    Et       CH.sub.2 CN      Ms    H                               Pri       H    Et       CH.sub.2 SMe     Ms    H                               Pri       H    Et       CH.sub.2 SEt     Ms    H                               Pri       H    Et       CH.sub.2 SOMe    Ms    H                               Pri       H    Et       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       H    Et       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       H    Et       CHMeSMe          Ms    H                               Pri       H    Et       CHMeSO.sub.2 Me  Ms    H                               Pri       H    Et       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    Et       CH.sub.2 OCOMe   Ms    H                               Pri       H    Et       CHMeOCOMe        Ms    H                               Pri       H    Et       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       H    Et       CHMeOSO.sub.2 Me Ms    H                               Me        Me   Br       CH.sub.2 OH      Ms    H                               Me        Me   Br       CH.sub.2 OMe     Ms    H                               Me        Me   Br       CH.sub.2 OMe     Cl    H                               Me        Me   Br       CH.sub.2 OMe     MeS   H                               Me        Me   Br       CH.sub.2 OMe     MeSO  H                               Me        Me   Br       CH.sub.2 OEt     Ms    H                               Me        Me   Br       CH.sub.2 OEt     Cl    H                               Me        Me   Br       CH.sub.2 OEt     MeS   H                               Me        Me   Br       CH.sub.2 OEt     MeSO  H                               Me        Me   Br       CH.sub.2 OPri    Ms    H                               Me        Me   Br       CH.sub.2 OPrn    Ms    H                               Me        Me   Br       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   Br       CHMeOH           Ms    H                               Me        Me   Br       CHMeOMe          Ms    H                               Me        Me   Br       CHMeOMe          Cl    H                               Me        Me   Br       CHMeOMe          MeS   H                               Me        Me   Br       CHMeOMe          MeSO  H                               Me        Me   Br       CHMeOEt          Ms    H                               Me        Me   Br       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   Br       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   Br       CHEtOH           Ms    H                               Me        Me   Br       CHEtOMe          Ms    H                               Me        Me   Br       CHEtOEt          Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Br       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   Br       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   Br       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   Br       CH.sub.2 CN      Ms    H                               Me        Me   Br       CH.sub.2 SMe     Ms    H                               Me        Me   Br       CH.sub.2 SEt     Ms    H                               Me        Me   Br       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   Br       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        Me   Br       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Br       CH.sub.2 OCOMe   Ms    H                               Me        Me   Br       CHMeOCOMe        Ms    H                               Me        Me   Br       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   Br       CHMeOSO.sub.2 Me Ms    H                               Et        Me   Br       CH.sub.2 OH      Ms    H                               Et        Me   Br       CH.sub.2 OMe     Ms    H                               Et        Me   Br       CH.sub.2 OMe     Cl    H                               Et        Me   Br       CH.sub.2 OMe     MeS   H                               Et        Me   Br       CH.sub.2 OMe     MeSO  H                               Et        Me   Br       CH.sub.2 OEt     Ms    H                               Et        Me   Br       CH.sub.2 OEt     Cl    H                               Et        Me   Br       CH.sub.2 OEt     MeS   H                               Et        Me   Br       CH.sub.2 OEt     MeSO  H                               Et        Me   Br       CH.sub.2 OPri    Ms    H                               Et        Me   Br       CH.sub.2 OPrn    Ms    H                               Et        Me   Br       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   Br       CHMeOH           Ms    H                               Et        Me   Br       CHMeOMe          Ms    H                               Et        Me   Br       CHMeOMe          Cl    H                               Et        Me   Br       CHMeOMe          MeS   H                               Et        Me   Br       CHMeOMe          MeSO  H                               Et        Me   Br       CHMeOEt          Ms    H                               Et        Me   Br       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   Br       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   Br       CHEtOH           Ms    H                               Et        Me   Br       CHEtOMe          Ms    H                               Et        Me   Br       CHEtOEt          Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Br       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Me   Br       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   Br       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        Me   Br       CH.sub.2 CN      Ms    H                               Et        Me   Br       CH.sub.2 SMe     Ms    H                               Et        Me   Br       CH.sub.2 SEt     Ms    H                               Et        Me   Br       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   Br       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        Me   Br       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR44##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Et        Me   Br       CH.sub.2 OCOMe   Ms    H                               Et        Me   Br       CHMeOCOMe        Ms    H                               Et        Me   Br       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   Br       CHMeOSO.sub.2 Me Ms    H                               Pri       Me   Br       CH.sub.2 OH      Ms    H                               Pri       Me   Br       CH.sub.2 OMe     Ms    H                               Pri       Me   Br       CH.sub.2 OMe     Cl    H                               Pri       Me   Br       CH.sub.2 OMe     MeS   H                               Pri       Me   Br       CH.sub.2 OMe     MeSO  H                               Pri       Me   Br       CH.sub.2 OEt     Ms    H                               Pri       Me   Br       CH.sub.2 OEt     Cl    H                               Pri       Me   Br       CH.sub.2 OEt     MeS   H                               Pri       Me   Br       CH.sub.2 OEt     MeSO  H                               Pri       Me   Br       CH.sub.2 OPri    Ms    H                               Pr i      Me   Br       CH.sub.2 OPrn    Ms    H                               Pri       Me   Br       CH.sub.2 OCH CH.sub.2                                                                           Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   Br       CHMeOH           Ms    H                               Pri       Me   Br       CHMeOMe          Ms    H                               Pri       Me   Br       CHMeOMe          Cl    H                               Pri       Me   Br       CHMeOMe          MeS   H                               Pri       Me   Br       CHMeOMe          MeSO  H                               Pri       Me   Br       CHMeOEt          Ms    H                               Pri       Me   Br       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Me   Br       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Me   Br       CHEtOH           Ms    H                               Pri       Me   Br       CHEtOMe          Ms    H                               Pri       Me   Br       CHEtOEt          Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Br       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Me   Br       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       Me   Br       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       Me   Br       CH.sub.2 CN      Ms    H                               Pri       Me   Br       CH.sub.2 SMe     Ms    H                               Pri       Me   Br       CH.sub.2 SEt     Ms    H                               Pri       Me   Br       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   Br       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       Me   Br       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Br       CH.sub.2 OCOMe   Ms    H                               Pri       Me   Br       CHMeOCOMe        Ms    H                               Pri       Me   Br       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Me   Br       CHMeOSO.sub.2 Me Ms    H                               Me        Me   I        CH.sub.2 OH      Ms    H                               Me        Me   I        CH.sub.2 OMe     Ms    H                               Me        Me   I        CH.sub.2 OMe     Cl    H                               Me        Me   I        CH.sub.2 OMe     MeS   H                               Me        Me   I        CH.sub.2 OMe     MeSO  H                               Me        Me   I        CH.sub.2 OEt     Ms    H                               Me        Me   I        CH.sub.2 OEt     Cl    H                               Me        Me   I        CH.sub.2 OEt     MeS   H                               Me        Me   I        CH.sub.2 OEt     MeSO  H                               Me        Me   I        CH.sub.2 OPr i   Ms    H                               Me        Me   I        CH.sub.2 OPrn    Ms    H                               Me        Me   I        CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   I        CHMeOH           Ms    H                               Me        Me   I        CHMeOMe          Ms    H                               Me        Me   I        CHMeOMe          Cl    H                               Me        Me   I        CHMeOMe          MeS   H                               Me        Me   I        CHMeOMe          MeSO  H                               Me        Me   I        CHMeOEt          Ms    H                               Me        Me   I        CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   I        CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   I        CHEtOH           Ms    H                               Me        Me   I        CHEtOMe          Ms    H                               Me        Me   I        CHEtOEt          Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   I        CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   I        CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   I        CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   I        CH.sub.2 CN      Ms    H                               Me        Me   I        CH.sub.2 SMe     Ms    H                               Me        Me   I        CH.sub.2 SEt     Ms    H                               Me        Me   I        CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   I        CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        Me   I        CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   I        CH.sub.2 OCOMe   Ms    H                               Me        Me   I        CHMeOCOMe        Ms    H                               Me        Me   I        CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   I        CH.sub.2 MeOSO.sub.2 Me                                                                         Ms    H                               Et        Me   I        CH.sub.2 OH      Ms    H                               Et        Me   I        CH.sub.2 OMe     Ms    H                               Et        Me   I        CH.sub.2 OMe     Cl    H                               Et        Me   I        CH.sub.2 OMe     MeS   H                               Et        Me   I        CH.sub.2 OMe     MeSO  H                               Et        Me   I        CH.sub.2 OEt     Ms    H                               Et        Me   I        CH.sub.2 OEt     Cl    H                               Et        Me   I        CH.sub.2 OEt     MeS   H                               Et        Me   I        CH.sub.2 OEt     MeSO  H                               Et        Me   I        CH.sub.2 OPri    Ms    H                               Et        Me   I        CH.sub.2 OPrn    Ms    H                               Et        Me   I        CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   I        CHMeOH           Ms    H                               Et        Me   I        CHMeOMe          Ms    H                               Et        Me   I        CHMeOMe          Cl    H                               Et        Me   I        CHMeOMe          MeS   H                               Et        Me   I        CHMeOMe          MeSO  H                               Et        Me   I        CHMeOEt          Ms    H                               Et        Me   I        CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   I        CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   I        CHEtOH           Ms    H                               Et        Me   I        CHEtOMe          Ms    H                               Et        Me   I        CHEtOEt          Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   I        CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Me   I        CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   I        CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        Me   I        CH.sub.2 CN      Ms    H                               Et        Me   I        CH.sub.2 SMe     Ms    H                               Et        Me   I        CH.sub.2 SEt     Ms    H                               Et        Me   I        CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   I        CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        Me   I        CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   I        CH.sub.2 OCOMe   Ms    H                               Et        Me   I        CHMeOCOMe        Ms    H                               Et        Me   I        CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   I        CHMeOSO.sub.2 Me Ms    H                               Pri       Me   I        CH.sub.2 OH      Ms    H                               Pri       Me   I        CH.sub.2 OMe     Ms    H                               Pri       Me   I        CH.sub.2 OMe     Cl    H                               Pri       Me   I        CH.sub.2 OMe     MeS   H                               Pri       Me   I        CH.sub.2 OMe     MeSO  H                               Pri       Me   I        CH.sub.2 OEt     Ms    H                               Pri       Me   I        CH.sub.2 OEt     Cl    H                               Pri       Me   I        CH.sub.2 OEt     MeS   H                               Pri       Me   I        CH.sub.2 OEt     MeSO  H                               Pri       Me   I        CH.sub.2 OPri    Ms    H                               Pri       Me   I        CH.sub.2 OPrn    Ms    H                               Pri       Me   I        CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 C CH                                                                         Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   I        CHMeOH           Ms    H                               Pri       Me   I        CHMeOMe          Ms    H                               Pri       Me   I        CHMeOMe          Cl    H                               Pri       Me   I        CHMeOMe          MeS   H                               Pri       Me   I        CHMeOMe          MeSO  H                               Pri       Me   I        CHMeOEt          Ms    H                               Pri       Me   I        CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Me   I        CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Me   I        CHEtOH           Ms    H                               Pri       Me   I        CHEtOMe          Ms    H                               Pri       Me   I        CHEtOEt          Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   I        CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Me   I        CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       Me   I        CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       Me   I        CH.sub.2 CN      Ms    H                               Pri       Me   I        CH.sub.2 SMe     Ms    H                               Pr i      Me   I        CH.sub.2 SEt     Ms    H                               Pri       Me   I        CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   I        CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       Me   I        CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   I        CH.sub.2 OCOMe   Ms    H                               Pri       Me   I        CHMeOCOMe        Ms    H                               Pri       Me   I        CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Me   I        CHMeOSO.sub.2 Me Ms    H                               Me        Me   Et       CH.sub.2 OH      Ms    H                               Me        Me   Et       CH.sub.2 OMe     Ms    H                               Me        Me   Et       CH.sub.2 OMe     Cl    H                               Me        Me   Et       CH.sub.2 OMe     MeS   H                               Me        Me   Et       CH.sub.2 OMe     MeSO  H                               Me        Me   Et       CH.sub.2 OEt     Ms    H                               Me        Me   Et       CH.sub.2 OEt     Cl    H                               Me        Me   Et       CH.sub.2 OEt     MeS   H                               Me        Me   Et       CH.sub.2 OEt     MeSO  H                               Me        Me   Et       CH.sub.2 OPri    Ms    H                               Me        Me   Et       CH.sub.2 OPrn    Ms    H                               Me        Me   Et       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 C CH                                                                         Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   Et       CHMeOH           Ms    H                               Me        Me   Et       CHMeOMe          Ms    H                               Me        Me   Et       CHMeOMe          Cl    H                               Me        Me   Et       CHMeOMe          MeS   H                               Me        Me   Et       CHMeOMe          MeSO  H                               Me        Me   Et       CHMeOEt          Ms    H                               Me        Me   Et       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   Et       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   Et       CHEtOH           Ms    H                               Me        Me   Et       CHEtOMe          Ms    H                               Me        Me   Et       CHEtOEt          Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Et       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   Et       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   Et       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   Et       CH.sub.2 CN      Ms    H                               Me        Me   Et       CH.sub.2 SMe     Ms    H                               Me        Me   Et       CH.sub.2 SEt     Ms    H                               Me        Me   Et       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   Et       CH.sub. 2 SO.sub.2 Et                                                                           Ms    H                               Me        Me   Et       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   Et       CH.sub.2 OCOMe   Ms    H                               Me        Me   Et       CHMeOCOMe        Ms    H                               Me        Me   Et       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   Et       CHMeOSO.sub.2 Me Ms    H                               Et        Me   Et       CH.sub.2 OH      Ms    H                               Et        Me   Et       CH.sub.2 OMe     Ms    H                               Et        Me   Et       CH.sub.2 OMe     Cl    H                               Et        Me   Et       CH.sub.2 OMe     MeS   H                               Et        Me   Et       CH.sub.2 OMe     MeSO  H                               Et        Me   Et       CH.sub.2 OEt     Ms    H                               Et        Me   Et       CH.sub.2 OEt     Cl    H                               Et        Me   Et       CH.sub.2 OEt     MeS   H                               Et        Me   Et       CH.sub.2 OEt     MeSO  H                               Et        Me   Et       CH.sub.2 OPri    Ms    H                               Et        Me   Et       CH.sub.2 OPrn    Ms    H                               Et        Me   Et       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   Et       CHMeOH           Ms    H                               Et        Me   Et       CHMeOMe          Ms    H                               Et        Me   Et       CHMeOMe          Cl    H                               Et        Me   Et       CHMeOMe          MeS   H                               Et        Me   Et       CHMeOMe          MeSO  H                               Et        Me   Et       CHMeOEt          Ms    H                               Et        Me   Et       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   Et       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   Et       CHEtOH           Ms    H                               Et        Me   Et       CHEtOMe          Ms    H                               Et        Me   Et       CHEtOEt          Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Et       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Me   Et       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   Et       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        Me   Et       CH.sub.2 CN      Ms    H                               Et        Me   Et       CH.sub.2 SMe     Ms    H                               Et        Me   Et       CH.sub.2 SEt     Ms    H                               Et        Me   Et       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   Et       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        Me   Et       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   Et       CH.sub.2 OCOMe   Ms    H                               Et        Me   Et       CHMeOCOMe        Ms    H                               Et        Me   Et       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   Et       CHMeOSO.sub.2 Me Ms    H                               Pri       Me   Et       CH.sub.2 OH      Ms    H                               Pri       Me   Et       CH.sub.2 OMe     Ms    H                               Pri       Me   Et       CH.sub.2 OMe     Cl    H                               Pri       Me   Et       CH.sub.2 OMe     MeS   H                               Pri       Me   Et       CH.sub.2 OMe     MeSO  H                               Pri       Me   Et       CH.sub.2 OEt     Ms    H                               Pri       Me   Et       CH.sub.2 OEt     Cl    H                               Pri       Me   Et       CH.sub.2 OEt     MeS   H                               Pri       Me   Et       CH.sub.2 OEt     MeSO  H                               Pri       Me   Et       CH.sub.2 OPri    Ms    H                               Pri       Me   Et       CH.sub.2 OPrn    Ms    H                               Pri       Me   Et       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   Et       CHMeOH           Ms    H                               Pri       Me   Et       CHMeOMe          Ms    H                               Pri       Me   Et       CHMeOMe          Cl    H                               Pri       Me   Et       CHMeOMe          MeS   H                               Pri       Me   Et       CHMeOMe          MeSO  H                               Pri       Me   Et       CHMeOEt          Ms    H                               Pri       Me   Et       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Me   Et       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Me   Et       CHEtOH           Ms    H                               Pri       Me   Et       CHEtOMe          Ms    H                               Pri       Me   Et       CHEtOEt          Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Et       CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Me   Et       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       Me   Et       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       Me   Et       CH.sub.2 CN      Ms    H                               Pri       Me   Et       CH.sub.2 SMe     Ms    H                               Pri       Me   Et       CH.sub.2 SEt     Ms    H                               Pri       Me   Et       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   Et       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       Me   Et       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   Et       CH.sub.2 OCOMe   Ms    H                               Pri       Me   Et       CHMeOCOMe        Ms    H                               Pri       Me   Et       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Me   Et       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OH      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OMe     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OMe     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OEt     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OEt     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OPri    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOMe          Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOMe          MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOMe          MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCH.sub.2 CCH                                                                               Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CMe.sub.2 OH     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CMe.sub.2 OMe    Ms    H                               CH.sub.2 CHCH.sub. 2                                                                     H    Me       CMe.sub.2 OEt    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHEtOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHEtOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHEtOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeNMe.sub.2    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCH.sub.2 Ph Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 CN      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 SMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 SEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 SOMe    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeSMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeSO.sub.2 Me  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOCOMe        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Me       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OH      Ms    H                               CH.sub.2 C CH                                                                            H    Me       CH.sub.2 OMe     Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OMe     Cl    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OMe     MeS   H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OEt     Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OEt     Cl    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OEt     MeS   H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OPri    Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OPrn    Ms    H                               CH.sub.2 C CH                                                                            H    Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOH           Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOMe          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOMe          Cl    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOMe          MeS   H                               CH.sub.2 CCH                                                                             H    Me       CHMeOMe          MeSO  H                               CH.sub.2 CCH                                                                             H    Me       CHMeOEt          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCH.sub.2 CCH                                                                               Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               CH.sub.2 CCH                                                                             H    Me       CMe.sub.2 OH     Ms    H                               CH.sub.2 CCH                                                                             H    Me       CMe.sub.2 OMe    Ms    H                               CH.sub.2 CCH                                                                             H    Me       CMe.sub.2 OEt    Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 C CH                                                                            H    Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHEtOH           Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHEtOMe          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHEtOEt          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeNMe.sub.2    Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub. 2 Ph                                                                          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCH.sub.2 Ph Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 CN      Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 SMe     Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 SEt     Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 SOMe    Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 C CH                                                                            H    Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeSMe          Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeSO.sub.2 Me  Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOCOMe        Ms    H                               CH.sub.2 CCH                                                                             H    Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    Me       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OH      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OMe     Cl    H                               CH.sub.2 CHCH.sub. 2                                                                     H    Cl       CH.sub.2 OMe     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OEt     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OEt     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OPri    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOMe          Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOMe          MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOMe          MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCH.sub.2 CCH                                                                               Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CMe.sub.2 OH     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CMe.sub.2 OMe    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CMe.sub.2 OEt    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHEtOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHEtOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHEtOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub. 2 OCH.sub.2 CH.sub.2 OMe                                                                Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeNMe.sub.2    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCH.sub.2 Ph Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 CN      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 SMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 SEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 SOMe    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeSMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeSO.sub.2 Me  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOCOMe        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    Cl       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OH      Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OMe     Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OMe     Cl    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OMe     MeS   H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OMe     MeSO  H                               CH.sub.2 C CH                                                                            H    Cl       CH.sub.2 OEt     Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OEt     Cl    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OEt     MeS   H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OPri    Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 C CH                                                                            H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOH           Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOMe          Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOMe          Cl    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOMe          MeS   H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOMe          MeSO  H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOEt          Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               CH.sub.2 C CH                                                                            H    Cl       CHMeOCH.sub.2 CCH                                                                               Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CMe.sub.2 OH     Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CMe.sub.2 OMe    Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CMe.sub.2 OEt    Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR45##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHEtOH           Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHEtOMe          Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHEtOEt          Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeNMe.sub.2    Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCH.sub.2 Ph Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 C CH                                                                            H    Cl       CH.sub.2 CN      Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 SMe     Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 SEt     Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 SOMe    Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeSMe          Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeSO.sub.2 Me  Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOCOMe        Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    Cl       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OH      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OMe     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OMe     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OMe     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OEt     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OEt     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OEt     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OPri    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OPrn    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOMe          Cl    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOMe          MeS   H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOMe          MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCH.sub.2 CCH                                                                               Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               CH.sub. 2 CHCH.sub.2                                                                     H    MeO      CMe.sub.2 OH     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CMe.sub.2 OMe    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CMe.sub.2 OEt    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHEtOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHEtOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHEtOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeNMe.sub.2    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCH.sub.2 Ph Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 CO.sub. 2 Me                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 CN      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 SMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 SEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 SOMe    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeSMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeSO.sub.2 Me  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOCOMe        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      H    MeO      CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 C CH                                                                            H    MeO      CH.sub.2 OH      Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OMe     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OMe     Cl    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OMe     MeS   H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OMe     MeSO  H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OEt     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OEt     Cl    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OEt     MeS   H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OEt     MeSO  H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OPri    Ms    H                               CH.sub.2 C CH                                                                            H    MeO      CH.sub.2 OPrn    Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOH           Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOMe          Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOMe          Cl    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOMe          MeS   H                               CH.sub.2 C CH                                                                            H    MeO      CHMeOMe          MeSO  H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOEt          Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCHCH.sub.2  Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCH.sub.2 CCH                                                                               Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CMe.sub.2 OH     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CMe.sub.2 OMe    Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CMe.sub.2 OEt    Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHEtOH           Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHEtOMe          Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHEtOEt          Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 NMe     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeNMe.sub.2    Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCH.sub.2 Ph Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 CN      Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 SMe     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 SEt     Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 SOMe    Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeSMe          Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeSO.sub.2 Me  Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOCOMe        Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CCH                                                                             H    MeO      CHMeOSO.sub.2 Me MS    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OH      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OMe     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OMe     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OEt     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OEt     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OPri    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOMe          Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOMe          MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOMe          MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHEtOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHEtOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHEtOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CH CH.sub.2                                                                     Me   Me       CH.sub.2 CN      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 SMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 SEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOCOMe        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Me       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OH      Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OMe     Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OMe     Cl    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OMe     MeS   H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OEt     Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OEt     Cl    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OEt     MeS   H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OPri    Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 C CH                                                                            Me   Me       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOH           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOMe          Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOMe          Cl    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOMe          MeS   H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOMe          MeSO  H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOEt          Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHEtOH           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHEtOMe          Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHEtOEt          Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 C CH                                                                            Me   Me       CH.sub.2 CN      Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 SMe     Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 SEt     Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOCOMe        Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OH      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OMe     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OMe     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OEt     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OEt     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OPri    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 CH.sub. 2 Cl                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOMe          Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOMe          MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOMe          MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHEtOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHEtOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHEtOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CH CH.sub.2                                                                     Me   Cl       CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 CN      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 SMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 SEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOCOMe        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   Cl       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OH      Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OMe     Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OMe     Cl    H                               CH.sub. 2 CCH                                                                            Me   Cl       CH.sub.2 OMe     MeS   H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OMe     MeSO  H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OEt     Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OEt     Cl    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OEt     MeS   H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OEt     MeSO  H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OPri    Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OPrn    Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOH           Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOMe          Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOMe          Cl    H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOMe          MeS   H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOMe          MeSO  H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOEt          Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 C CH                                                                            Me   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHEtOH           Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHEtOMe          Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHEtOEt          Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub. 2 OCHMeCO.sub.2 Me                                                                      Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 CN      Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 SMe     Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 SEt     Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CHMeOCOMe        Ms    H                               CH.sub.2 CCH                                                                             Me   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 C CH                                                                            Me   Cl       CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OH      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OMe     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OMe     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OMe     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OEt     Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OEt     MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OEt     MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OPri    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OPrn    Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOMe          Cl    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOMe          MeS   H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOMe          MeSO  H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHEtOH           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHEtOMe          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHEtOEt          Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 CN      Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 SMe     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 SEt     Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOCOMe        Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CHCH.sub.2                                                                      Me   MeO      CHMeOSO.sub.2 Me Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OH      Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OMe     Ms    H                               CH.sub.2 C CH                                                                            Me   MeO      CH.sub.2 OMe     Cl    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OMe     MeS   H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OMe     MeSO  H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OEt     Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OEt     Cl    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OEt     MeS   H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OEt     MeSO  H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OPri    Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OPrn    Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               CH.sub.2 C CH                                                                            Me   MeO      CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOH           Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOMe          Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOMe          Cl    H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOMe          MeS   H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOMe          MeSO  H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOEt          Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHEtOH           Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHEtOMe          Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHEtOEt          Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 NMe.sub.2                                                                              Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 CN      Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 SMe     Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 SEt     Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OCOMe   Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CHMeOCOMe        Ms    H                               CH.sub.2 CCH                                                                             Me   MeO      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               CH.sub.2 CCH                                                                             Me   Me       CHMeOSO.sub.2 Me Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 OMe     Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 OEt     Ms    H                               Me        CF.sub.3                                                                            Me       CHMeOMe          Ms    H                               Me        CF.sub.3                                                                            Me       CHMeOEt          Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        CF.sub.3                                                                            Me       CHEtOMe          Ms    H                               Me        CF.sub.3                                                                            Me       CHEtOEt          Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 SMe     Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 SEt     Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 OCOMe   Ms    H                               Me        CF.sub.3                                                                            Me       CHMeOCOMe        Ms    H                               Me        CF.sub.3                                                                            Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        CF.sub.3                                                                            Me       CHMeOSO.sub.2 Me Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 OMe     Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 OEt     Ms    H                               Et        CF.sub.3                                                                            Me       CHMeOMe          Ms    H                               Et        CF.sub.3                                                                            Me       CHMeOEt          Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        CF.sub.3                                                                            Me       CHEtOMe          Ms    H                               Et        CF.sub.3                                                                            Me       CHEtOEt          Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 SMe     Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 SEt     Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 OCOMe   Ms    H                               Et        CF.sub.3                                                                            Me       CHMeOCOMe        Ms    H                               Et        CF.sub.3                                                                            Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        CF.sub.3                                                                            Me       CHMeOSO.sub.2 Me Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 OMe     Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 OEt     Ms    H                               Pri       CF.sub.3                                                                            Me       CHMeOMe          Ms    H                               Pri       CF.sub.3                                                                            Me       CHMeOEt          Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       CF.sub.3                                                                            Me       CHEtOMe          Ms    H                               Pri       CF.sub.3                                                                            Me       CHEtOEt          Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 SMe     Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 SEt     Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 OCOMe   Ms    H                               Pri       CF.sub.3                                                                            Me       CHMeOCOMe        Ms    H                               Pri       CF.sub.3                                                                            Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       CF.sub.3                                                                            Me       CHMeOSO.sub.2 Me Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 OMe     Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 OEt     Ms    H                               Me        CF.sub.3                                                                            Cl       CHMeOMe          Ms    H                               Me        CF.sub.3                                                                            Cl       CHMeOEt          Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        CF.sub.3                                                                            Cl       CHEtOMe          Ms    H                               Me        CF.sub.3                                                                            Cl       CHEtOEt          Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 SMe     Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 SEt     Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 OCOMe   Ms    H                               Me        CF.sub.3                                                                            Cl       CHMeOCOMe        Ms    H                               Me        CF.sub.3                                                                            Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        CF.sub.3                                                                            Cl       CHMeOSO.sub.2 Me Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 OMe     Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 OEt     Ms    H                               Et        CF.sub.3                                                                            Cl       CHMeOMe          Ms    H                               Et        CF.sub.3                                                                            Cl       CMeOEt           Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        CF.sub.3                                                                            Cl       CHEtOMe          Ms    H                               Et        CF.sub.3                                                                            Cl       CHEtOEt          Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 SMe     Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 SEt     Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 OCOMe   Ms    H                               Et        CF.sub.3                                                                            Cl       CHMeOCOMe        Ms    H                               Et        CF.sub.3                                                                            Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        CF.sub.3                                                                            Cl       CHMeOSO.sub.2 Me Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 OMe     Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 OEt     Ms    H                               Pri       CF.sub.3                                                                            Cl       CHMeOMe          Ms    H                               Pri       CF.sub.3                                                                            Cl       CHMeOEt          Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       CF.sub.3                                                                            Cl       CHEtOMe          Ms    H                               Pri       CF.sub.3                                                                            Cl       CHEtOEt          Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 SMe     Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 SEt     Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 OCOMe   Ms    H                               Pri       CF.sub.3                                                                            Cl       CHMeOCOMe        Ms    H                               Pri       CF.sub.3                                                                            Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       CF.sub.3                                                                            Cl       CHMeOSO.sub.2 Me Ms    H                               Me        Et   Me       CH.sub.2 OMe     Ms    H                               Me        Et   Me       CH.sub.2 OEt     Ms    H                               Me        Et   Me       CHMeOMe          Ms    H                               Me        Et   Me       CHMeOEt          Ms    H                               Me        Et   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Et   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Et   Me       CHEtOMe          Ms    H                               Me        Et   Me       CHEtOEt          Ms    H                               Me        Et   Me       CH.sub. 2 OCH.sub.2 CO.sub.2 Me                                                                 Ms    H                               Me        Et   Me       CH.sub.2 SMe     Ms    H                               Me        Et   Me       CH.sub.2 SEt     Ms    H                               Me        Et   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Et   Me       CH.sub.2 OCOMe   Ms    H                               Me        Et   Me       CHMeOCOMe        Ms    H                               Me        Et   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Et   Me       CHMeOSO.sub.2 Me Ms    H                               Et        Et   Me       CH.sub.2 OMe     Ms    H                               Et        Et   Me       CH.sub.2 OEt     Ms    H                               Et        Et   Me       CHMeOMe          Ms    H                               Et        Et   Me       CHMeOEt          Ms    H                               Et        Et   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Et   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Et   Me       CHEtOMe          Ms    H                               Et        Et   Me       CHEtOEt          Ms    H                               Et        Et   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Et   Me       CH.sub.2 SMe     Ms    H                               Et        Et   Me       CH.sub.2 SEt     Ms    H                               Et        Et   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Et   Me       CH.sub.2 OCOMe   Ms    H                               Et        Et   Me       CHMeOCOMe        Ms    H                               Et        Et   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Et   Me       CHMeOSO.sub.2 Me Ms    H                               Pri       Et   Me       CH.sub.2 OMe     Ms    H                               Pri       Et   Me       CH.sub.2 OEt     Ms    H                               Pri       Et   Me       CHMeOMe          Ms    H                               Pri       Et   Me       CHMeOEt          Ms    H                               Pri       Et   Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Et   Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Et   Me       CHEtOMe          Ms    H                               Pri       Et   Me       CHEtOEt          Ms    H                               Pri       Et   Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Et   Me       CH.sub.2 SMe     Ms    H                               Pri       Et   Me       CH.sub.2 SEt     Ms    H                               Pri       Et   Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Et   Me       CH.sub.2 OCOMe   Ms    H                               Pri       Et   Me       CHMeOCOMe        Ms    H                               Pri       Et   Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Et   Me       CHMeOSO.sub.2 Me Ms    H                               Me        Et   Cl       CH.sub.2 OMe     Ms    H                               Me        Et   Cl       CH.sub.2 OEt     Ms    H                               Me        Et   Cl       CHMeOMe          Ms    H                               Me        Et   Cl       CHMeOEt          Ms    H                               Me        Et   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Et   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Et   Cl       CHEtOMe          Ms    H                               Me        Et   Cl       CHEtOEt          Ms    H                               Me        Et   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Et   Cl       CH.sub.2 SMe     Ms    H                               Me        Et   Cl       CH.sub.2 SEt     Ms    H                               Me        Et   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Et   Cl       CH.sub.2 OCOMe   Ms    H                               Me        Et   Cl       CHMeOCOMe        Ms    H                               Me        Et   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Et   Cl       CHMeOSO.sub.2 Me Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR46##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Et        Et   Cl       CH.sub.2 OMe     Ms    H                               Et        Et   Cl       CH.sub.2 OEt     Ms    H                               Et        Et   Cl       CHMeOMe          Ms    H                               Et        Et   Cl       CHMeOEt          Ms    H                               Et        Et   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Et   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Et   Cl       CHEtOMe          Ms    H                               Et        Et   Cl       CHEtOEt          Ms    H                               Et        Et   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Et   Cl       CH.sub.2 SMe     Ms    H                               Et        Et   Cl       CH.sub.2 SEt     Ms    H                               Et        Et   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Et   Cl       CH.sub.2 OCOMe   Ms    H                               Et        Et   Cl       CHMeOCOMe        Ms    H                               Et        Et   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Et   Cl       CHMeOSO.sub.2 Me Ms    H                               Pri       Et   Cl       CH.sub.2 OMe     Ms    H                               Pri       Et   Cl       CH.sub.2 OEt     Ms    H                               Pri       Et   Cl       CHMeOMe          Ms    H                               Pri       Et   Cl       CHMeOEt          Ms    H                               Pri       Et   Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Et   Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Et   Cl       CHEtOMe          Ms    H                               Pri       Et   Cl       CHEtOEt          Ms    H                               Pri       Et   Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Et   Cl       CH.sub.2 SMe     Ms    H                               Pri       Et   Cl       CH.sub.2 SEt     Ms    H                               Pri       Et   Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Et   Cl       CH.sub.2 OCOMe   Ms    H                               Pri       Et   Cl       CHMeOCOMe        Ms    H                               Pri       Et   Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Et   Cl       CHMeOSO.sub.2 Me Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 OMe     Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 OEt     Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CHMeOMe          Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CHMeOEt          Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CHEtOMe          Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CHEtOEt          Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 SMe     Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 SEt     Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 OCOMe   Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CHMeOCOMe        Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        CH.sub.2 OMe                                                                        Me       CHMeOSO.sub.2 Me Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 OMe     Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 OEt     Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CHMeOMe          Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CHMeOEt          Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CHEtOMe          Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CHEtOEt          Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 OCH.sub.2 CO.sub. 2 Me                                                                 Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 SMe     Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 SEt     Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 OCOMe   Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CHMeOCOMe        Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        CH.sub.2 OMe                                                                        Me       CHMeOSO.sub.2 Me Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 OMe     Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 OEt     Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CHMeOMe          Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CHMeOEt          Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CHEtOMe          Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CHEtOEt          Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 SMe     Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 SEt     Ms    H                               Pri       CH.sub. 2 OMe                                                                       Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 OCOMe   Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CHMeOCOMe        Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       CH.sub.2 OMe                                                                        Me       CHMeOSO.sub.2 Me Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OMe     Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OEt     Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CHMeOMe          Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CHMeOEt          Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CHEtOMe          Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CHEtOEt          Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 SMe     Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 SEt     Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OCOMe   Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CHMeOCOMe        Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CH.sub. 2 OSO.sub.2 Me                                                                          Ms    H                               Me        CH.sub.2 OMe                                                                        Cl       CHMeOSO.sub.2 Me Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OMe     Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OEt     Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CHMeOMe          Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CHMeOEt          Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CHEtOMe          Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CHEtOEt          Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 SMe     Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 SEt     Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OCOMe   Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CHMeOCOMe        Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        CH.sub.2 OMe                                                                        Cl       CHMeOSO.sub.2 Me Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 OMe     Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 OEt     Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CHMeOMe          Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CHMeOEt          Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CHEtOMe          Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CHEtOEt          Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 SMe     Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 SEt     Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 OCOMe   Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CHMeOCOMe        Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       CH.sub.2 OMe                                                                        Cl       CHMeOSO.sub.2 Me Ms    H                               Me        OMe  Me       CH.sub.2 OMe     Ms    H                               Me        OMe  Me       CH.sub.2 OEt     Ms    H                               Me        OMe  Me       CHMeOMe          Ms    H                               Me        OMe  Me       CHMeOEt          Ms    H                               Me        OMe  Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        OMe  Me       CH.sub.2 CH.sub. 2 OEt                                                                          Ms    H                               Me        OMe  Me       CHEtOMe          Ms    H                               Me        OMe  Me       CHEtOEt          Ms    H                               Me        OMe  Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        OMe  Me       CH.sub.2 SMe     Ms    H                               Me        OMe  Me       CH.sub.2 SEt     Ms    H                               Me        OMe  Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        OMe  Me       CH.sub.2 OCOMe   Ms    H                               Me        OMe  Me       CHMeOCOMe        Ms    H                               Me        OMe  Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        OMe  Me       CHMeOSO.sub.2 Me Ms    H                               Et        OMe  Me       CH.sub.2 OMe     Ms    H                               Et        OMe  Me       CH.sub.2 OEt     Ms    H                               Et        OMe  Me       CHMeOMe          Ms    H                               Et        OMe  Me       CHMeOEt          Ms    H                               Et        OMe  Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        OMe  Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        OMe  Me       CHEtOMe          Ms    H                               Et        OMe  Me       CHEtOEt          Ms    H                               Et        OMe  Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        OMe  Me       CH.sub.2 SMe     Ms    H                               Et        OMe  Me       CH.sub.2 SEt     Ms    H                               Et        OMe  Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        OMe  Me       CH.sub.2 OCOMe   Ms    H                               Et        OMe  Me       CHMeOCOMe        Ms    H                               Et        OMe  Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        OMe  Me       CHMeOSO.sub.2 Me Ms    H                               Pri       OMe  Me       CH.sub.2 OMe     Ms    H                               Pri       OMe  Me       CH.sub.2 OEt     Ms    H                               Pri       OMe  Me       CHMeOMe          Ms    H                               Pri       OMe  Me       CHMeOEt          Ms    H                               Pri       OMe  Me       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       OMe  Me       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       OMe  Me       CHEtOMe          Ms    H                               Pri       OMe  Me       CHEtOEt          Ms    H                               Pri       OMe  Me       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       OMe  Me       CH.sub.2 SMe     Ms    H                               Pri       OMe  Me       CH.sub.2 SEt     Ms    H                               Pri       OMe  Me       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       OMe  Me       CH.sub.2 OCOMe   Ms    H                               Pri       OMe  Me       CHMeOCOMe        Ms    H                               Pri       OMe  Me       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       OMe  Me       CHMeOSO.sub.2 Me Ms    H                               Me        OMe  Cl       CH.sub.2 OMe     Ms    H                               Me        OMe  Cl       CH.sub.2 OEt     Ms    H                               Me        OMe  Cl       CHMeOMe          Ms    H                               Me        OMe  Cl       CHMeOEt          Ms    H                               Me        OMe  Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        OMe  Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        OMe  Cl       CHEtOMe          Ms    H                               Me        OMe  Cl       CHEtOEt          Ms    H                               Me        OMe  Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        OMe  Cl       CH.sub.2 SMe     Ms    H                               Me        OMe  Cl       CH.sub.2 SEt     Ms    H                               Me        OMe  Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        OMe  Cl       CH.sub.2 OCOMe   Ms    H                               Me        OMe  Cl       CHMeOCOMe        Ms    H                               Me        OMe  Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        OMe  Cl       CHMeOSO.sub.2 Me Ms    H                               Et        OMe  Cl       CH.sub.2 OMe     Ms    H                               Et        OMe  Cl       CH.sub.2 OEt     Ms    H                               Et        OMe  Cl       CHMeOMe          MS    H                               Et        OMe  Cl       CHMeOEt          Ms    H                               Et        OMe  Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        OMe  Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        OMe  Cl       CHEtOMe          Ms    H                               Et        OMe  Cl       CHEtOEt          Ms    H                               Et        OMe  Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        OMe  Cl       CH.sub.2 SMe     Ms    H                               Et        OMe  Cl       CH.sub.2 SEt     Ms    H                               Et        OMe  Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        OMe  Cl       CH.sub.2 OCOMe   Ms    H                               Et        OMe  Cl       CHMeOCOMe        Ms    H                               Et        OMe  Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        OMe  Cl       CHMeOSO.sub.2 Me Ms    H                               Pri       OMe  Cl       CH.sub.2 OMe     Ms    H                               Pri       OMe  Cl       CH.sub.2 OEt     Ms    H                               Pri       OMe  Cl       CHMeOMe          Ms    H                               Pri       OMe  Cl       CHMeOEt          Ms    H                               Pri       OMe  Cl       CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       OMe  Cl       CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       OMe  Cl       CHEtOMe          Ms    H                               Pri       OMe  Cl       CHEtOEt          Ms    H                               Pri       OMe  Cl       CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       OMe  Cl       CH.sub.2 SMe     Ms    H                               Pri       OMe  Cl       CH.sub.2 SEt     Ms    H                               Pri       OMe  Cl       CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       OMe  Cl       CH.sub.2 OCOMe   Ms    H                               Pri       OMe  Cl       CHMeOCOMe        Ms    H                               Pri       OMe  Cl       CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       OMe  Cl       CHMeOSO.sub.2 Me Ms    H                               Me        SMe  Me       CH.sub.2 OMe     Ms    H                               Me        SMe  Me       CH.sub.2 OEt     Ms    H                               Me        SMe  Me       CHMeOMe          Ms    H                               Me        SMe  Me       CHMeOEt          Ms    H                               Me        SMe  Me       CHEtOMe          Ms    H                               Me        SMe  Me       CHEtOEt          Ms    H                               Me        SMe  Me       CH.sub.2 OMe     Ms    H                               Me        SMe  Me       CH.sub.2 OEt     Ms    H                               Me        SMe  Me       CHMeOMe          Ms    H                               Me        SMe  Me       CHMeOEt          Ms    H                               Et        SMe  Me       CH.sub.2 OMe     Ms    H                               Et        SMe  Me       CH.sub.2 OEt     Ms    H                               Et        SMe  Me       CHMeOMe          Ms    H                               Et        SMe  Me       CHMeOEt          Ms    H                               Et        SMe  Me       CHEtOMe          Ms    H                               Et        SMe  Me       CHEtOEt          Ms    H                               Et        SMe  Cl       CH.sub.2 OMe     Ms    H                               Et        SMe  Cl       CH.sub.2 OEt     Ms    H                               Et        SMe  Cl       CHMeOMe          Ms    H                               Et        SMe  Cl       CHMeOEt          Ms    H                               Pri       SMe  Me       CH.sub.2 OMe     Ms    H                               Pri       SMe  Me       CH.sub.2 OEt     Ms    H                               Pri       SMe  Me       CHMeOMe          Ms    H                               Pri       SMe  Me       CHMeOEt          Ms    H                               Pri       SMe  Me       CHEtOMe          Ms    H                               Pri       SMe  Me       CHEtOEt          Ms    H                               Pri       SMe  Cl       CH.sub.2 OMe     Ms    H                               Pri       SMe  Cl       CH.sub.2 OEt     Ms    H                               Pri       SMe  Cl       CHMeOMe          Ms    H                               Pri       SMe  Cl       CHMeOEt          Ms    H                               Me        CH.sub.2 SMe                                                                        Me       CH.sub.2 OMe     Ms    H                               Me        CH.sub.2 SMe                                                                        Me       CH.sub.2 OEt     Ms    H                               Me        CH.sub.2 SMe                                                                        Me       CHMeOMe          Ms    H                               Me        CH.sub.2 SMe                                                                        Me       CHMeOEt          Ms    H                               Me        CH.sub.2 SMe                                                                        Me       CHEtOMe          Ms    H                               Me        CH.sub.2 SMe                                                                        Me       CHEtOEt          Ms    H                               Me        CH.sub.2 SMe                                                                        Cl       CH.sub.2 OMe     Ms    H                               Me        CH.sub.2 SMe                                                                        Cl       CH.sub.2 OEt     Ms    H                               Me        CH.sub.2 SMe                                                                        Cl       CHMeOMe          Ms    H                               Me        CH.sub.2 SMe                                                                        Cl       CHMeOEt          Ms    H                               Et        CH.sub.2 SMe                                                                        Me       CH.sub.2 OMe     Ms    H                               Et        CH.sub.2 SMe                                                                        Me       CH.sub.2 OEt     Ms    H                               Et        CH.sub.2 SMe                                                                        Me       CHMeOMe          Ms    H                               Et        CH.sub.2 SMe                                                                        Me       CHMeOEt          Ms    H                               Et        CH.sub.2 SMe                                                                        Me       CHEtOMe          Ms    H                               Et        CH.sub.2 SMe                                                                        Me       CHEtOEt          Ms    H                               Et        CH.sub.2 SMe                                                                        Cl       CH.sub.2 OMe     Ms    H                               Et        CH.sub.2 SMe                                                                        Cl       CH.sub.2 OEt     Ms    H                               Et        CH.sub.2 SMe                                                                        Cl       CHMeOMe          Ms    H                               Et        CH.sub.2 SMe                                                                        Cl       CHMeOEt          Ms    H                               Pri       CH.sub.2 SMe                                                                        Me       CH.sub.2 OMe     Ms    H                               Pri       CH.sub.2 SMe                                                                        Me       CH.sub.2 OEt     Ms    H                               Pri       CH.sub.2 SMe                                                                        Me       CHMeOMe          Ms    H                               Pri       CH.sub.2 SMe                                                                        Me       CHMeOEt          Ms    H                               Pri       CH.sub.2 SMe                                                                        Me       CHEtOMe          Ms    H                               Pri       CH.sub.2 SMe                                                                        Me       CHEtOEt          Ms    H                               Pri       CH.sub.2 SMe                                                                        Cl       CH.sub.2 OMe     Ms    H                               Pri       CH.sub.2 SMe                                                                        Cl       CH.sub.2 OEt     Ms    H                               Pri       CH.sub.2 SMe                                                                        Cl       CHMeOMe          Ms    H                               Pri       CH.sub.2 SMe                                                                        Cl       CHMeOEt          Ms    H                               Me        CH.sub.2 Cl                                                                         Me       CH.sub.2 OMe     Ms    H                               Me        CH.sub.2 Cl                                                                         Me       CH.sub.2 OEt     Ms    H                               Me        CH.sub.2 Cl                                                                         Me       CHMeOMe          Ms    H                               Me        CH.sub.2 Cl                                                                         Me       CHMeOEt          Ms    H                               Me        CH.sub.2 Cl                                                                         Me       CHEtOMe          Ms    H                               Me        CH.sub.2 Cl                                                                         Me       CHEtOEt          Ms    H                               Me        CH.sub.2 Cl                                                                         Cl       CH.sub.2 OMe     Ms    H                               Me        CH.sub.2 Cl                                                                         Cl       CH.sub.2 OEt     Ms    H                               Me        CH.sub.2 Cl                                                                         Cl       CHMeOMe          Ms    H                               Me        CH.sub.2 Cl                                                                         Cl       CHMeOEt          Ms    H                               Et        CH.sub.2 Cl                                                                         Me       CH.sub.2 OMe     Ms    H                               Et        CH.sub.2 Cl                                                                         Me       CH.sub.2 OEt     Ms    H                               Et        CH.sub.2 Cl                                                                         Me       CHMeOMe          Ms    H                               Et        CH.sub.2 Cl                                                                         Me       CHMeOEt          Ms    H                               Et        CH.sub.2 Cl                                                                         Me       CHEtOMe          Ms    H                               Et        CH.sub.2 Cl                                                                         Me       CHEtOEt          Ms    H                               Et        CH.sub.2 Cl                                                                         Cl       CH.sub.2 OMe     Ms    H                               Et        CH.sub.2 Cl                                                                         Cl       CH.sub.2 OEt     Ms    H                               Et        CH.sub.2 Cl                                                                         Cl       CHMeOMe          Ms    H                               Et        CH.sub.2 Cl                                                                         Cl       CHMeOEt          Ms    H                               Pri       CH.sub.2 Cl                                                                         Me       CH.sub.2 OMe     Ms    H                               Pri       CH.sub.2 Cl                                                                         Me       CH.sub.2 OEt     Ms    H                               Pri       CH.sub.2 Cl                                                                         Me       CHMeOMe          Ms    H                               Pri       CH.sub.2 Cl                                                                         Me       CHMeOEt          Ms    H                               Pri       CH.sub.2 Cl                                                                         Me       CHEtOMe          Ms    H                               Pri       CH.sub.2 Cl                                                                         Me       CHEtOEt          Ms    H                               Pri       CH.sub.2 Cl                                                                         Cl       CH.sub.2 OMe     Ms    H                               Pri       CH.sub.2 Cl                                                                         Cl       CH.sub.2 OEt     Ms    H                               Pri       CH.sub.2 Cl                                                                         Cl       CHMeOMe          Ms    H                               Pri       CH.sub.2 Cl                                                                         Cl       CHMeOEt          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OH      Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     Cl    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeS   H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeSO  H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     Cl    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeS   H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeSO  H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OPri    Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OPrn    Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOH           Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOMe          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOMe          Cl    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOMe          MeS   H                               Me        H    CH.sub.2 OMe                                                                            CHMeOMe          MeSO  H                               Me        H    CH.sub.2 OMe                                                                            CHMeOEt          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCHCH.sub.2  Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCHCH.sub.2  Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH CH                                                                             Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Me        H    CH.sub.2 OMe                                                                            CMe.sub.2 OH     Ms    H                               Me        H    CH.sub.2 OMe                                                                            CMe.sub.2 OMe    Ms    H                               Me        H    CH.sub.2 OMe                                                                            CMe.sub.2 OEt    Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHEtOH           Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHEtOMe          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHEtOEt          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeNMe.sub.2    Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 Ph Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 CN      Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 SMe     Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 SEt     Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 SOMe    Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeSMe          Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeSO.sub.2 ME  Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.2 OCOMe   Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOCOMe        Ms    H                               Me        H    CH.sub.2 OMe                                                                            CH.sub.OSO.sub.2 Me                                                                             Ms    H                               Me        H    CH.sub.2 OMe                                                                            CHMeOSO.sub.2 Me Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OH      Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     Cl    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeS   H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeSO  H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     Cl    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeS   H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeSO  H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OPri    Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OPrn    Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOH           Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOMe          Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOMe          Cl    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOMe          MeS   H                               Et        H    CH.sub.2 OMe                                                                            CHMeOMe          MeSO  H                               Et        H    CH.sub.2 OMe                                                                            CHMeOEt          Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCHCH.sub.2  Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCHCH.sub.2  Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH CH.sub.2                                                                       Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CCH                                                                               Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Et        H    CH.sub.2 OMe                                                                            CMe.sub.2 OH     Ms    H                               Et        H    CH.sub.2 OMe                                                                            CMe.sub.2 OMe    Ms    H                               Et        H    CH.sub.2 OMe                                                                            CMe.sub.2 OEt    Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHEtOH           Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHEtOMe          Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHEtOEt          Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeNMe.sub.2    Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 Ph Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 CN      Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 SMe     Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 SEt     Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 SOMe    Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeSMe          Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeSO.sub.2 Me  Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OCOMe   Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOCOMe        Ms    H                               Et        H    CH.sub.2 OMe                                                                            CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    CH.sub.2 OMe                                                                            CHMeOSO.sub.2 Me Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OH      Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub. 2 OMe    Cl    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeS   H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeSO  H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     Cl    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeS   H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeSO  H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OPri    Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OPrn    Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOH           Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOMe          Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOMe          Cl    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOMe          MeS   H                               Pri       H    CH.sub. 2 OMe                                                                           CHMeOMe          MeSO  H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOEt          Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCHCH.sub.2  Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCHCH.sub.2  Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CHCH.sub.2                                                                        Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CCH                                                                               Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH.sub.2 Cl                                                                       Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CMe.sub.2 OH     Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CMe.sub.2 OMe    Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CMe.sub.2 OEt    Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHEtOH           Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHEtOMe          Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHEtOEt          Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 CH.sub.2 OMe                                                                      Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeNMe.sub.2    Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 NMe.sub.2                                                                     Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCH.sub.2 Ph Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCHMeCO.sub.2 ME                                                                       Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 CN      Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 SMe     Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 SEt     Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 SOMe    Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeSMe          Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeSO.sub.2 Me  Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OCOMe   Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOCOMe        Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       H    CH.sub.2 OMe                                                                            CHMeOSO.sub.2 Me Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OH      Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     Cl    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeS   H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeSO  H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     Cl    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeS   H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeSO  H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OPri    Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OPrn    Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 C CH                                                                         Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOH           Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOMe          Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOMe          Cl    H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOMe          MeS   H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOMe          MeSO  H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOEt          Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHEtOH           Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHEtOMe          Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHEtOEt          Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 NMe.sub.2                                                                              Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 CN      Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 SMe     Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 SEt     Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCOMe   Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOCOMe        Ms    H                          

                                      TABLE 5                                      __________________________________________________________________________      ##STR47##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Me        Me   CH.sub.2 OMe                                                                            CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        Me   CH.sub.2 OMe                                                                            CHMeOSO.sub.2 Me Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OH      Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     Cl    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeS   H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeSO  H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     Cl    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeS   H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeSO  H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OPri    Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OPrn    Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 CHCH.sub.2                                                                             Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOH           Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOMe          Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOMe          Cl    H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOMe          MeS   H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOMe          MeSO  H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOEt          Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHEtOH           Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHEtOMe          Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHEtOEt          Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 NMe.sub.2                                                                              Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 CN      Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 SMe     Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 SEt     Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 SCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OCOMe   Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOCOMe        Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        Me   CH.sub.2 OMe                                                                            CHMeOSO.sub.2 Me Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OH      Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     Cl    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeS   H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OMe     MeSO  H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     Cl    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeS   H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OEt     MeSO  H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OPri    Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OPrn    Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCHCH.sub.2                                                                            Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CHCH.sub.2                                                                   Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CCH                                                                          Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 Cl                                                                  Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOH           Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOMe          Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOMe          Cl    H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOMe          MeS   H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOMe          MeSO  H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOEt          Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OMe                                                                           Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 CH.sub.2 OEt                                                                           Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHEtOH           Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHEtOMe          Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHEtOEt          Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                                 Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 NMe.sub.2                                                                              Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 Ph                                                                           Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Me                                                                  Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCH.sub.2 CO.sub.2 Et                                                                  Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCHMeCO.sub.2 Me                                                                       Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 CN      Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 SMe     Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 SEt     Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 SO.sub.2 Et                                                                            Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 SCH.sub.2 CH.sub. 2 OMe                                                                Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OCOMe   Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOCOMe        Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       Me   CH.sub.2 OMe                                                                            CHMeOSO.sub.2 Me Ms    H                               Me        H    Pri      CH.sub.2 OMe     Ms    H                               Me        H    Pri      CH.sub.2 OEt     Ms    H                               Me        H    Pri      CHMeOMe          Ms    H                               Me        H    Pri      CHMeOEt          Ms    H                               Me        H    Pri      CHEtOMe          Ms    H                               Me        H    Pri      CHEtOEt          Ms    H                               Me        H    Pri      CH.sub.2 SMe     Ms    H                               Me        H    Pri      CH.sub.2 SEt     Ms    H                               Me        H    Pri      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    Pri      CH.sub.2 OCOMe   Ms    H                               Me        H    Pri      CHMeOCOMe        Ms    H                               Me        H    Pri      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Me        H    Pri      CHMeOSO.sub.2 Me Ms    H                               Et        H    Pri      CH.sub.2 OMe     Ms    H                               Et        H    Pri      CH.sub.2 OEt     Ms    H                               Et        H    Pri      CHMeOMe          Ms    H                               Et        H    Pri      CHMeOEt          Ms    H                               Et        H    Pri      CHEtOMe          Ms    H                               Et        H    Pri      CHEtOEt          Ms    H                               Et        H    Pri      CH.sub.2 SMe     Ms    H                               Et        H    Pri      CH.sub.2 SEt     Ms    H                               Et        H    Pri      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        H    Pri      CH.sub.2 OCOMe   Ms    H                               Et        H    Pri      CHMeOCOMe        Ms    H                               Et        H    Pri      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Et        H    Pri      CHMeOSO.sub.2 Me Ms    H                               Pri       H    Pri      CH.sub.2 OMe     Ms    H                               Pri       H    Pri      CH.sub.2 OEt     Ms    H                               Pri       H    Pri      CHMeOMe          Ms    H                               Pri       H    Pri      CHMeOEt          Ms    H                               Pri       H    Pri      CHEtOMe          Ms    H                               Pri       H    Pri      CHEtOEt          Ms    H                               Pri       H    Pri      CH.sub.2 SMe     Ms    H                               Pri       H    Pri      CH.sub.2 SEt     Ms    H                               Pri       H    Pri      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       H    Pri      CH.sub.2 OCOMe   Ms    H                               Pri       H    Pri      CHMeOCOMe        Ms    H                               Pri       H    Pri      CH.sub.2 OSO.sub.2 Me                                                                           Ms    H                               Pri       H    Pri      CHMeOSO.sub.2 Me Ms    H                               Me        Me   Pri      CH.sub.2 OMe     Ms    H                               Me        Me   Pri      CH.sub.2 OEt     Ms    H                               Me        Me   Pri      CHMeOMe          Ms    H                               Me        Me   Pri      CHMeOEt          Ms    H                               Me        Me   Pri      CH.sub.2 SMe     Ms    H                               Me        Me   Pri      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Et        Me   Pri      CH.sub.2 OMe     Ms    H                               Et        Me   Pri      CH.sub.2 OEt     Ms    H                               Et        Me   Pri      CHMeOMe          Ms    H                               Et        Me   Pri      CHMeOEt          Ms    H                               Et        Me   Pri      CH.sub.2 SMe     Ms    H                               Et        Me   Pri      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Pri       Me   Pri      CH.sub.2 OMe     Ms    H                               Pri       Me   Pri      CH.sub.2 OEt     Ms    H                               Pri       Me   Pri      CHMeOMe          Ms    H                               Pri       Me   Pri      CHMeOEt          Ms    H                               Pri       Me   Pri      CH.sub.2 SMe     Ms    H                               Pri       Me   Pri      CH.sub.2 SO.sub.2 Me                                                                            Ms    H                               Me        H    F        CH.sub.2 OMe     Ms    H                               Me        H    F        CH.sub.2 OEt     Ms    H                               Me        H    F        CHMeOMe          Ms    H                               Et        H    F        CH.sub.2 OMe     Ms    H                               Et        H    F        CH.sub.2 OEt     Ms    H                               Et        H    F        CHMeOMe          Ms    H                               Et        H    F        CHMeOEt          Ms    H                               Pri       H    F        CH.sub.2 OMe     Ms    H                               Pri       H    F        CH.sub.2 OEt     Ms    H                               Pri       H    F        CHMeOMe          Ms    H                               Me        Me   F        CH.sub.2 OMe     Ms    H                               Me        Me   F        CH.sub.2 OEt     Ms    H                               Et        Me   F        CH.sub.2 OMe     Ms    H                               Et        Me   F        CH.sub.2 OEt     Ms    H                               Et        Me   F        CHMeOMe          Ms    H                               Pri       Me   F        CH.sub.2 OMe     Ms    H                               Pri       Me   F        CH.sub.2 OEt     Ms    H                               Me        H    NO.sub.2 CH.sub.2 OMe     Ms    H                               Me        H    NO.sub.2 CH.sub.2 OEt     Ms    H                               Me        H    NO.sub.2 CHMeOMe          Ms    H                               Et        H    NO.sub.2 CH.sub.2 OMe     Ms    H                               Et        H    NO.sub.2 CH.sub.2 OEt     Ms    H                               Et        H    NO.sub.2 CHMeOMe          Ms    H                               Et        H    NO.sub.2 CHMeOEt          Ms    H                               Pri       H    NO.sub.2 CH.sub.2 OMe     Ms    H                               Pri       H    NO.sub.2 CH.sub.2 OEt     Ms    H                               Pri       H    NO.sub.2 CHMeOMe          Ms    H                               Me        Me   NO.sub.2 CH.sub.2 OMe     Ms    H                               Me        Me   NO.sub.2 CH.sub.2 OEt     Ms    H                               Et        Me   NO.sub.2 CH.sub.2 OMe     Ms    H                               Et        Me   NO.sub.2 CH.sub.2 OEt     Ms    H                               Et        Me   NO.sub.2 CHMeOMe          Ms    H                               Pri       Me   NO.sub.2 CH.sub.2 OMe     Ms    H                               Pri       Me   NO.sub.2 CH.sub.2 OEt     Ms    H                               Me        H    CF.sub.3 CH.sub.2 OMe     Ms    H                               Me        H    CF.sub.3 CH.sub.2 OEt     Ms    H                               Me        H    CF.sub.3 CHMeOMe          Ms    H                               Et        H    CF.sub.3 CH.sub.2 OMe     Ms    H                               Et        H    CF.sub.3 CH.sub.2 OEt     Ms    H                               Et        H    CF.sub.3 CHMeOMe          Ms    H                               Et        H    CF.sub.3 CHMeOEt          Ms    H                               Pri       H    CF.sub.3 CH.sub.2 OMe     Ms    H                               Pri       H    CF.sub.3 CH.sub.2 OEt     Ms    H                               Pri       H    CF.sub.3 CHMeOMe          Ms    H                               Me        Me   CF.sub.3 CH.sub.2 OMe     Ms    H                               Me        Me   CF.sub.3 CH.sub.2 OEt     Ms    H                               Et        Me   CF.sub.3 CH.sub.2 OMe     Ms    H                               Et        Me   CF.sub.3 CH.sub.2 OEt     Ms    H                               Et        Me   CF.sub.3 CHMeOMe          Ms    H                               Pri       Me   CF.sub.3 CH.sub.2 OMe     Ms    H                               Pri       Me   CF.sub.3 CH.sub.2 OEt     Ms    H                               Me        H    COCH.sub.3                                                                              CH.sub.2 OMe     Ms    H                               Me        H    COCH.sub.3                                                                              CH.sub.2 OEt     Ms    H                               Et        H    COCH.sub.3                                                                              CH.sub.2 OMe     Ms    H                               Et        H    COCH.sub.3                                                                              CH.sub.2 OEt     Ms    H                               Et        H    COCH.sub.3                                                                              CHMeOMe          Ms    H                               Pri       H    COCH.sub.3                                                                              CH.sub.2 OMe     Ms    H                               Pri       H    COCH.sub.3                                                                              CH.sub.2 OEt     Ms    H                               Me        Me   COCH.sub.3                                                                              CH.sub.2 OMe     Ms    H                               Et        Me   COCH.sub.3                                                                              CH.sub.2 OMe     Ms    H                               Et        Me   COCH.sub.3                                                                              CH.sub.2 OEt     Ms    H                               Pri       Me   COCH.sub.3                                                                              CH.sub.2 OMe     Ms    H                               Me        H    SCH.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Me        H    SCH.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Et        H    SCH.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Et        H    SCH.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Et        H    SCH.sub.3                                                                               CHMeOEt          Ms    H                               Pri       H    SCH.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Me        Me   SCH.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Et        Me   SCH.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Et        Me   SCH.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Pri       Me   SCH.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Me        H    OCHF.sub.2                                                                              CH.sub.2 OMe     Ms    H                               Me        H    OCHF.sub.2                                                                              CH.sub.2 OEt     Ms    H                               Et        H    OCHF.sub.2                                                                              CH.sub.2 OMe     Ms    H                               Et        H    OCHF.sub.2                                                                              CH.sub.2 OEt     Ms    H                               Et        H    OCHF.sub.2                                                                              CHMeOEt          Ms    H                               Pri       H    OCHF.sub.2                                                                              CH.sub.2 OMe     Ms    H                               Pri       H    OCHF.sub.2                                                                              CH.sub.2 OEt     Ms    H                               Me        Me   OCHF.sub.2                                                                              CH.sub.2 OMe     Ms    H                               Me        Me   OCHF.sub.2                                                                              CH.sub.2 OEt     Ms    H                               Et        Me   OCHF.sub.2                                                                              CH.sub.2 OMe     Ms    H                               Et        Me   OCHF.sub.2                                                                              CH.sub.2 OEt     Ms    H                               Pri       Me   OCHF.sub.2                                                                              CH.sub.2 OMe     Ms    H                               Pri       Me   OCHF.sub.2                                                                              CH.sub.2 OEt     Ms    H                               Me        H    OCF.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Me        H    OCF.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Et        H    OCF.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Et        H    OCF.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Et        H    OCF.sub.3                                                                               CHMeOEt          Ms    H                               Pri       H    OCF.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Pri       H    OCF.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Me        Me   OCF.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Et        Me   OCF.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Et        Me   OCF.sub.3                                                                               CH.sub.2 OEt     Ms    H                               Pri       Me   OCF.sub.3                                                                               CH.sub.2 OMe     Ms    H                               Me        H    CH.sub.2 SMe                                                                            CH.sub.2 OMe     Ms    H                               Et        H    CH.sub.2 SMe                                                                            CH.sub.2 OMe     Ms    H                               Et        H    CH.sub.2 SMe                                                                            CH.sub.2 OEt     Ms    H                               Et        H    CH.sub.2 SMe                                                                            CHMeOEt          Ms    H                               Pri       H    CH.sub.2 SMe                                                                            CH.sub.2 OMe     Ms    H                               Pri       H    CH.sub.2 SMe                                                                            CHMeOMe          Ms    H                               Me        Me   CH.sub.2 SMe                                                                            CH.sub.2 OMe     Ms    H                               Et        Me   CH.sub.2 SMe                                                                            CH.sub.2 OMe     Ms    H                               Et        Me   CH.sub.2 SMe                                                                            CH.sub.2 OEt     Ms    H                               Pri       Me   CH.sub.2 SMe                                                                            CH.sub.2 OMe     Ms    H                               Me        H    CN       CH.sub.2 OMe     Ms    H                               Et        H    CN       CH.sub.2 OMe     Ms    H                               Et        H    CN       CH.sub.2 OEt     Ms    H                               Pri       H    CN       CH.sub.2 OMe     Ms    H                               Me        Me   CN       CH.sub.2 OMe     Ms    H                               Et        Me   CN       CH.sub.2 OMe     Ms    H                               Pri       Me   CN       CH.sub.2 OMe     Ms    H                               Me        H    CO.sub.2 Me                                                                             CH.sub.2 OMe     Ms    H                               Et        H    CO.sub.2 Me                                                                             CH.sub.2 OMe     Ms    H                               Et        H    CO.sub.2 Me                                                                             CH.sub.2 OEt     Ms    H                               Pri       H    CO.sub.2 Me                                                                             CH.sub.2 OMe     Ms    H                               Me        Me   CO.sub.2 Me                                                                             CH.sub.2 OMe     Ms    H                               Et        Me   CO.sub.2 Me                                                                             CH.sub.2 OMe     Ms    H                               Pri       Me   CO.sub.2 Me                                                                             CH.sub.2 OMe     Ms    H                               Me        H    CONMe.sub.2                                                                             CH.sub.2 OMe     Ms    H                               Et        H    CONMe.sub.2                                                                             CH.sub.2 OMe     Ms    H                               Pri       H    CONMe.sub.2                                                                             CH.sub.2 OMe     Ms    H                               Me        H    Me       CH.sub.2 OMe     NO.sub.2                                                                             H                               Me        H    Me       CH.sub.2 OEt     NO.sub.2                                                                             H                               Et        H    Me       CH.sub.2 OMe     NO.sub.2                                                                             H                               Et        H    Me       CH.sub.2 OEt     NO.sub.2                                                                             H                               Et        H    Me       CHMeOMe          NO.sub.2                                                                             H                               Pri       H    Me       CH.sub.2 OMe     NO.sub.2                                                                             H                               Pri       H    Me       CH.sub.2 OEt     NO.sub.2                                                                             H                               Me        H    Cl       CH.sub.2 OMe     NO.sub.2                                                                             H                               Me        H    Cl       CH.sub.2 OEt     NO.sub.2                                                                             H                               Et        H    Cl       CH.sub.2 OMe     NO.sub.2                                                                             H                               Et        H    Cl       CH.sub.2 OEt     NO.sub.2                                                                             H                               Et        H    Cl       CHMeOMe          NO.sub.2                                                                             H                               Pri       H    Cl       CH.sub.2 OMe     NO.sub.2                                                                             H                               Pri       H    Cl       CH.sub.2 OEt     NO.sub.2                                                                             H                               Me        Me   Me       CH.sub.2 OMe     NO.sub.2                                                                             H                               Et        Me   Me       CH.sub.2 OMe     NO.sub.2                                                                             H                               Et        Me   Me       CH.sub.2 OEt     NO.sub. 2                                                                            H                               Pri       Me   Me       CH.sub.2 OMe     NO.sub.2                                                                             H                               Me        Me   Cl       CH.sub.2 OMe     NO.sub.2                                                                             H                               Et        Me   Cl       CH.sub.2 OMe     NO.sub.2                                                                             H                               Et        Me   Cl       CH.sub.2 OEt     NO.sub.2                                                                             H                               Et        Me   Cl       CHMeOMe          NO.sub.2                                                                             H                               Pri       Me   Cl       CH.sub.2 OMe     NO.sub.2                                                                             H                               Me        H    Me       CH.sub.2 OMe     CF.sub.3                                                                             H                               Me        H    Me       CH.sub.2 OEt     CF.sub.3                                                                             H                               Et        H    Me       CH.sub.2 OMe     CF.sub.3                                                                             H                               Et        H    Me       CH.sub.2 OEt     CF.sub.3                                                                             H                               Et        H    Me       CHMeOMe          CF.sub.3                                                                             H                               Pri       H    Me       CH.sub.2 OMe     CF.sub.3                                                                             H                               Pri       H    Me       CH.sub.2 OEt     CF.sub.3                                                                             H                               Me        H    Cl       CH.sub.2 OMe     CF.sub.3                                                                             H                               Me        H    Cl       CH.sub.2 OEt     CF.sub.3                                                                             H                               Et        H    Cl       CH.sub.2 OMe     CF.sub.3                                                                             H                               Et        H    Cl       CH.sub.2 OEt     CF.sub.3                                                                             H                               Et        H    Cl       CHMeOMe          CF.sub.3                                                                             H                               Pri       H    Cl       CH.sub.2 OMe     CF.sub.3                                                                             H                               Pri       H    Cl       CH.sub.2 OEt     CF.sub.3                                                                             H                               Me        Me   Me       CH.sub.2 OMe     CF.sub.3                                                                             H                               Et        Me   Me       CH.sub.2 OMe     CF.sub.3                                                                             H                               Et        Me   Me       CH.sub.2 OEt     CF.sub.3                                                                             H                               Pri       Me   Me       CH.sub.2 OMe     CF.sub.3                                                                             H                               Me        Me   Cl       CH.sub.2 OMe     CF.sub.3                                                                             H                               Et        Me   Cl       CH.sub.2 OMe     CF.sub.3                                                                             H                               Et        Me   Cl       CH.sub.2 OEt     CF.sub.3                                                                             H                               Et        Me   Cl       CHMeOMe          CF.sub.3                                                                             H                               Pri       Me   Cl       CH.sub.2 OMe     CF.sub.3                                                                             H                               Me        H    Me       CH.sub.2 OMe     CN    H                               Me        H    Me       CH.sub.2 OEt     CN    H                               Et        H    Me       CH.sub.2 OMe     CN    H                               Et        H    Me       CH.sub.2 OEt     CN    H                               Et        H    Me       CHMeOMe          CN    H                               Pri       H    Me       CH.sub.2 OMe     CN    H                               Pri       H    Me       CH.sub.2 OEt     CN    H                               Me        H    Cl       CH.sub.2 OMe     CN    H                               Me        H    Cl       CH.sub.2 OEt     CN    H                               Et        H    Cl       CH.sub.2 OMe     CN    H                               Et        H    Cl       CH.sub.2 OEt     CN    H                               Et        H    Cl       CHMeOMe          CN    H                               Pri       H    Cl       CH.sub.2 OMe     CN    H                               Pri       H    Cl       CH.sub.2 OEt     CN    H                               Me        Me   Me       CH.sub.2 OMe     CN    H                               Et        Me   Me       CH.sub.2 OMe     CN    H                               Et        Me   Me       CH.sub.2 OEt     CN    H                               Pr i      Me   Me       CH.sub.2 OMe     CN    H                               Me        Me   Cl       CH.sub.2 OMe     CN    H                               Et        Me   Cl       CH.sub.2 OMe     CN    H                               Et        Me   Cl       CH.sub.2 OEt     CN    H                               Et        Me   Cl       CHMeOMe          CN    H                               Pri       Me   Cl       CH.sub.2 OMe     CN    H                               Me        H    Me       CH.sub.2 OMe     OMe   H                               Me        H    Me       CH.sub.2 OEt     OMe   H                               Et        H    Me       CH.sub.2 OMe     OMe   H                               Et        H    Me       CH.sub.2 OEt     OMe   H                               Et        H    Me       CHMeOMe          OME   H                               Pri       H    Me       CH.sub.2 OMe     OMe   H                               Pri       H    Me       CH.sub.2 OEt     OMe   H                               Me        H    Cl       CH.sub.2 OMe     OMe   H                               Me        H    Cl       CH.sub.2 OEt     OMe   H                               Et        H    Cl       CH.sub.2 OMe     OMe   H                               Et        H    Cl       CH.sub.2 OEt     OMe   H                               Et        H    Cl       CHMeOMe          OMe   H                               Pri       H    Cl       CH.sub.2 OMe     OMe   H                               Pri       H    Cl       CH.sub.2 OEt     OMe   H                               Me        Me   Me       CH.sub.2 OMe     OMe   H                               Et        Me   Me       CH.sub.2 OMe     OMe   H                               Et        Me   Me       CH.sub.2 OEt     OMe   H                               Pri       Me   Me       CH.sub.2 OMe     OMe   H                               Me        Me   Cl       CH.sub.2 OMe     OMe   H                               Et        Me   Cl       CH.sub.2 OMe     OMe   H                               Et        Me   Cl       CH.sub.2 OEt     OMe   H                               Et        Me   Cl       CHMeOMe          OMe   H                               Pri       Me   Cl       CH.sub.2 OMe     OMe   H                               Me        H    Me       CH.sub.2 OMe     Br    H                               Me        H    Me       CH.sub.2 OEt     Br    H                               Et        H    Me       CH.sub.2 OMe     Br    H                               Et        H    Me       CH.sub.2 OEt     Br    H                               Et        H    Me       CHMeOMe          Br    H                               Pri       H    Me       CH.sub.2 OMe     Br    H                               Pri       H    Me       CH.sub.2 OEt     Br    H                               Me        H    Cl       CH.sub.2 OMe     Br    H                               Me        H    Cl       CH.sub.2 OEt     Br    H                               Et        H    Cl       CH.sub.2 OMe     Br    H                               Et        H    Cl       CH.sub.2 OEt     Br    H                               Et        H    Cl       CHMeOMe          Br    H                               Pri       H    Cl       CH.sub.2 OMe     Br    H                               Pri       H    Cl       CH.sub.2 OEt     Br    H                               Me        Me   Me       CH.sub.2 OMe     Br    H                               Et        Me   Me       CH.sub.2 OMe     Br    H                               Et        Me   Me       CH.sub.2 OEt     Br    H                               Pri       Me   Me       CH.sub.2 OMe     Br    H                               Me        Me   Cl       CH.sub.2 OMe     Br    H                               Et        Me   Cl       CH.sub.2 OMe     Br    H                               Et        Me   Cl       CH.sub.2 OEt     Br    H                               Et        Me   Cl       CHMeOMe          Br    H                               Pri       Me   Cl       CH.sub.2 OMe     Br    H                               Me        H    Me       CH.sub.2 OMe     I     H                               Me        H    Me       CH.sub.2 OEt     I     H                               Et        H    Me       CH.sub.2 OMe     I     H                               Et        H    Me       CH.sub.2 OEt     I     H                               Et        H    Me       CHMeOMe          I     H                               Pri       H    Me       CH.sub.2 OMe     I     H                               Pri       H    Me       CH.sub.2 OEt     I     H                               Me        H    Cl       CH.sub.2 OMe     I     H                               Me        H    Cl       CH.sub.2 OEt     I     H                               Et        H    Cl       CH.sub.2 OMe     I     H                               Et        H    Cl       CH.sub.2 OEt     I     H                               Et        H    Cl       CHMeOMe          I     H                               Pri       H    Cl       CH.sub.2 OMe     I     H                               Pri       H    Cl       CH.sub.2 OEt     I     H                               Me        Me   Me       CH.sub.2 OMe     I     H                               Et        Me   Me       CH.sub.2 OMe     I     H                               Et        Me   Me       CH.sub.2 OEt     I     H                               Pri       Me   Me       CH.sub.2 OMe     I     H                               Me        Me   Cl       CH.sub.2 OMe     I     H                               Et        Me   Cl       CH.sub.2 OMe     I     H                               Et        Me   Cl       CH.sub.2 OEt     I     H                               Et        Me   Cl       CHMeOMe          I     H                               Pri       Me   Cl       CH.sub.2 OMe     I     H                               Me        H    Me       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Me        H    Me       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Et        H    Me       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Et        H    Me       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Et        H    Me       CHMeOMe          SCF.sub.3                                                                            H                               Pri       H    Me       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Pri       H    Me       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Me        H    Cl       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Me        H    Cl       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Et        H    Cl       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Et        H    Cl       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Et        H    Cl       CHMeOMe          SCF.sub.3                                                                            H                               Pri       H    Cl       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Pri       H    Cl       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Me        Me   Me       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Et        Me   Me       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Et        Me   Me       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Pri       Me   Me       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Me        Me   Cl       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Et        Me   Cl       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Et        Me   Cl       CH.sub.2 OEt     SCF.sub.3                                                                            H                               Et        Me   Cl       CHMeOMe          SCF.sub.3                                                                            H                               Pri       Me   Cl       CH.sub.2 OMe     SCF.sub.3                                                                            H                               Me        H    Me       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Me        H    Me       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Et        H    Me       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Et        H    Me       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Et        H    Me       CHMeOMe          SO.sub.2 CF.sub.3                                                                    H                               Pri       H    Me       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Pri       H    Me       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Me        H    Cl       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Me        H    Cl       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Et        H    Cl       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Et        H    Cl       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Et        H    Cl       CHMeOMe          SO.sub.2 CF.sub.3                                                                    H                               Pri       H    Cl       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Pri       H    Cl       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Me        Me   Me       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Et        Me   Me       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Et        Me   Me       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Pri       Me   Me       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Me        Me   Cl       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Et        Me   Cl       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Et        Me   Cl       CH.sub.2 OEt     SO.sub.2 CF.sub.3                                                                    H                               Et        Me   Cl       CHMeOMe          SO.sub.2 CF.sub.3                                                                    H                               Pri       Me   Cl       CH.sub.2 OMe     SO.sub.2 CF.sub.3                                                                    H                               Me        H    Me       COOMe            Ms    Na                              Me        H    Me       COOMe            Ms    K                               Me        H    Me       COOMe            Ms    Ca.sub.1/2                      Me        H    Me       COOMe            Ms    Mg.sub.1/2                      Me        H    Me       COOMe            Ms    EtN.sup.+  H.sub.3              Me        H    Me       COOMe            Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       COOMe            Ms    Na                              Et        H    Me       COOMe            Ms    K                               Et        H    Me       COOMe            Ms    Ca.sub.1/2                      Et        H    Me       COOMe            Ms    Mg.sub.1/2                      Et        H    Me       COOMe            Ms    EtN.sup.+  H.sub.3              Et        H    Me       COOMe            Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       COOMe            Ms    Et.sub.2 N.sup.+  H.sub.                                                       2                               Et        H    Me       COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       COOMe            Ms    Na                              i-Pr      H    Me       COOMe            Ms    K                               i-Pr      H    Me       COOMe            Ms    Ca.sub.1/2                      i-Pr      H    Me       COOMe            Ms    Mg.sub.1/2                      i-Pr      H    Me       COOMe            Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       COOMe            Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       COOMe            Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       COOMe            Ms    Na                              Et        Me   Me       COOMe            Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       COOMe            Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOMe            Ms    Na                              Me        H    Cl       COOMe            Ms    K                               Me        H    Cl       COOMe            Ms    Ca.sub.1/2                      Me        H    Cl       COOMe            Ms    Mg.sub.1/2                      Me        H    Cl       COOMe            Ms    EtN.sup.+  H.sub.3              Me        H    Cl       COOMe            Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       COOMe            Ms    Na                              Et        H    Cl       COOMe            Ms    K                               Et        H    Cl       COOMe            Ms    Ca.sub.1/2                      Et        H    Cl       COOMe            Ms    Mg.sub.1/2                      Et        H    Cl       COOMe            Ms    EtN.sup.+  H.sub.3              Et        H    Cl       COOMe            Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       COOMe            Ms    Na                              i-Pr      H    Cl       COOMe            Ms    K                               i-Pr      H    Cl       COOMe            Ms    Ca.sub.1/2                      i-Pr      H    Cl       COOMe            Ms    Mg.sub.1/2                      i-Pr      H    Cl       COOMe            Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       COOMe            Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       COOMe            Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       COOMe            Ms    Na                              Et        Me   Cl       COOMe            Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       COOMe            Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOMe            Ms    Na                              Me        H    OMe      COOMe            Ms    K                               Me        H    OMe      COOMe            Ms    Ca1/2                           Me        H    OMe      COOMe            Ms    Mg.sub.1/2                      Me        H    OMe      COOMe            Ms    EtN.sup.+  H.sub.3              Me        H    OMe      COOMe            Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      COOMe            Ms    Na                              Et        H    OMe      COOMe            Ms    K                               Et        H    OMe      COOMe            Ms    Ca.sub.1/2                      Et        H    OMe      COOMe            Ms    Mg.sub.1/2                      Et        H    OMe      COOMe            Ms    EtN.sup.+  H.sub.3              Et        H    OMe      COOMe            Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      COOMe            Ms    Na                              i-Pr      H    OMe      COOMe            Ms    K                               i-Pr      H    OMe      COOMe            Ms    Ca.sub.1/2                      i-Pr      H    OMe      COOMe            Ms    Mg.sub.1/2                      i-Pr      H    OMe      COOMe            Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      COOMe            Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      COOMe            Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      COOMe            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                

                                      TABLE 5                                      __________________________________________________________________________      ##STR48##                                                                     A         B    X        Y                Z     Q                               __________________________________________________________________________     Et        Me   OMe      COOMe            Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOEt            Ms    Na                              Me        H    Me       COOEt            Ms    K                               Me        H    Me       COOEt            Ms    Ca.sub.1/2                      Me        H    Me       COOEt            Ms    Mg.sub.1/2                      Me        H    Me       COOEt            Ms    EtN.sup.+  H.sub.3              Me        H    Me       COOEt            Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       COOEt            Ms    Na                              Et        H    Me       COOEt            Ms    K                               Et        H    Me       COOEt            Ms    Ca.sub.1/2                      Et        H    Me       COOEt            Ms    Mg.sub.1/2                      Et        H    Me       COOEt            Ms    EtN.sup. +  H.sub.3             Et        H    Me       COOEt            Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       COOEt            Ms    Na                              i-Pr      H    Me       COOEt            Ms    K                               i-Pr      H    Me       COOEt            Ms    Ca.sub.1/2                      i-Pr      H    Me       COOEt            Ms    Mg.sub.1/2                      i-Pr      H    Me       COOEt            Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       COOEt            Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       COOEt            Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       COOEt            Ms    Na                              Et        Me   Me       COOEt            Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       COOEt            Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOEt            Ms    Na                              Me        H    Cl       COOEt            Ms    K                               Me        H    Cl       COOEt            Ms    Ca.sub.1/2                      Me        H    Cl       COOEt            Ms    Mg.sub.1/2                      Me        H    Cl       COOEt            Ms    EtN.sup.+   H.sub.3             Me        H    Cl       COOEt            Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       COOEt            Ms    Na                              Et        H    Cl       COOEt            Ms    K                               Et        H    Cl       COOEt            Ms    Ca.sub.1/2                      Et        H    Cl       COOEt            Ms    Mg.sub.1/2                      Et        H    Cl       COOEt            Ms    EtN.sup.+  H.sub.3              Et        H    Cl       COOEt            Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       COOEt            Ms    Na                              i-Pr      H    Cl       COOEt            Ms    K                               i-Pr      H    Cl       COOEt            Ms    Ca.sub.1/2                      i-Pr      H    Cl       COOEt            Ms    Mg.sub.1/2                      i-Pr      H    Cl       COOEt            Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       COOEt            Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       COOEt            Ms    Et.sub.2 N.sup.+  H.sub.3       i-Pr      H    Cl       COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       COOEt            Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       COOEt            Ms    Na                              Et        Me   Cl       COOEt            Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       COOEt            Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOEt            Ms    Na                              Me        H    OMe      COOEt            Ms    K                               Me        H    OMe      COOEt            Ms    Ca.sub.1/2                      Me        H    OMe      COOEt            Ms    Mg.sub.1/2                      Me        H    OMe      COOEt            Ms    EtN.sup.+  H.sub.3              Me        H    OMe      COOEt            Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      COOEt            Ms    Na                              Et        H    OMe      COOEt            Ms    K                               Et        H    OMe      COOEt            Ms    Ca.sub.1/2                      Et        H    OMe      COOEt            Ms    Mg.sub.1/2                      Et        H    OMe      COOEt            Ms    EtN.sup.+  H.sub.3              Et        H    OMe      COOEt            Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      COOEt            Ms    Na                              i-Pr      H    OMe      COOEt            Ms    K                               i-Pr      H    OMe      COOEt            Ms    Ca.sub.1/2                      i-Pr      H    OMe      COOEt            Ms    Mg.sub.1/2                      i-Pr      H    OMe      COOEt            Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      COOEt            Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      COOEt            Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      COOEt            Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        Me   OMe      COOEt            Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOPri           Ms    Na                              Me        H    Me       COOPri           Ms    K                               Me        H    Me       COOPri           Ms    Ca.sub.1/2                      Me        H    Me       COOPri           Ms    Mg.sub.1/2                      Me        H    Me       COOPri           Ms    EtN.sup.+  H.sub.3              Me        H    Me       COOPri           Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       COOPri           Ms    Na                              Et        H    Me       COOPri           Ms    K                               Et        H    Me       COOPri           Ms    Ca.sub.1/2                      Et        H    Me       COOPri           Ms    Mg.sub.1/2                      Et        H    Me       COOPri           Ms    EtN.sup.+  H.sub.3              Et        H    Me       COOPri           Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       COOPri           Ms    Na                              i-Pr      H    Me       COOPri           Ms    K                               i-Pr      H    Me       COOPri           Ms    Ca.sub.1/2                      i-Pr      H    Me       COOPri           Ms    Mg.sub.1/2                      i-Pr      H    Me       COOPri           Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       COOPri           Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       COOPri           Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       COOPri           Ms    Na                              Et        Me   Me       COOPri           Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       COOPri           Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOPri           Ms    Na                              Me        H    Cl       COOPri           Ms    K                               Me        H    Cl       COOPri           Ms    Ca.sub.1/2                      Me        H    Cl       COOPri           Ms    Mg.sub.1/2                      Me        H    Cl       COOPri           Ms    EtN.sup.+  H.sub.3              Me        H    Cl       COOPri           Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       COOPri           Ms    Na                              Et        H    Cl       COOPri           Ms    K                               Et        H    Cl       COOPri           Ms    Ca.sub.1/2                      Et        H    Cl       COOPri           Ms    Mg.sub.1/2                      Et        H    Cl       COOPri           Ms    EtN.sup.+  H.sub.3              Et        H    Cl       COOPri           Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       COOPri           Ms    Na                              i-Pr      H    Cl       COOPri           Ms    K                               i-Pr      H    Cl       COOPri           Ms    Ca.sub.1/2                      i-Pr      H    Cl       COOPri           Ms    Mg.sub.1/2                      i-Pr      H    Cl       COOPri           Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       COOPri           Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       COOPri           Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       COOPri           Ms    Na                              Et        Me   Cl       COOPri           Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       COOPri           Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOPri           Ms    Na                              Me        H    OMe      COOPri           Ms    K                               Me        H    OMe      COOPri           Ms    Ca.sub.1/2                      Me        H    OMe      COOPri           Ms    Mg.sub.1/2                      Me        H    OMe      COOPri           Ms    EtN.sup.+ 0 H.sub.3             Me        H    OMe      COOPri           Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      COOPri           Ms    Na                              Et        H    OMe      COOPri           Ms    K                               Et        H    OMe      COOPr i          Ms    Ca.sub.1/2                      Et        H    OMe      COOPri           Ms    Mg.sub.1/2                      Et        H    OMe      COOPri           Ms    EtN.sup.+  H.sub.3              Et        H    OMe      COOPri           Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      COOPri           Ms    Na                              i-Pr      H    OMe      COOPri           Ms    K                               i-Pr      H    OMe      COOPri           Ms    Ca.sub.1/2                      i-Pr      H    OMe      COOPri           Ms    Mg.sub.1/2                      i-Pr      H    OMe      COOPri           Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      COOPri           Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      COOPri           Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      COOPri           Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        Me   OMe      COOPri           Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Et        Me   Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Et        Me   Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Na                              i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    K                               i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Ca.sub.1/2                      i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Mg.sub.1/2                      i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        Me   OMe      COOCH.sub.2 CH.sub.2 OMe                                                                        Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CH.sub.2 OMe     Ms    Na                              Me        H    Me       CH.sub.2 OMe     Ms    K                               Me        H    Me       CH.sub.2 OMe     Ms    Ca.sub.1/2                      Me        H    Me       CH.sub.2 OMe     Ms    Mg.sub.1/2                      Me        H    Me       CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              Me        H    Me       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       CH.sub.2 OMe     Ms    Na                              Et        H    Me       CH.sub.2 OMe     Ms    K                               Et        H    Me       CH.sub.2 OMe     Ms    Ca.sub.1/2                      Et        H    Me       CH.sub.2 OMe     Ms    Mg.sub.1/2                      Et        H    Me       CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              Et        H    Me       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       CH.sub.2 OMe     Ms    Na                              i-Pr      H    Me       CH.sub.2 OMe     Ms    K                               i-Pr      H    Me       CH.sub.2 OMe     Ms    Ca.sub.1/2                      i-Pr      H    Me       CH.sub.2 OMe     Ms    Mg.sub.1/2                      i-Pr      H    Me       CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       CH.sub.2 OMe     Ms    Na                              Et        Me   Me       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CH.sub.2 OMe     Ms    Na                              Me        H    Cl       CH.sub.2 OMe     Ms    K                               Me        H    Cl       CH.sub.2 OMe     Ms    Ca.sub.1/2                      Me        H    Cl       CH.sub.2 OMe     Ms    Mg.sub.1/2                      Me        H    Cl       CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              Me        H    Cl       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       CH.sub.2 OMe     Ms    Na                              Et        H    Cl       CH.sub.2 OMe     Ms    K                               Et        H    Cl       CH.sub.2 OMe     Ms    Ca.sub.1/2                      Et        H    Cl       CH.sub.2 OMe     Ms    Mg.sub.1/2                      Et        H    Cl       CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              Et        H    Cl       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       CH.sub. 2 OMe    Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       CH.sub.2 OMe     Ms    Na                              i-Pr      H    Cl       CH.sub.2 OMe     Ms    K                               i-Pr      H    Cl       CH.sub.2 OMe     Ms    Ca.sub.1/2                      i-Pr      H    Cl       CH.sub.2 OMe     Ms    Mg.sub.1/2                      i-Pr      H    Cl       CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       CH.sub.2 OMe     Ms    Na                              Et        Me   Cl       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CH.sub.2 OMe     Ms    Na                              Me        H    OMe      CH.sub.2 OMe     Ms    K                               Me        H    OMe      CH.sub.2 OMe     Ms    Ca.sub.1/2                      Me        H    OMe      CH.sub.2 OMe     Ms    Mg.sub.1/2                      Me        H    OMe      CH.sub.2 OMe     Ms    EtN.sup. +  H.sub.3             Me        H    OMe      CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      CH.sub.2 OMe     Ms    Na                              Et        H    OMe      CH.sub.2 OMe     Ms    K                               Et        H    OMe      CH.sub.2 OMe     Ms    Ca.sub.1/2                      Et        H    OMe      CH.sub.2 OMe     Ms    Mg.sub.1/2                      Et        H    OMe      CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              Et        H    OMe      CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      CH.sub.2 OMe     Ms    Na                              i-Pr      H    OMe      CH.sub.2 OMe     Ms    K                               i-Pr      H    OMe      CH.sub.2 OMe     Ms    Ca.sub.1/2                      i-Pr      H    OMe      CH.sub.2 OMe     Ms    Mg.sub.1/2                      i-Pr      H    OMe      CH.sub.2 OMe     Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      CH.sub.2 OMe     Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      CH.sub.2 OMe     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        Me   OMe      CH.sub.2 OMe     Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CH.sub.2 OEt     Ms    Na                              Me        H    Me       CH.sub.2 OEt     Ms    K                               Me        H    Me       CH.sub.2 OEt     Ms    Ca.sub.1/2                      Me        H    Me       CH.sub.2 OEt     Ms    Mg.sub.1/2                      Me        H    Me       CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              Me        H    Me       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       CH.sub.2 OEt     Ms    Na                              Et        H    Me       CH.sub.2 OEt     Ms    K                               Et        H    Me       CH.sub.2 OEt     Ms    Ca.sub.1/2                      Et        H    Me       CH.sub.2 OEt     Ms    Mg.sub.1/2                      Et        H    Me       CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              Et        H    Me       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       CH.sub.2 OEt     Ms    Na                              i-Pr      H    Me       CH.sub.2 OEt     Ms    K                               i-Pr      H    Me       CH.sub.2 OEt     Ms    Ca.sub.1/2                      i-Pr      H    Me       CH.sub.2 OEt     Ms    Mg.sub.1/2                      i-Pr      H    Me       CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       CH.sub.2 OEt     Ms    Na                              Et        Me   Me       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CH.sub.2 OEt     Ms    Na                              Me        H    Cl       CH.sub.2 OEt     Ms    K                               Me        H    Cl       CH.sub.2 OEt     Ms    Ca.sub.1/2                      Me        H    Cl       CH.sub.2 OEt     Ms    Mg.sub.1/2                      Me        H    Cl       CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              Me        H    Cl       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       CH.sub.2 OEt     Ms    Na                              Et        H    Cl       CH.sub.2 OEt     Ms    K                               Et        H    Cl       CH.sub.2 OEt     Ms    Ca.sub.1/2                      Et        H    Cl       CH.sub.2 OEt     Ms    Mg.sub.1/2                      Et        H    Cl       CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              Et        H    Cl       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       CH.sub.2 OEt     Ms    Na                              i-Pr      H    Cl       CH.sub.2 OEt     Ms    K                               i-Pr      H    Cl       CH.sub.2 OEt     Ms    Ca.sub. 1/2                     i-Pr      H    Cl       CH.sub.2 OEt     Ms    Mg.sub.1/2                      i-Pr      H    Cl       CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       CH.sub.2 OEt     Ms    Na                              Et        Me   Cl       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CH.sub.2 OEt     Ms    Na                              Me        H    OMe      CH.sub.2 OEt     Ms    K                               Me        H    OMe      CH.sub.2 OEt     Ms    Ca.sub.1/2                      Me        H    OMe      CH.sub.2 OEt     Ms    Mg.sub.1/2                      Me        H    OMe      CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              Me        H    OMe      CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      CH.sub.2 OEt     Ms    Na                              Et        H    OMe      CH.sub.2 OEt     Ms    K                               Et        H    OMe      CH.sub.2 OEt     Ms    Ca.sub.1/2                      Et        H    OMe      CH.sub.2 OEt     Ms    Mg.sub.1/2                      Et        H    OMe      CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              Et        H    OMe      CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      CH.sub.2 OEt     Ms    Na                              i-Pr      H    OMe      CH.sub.2 OEt     Ms    K                               i-Pr      H    OMe      CH.sub.2 OEt     Ms    Ca.sub.1/2                      i-Pr      H    OMe      CH.sub.2 OEt     Ms    Mg.sub.1/2                      i-Pr      H    OMe      CH.sub.2 OEt     Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      CH.sub.2 OEt     Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      CH.sub.2 OEt     Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        Me   OMe      CH.sub.2 OEt     Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CHMeOMe          Ms    Na                              Me        H    Me       CHMeOMe          Ms    K                               Me        H    Me       CHMeOMe          Ms    Ca.sub.1/2                      Me        H    Me       CHMeOMe          Ms    Mg.sub.1/2                      Me        H    Me       CHMeOMe          Ms    EtN.sup.+  H.sub.3              Me        H    Me       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       CHMeOMe          Ms    Na                              Et        H    Me       CHMeOMe          Ms    K                               Et        H    Me       CHMeOMe          Ms    Ca.sub.1/2                      Et        H    Me       CHMeOMe          Ms    Mg.sub.1/2                      Et        H    Me       CHMeOMe          Ms    EtN.sup.+  H.sub.3              Et        H    Me       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       CHMeOMe          Ms    Na                              i-Pr      H    Me       CHMeOMe          Ms    K                               i-Pr      H    Me       CHMeOMe          Ms    Ca.sub.1/2                      i-Pr      H    Me       CHMeOMe          Ms    Mg.sub. 1/2                     i-Pr      H    Me       CHMeOMe          Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       CHMeOMe          Ms    Na                              Et        Me   Me       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CHMeOMe          Ms    Na                              Me        H    Cl       CHMeOMe          Ms    K                               Me        H    Cl       CHMeOMe          Ms    Ca.sub.1/2                      Me        H    Cl       CHMeOMe          Ms    Mg.sub.1/2                      Me        H    Cl       CHMeOMe          Ms    EtN.sup.+  H.sub.3              Me        H    Cl       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       CHMeOMe          Ms    Na                              Et        H    Cl       CHMeOMe          Ms    K                               Et        H    Cl       CHMeOMe          Ms    Ca.sub.1/2                      Et        H    Cl       CHMeOMe          Ms    Mg.sub.1/2                      Et        H    Cl       CHMeOMe          Ms    EtN.sup.+  H.sub.3              Et        H    Cl       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       CHMeOMe          Ms    Na                              i-Pr      H    Cl       CHMeOMe          Ms    K                               i-Pr      H    Cl       CHMeOMe          Ms    Ca.sub.1/2                      i-Pr      H    Cl       CHMeOMe          Ms    Mg.sub.1/2                      i-Pr      H    Cl       CHMeOMe          Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       CHMeOMe          Ms    Na                              Et        Me   Cl       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CHMeOMe          Ms    Na                              Me        H    OMe      CHMeOMe          Ms    K                               Me        H    OMe      CHMeOMe          Ms    Ca.sub.1/2                      Me        H    OMe      CHMeOMe          Ms    Mg.sub.1/2                      Me        H    OMe      CHMeOMe          Ms    EtN.sup.+  H.sub.3              Me        H    OMe      CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      CHMeOMe          Ms    Na                              Et        H    OMe      CHMeOMe          Ms    K                               Et        H    OMe      CHMeOMe          Ms    Ca.sub.1/2                      Et        H    OMe      CHMeOMe          Ms    Mg.sub.1/2                      Et        H    OMe      CHMeOMe          Ms    EtN.sup.+  H.sub.3              Et        H    OMe      CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      CHMeOMe          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      CHMeOMe          Ms    Na                              i-Pr      H    OMe      CHMeOMe          Ms    K                               i-Pr      H    OMe      CHMeOMe          Ms    Ca.sub.1/2                      i-Pr      H    OMe      CHMeOMe          Ms    Mg.sub.1/2                      i-Pr      H    OMe      CHMeOMe          Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      CHMeOMe          Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      CHMeOMe          Ms    Me.sub.3 N.sup.+                                                               CH.sub.2 CH.sub.2 OH            Et        Me   OMe      CHMeOMe          Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CHMeOEt          Ms    Na                              Me        H    Me       CHMeOEt          Ms    K                               Me        H    Me       CHMeOEt          Ms    Ca.sub.1/2                      Me        H    Me       CHMeOEt          Ms    Mg.sub.1/2                      Me        H    Me       CHMeOEt          Ms    EtN.sup.+  H.sub.3              Me        H    Me       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Me        H    Me       CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Me       CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Me       CHMeOEt          Ms    Na                              Et        H    Me       CHMeOEt          Ms    K                               Et        H    Me       CHMeOEt          Ms    Ca.sub.1/2                      Et        H    Me       CHMeOEt          Ms    Mg.sub.1/2                      Et        H    Me       CHMeOEt          Ms    EtN.sup.+  H.sub.3              Et        H    Me       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Et        H    Me       CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Me       CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Me       CHMeOEt          Ms    Na                              i-Pr      H    Me       CHMeOEt          Ms    K                               i-Pr      H    Me       CHMeOEt          Ms    Ca.sub.1/2                      i-Pr      H    Me       CHMeOEt          Ms    Mg.sub. 1/2                     i-Pr      H    Me       CHMeOEt          Ms    EtN.sup.+  H.sub.3              i-Pr      H    Me       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Me       CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Me       CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Me       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Et        Me   Me       CHMeOEt          Ms    Na                              Et        Me   Me       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Me       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CHMeOEt          Ms    Na                              Me        H    Cl       CHMeOEt          Ms    K                               Me        H    Cl       CHMeOEt          Ms    Ca.sub.1/2                      Me        H    Cl       CHMeOEt          Ms    Mg.sub.1/2                      Me        H    Cl       CHMeOEt          Ms    EtN.sup.+  H.sub.3              Me        H    Cl       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Me        H    Cl       CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    Cl       CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    Cl       CHMeOEt          Ms    Na                              Et        H    Cl       CHMeOEt          Ms    K                               Et        H    Cl       CHMeOEt          Ms    Ca.sub.1/2                      Et        H    Cl       CHMeOEt          Ms    Mg.sub.1/2                      Et        H    Cl       CHMeOEt          Ms    EtN.sup.+  H.sub.3              Et        H    Cl       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Et        H    Cl       CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    Cl       CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    Cl       CHMeOEt          Ms    Na                              i-Pr      H    Cl       CHMeOEt          Ms    K                               i-Pr      H    Cl       CHMeOEt          Ms    Ca.sub.1/2                      i-Pr      H    Cl       CHMeOEt          Ms    Mg.sub.1/2                      i-Pr      H    Cl       CHMeOEt          Ms    EtN.sup.+  H.sub.3              i-Pr      H    Cl       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    Cl       CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    Cl       CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Me        Me   Cl       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Et        Me   Cl       CHMeOEt          Ms    Na                              Et        Me   Cl       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            i-Pr      Me   Cl       CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CHMeOEt          Ms    Na                              Me        H    OMe      CHMeOEt          Ms    K                               Me        H    OMe      CHMeOEt          Ms    Ca.sub.1/2                      Me        H    OMe      CHMeOEt          Ms    Mg.sub.1/2                      Me        H    OMe      CHMeOEt          Ms    EtN.sup.+  H.sub.3              Me        H    OMe      CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Me        H    OMe      CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       Me        H    OMe      CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     Et        H    OMe      CHMeOEt          Ms    Na                              Et        H    OMe      CHMeOEt          Ms    K                               Et        H    OMe      CHMeOEt          Ms    Ca.sub.1/2                      Et        H    OMe      CHMeOEt          Ms    Mg.sub.1/2                      Et        H    OMe      CHMeOEt          Ms    EtN.sup.+  H.sub.3              Et        H    OMe      CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            Et        H    OMe      CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       Et        H    OMe      CHMeOEt          Ms    Me.sub.3 N.sup.+  CH.sub.2                                                     CH.sub.2 OH                     i-Pr      H    OMe      CHMeOEt          Ms    Na                              i-Pr      H    OMe      CHMeOEt          Ms    K                               i-Pr      H    OMe      CHMeOEt          Ms    Ca.sub.1/2                      i-Pr      H    OMe      CHMeOEt          Ms    Mg.sub.1/2                      i-Pr      H    OMe      CHMeOEt          Ms    EtN.sup.+  H.sub.3              i-Pr      H    OMe      CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            i-Pr      H    OMe      CHMeOEt          Ms    Et.sub.2 N.sup.+  H.sub.2       i-Pr      H    OMe      CHMeOEt          Ms    Me.sub.3 N.sup.+                                                               CH.sub.2 CH.sub.2 OH            Et        Me   OMe      CHMeOEt          Ms    i-PrN.sup.+  H.sub.3            __________________________________________________________________________

When the compound of the present invention is to be used as an agricultural or horticultural herbicide, it is usually mixed with a suitable carrier, for instance, a solid carrier such as clay, talc, bentonite or diatomaceous earth, or a liquid carrier such as water, an alcohol (such as methanol or ethanol), an aromatic hydrocarbon (such as benzene, toluene or xylene), a chlorinated hydrocarbon, an ether, a ketone, an ester (such as ethyl acetate) or an acid amide (such as dimethylformamide). If desired, an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader or a stabilizer may be added to prepare an optional formulation such as a liquid formulation, an emulsifiable concentrate, a wettable powder, a dust, a granule or a flowable.

Further, if desired, other herbicides, various insecticides, bacteriocides, plant regulating agents or synergism agents may be combined at the time of the preparation of the formulations or at a time of the application of the herbicides.

As other herbicides to be combined with the herbicide of the present invention, there may be mentioned, for instance, compounds disclosed in Farm Chemicals Handbook, the 73rd Edition (1987). Among them, there may be mentioned, for example, atrazine, cyanazine, alachlor, metolachlor, EPTC, 2,4-D, butylate, dicamba, bromoxynil and tridiphane. Further, N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide or N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-bromo-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide as disclosed in U.S. Pat. No. 4,668,277 may also be combined with the herbicide of the present invention.

The dose varies depending upon the application site, the season for application, the method for application, the type of the crop plant, etc. In general, however, the dose is usually within a range of from 0.001 to 10 kg per hectare as the amount of the active ingredient.

Now, Formulation Examples of the herbicides containing the compounds of the present invention as active ingredients, will be given. However, it should be understood that the present invention is by no means restricted to such specific Examples. In the following Formulation Examples, "parts" means "parts by weight".

    ______________________________________                                         FORMULATION EXAMPLE 1: Wettable powder                                         ______________________________________                                         Compound No. 3 of the present invention                                                                    60 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  33 parts                                           clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of                                      a surfactant and fine silica powder,                                           manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

    ______________________________________                                         FORMULATION EXAMPLE 2: Wettable powder                                         Compound No. 7 of the present invention                                                                    60 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  33 parts                                           clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of                                      a surfactant and fine silica powder,                                           manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     FORMULATION EXAMPLE 3: Wettable powder                                         Compound No. 15 of the present invention                                                                   60 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  33 parts                                           clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of                                      a surfactant and fine silica powder,                                           manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     FORMULATION EXAMPLE 4: Wettable powder                                         Compound No. 21 of the present invention                                                                   60 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  33 parts                                           clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of                                      a surfactant and fine silica powder,                                           manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     FORMULATION EXAMPLE 5: Wettable powder                                         Compound No. 25 of the present invention                                                                   60 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  33 parts                                           clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of                                      a surfactant and fine silica powder,                                           manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     FORMULATION EXAMPLE 6: Wettable powder                                         Compound No. 35 of the present invention                                                                   60 parts                                           Zeeklite PFP (tradename for a kaolin-type                                                                  33 parts                                           clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                  5 parts                                            nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                      2 parts                                            preventing agent composed of a mixture of                                      a surfactant and fine silica powder,                                           manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     FORMULATION EXAMPLE 7: Emulsifiable concentrate                                Compound No. 3 of the present invention                                                                    1.5 parts                                          Xylene                      78.5 parts                                         N,N--dimethylformamide      15 parts                                           Sorpol 2680 (tradename for a mixture of                                                                    5 parts                                            a nonionic surfactant and an anionic                                           surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously mixed to obtain an emulsifiable concentrate.

    ______________________________________                                         FORMULATION EXAMPLE 8: Emulsifiable concentrate                                Compound No. 11 of the present invention                                                                   1.5 parts                                          Xylene                      78.5 parts                                         N,N--dimethylformamide      15 parts                                           Sorpol 2680 (tradename for a mixture of                                                                    5 parts                                            a nonionic surfactant and an anionic                                           surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     FORMULATION EXAMPLE 9: Flowable                                                Compuund No. 3 of the present invention                                                                    40 parts                                           Agrizole B-710 (tradename for a nonionic                                                                   10 parts                                           surfactant, manufactured by Kao Corporation)                                   Runox 1000C (tradename for an anionic                                                                      0.5 part                                           surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     1% Rodopol water (tradename for a                                                                          20 parts                                           thickener, manufactured by Rhone-Poulenc)                                      Water                       29.5 parts                                         ______________________________________                                    

The above ingredients are homogeneously mixed to form a flowable.

    ______________________________________                                         FORMULATION EXAMPLE 10: Flowable                                               Compound No. 10 of the present invention                                                                   40 parts                                           Agrizole B-710 (tradename for a nonionic                                                                   10 parts                                           surfactant, manufactured by Kao Corporation)                                   Runox 1000C (tradename for an anionic                                                                      0.5 part                                           surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     1% Rodopol water (tradename for a                                                                          20 parts                                           thickener, manufactured by Rhone-Poulenc)                                      Water                       29.5 parts                                         FORMULATION EXAMPLE 11: Liquid formulation                                     Compound No. 39 of the present invention                                                                   30 parts                                           Nippol (tradename for a nonionic surfactant,                                                               10 parts                                           manufactured by Nissan Chemical Industries,                                    Ltd.)                                                                          Water                       60 parts                                           ______________________________________                                    

The above ingredients are homogeneously mixed to obtain a liquid formulation.

    ______________________________________                                         FORMULATION EXAMPLE 12: Liquid formulation                                     Compound No. 40 of the present invention                                                                   30 parts                                           Nippol (tradename for a nonionic surfactant,                                   manufactured by Nissan Chemical Industries,                                    Ltd.)                       10 parts                                           Water                       60 parts                                           FORMULATION EXAMPLE 13: Liquid formulation                                     Compound No. 46 of the present invention                                                                   30 parts                                           Nippol (tradename for a nonionic surfactant,                                   manufactured by Nissan Chemical Industries,                                    Ltd.)                       10 parts                                           Water                       60 parts                                           FORMULATION EXAMPLE 14: Liquid formulation                                     Compound No. 41 of the present invention                                                                   10 parts                                           Sorpol W-150 (tradename for a nonionic                                         surfactant, manufactured by Toho                                               Chemical Co., Ltd.)         10 parts                                           Water                       80 parts                                           ______________________________________                                    

The above ingredients are homogeneously mixed to form a liquid formulation.

In their use, the above wettable powders, emulsifiable concentrates, flowables or liquid formulations are diluted with water from 50 to 1,000 times and applied so that the respective active ingredients will be from 0.001 to 5 kg per hectare.

The compounds of the present invention are applicable not only to agricultural and horticultural fields such as upland fields, paddy fields and orchards, but to non-agricultural fields such as athletic fields, vacant fields and railway sides for the control of various weeds. The dose in their application varies depending upon the application site, the season for application, the type of crop plants, etc. However, it is usually within a range of from 0.001 to 5 kg per hectare.

Now, the herbicidal activities of the compounds of the present invention will be described with respect to specific Test Examples.

TEST EXAMPLE 1 Test on the herbicidal effects in soil treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds Echinochloa crus-galli, Setaria viridis, Eleusine indica, Digitaria adscendens, Panicum dichotomiflorum, Abutilon theophrasti, Amaranthus lividus, Polygonum longisetum and Zea mays were sown, and tubers of Cyperus esculentus were further planted. The soil was covered thereon in the thickness of about 1.5 cm, and then a herbicide solution was applied onto the surface of the soil uniformly so that the active ingredient is distributed at a predetermined concentration. The herbicide solution was prepared by diluting the wettable powder, the emulsifiable concentrate, the liquid formulation or the flowable as described in the foregoing Formulation Examples with water and applied onto the entire soil surface by means of a small spray. Three weeks after the application of the herbicidal solution, the herbicidal effects against each weed were determined on the basis of the following standard ratings. The results thereby obtained are shown in Table 6. The Compounds Nos. correspond to the Compound Nos. in Table 3.

Standard ratings:

5: Growth control rate of more than 90% (almost completely withered)

4: Growth control rate of from 70 to 90%

3: Growth control rate of from 40 to 70%

2: Growth control rate of from 20 to 40%

1: Growth control rate of from 5 to 20%

0: Growth control rate of less than 5% (almost non-effective)

The above growth control rates were calculated by the following equation:

    Growth control rate (%)=(1-T/N)×100

where:

T: Weight of the weed growth above the soil surface of the treated area

N: Weight of the weed grown above the soil surface of the non-treated area

TEST EXAMPLE 2 Test on the herbicidal effects in foliage treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Setaria viridis, Eleusine indica, Digitaria adscendens, Panicum dichotomiflorum, Xanthium strumarium, Abutilon theophrasti, Amaranthus lividus, Polygonum longisetum and Zea mays were spot-wisely sown, and tubers of Cyperus esculentus were further planted. Then, the soil was covered thereon in a thickness of about 1.5 cm. When the various weeds and crops grew to the 2 or 3 leaf stage, a herbicidal solution was uniformly sprayed on the foliages so that the active ingredient is applied in a predetermined concentration.

The herbicidal solution was prepared by diluting the wettable powder, the emulsifiable concentrate, the liquid formulation or the flowable as described in the above Formulation Examples with water and applied onto the entire surface of the foliages of the weeds and the crop plants by a small spray. Two weeks after the application of the herbicide solution, the herbicidal effects against each weed were determined on the basis of the standard ratings described in Test Example 1, and the phytotoxicity against each crop plant was determined on the basis of the standard ratings in Test Example 1. The results are shown in Table 7. The Compound Nos. in Table 7 correspond to the Compound Nos. in Table 3.

In Tables 6 and 7, the following abbreviations are used:

Dose: Dose of active ingredient (g/are)

EC: Echinochloa crus-galli (barnyardgrass)

SE: Setaria viridis (green foxtail)

EL: Eleusine indica (goosegrass)

DI: Digitaria adscendens (large crabgrass)

PA: Panicum dichotomiflorum (fall panicum)

AB: Abutilon theophrasti (velvet leaf)

AM: Amaranthus lividus (livid amaranth)

PO: Polygonum longisetum (persicaria blumei gross)

XA: Xanthium strumarium (cocklebur)

CY: Cyperus esculentus (yellow nutsedge)

ZE: Zea mays (corn)

                                      TABLE 6                                      __________________________________________________________________________     Compound                                                                       No.   Dose                                                                              EC SE                                                                               EL DI                                                                               PA AB AM PO CY ZE                                           __________________________________________________________________________           0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            1     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            2     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            3     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            4     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            6     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            7     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            8     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            9     1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            10    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            11    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            12    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            13    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            14    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            15    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            16    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            17    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            18    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            19    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            20    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            21    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            22    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            23    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            24    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            25    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            26    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            27    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            28    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            29    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            30    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            34    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            35    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            36    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            37    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            39    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            40    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            41    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            42    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            43    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            44    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            45    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            46    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            47    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            48    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            49    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                                  0.5                                                                               5  5 5  5 5  5  5  5  5  0                                            50    1  5  5 5  5 5  5  5  5  5  0                                                  2  5  5 5  5 5  5  5  5  5  0                                            Reference                                                                            4  3  1 3  3 1  4  5  5  0  0                                            Compound                                                                             8  4  2 4  4 2  5  5  5  0  0                                            A     16 5  3 5  5 3  5  5  5  1  1                                            Reference                                                                            4  5  5 5  5 5  1  1  1  2  0                                            Compound                                                                             8  5  5 5  5 5  2  2  2  3  0                                            B     16 5  5 5  5 5  3  3  3  4                                               __________________________________________________________________________

                                      TABLE 7                                      __________________________________________________________________________     Compound                                                                       No.   Dose                                                                              EC SE                                                                               EL DI                                                                               PA AB AM PO XA CY ZE                                        __________________________________________________________________________           0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         1     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         2     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         3     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         4     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         6     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         7     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         8     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         9     1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         10    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         11    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         12    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         13    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         14    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         15    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         16    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         17    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         18    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         19    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         20    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         21    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         22    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         23    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         24    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         25    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         26    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         27    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         28    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         29    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         30    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         34    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         35    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         36    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         37    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         39    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         40    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         41    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         42    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         43    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         44    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         45    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         46    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         47    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         48    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         49    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                               0.5                                                                               5  5 5  5 5  5  5  5  5  5  0                                         50    1  5  5 5  5 5  5  5  5  5  5  0                                               2  5  5 5  5 5  5  5  5  5  5  0                                         Reference                                                                            4  3  1 2  3 0  3  5  5  4  0  0                                         Compound                                                                             8  4  2 3  4 1  5  5  5  5  0  1                                         A     16 5  3 4  5 2  5  5  5  5  1  2                                         Reference                                                                            4  4  3 3  4 3  0  2  2  0  1  0                                         Compound                                                                             8  4  4 4  4 4  1  3  3  1  2  1                                         B     16 5  5 5  5 5  2  4  4  2  3  2                                         __________________________________________________________________________

In Tables 6 and 7, the Comparative Compounds are as follows:

Comparative Compound A: Atrazine ##STR49##

Comparative Compound B: Alachlor ##STR50## 

What is claimed is:
 1. A pyrazole derivative having the formula:wherein A is an alkyl group having from 1 to 3 carbon atoms, an alkenyl group having from 2 to 4 carbon atoms or an alkynyl group having from 2 to 4 carbon atoms; B is a hydrogen atom, an alkyl group having from 1 to 3 carbon atoms, a halogen atom, a haloalkyl group having from 1 to 3 carbon atoms, an alkoxy group having from 1 to 3 carbon atoms, an alkylthio group having from 1 to 3 carbon atoms, an alkoxyalkyl group having from 2 to 4 carbon atoms, an alkylthioalkyl group having from 2 to 4 carbon atoms or an alkoxycarbonyl group having from 2 to 4 carbon atoms; X is an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, a cyano group, a haloalkyl group having from 1 to 6 carbon atoms, an alkoxyalkyl group having from 2 to 6 carbon atoms, an alkylcarbonyl group having from 2 to 6 carbon atoms, an alkoxy group having from 2 to 6 carbon atoms, an aminocarbonyl group substituted independently by hydrogen or alkyl having from 1 to 6 carbon atoms, a haloalkoxy group having from 1 to 6 carbon atoms, an alkylthio group having from 1 to 6 carbon atoms or an alkylthioalkyl group having from 2 to 6 carbon atoms; Y is a --COOR1 group (wherein R1 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a cycloalkylalkyl group having from 4 to 8 carbon atoms, an alkynyl group having from 3 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, a halocycloalkyl group having from 3 to 8 carbon atoms, a haloalkynyl group having from 3 to 6 carbon atoms, a haloakenyl group having from 2 to 6 carbon atoms or a phenyl group which may be substituted by alkyl having from 1 to 3 carbon atoms, halogen, nitro or alkoxy having from 1 to 3 carbon atoms), a --COO--L--OR1 group (wherein L is an alkylene group having from 1 to 6 carbon atoms which may be substituted by alkyl having from 1 to 3 carbon atoms, and R1 is as defined above), a --COO--L--R2 group (wherein L is as defined above, and R2 is a phenyl group which may be substituted by alkyl having from 1 to 3 carbon atoms, halogen, nitro or alkoxy having from 1 to 3 carbon atoms), a COO--L--O--L--R2 group (wherein L and R2 are as defined above), a --COO--L--S(O)_(n) --R1 group (wherein L and R1 are as defined above, and n is an integer of from 0 to 2), a --CON(R3)(R4) group (wherein each of R3 and R4 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a cycloalkylalkyl group having from 4 to 8 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an alkynyl group having from 2 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, a halocycloalkyl group having from 3 to 8 carbon atoms, a haloalkynyl group having from 2 to 6 carbon atoms, a haloalkenyl group having from 2 to 6 carbon atoms or a phenyl group which may be substituted by alkyl having from 1 to 3 carbon atoms, halogen, nitro or alkoxy having from 1 to 3 carbon atoms, --COO--L--N(R3)(R4) group (wherein L, R3 and R4 are as defined above), a --COO--L--CO--R1 group (wherein L and R1 are as defined above), a --COO--L--CO--O--R1 group (wherein L and R1 are as defined above), a --COO--L--CN group (wherein L is as defined above), a --COO--L--NO₂ group (wherein L is as defined above), a --COOSi(R5)₃ group (wherein R5 is as defined above), a --COO--N═C(R6)(R7) group (wherein each of R6 and R7 which may be the same or different is an alkyl group having from 1 to 3 carbon atoms), a --COO--N═C--(CH₂)_(n) group (wherein n is an integer of from 4 to 6), a --COO--L--O--SO₂ --R1 group (wherein L and R1 are as defined above), a --COO--L--O--CO--R1 group (wherein L and R1 are as defined above, a --COO--L--O--L--O--R1 group (wherein L and R1 are as defined above), a --COO--L--Si(R5)₃ group (wherein L and R5 are as defined above); Z is a halogen atom, a nitro group, an alkoxy group having from 1 to 3 carbon atoms, a trifluoromethyl group, a cyano group or a --S(O)_(n) R10 group (wherein R10 is an alkyl group having from 1 to 3 carbon atoms or a haloalkyl group having from 1 to 3 carbon atoms, and n is an integer of from 0 to 2); Q is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted by halogen, an alkenyl group having from 1 to 6 carbon atoms which may be substituted by halogen, an alkynyl group having from 1 to 6 carbon atoms which may be substituted by halogen, a cyanomethyl group, a --C(O)--R11 group (wherein R11 is a phenyl group which may be substituted by the same or different substituents selected from the group consisting of alkyl having from 1 to 6 carbon atoms, alkenyl having from 1 to 6 carbon atoms, alkynyl having from 1 to 6 carbon atoms, haloalkyl having from 1 to 6 carbon atoms, haloalkenyl having from 1 to 6 carbon atoms, haloalkynyl having from 1 to 6 carbon atoms, halogen, nitro and trifluoromethyl, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms or a hydroxyl group), a --S(O)₂ R11 group (wherein R11 is as defined above), a --P(O)(OR11)₂ group (wherein R11 is as defined above), a --L--C(O)--R11 group (wherein L and R11 are as defined above), a --L--C(O)--N(R12)(R13) (wherein L is as defined above, each of R12 and R13 is a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms), a --L--R14 group (wherein L is as defined above, R14 is a different substituents selected from the group consisting of halogen, nitro and trifluoromethyl, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms or a hydroxy group), a --L--N(R12)(R13) group (wherein L, R12 and R13 are as defined above), a --L--OR15 group (wherein R15 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an alkenyl group having from 1 to 6 carbon atoms), a --L--OC(O)R16 group (wherein R16 is an alkyl group having from 1 to 6 carbon atoms or an alkoxy group having from 1 to 6 carbon atoms), a --L--S(O)_(n) R15 group (wherein R15 is as defined above, and n is an integer of 0 or 2), a --L--SC(O)R12 group (wherein R12 is as defined above), or a salt thereof.
 2. The pyrazole derivative according to claim 1, wherein A, B, X, Y, Z and Q in the formula I are respectively selected from the following substituents:A: Me, Et, n-Pr, i-Pr, CH₂ CH═CH₂, CH₂ C.tbd.CH B: H, Me, Et, n-Pr, i-Pr, Cl, Br, CH₂ Cl, CF₃, OMe, OEt, Opr-i, SME, CH₂ OMe, CH₂ SMe, CO₂ Me, CO₂ Et X: Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, OMe, OEt, OPr-n, OPr-i, OBu-n, OBu-i, OBu-s, OBu-t, F, Cl, Br, I, NO₂, CN, CH₂ F, CHF₂, CF₃, CH₂ CF₃, CH₂ Cl, CCl₃, CHClMe, CH₂ CH₂ Cl, CHClCH₂ Cl, CH₂ Br, CHBrMe, CH₂ CH₂ Br, CH₂ OMe, CH₂ OEt, CH₂ OPr-n, CH₂ OPr-i, CH₂ OBu-n, CH₂ OBu-i, CH₂ OBu-s, CH₂ OBu-t, CHMeOMe, CHMeOEt, CHMeOPr-n, CHMeOPr-i, CHMeOBu-n, CHMeOBu-i, CHMeOBu-s, CHMeOBu-t, CH₂ CH₂ OMe, CH₂ CH₂ OEt, CH₂ CH₂ OPr-i, Ac, COEt, COPr-n, COPr-i, COOMe, COOEt, COOPr-i, CONHMe, CONHEt, CONMe₂, CONEt₂, CONEtMe, OCHF₂, OCF₃, OCH₂ CF₃, SME, SEt, CH₂ SMe, CH₂ SEt, CHMeSMe, CHMeSEt Y: COOH, COOMe, COOEt, COOPr-n, COOPr-i, COOBu-n, COOBu-s, COOBu-i, COOBu-t, COOAm-i, ##STR51## COOCH₂ CH═CH₂, COOCH₂ C.tbd.CH, COOCH₂ CMe═CH₂, COOCH₂ CH₂ Br, COOCH₂ CH₂ Cl COOCH₂ CH₂ F, COOCH₂ CCl₃, COOCH₂ CHF₂, COOCH₂ CF₃, ##STR52## COOCH₂ CCl═CH₂, COOCH₂ CCl═CHCl, COOCH₂ OMe, COOCH₂ CH₂ OMe, COOCH₂ CH₂ OEt, COOCH₂ OEt, COOCH₂ SMe, COOCH₂ CH₂ SMe, COOCH₂ CH₂ SEt, COOCH₂ CH₂ SCH₂ CH₂ Cl, COOCH₂ SOMe, COOCH₂ CH₂ SOMe, COOCH₂ CH₂ OCH₂ CH₂ Cl, COOCH₂ CH₂ OCH₂ CH₂ Br, COOCH₂ CH₂ OSO₂ Me, COOCH₂ CH₂ OSO₂ Ph-Me-4, COOCH₂ OCH₂ CH₂ OMe, COOCH₂ CH₂ SO₂ Et, COOCH₂ SO₂ Me, COOCH₂ CN, COOCH₂ CH₂ CN, COOCH₂ CH₂ CH₂ CN, COOCH₂ CH₂ NHMe, COOCH₂ CH₂ NMe₂, COOCH₂ NMe₂, COOCH₂ CH₂ NO₂, COOCH₂ CH₂ CH₂ NO₂, COOCH₂ OH, ##STR53## COOCH₂ COMe, COOCH₂ COBu-t, COOCH₂ COPr-i, COOCH₂ COPh, COOCH₂ COOMe, COOCH₂ COOEt, COOCHMeCOOMe, COOCMe₂ OOMe, COOCH₂ CH₂ OCH₂ CH═CH₂, COOCH₂ CH₂ OCH₂ C.tbd.CH, COOCH₂ CH₂ OPh, COOCH₂ OPh, COOCH₂ CH₂ OCH₂ Ph, COOCH₂ SiMe₃, COOSiMe₃, COOSiEt₃, COOPh, COOPh-Cl-4, COOPh-Me-4, COOPh-OMe-4, COOPh-NO₂ -4, COOCH₂ Ph, COOCH₂ Ph-Cl-2, COOCH₂ Ph-Cl-4, COOCHMePh, COOCH₂ CH₂ Ph, CONMe₂, CONHMe, CONEt₂, CONHEt, CONHPr-n, CONHPr-i, CONHBu-t, CONHBu-s, CONHBu-i, CONHBu-n, CONHAm-t, CONPr₂ -i, CONPr₂ -n, CONHPh, CONHPh-Me-4, CONHPh-NO₂ -4, CONMeOMe, CONHCH₂ CH═CH₂, CON(CH₂ CH═CH₂)₂, CONHCH₂ C.tbd.CH, CON(CH₂ C.tbd.CH)₂, CONMePh, CONEtPh, CON(Me)Ph-Me-4, CONHSO₂ Me, CONHSO₂ CF₃, COON═CMe₂, ##STR54## COOCH₂ OCOMe, COOCH₂ OCOBu-t, Z: F, Cl, Br, I, NO₂, OMe, OEt, OPr-n, OPr-i, CF₃, CN, SMe, SOMe, SO₂ Me, SCF₃, SOCF₃, SO₂ CF₃ Q: H, Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, CH₂ CH₂ Cl, CH₂ CF₃, CHClMe, CH₂ CH₂ Br, CHClCH₂ Cl, CH₂ CH═CH₂, CH₂ CMe═CH₂, CH₂ CH═CHMe, CH₂ C.tbd.CH, CH₂ CCl═CH₂, CH₂ CN, CH₂ Ph, CH₂ Ph-Cl-2, CH₂ Ph-Cl-3, CH₂ Ph-Me-2, ##STR55## CH₂ Ph-Me₂ -2,4, CH₂ Ph-Me-4, CHMePh, CHEtPh, CH₂ Ph-NO₂ -2, CH₂ Ph-CF₃ -3, CH₂ OMe, CH₂ OEt, CH₂ OH, CHMeOH, CH₂ NHMe, CH₂ NMe₂, CHMeNMe₂, CH₂ COPh, CH₂ COPh-NO₂ -4, CH₂ COPh-Me-4, CH₂ COPh-Cl-4, CH₂ COPh-Me₂ -2,4,CH₂ COPh-CF₃ -4, CH₂ Ac, CH₂ COEt, CHMeAc, CH₂ CO₂ Me, CH₂ CO₂ Et, CH₂ CO₂ Pr-n, CH₂ CO₂ Pr-i, CH₂ CO₂ Bu-t, CH₂ CO₂ H, CHMeCO₂ H, CH₂ CONMe, CH₂ CONMe₂, CH₂ CONHEt, CH₂ CONEt₂, CH₂ CONPr-n₂, CH₂ OCH₂ CH═CH₂, CH₂ OAc, CH₂ COEt, CH₂ COPr-i, CH₂ COBu-t, CH₂ OCO₂ Me, CH₂ OCO₂ Et, CH₂ OCO₂ Pr-i, CH₂ OCO₂ Bu-t, CH₂ SMe, CH₂ SEt, CH₂ SCH₂ CH═CH₂, CH₂ SAc, CH₂ SCOBu-t, CH₂ SO₂ Me, CH₂ SO₂ Et, CH₂ SO₂ CH₂ CH═CH₂, CH₂ NHCH₂ CH═CH₂, CH₂ NMeCH₂ CH═CH₂, CH₂ NHAc, CH₂ NHCOEt, CH₂ NHCO₂ Me, CH₂ NHCO₂ Et, CH₂ NMeCO₂ Me, COPh, COPh-Me-4, COPh-NO₂ -2, COPh-Cl₂ -2,4, Ac, COEt, COPr-n, COPr-i, COBu-n, COBu-t, COCH₂ Cl, COCHCl₂, COCCl₃, COCF₃, COCH₂ OMe, COCH₂ OPh, COCH₂ CH═CHCH₃, CO₂ Me, CO₂ Et, CO₂ Bu-t, CO₂ Pr-i, CONHMe, CONMe₂, CONHEt, CONEt₂, CONPr-n₂, CON(CH₂ CH═CH₂)₂, CONMePh, CO₂ CH₂ Ph, CO₂ Ph, SO₂ Me, SO₂ Et, SO₂ CH₂ CH═CH₂, SO₂ Ph, SO₂ Ph-Me-4, SO₂ Ph-Cl-4, SO₂ Ph-(NO₂)₂ -2,4, SO₂ CF₃, P(═O)(OMe)₂, P(═O)(OEt)₂, P(═O)(OPr-n)₂, P(═O)(OPr-i)₂, P(═S)(OMe)₂, P(═S)(OEt)₂, P(═O)OMeOPh, P(═O)(OCH₂ CH═CH₂)₂, P(═O)OPhOCH₂ CH═CH₂.
 3. The pyrazole derivative according to claim 1, wherein A, B, X, Y, Z and Q in the formula I are respectively selected from the following substituents:A: Me, Et, n-Pr, i-Pr, CH₂ CH═CH₂, CH₂ C.tbd.CH B: H, Me, X: Me, Et, i-Pr, OMe, OEt, OPr-i F, Cl, Br, I, NO₂, CN, OBu-t, CF₃, CH₂ OMe, Ac, COOMe, COOEt, COOPr-i, OCHF₂, OCF₃, OCH₂ CF₃, SMe, CH₂ SMe, Y: COOMe, COOEt, COOPr-n, COOPr-i, COOBu-t, COOAm-i, COOCH₂ CH═CH₂,COOCH₂ C.tbd.CH, COOCH₂ CH₂ Cl COOCH₂ CF₃, COOCH₂ CH₂ OMe, COOCH₂ CH₂ CN COOCH₂ COOMe, COOCH₂ COOEt, COOCH₂ COOPr-i, COOCH₂ COOBu-t, CONMe₂, COON═CMe₂, Z: F, Cl, Br, I, NO₂, OMe, CF₃, CN, SMe, SOMe, SO₂ Me, SCF₃, SOCF₃, SO₂ CF₃ Q: H, --CH₂ Ph, CH₂ COPh, SO₂ (4-Me-Phenyl) CH₂ OC(O)Bu-t, CH₂ COMe, CH₂ OMe, CH₂ CO(4-Me-Phenyl), CH₂ COOH.
 4. A selective herbicidal composition comprising a herbicidally effective amount of a pyrazole derivative of the formula I as defined in claim 1 or its salt and an agricultural carrier or diluent.
 5. A method for controlling weeds, which comprises applying a herbicidally effective amount of a pyrazole derivative of the formula I as defined in claim 1 or its salt to a locus to be protected. 